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Organocatalytic difluorobenzylation of 1,2-diketones via mild cleavage of carbon-carbon bonds

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Organic Chemistry Frontiers 2022年第3期9卷 745-751页

作者： Yong zhang Guo-Wei Lai Long-Jun Nie qifang He Mei-Juan Lin Rong Chi Dong-Liang Lu Xiaolin Fan Key Laboratory of Organo-Pharmaceutical Chemistry Gannan Normal UniversityGanzhou 341000P.R.China

α-Aryl-α,α-difluoroacetophenones(DFAPs)are developed as a new class of difluorobenzylation reagents that can be facilely prepared from readily available and cheap starting *** situ carbon-carbon bond cleavage of electron-deficient DFAPs gives difluorobenzyl carbanions that undergo base-catalyzed nucleophilic addition to isatins.

关键词： materials benzyl cleavage

Piwil2蛋白和CyclinD1蛋白在乳腺恶性叶状肿瘤组织中表达及其相关性研究

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医学综述 2021年第2期27卷 385-389页

作者：李伟李双霞孟元华李凤玉张奇芳黄勇牛晓东朱利利陆军第八十一集团军医院病理科河北张家口075000 陆军第八十一集团军医院检验科河北张家口075000 陆军第八十一集团军医院肿瘤科河北张家口075000 陆军第八十一集团军医院麻醉科河北张家口075000 张家口市第一人民医院超声科河北张家口075000 解放军总医院第七医学中心妇科北京100700

目的探讨Piwil2蛋白和细胞周期蛋白D1(CyclinD1蛋白)在乳腺恶性叶状肿瘤组织中的表达及其相关性。方法收集1990年1月至2015年2月陆军第八十一集团军医院病理科和解放军总医院第七医学中心病理科存档的60例女性乳腺恶性叶状肿瘤患者的资... 详细信息

目的探讨Piwil2蛋白和细胞周期蛋白D1(CyclinD1蛋白)在乳腺恶性叶状肿瘤组织中的表达及其相关性。方法收集1990年1月至2015年2月陆军第八十一集团军医院病理科和解放军总医院第七医学中心病理科存档的60例女性乳腺恶性叶状肿瘤患者的资料进行回顾性分析,同时选取60例正常乳腺组织作为对照组。采用免疫组织化学(EnVision TM)法分别检测乳腺恶性叶状肿瘤组织和正常乳腺组织中Piwil2蛋白和CyclinD1蛋白的阳性表达情况,分析其表达与乳腺恶性叶状肿瘤相关临床病理因素之间的关系以及Piwil2蛋白和CyclinD1蛋白的相关性。结果Piwil2蛋白和CyclinD1蛋白在乳腺恶性叶状肿瘤组织中的阳性表达率分别为88.33%(53/60)、76.67%(46/60),但在正常乳腺组织均未表达。肿瘤直径≥9 cm、Ki-67≥25%、瘤细胞异型显著以及核分裂象≥15个/10个高倍镜视野的患者Piwil2蛋白表达水平高于肿瘤直径<9 cm、Ki-67<25%、瘤细胞异型不显著以及核分裂象<15个/10个高倍镜视野者(P<0.05)。Ki-67≥25%、瘤细胞异型性显著及核分裂象≥15个/10个高倍镜视野者CyclinD1蛋白的表达水平高于Ki-67<25%、瘤细胞异型不显著以及核分裂象<15个/10个高倍镜视野者(P<0.05)。乳腺恶性叶状肿瘤组织中Piwil2蛋白的表达与CyclinD1蛋白的表达呈正相关(r=0.413,P<0.01)。结论Piwil2蛋白和CyclinD1蛋白的过表达参与了乳腺恶性叶状肿瘤的形成,其表达水平可作为评判瘤细胞分裂、增殖的参考指标。

关键词：乳腺恶性叶状肿瘤 Piwil2蛋白细胞周期蛋白D1 增殖相关性

笑氧混合气体在老年患者舒适结肠镜检查中的临床应用

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右江医学 2016年第6期44卷 649-652页

作者：牛桂军张启芳陈卓琳李晓燕马玲玲谭显清黄福全广西壮族自治区南溪山医院消化内科桂林541002

目的评价笑氧混合气体应用于老年结肠镜诊疗的效果。方法将老年行结肠镜诊疗患者分为三组,笑气组(A组)300例,丙泊酚组(B组)300例,常规结肠镜检查组(C组)300例。比较三组镇痛效果和不良反应。结果三组镇痛效果比较差异有统计学意义(P0.5 ... 详细信息

目的评价笑氧混合气体应用于老年结肠镜诊疗的效果。方法将老年行结肠镜诊疗患者分为三组,笑气组(A组)300例,丙泊酚组(B组)300例,常规结肠镜检查组(C组)300例。比较三组镇痛效果和不良反应。结果三组镇痛效果比较差异有统计学意义(P0.5 h、头昏及乏力的发生率比较差异均有统计学意义(P<0.001),其中A组的低血压、心动过缓、低氧血症及清醒延迟率显著低于B组(P<0.001)。结论笑气应用于老年结肠镜检查止痛效果较好,安全性高,特别适于合并心、肺基础疾病的老年患者。

关键词：老年结肠镜检查舒适一氧化二氮丙泊酚

广西地区6家医院结肠镜下结直肠癌检出率的分析研究

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微创医学 2022年第3期17卷 272-276,281页

作者：梁斌姜志勇罗显克张启芳杨悦军何咖鲒卢东诚胡榜利姜海行广西医科大学第一附属医院消化内科广西南宁市530021 贵港市人民医院消化内科广西贵港市537199 广西壮族自治区民族医院消化内科广西南宁市530001 广西壮族自治区南溪山医院消化内科广西桂林市541002 梧州市工人医院消化内科广西梧州市543099 北海市人民医院消化内科广西北海市536006 广西医科大学附属肿瘤医院实验研究部广西南宁市530021

目的分析广西地区6家医院结肠镜下结直肠癌的检出率情况。方法收集2019年6月至2021年6月在广西5个地区6家三甲医院行结肠镜检查者的资料,根据不同年份、性别、年龄和医院进行分层,分别计算结肠镜下结直肠癌的检出率。结果共收集61786例... 详细信息

目的分析广西地区6家医院结肠镜下结直肠癌的检出率情况。方法收集2019年6月至2021年6月在广西5个地区6家三甲医院行结肠镜检查者的资料,根据不同年份、性别、年龄和医院进行分层,分别计算结肠镜下结直肠癌的检出率。结果共收集61786例行结肠镜检查者的资料,结直肠癌的总检出率为2.81%。与2019年、2021年相比,2020年结直肠癌的检出率最高(P<0.05);男性的结直肠癌检出率显著高于女性(P<0.05);不同年龄段结直肠癌检出率差异有统计学意义(P<0.05);北海市人民医院的结直肠癌检出率高于其他5家医院(P<0.05)。男性的结肠癌检出率、直肠癌检出率均高于女性(均P<0.05),北海市人民医院结肠癌检出率、直肠癌检出率均高于其他医院(均P<0.05);男性和女性结肠癌检出率均高于直肠癌检出率,30~79岁人群结肠癌检出率高于直肠癌检出率(均P<0.05)。结论广西地区结肠镜下结直肠癌的检出率为2.81%,不同年份、性别、年龄、医院之间结直肠癌的检出率存在差异,结肠癌检出率总体高于直肠癌。

关键词：结直肠癌结肠镜检出率广西

Centralized Bi-level Spatial-Temporal Coordination Charging Strategy for Area Electric Vehicles

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CSEE Journal of Power and Energy Systems 2015年第4期1卷 74-83页

作者： Lei Yu Tianyang Zhao qifang Chen Jianhua zhang State Key Laboratory of Alternate Power System with Renewable Energy Resources North China Electric Power UniversityBeijing 102206China

Increased penetration of electric vehicles(EVs)is expected to impact power system performance in adverse ways,e.g.,overloading,uncertain power quality,and increased voltage fluctuation,particularly at the distribution *** EV charging control strategies that have been proposed only benefit the grid or EV users.A centralized EV charging strategy based on bilevel optimization is proposed in this paper with the objectives of deriving benefits for the grid and EV users *** proposed strategy involves distributing the EV charging load more beneficially across both spatial and temporal *** the spatial problem,the whole fleet of EVs is controlled to minimize load variance as spatial coordination,with total charging rate and energy needed as the *** in the temporal problem,EVs in each aggregator are controlled to minimize the charging cost or maximize the EV user’s degree of satisfaction with each aggregator’s charging rate and energy needed as the *** proposed bi-level charging strategy is transformed to a single-stage optimization problem and solved using the classical optimization *** impacts of uncontrolled charging on the grid and EV users are studied using the Monte Carlo Simulation(MCS)***,the effectiveness of the proposed charging strategy is demonstrated via results obtained in the MCS.

关键词： Bi-level optimization centralized charging electric vehicles spatial temporal coordination

俄罗斯进口原油中饱和蒸气压检验标准的比对研究

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检验检疫学刊 2015年第2期25卷 67-70页

作者：刘名扬张其芳马嗣同王艳君郭慧慧任玉伟李卫刚赵景红陈会明大连交通大学环境科学与工程学院辽宁大连116028 辽宁出入境检验检疫局深圳出入境检验检疫局中国检验检疫科学研究院

通过比对ГОSТ标准、ISO标准、ASTM标准和我国原油检验GB标准,对进口俄罗斯原油中饱和蒸气压进行了实验比对分析研究。结果表明:采用ГОSТ和GB标准对相同原油样品中饱和蒸气压的检测结果存在明显偏差,从而为国际原油贸易谈判和争端... 详细信息

通过比对ГОSТ标准、ISO标准、ASTM标准和我国原油检验GB标准,对进口俄罗斯原油中饱和蒸气压进行了实验比对分析研究。结果表明:采用ГОSТ和GB标准对相同原油样品中饱和蒸气压的检测结果存在明显偏差,从而为国际原油贸易谈判和争端的解决提供了理论和实验依据。

关键词：原油检验标准饱和蒸气压比对

Herbicide 2,4-dichlorophenoxyacetic acid interferes with MAP kinase signaling in Fusarium graminearum and is inhibitory to fungal growth and pathogenesis

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Stress Biology 2023年第1期3卷 345-361页

作者： Kaili Duan qifang Shen Yu Wang Ping Xiang Yutong Shi Chenfei Yang Cong Jiang Guanghui Wang Jin-Rong Xu Xue zhang State Key Laboratory of Crop Stress Biology for Arid Areas College of Plant ProtectionNorthwest A&F UniversityYangling 712100ShaanxiChina Department of Botany and Plant Pathology Purdue UniversityWest LafayetteIN 47907USA

Plant hormones are important for regulating growth,development,and plant-pathogen *** of them are inhibitory to growth of fungal pathogens but the underlying mechanism is not *** this study,we found that hyphal growth of Fusarium graminearum was significantly reduced by high concentrations of IAA and its metabolically stable analogue 2,4-dichlorophenoxyacetic acid(2,4-D).Besides inhibitory effects on growth rate,treatments with 2,4-D also caused significant reduction in conidiation,conidium germination,and germ tube *** with 2,4-D had no obvious effect on sexual reproduction but significantly reduced TRI gene expression,toxisome formation,and DON *** importantly,treatments with 2,4-D were inhibitory to infection structure formation and pathogenesis at concentrations higher than 100μ*** presence of 1000μM 2,4-D almost completely inhibited plant infection and invasive *** ***,2,4-D induced ROS accumulation and FgHog1 activation but reduced the phosphorylation level of Gpmk1 MAP *** analysis showed that the accumulation of a number of metabolites such as glycerol and arabitol was increased by 2,4-D treatment in the wild type but not in the Fghog1 *** expressing the dominant active FgPBS2^(S451D T455D) allele were less sensitive to 2,4-D and had elevated levels of intracellular glycerol and arabitol induced by 2,4-D in *** together,our results showed that treatments with 2,4-D interfere with two important MAP kinase pathways and are inhibitory to hyphal growth,DON biosynthesis,and plant infection in ***.

关键词： Fungal pathogenesis MAP kinase pathways 2,4-D,Fusarium graminearum

Rationale and Design of a Randomized Controlled Trial on Intensive Management of Blood PRESSure and Cholesterol in Elderly Chinese with Hypertension and Atrial FibrillatION (IMPRESSION)

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Cardiology Discovery 2021年第3期1卷 173-178页

作者： Wei zhang Yi Chen qifang Huang Ji-Guang Wang Department of Cardiovascular Medicine Centre for Epidemiological Studies and Clinical TrialsShanghai Key Laboratory of HypertensionThe Shanghai Institute of HypertensionDepartment of HypertensionRuijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China

Hypertension significantly increases the risk of embolic stroke and systemic embolism in patients with atrial fibrillation, while statin therapy can improve long-term outcomes in hypertensive patients at high risk. However, it is still unclear whether patients with both hypertension and atrial fibrillation can benefit from intensive management of blood pressure and cholesterol. IMPRESSION is a 3-year prospective, randomized, open-label, blinded-endpoint investigation. A total of 1200 hypertensive patients with atrial fibrillation from about 40 clinical centers nationwide will be included upon confirming the presence of both hypertension and atrial fibrillation and will be randomly assigned to groups for intensive or standard management of blood pressure and cholesterol. Patients in all groups will have office and home blood pressure measured by the end of the first month and every 3 months thereafter. The effects of blood pressure and cholesterol management strategies in patients with hypertension and atrial fibrillation on fatal and non-fatal stroke, acute myocardial infarction, and cardiovascular death at 3 years will be assessed. The IMPRESSION study protocol has received approval from the Ethics Committee of Ruijin Hospital, Shanghai Jiaotong University School of Medicine. The procedures set out in this protocol are in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice guidelines. The results will be published following the CONSORT statement in a peer-reviewed scientific journal (Trial registration number: NCT04111419).

关键词： Atrial fibrillation Blood pressure Hypertension

基于贝塞尔函数基信号分解的微动群目标特征提取方法

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电子与信息学报 2016年第12期38卷 3056-3062页

作者：张群何其芳罗迎空军工程大学信息与导航学院西安710077 信息感知技术协同创新中心西安710077

微动特征提取是群目标分辨的有效手段,以往针对孤立目标的特征提取技术不再适用。针对此该文提出了一种基于信号分解的微动群目标特征提取方法。首先通过分析微动信号的正弦调频(SFM)形式,推导了SFM信号相位项在k-分辨率贝塞尔函数基上... 详细信息

微动特征提取是群目标分辨的有效手段,以往针对孤立目标的特征提取技术不再适用。针对此该文提出了一种基于信号分解的微动群目标特征提取方法。首先通过分析微动信号的正弦调频(SFM)形式,推导了SFM信号相位项在k-分辨率贝塞尔函数基上的分解结果;然后根据回波分解结果中微动频率与函数基的一一对应关系进行频率粗略估计,并针对误差产生原因给出了精确的微动频率估计方法;最后在离散信号相位解模糊的基础上,完成各子目标的微动频率提取。仿真实验验证了算法的有效性,且与正弦调频傅里叶变换(SFMFT)算法和平均幅度差函数(AMDF)算法相比具有更高精度。

关键词：微多普勒群目标贝塞尔函数基特征提取参数估计