检索结果-南通市图书馆

Design and Development of an <i>in Vitro</i>Assay for Evaluation of Solid Vaginal Dosage Forms

在线全文

学校读者我要写书评

暂无评论

Pharmacology & Pharmacy 2011年第4期2卷 289-298页

作者： Jyoti Gupta Jason qihai Tao Sanjay Garg Raida Al-Kassas 不详

Vaginal dosage forms are seen as a viable option for empowering women to protect themselves from the risk of HIV transmission. Because of limited research in the field, there is a lack of suitable dissolution methods established for determination of drug release from vaginal formulations inside the vaginal tract. The main aim of this study was to develop a simple, reliable and reproducible in vitro release method for evaluation of solid vaginal dosage forms (VDFs) which was hoped to exhibit a close in vitro-in vivo correlation. Dapivirine, a drug being developed as a microbicide and a well established marketed anti fungal drug, Clotrimazole were used as model drugs. Two doses (0.5 mg and 1.25 mg) of Dapivirine were prepared as novel rapidly disintegrating, bioadhesive tablets. Clotrimazole 100 mg, prepared in house as conventional release tablets and commercially available Canesten (Clotrimazole tablet 100 mg) were used. The in vitro drug release testing of these tablets was carried out using a designed system which consisted of modified USP dissolution Apparatus II in conjunction with Enhancer cell (as sample holder) in 150 ml capacity flasks instead of the standard 900 ml flasks. The suitability of the system was investigated for variable parameters such as formulation types, drug concentration, stirring speeds, media volume and comparison of in house product with marketed product. The method was successfully optimized at a volume of 100 ml and a low speed of 25 rpm at pH 4 and was found sensitive enough to distinguish between formulations and evaluate products of different strengths. A linear drug release profile (R2 = 0.99) was obtained in case of Dapivirine, indicating that drug release is controlled by diffusion. The developed dissolution system has a potential to exhibit a good in vitro-in vivo correlation in addition to carrying out routine dissolution tests for solid VDFs.

关键词： Vaginal Solid Dosage Forms Enhancer Cell Dapivirine Clotrimazole

我国农林牧渔业短期贷款企业违约判别实证分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

金融论坛 2006年第1期11卷 14-19页

作者：管七海招商银行博士后科研工作站

近几年,我国农林牧渔业短期贷款企业的违约严重程度一直居所有行业之首,从跨行业的角度评估该行业短期贷款企业的违约具有重要意义。本文基于全国跨银行的贷款企业海量数据库样本,针对农林牧渔业的短期贷款企业进行了分规模和分地区样... 详细信息

近几年,我国农林牧渔业短期贷款企业的违约严重程度一直居所有行业之首,从跨行业的角度评估该行业短期贷款企业的违约具有重要意义。本文基于全国跨银行的贷款企业海量数据库样本,针对农林牧渔业的短期贷款企业进行了分规模和分地区样本的多元判别分析模型、Logistic模型与神经网络模型等的构建与实证探索,进而找出了影响我国农林牧渔业企业违约的关键变量,构建了最佳违约判别模型。这些关键变量和判别模型对中国人民银行和各商业银行监测该行业企业的信用风险具有重要的参考价值。

关键词：农林牧渔业短期贷款企业违约模型多元判别模型 Logistic模型神经网络模型

Forest seasonality shapes diet of limestone-living rhesus macaques at Nonggang, China

在线全文

学校读者我要写书评

暂无评论

Forest seasonality shapes diet of limestone-living rhesus ma...

第十三届全国野生动物生态与资源保护学术研讨会暨第六届中国西部动物学学术研讨会

作者： Chuangbin Tang Libin Huang Zhonghao Huang Changhu Lu qihai Zhou College of Biology and the Environment Nanjing Forestry University Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection Ministry of Education

Limestone forests are an unusual habitat for primates,but little information is available for the genus Macaca in such habitats,making a comparative understanding of extant limestone primates’behavioral adaptation *** collected data on the diet of rhesus macaques(Macaca mulatta)in limestone habitat at Nonggang Nature Reserve,southwestern Guangxi,China,and examined the effects of forest seasonality on their *** results

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

程序设计新工具:N-S-Z 图结构化技术

计算机科学 1992年第1期19卷 46-49页

作者：周启海西南财经大学成都610074

一、引言程序设计描述技术,归根到底,无非是以图形为描述基础的图示技术(例如：N-S图、Jackson图、PAD方法等)

关键词：程序设计 N-S-Z图结构化技术

基于迁移学习的小样本垂直阵目标距离估计方法

在线全文

学校读者我要写书评

暂无评论

哈尔滨工程大学学报 2022年第6期43卷 761-769页

作者：姚琦海汪勇杨益新西北工业大学航海学院陕西西安710072 陕西省水下信息技术重点实验室陕西西安710072

针对仅有少量水声数据海域的目标距离估计问题,本文以声场复声压的实部和虚部为特征,构建迁移学习模型,在利用卷积神经网络对预选海域大量水声数据进行预训练的基础上,对探测海域小样本水声数据进行再训练,从而实现小样本水声数据下的... 详细信息

针对仅有少量水声数据海域的目标距离估计问题,本文以声场复声压的实部和虚部为特征,构建迁移学习模型,在利用卷积神经网络对预选海域大量水声数据进行预训练的基础上,对探测海域小样本水声数据进行再训练,从而实现小样本水声数据下的水下声源距离估计。利用SWellEX-96实验无强干扰的S5航次数据和有强干扰的S59航次数据进行了方法的验证,对实验中的浅源和深源实现距离估计,对比了匹配场处理、传统卷积神经网络和迁移学习3种方法的水下目标声源距离估计性能。实验结果表明:基于卷积神经网络的迁移学习模型在无强干扰和有强干扰2种环境中均可有效实现距离估计,且估计性能明显优于传统卷积神经网络和匹配场处理方法。

关键词：迁移学习小样本垂直阵距离估计强干扰卷积神经网络 SWellEX-96实验匹配场处理

建立我国贷款企业违约率测度的多维度分析体系研究

在线全文

学校读者我要写书评

暂无评论

金融论坛 2005年第8期10卷 41-45页

作者：管七海北京大学-招商银行博士后科研工作站

目前对各个信用等级违约概率进行简单历史平均值的统计测度,不足以精确说明中国贷款企业违约的实际状况。论文以巴塞尔新资本协议违约率测度为基础,针对中国贷款企业的实际特点,提出了能精确刻画企业违约状况的多维度违约率分析体系,即... 详细信息

目前对各个信用等级违约概率进行简单历史平均值的统计测度,不足以精确说明中国贷款企业违约的实际状况。论文以巴塞尔新资本协议违约率测度为基础,针对中国贷款企业的实际特点,提出了能精确刻画企业违约状况的多维度违约率分析体系,即企业的违约率测度要以信用等级违约率为核心,行业违约率、地区违约率、规模违约率、不同所有制违约率以及企业违约频率为补充的多维度体系,同时引入相应的定量指标及测算公式,并利用全国跨银行的贷款企业数据库,实际测算了我国短期贷款企业以上各种维度违约率的表现,结果表明:以上违约率在我国短期贷款企业所在的不同行业、不同地区、不同规模和不同所有制之间有显著差异性。

关键词：巴塞尔新资本协议中国贷款企业违约率多维度体系贷款企业统计测度维度分析体系研究企业违约信用等级

Genetic Diversity and Population Structure of North China Mountain Walnut Revealed by ISSR

在线全文

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2014年第21期5卷 3194-3202页

作者： Aiqing Ji Yina Wang Guoliang Wu Wenjiang Wu Hongyan Yang qihai Wang College of Horticultural Science Henan Agricultural University Zhengzhou China Department of Biology Science Technology Jinzhong College Jinzhong China Department of Food Science and Technology Henan Agricultural University Zhengzhou China Jinzhong Meteorological Bureau Jinzhong China

North China Mountain Walnut (NCMW) is one of the ancestors of extant cultivated species, and a valuable gene resource for resistance breeding of walnut in China. Inter-Simple Sequence Repeat (ISSR) primers were designed to evaluate the level and pattern of genetic diversity in eight populations of NCMW. Nine ISSR primers yielded 91 amplification products with different sizes, of which 84 (92.31%) were polymorphic. A high species-level genetic diversity was detected with Nei’s (H = 0.2592) and Shannon’s diversity (I = 0.4003). In contrast, the population-level genetic diversity was relatively lower (PPB = 43.27%, H = 0.1347, I = 0.1862). Coefficient of populations differentiation (GST) was 0.5066, indicating that inter-population and intra-population variation contributed 50.66% and 49.34% respectively to the total genetic variability. This relative level of variation was further supported by AMOVA analysis. Limited gene flow (Nm = 0.5133.), habitat fragmentation and geographical isolation might be responsible for the population structure of NCMW. UPGMA cluster analysis classified the eight populations into three groups which showed no significant relationship between the genetic similarity coefficient and geographic origin but showed remarkable association with morpho-physiological characters, particularly nut traits. The results of the study provide species-level and population-level genetic profiles for further exploitation and conservation of genetic diversity of NCMW.

关键词： North China Mountains Walnut (NCMW) Genetic Diversity Population Structure ISSR

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

套管内换向连续冲砂装置的研制与应用

石油机械 2007年第7期35卷 38-40,71+80页

作者：于启海辽河石油勘探局锦州工程技术处

为了解决传统停泵接冲砂管冲砂工艺中存在的诸多问题,研制了套管内换向连续冲砂装置,实现了套管内换向的不停泵连续冲砂作业模式,现场应用效果较好,该装置具有以下特点:(1)在冲砂过程中不需要停泵即可连接冲砂管,可有效避免因停泵接冲... 详细信息

为了解决传统停泵接冲砂管冲砂工艺中存在的诸多问题,研制了套管内换向连续冲砂装置,实现了套管内换向的不停泵连续冲砂作业模式,现场应用效果较好,该装置具有以下特点:(1)在冲砂过程中不需要停泵即可连接冲砂管,可有效避免因停泵接冲砂管而造成的沉砂卡管事故,减少处理砂卡及大修解卡施工;(2)不需要在油管上部连接冲砂油壬和水龙带,从而大大降低冲砂作业的劳动强度,避免弯头脱落造成落物伤人事故;(3)连续不停泵冲砂可以提高冲砂作业质量,延长油井生产周期,增加原油产量;(4)现场安装和使用都比较方便,尤其对于大井段冲砂和水平井冲砂具有明显优势。

关键词：连续冲砂井口自封换向阀衬管

Feeding Ecology of One group of Francois langur （Trachypithecus francoisi） in Nonggang Nature Reserve

在线全文

学校读者我要写书评

暂无评论

Feeding Ecology of One group of Francois langur （Trachypith...