检索结果-南通市图书馆

CMHX008,a PPAR γ partial agonist,enhances insulin sensitivity with minor influences on bone loss

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2018年第3期5卷 290-299页

作者： Yi Hou Xuemei Cao Xiangnan Hu Xinyu li Xiaoqin Shi Hongying Wang Chuan Peng Jiayu li Jibin li qifu li Chaodong Wu Xiaoqiu Xiao Department of Endocrinology The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016China College of Pharmacy Chongqing Medical UniversityChina The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016China Department of Nutrition and Food Hygiene School of Public Health and ManagementChongqing Medical UniversityChongqing400016China Canada-China-New Zealand Joint Laboratory of Maternal and Fetal Medicine Chongqing Medical UniversityChongqing400016China Department of Nutrition and Food Science Texas A&M UniversityCollege StationTX77843USA

Traditional thiazolidinediones(TZDs),such as rosiglitazone,are peroxisome proliferator-activated receptor g(PPARg)potent agonists that can be used to treat type 2 diabetes but carry unwanted effects,including increased risk for *** present work aimed to compare the insulin-sensitizing efficacies and bone-loss side effects of CMHX008,a novel TZDs-like PPARg partial agonist,with those of rosiglitazone.A TR-FRET PPARg competitive binding assay was used to compare the binding affinity between CMHX008 and *** were administered vehicle,CMHX008 or rosiglitazone for 16 *** stem cells(MSCs)were used to examine differences in differentiation into osteoblasts after compounds ***-FRET showed lower affinity to PPARg by CMHX008 compared with *** treated with CMHX008 showed insulin sensitization similar to that of mice treated with rosiglitazone,which was related to the significant inhibition of PPARg Ser273 phosphorylation and improved insulin sensitivity by facilitating the phosphorylation of insulin receptor and Akt in adipose ***-CT and histomorphometric analyses demonstrated that the degree of trabecular bone loss after treatment with CMHX008 was weaker than that observed with rosiglitazone,as evidenced by consistent changes in BV/TV,Tb.N,***,***,and the mineral apposition *** treated with CMHX008 showed higher ALP activity and mRNA levels of bone formation markers than did cells treated with rosiglitazone in the osteoblast differentiation ***,CMHX008 showed insulin-sensitizing effects similar to those of rosiglitazone with a lower risk of bone loss,suggesting that PPARg sparing eliminates the skeletal side effects of TZDs while maintaining their insulin-sensitizing properties.

关键词： Osteoblasts Peroxisome proliferator-activated receptor g Thiazolidinediones TR-FRET Type 2 diabetes mellitus

Effect of catgut embedding at acupoints versus non-acupoints in abdominal obesity:a randomized clinical trial

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2023年第4期43卷 780-786页

作者： ZHANG Xinghe li qifu YI Rong XING Chonghui JIN Yuhao MENG Jiangqiong FENG Jialei ZHAO Siwen liANG Fanrong GUO Taipin School of Second Clinical Medicine/The Second Affiliated Hospital Yunnan University of Chinese MedicineKunming 650500China Department of Acupuncture and Moxibustion Kunming Hospital of Traditional Chinese MedicineKunming 650200China Department of Acupuncture and Moxibustion the Sports Trauma Specialist Hospital of Yunnan ProvinceKunming 650051China Institute for History of Medicine and Medical literature China Academy of Chinese Medical SciencesBeijing 100027China School of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu 610075China

OBJECTIVE:To explore the difference of catgut embedding effect between acupoints and non-acupoints in patients with abdominal obesity(AO).METHODS:In this multicenter,double-blind,randomized controlled trial,all subjects were randomly assigned into the acupoint catgut embedding(ACE)group and control group(catgut embedding at non-acupoints).With a 12-week actual intervention period and a 4-week period of *** circumference(WC),body weight,body mass index(BMI),hip circumference(HC)and appetite were applied and assessed at baseline and after 6,12 and 16 ***:After the total intervention phase(12 weeks),the WC,body weight,BMI,HC and visual analogue scale scores of appetite,decreased significantly in the two groups as compared to the baseline(Pliver lasting results.

关键词： acupoint catgut embedding non-acupoints obesity abdominal waist circumference randomized controlled trial

同方期刊数据库

Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2022年第2期9卷 401-414页

作者： Min Wu Maolin liao Rongfeng Huang Chunxiu Chen Tian Tian Hongying Wang Jiayu li Jibin li Yuxiang Sun Chaodong Wu qifu li Xiaoqiu Xiao Department of Endocrinology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Department of Nutrition and Food Hygiene School of Public Health and ManagementChongqing Medical UniversityChongqing 400016PR China Department of Neurology Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou 550004PR China Department of Nutrition and Food Science Texas A&M UniversityCollege StationTX 77843USA

Type 2 diabetes mellitus(T2DM)and Alzheimer's disease(AD)share several common pathophysiological *** variants of triggering receptor expressed on myeloid cells 2(TREM2)increase the risk of developing AD,suggesting the involvement of TREM2 and innate immunity in AD *** is still unknown whether TREM2 is related to cognitive impairment in ***,we investigated the effects of the hippocampal overexpression of TREM2 on cognitive in long-term high-fat diet(HFD)-fed *** C57BL/6J mice were maintained on HFD for 50 ***2 was overexpressed in the hippocampus 36 weeks after HFD feeding using adeno-associated virus vector(AAV)-mediated gene *** results showed that the HFD feeding induced rapid and persistent weight gain,glucose intolerance and significant impairments in learning and *** with AAV-con,AAV-TREM2 significantly ameliorated cognitive impairment without altering body weight and glucose homeostasis in HFD *** overexpression of TREM2 upregulated the synaptic proteins spinophilin,PSD95 and synaptophysin,suggesting the improvement in synaptic *** complexity and spine density in the CA1 region were rescued after TREM2 ***,TREM2 markedly increased the number of iba-1/Arg-1-positive microglia in the hippocampus,suppressed neuroinflammation and microglial *** sum,hippocampal TREM2 plays an important role in improving HFD-induced cognitive dysfunction and promoting microglial polarization towards the M2 anti-inflammatory *** study also suggests that TREM2 might be a novel target for the intervention of obesity/diabetes-associated cognitive decline.

关键词： Diabetes Microglial polarization Neurodegeneration Neuroinflammation Obesity TREM2

Human herpesvirus 6B infection in mesial temporal lobe epilepsy:a meta-analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Epileptologica 2022年第2期5卷 97-104页

作者： Jingyi Tong Qin Zou Sheng Wang Jiaqi liu Rong Chen Yongmin Chen Wenjie Zhao lin Ma qifu li Department of Neurology Key Laboratory of Brain Disorders and Function ResearchThe First Affiliated Hospital of Hainan Medical University570102HaikouChina Key Laboratory of Brain Science Research&Transformation in Tropical Environment of Hainan Province Hainan Medical UniversityHaikou570102China Department of Psychology The First Affiliated Hospital of Hainan Medical UniversityHaikou570102China

Background Whether human herpesvirus 6B(HHV-6B)can affect mesial temporal lobe epilepsy(MTLE)remains *** present meta-analysis was aimed to evaluate whether HHV-6B is significantly associated with *** Six studies were included in this meta-analysis,comprising 183 MTLE patients and 75 *** these studies,HHV-6B infection in astrocytes and brain samples of MTLE patients and controls was investigated by polymerase chain reaction and *** The frequency of HHV-6B infection detection is significantly higher in the MTLE group than in the control group(OR=9.42,95%CI:3.66–24.25),(Plized to cells positive for GFAP that morphologically resemble ***-6B mainly infects astrocytes,oligodendrocytes and microglia,and could damage the vascular endothelial cells of the central nervous *** There is an association between HHV-6B infection and *** large-scale,multi-center,controlled,prospective studies are required to confirm these *** addition,the exact mechanism underlying the effects of HHV-6B infection on MTLE needs to be further investigated.

关键词： epilepsy infection analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

加强原发性醛固酮增多症的筛查:刻不容缓

重庆医科大学学报 2016年第11期41卷 1091-1093页

作者：李启富重庆医科大学附属第一医院内分泌科重庆400016

原发性醛固酮增多症简称"原醛症",是指肾上腺皮质病变导致自主性醛固酮分泌增多及肾素-血管紧张素系统受抑制,临床表现为高血压伴(或不伴)低血钾,实验室检查常提示血浆醛固酮水平增高和肾素水平降低。尽管针对原醛症已经具备有效的治疗... 详细信息

原发性醛固酮增多症简称"原醛症",是指肾上腺皮质病变导致自主性醛固酮分泌增多及肾素-血管紧张素系统受抑制,临床表现为高血压伴(或不伴)低血钾,实验室检查常提示血浆醛固酮水平增高和肾素水平降低。尽管针对原醛症已经具备有效的治疗方法,但目前国内外的现状是绝大部分患者仍未被发现和给予正确的治疗。本文重点就原醛症的流行病学、危害、诊断流程、诊断难点及解决办法作一评述。

关键词：原发性醛固酮增多症筛查

Molecular phylogenetic relationships of China Seas groupers based on cytochrome b gene fragment sequences

在线全文

学校读者我要写书评

暂无评论

Science China(life Sciences) 2006年第3期49卷 235-242页

作者： DING Shaoxiong, ZHUANG Xuan, GUO Feng, WANG Jun, SU Yongquan, ZHANG Qiyong & li qifu Department of Oceanography and Institute of Subtropical Oceanography, Xiamen University, Xiamen 361005, China Department of Biology, Xiamen University, Xiamen 361005, China Department of Oceanography and Institute of Subtropical Oceanography Xiamen University Xiamen China Department of Biology Xiamen University Xiamen China

The classification and evolutionary relationships are important issues in the study of the groupers. Cytochrome b gene fragment of twenty-eight grouper species within six genera of subfamily Epinephelinae was amplified using PCR techniques and the sequences were analyzed to derive the phylogenetic relationships of the groupers from the China Seas. Genetic information indexes, including Kimura-2 parameter genetic distance and Ts/Tv ratios, were generated by using a variety of biology softwares. With Niphon spinosus, Pagrus major and Pagrus auriga as the designated outgroups, phylogenetic trees, which invoke additional homologous sequences of other Epinephelus fishes from GenBank, were constructed based on the neighbor-joining (NJ), maximum-parsimony (MP), maximum-likelihood (ML) and minimum-evolution (ME) methods. Several conclusions were drawn from the DNA sequences analysis: (1) genus Plectropomus, which was early diverged, is the most primitive group in the subfamily Epinephelinae; (2) genus Variola is more closely related to genus Cephalopolis than the other four genera; (3) genus Cephalopolis is a monophyletic group and more primitive than genus Epinephelus; (4) Promicrops lanceolatus and Cromileptes altivelis should be included in genus Epinephelus; (5) there exist two sister groups in genus Epinephelus.

关键词： Epinephelinae, molecular phylogeny, cytochrome b, mitochondrial DNA.

Microsoft CryptoAPI安全框架分析及本地化策略

在线全文

学校读者我要写书评

暂无评论

微计算机信息 2006年第3X期22卷 42-44页

作者：李奇富北京华正天网信息安全技术有限公司无锡研发中心

本文分析了在Windows操作系统中广泛采用的MicrosoftCryptoAPI安全框架,并就如何针对中国的国情进行本地化改造的问题进行了一些探讨。

关键词： CryptoAPI 安全框架安全加密本地化

新型降糖药钠-葡萄糖共转运蛋白2抑制剂在降糖之外的贡献

在线全文

学校读者我要写书评

暂无评论

中华内分泌代谢杂志 2016年第3期32卷 261-264页

作者：李启富重庆医科大学附属第一医院内分泌科 400016

我国糖尿病患病率迅速升高。2010年中国慢病监测暨糖尿病专题调查显示，我国成人糖尿病患病率为11．6％（约1．139亿例）。尽管当前有多种治疗手段，很多糖尿病患者仍不能达到或维持血糖目标。现有治疗的不良反应，包括低血糖、体重增... 详细信息

我国糖尿病患病率迅速升高。2010年中国慢病监测暨糖尿病专题调查显示，我国成人糖尿病患病率为11．6％（约1．139亿例）。尽管当前有多种治疗手段，很多糖尿病患者仍不能达到或维持血糖目标。现有治疗的不良反应，包括低血糖、体重增加、液体潴留以及胃肠道反应等。钠一葡萄糖共转运蛋白2抑制剂（SGLT-2i）是具有独特作用机制的新型降糖药物，通过促进尿糖排泄使2型糖尿病患者排出过多的葡萄糖而发挥降糖作用。SGLT-2i不但降糖疗效确切，而且其减轻体重和降血压以及最近发现的降低心血管事件风险等额外获益令人耳目一新，为管理2型糖尿病增添了新型武器。

关键词：糖尿病 2型钠-葡萄糖共转运蛋白2抑制剂额外获益

支持国产密码算法的Windows下密码安全应用中间件

在线全文

学校读者我要写书评

暂无评论

微计算机信息 2006年第4X期22卷 20-22,184页

作者：李奇富北京华正天网信息安全技术有限公司无锡研发中心江苏无锡214000

本文提出一个在Windows操作系统下开发密码安全应用中间件的解决方案,包括四种中间件:“基本密码服务中间件”、“PKI应用中间件”、“MS-Office安全加密中间件”和“Windows系统登录认证中间件”。

关键词：中间件加密 PKI 密码算法密码安全