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Electrophoretic Carbon Nanotube Field Emission Layer for Plasma Display Panels

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Nano-Micro Letters 2012年第4期4卷 247-252页

作者： qifa liu Zhuoqing Yang Yan Wang Guifu Ding National Key Laboratory of Science and Technology on Nano/Micro Fabrication Technology Research Institute of Micro/Nano Science and Technology Shanghai Jiao Tong University

A carbon-nanotube(CNT) electrophoretic deposition(EPD) process has been developed to prepare a field emission layer in plasma display panels(PDP) for discharge voltage reduction. The CNT layer as a source of discharge priming electrons has been fabricated on the PDP front panel. The balling grinding,mix-acid treatment and EPD parameters have been investigated in order to obtain good uniformity and excellent field emission capability of CNT layer, in order to meet the specifications of CNTs in PDP cell. The measured turn-on field was around 1.1 V/μm in the field emission testing while the minimum sustaining voltage was decreased by 30~40 V with the use of CNT layer in the discharge testing.

关键词： EPD Field emission CNT PDP Sustaining voltage

Investigation on photonic crystal nanobeam cavity based on mixed diamond–circular holes

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Nanotechnology and Precision Engineering 2024年第1期7卷 63-70页

作者： Jingtong Bin Kerui Feng Shang Ma Ke liu Yong Cheng Jing Chen qifa liu College of Telecommunication and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210003China State Key Laboratory of Advanced Optical Communication Systems and Networks Shanghai Jiao Tong UniversityShanghai 200240China

A photonic crystal nanobeam cavity(M-PCNC)with a structure incorporating a mixture of diamond-shaped and circular air holes is *** performance of the cavity is simulated and studied *** theﬁnite-difference time-domain method,the parameters of the M-PCNC,including cavity thickness and width,lattice constant,and radii and numbers of holes,are optimized,with the quality factor Q and mode volume Vm as performance *** modulation of the lattice constant and hole radius enable the proposed M-PCNC to realize outstanding *** optimized cavity possesses a high quality factor Q 1.45105 and an ultra-small mode=×volume Vm 0.01(λ/n)[Zeng et al.,Opt Lett 2023:48;3981–3984]in the telecommunications wavelength *** can be progres-=sively squeezed in both the propagation direction and the perpendicular in-plane direction by a series of interlocked anti-slots and slots in the diamond-shaped hole ***,the energy can be conﬁned within a small mode volume to achieve an ultra-high Q/Vm ratio.

关键词： Photonic crystal nanobeam cavity Mixed diamond–circular holes Slots and anti-slots FDTD simulation Quality factor Mode volume

Comparison of efficacy between HLA6/6-and HLA3/6-matched haploidentical hematopoietic stem cell transplant in T-cell-replete transplants between parents and children

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Science China(Life Sciences) 2019年第1期62卷 104-111页

作者： Wenjing Yu Yu Wang Depei Wu qifa liu Lanping Xu Xiaohui Zhang Kaiyan liu Xiaojun Huang Peking University People's Hospital Peking University Institute of Hematology Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation The First Affiliated Hospital of Soochow University Nanfang Hospital Southern Medical University Peking-Tsinghua Center for Life Sciences

To compare the efficacy of HLA6/6-matched haploidentical hematopoietic stem cell transplant(haplo-HSCT) with that of HLA3/6-matched HSCT in T-cell-replete transplants, we recruited 27 consecutive recipients from multiple centers who received HLA6/6-matched haplo-HSCT from a parent or child donor between February 2010 and May 2016. A matched-pair analysis was designed. For each recipient from the study cohort, two recipients were randomly selected from the control cohort and matched(according to patient age, patient sex, disease type, disease status, donor age, donor sex, and recipient-donor relationship). No significant differences were found in hematopoietic recovery. The incidence of grade II–IV and III–IV acute graft versus host disease was similar(18.5% vs. 31.5%, P=0.216; 11.1% vs. 9.3%, P=0.792) in the HLA6/6 and HLA3/6 groups, respectively. The3-year cumulative incidence of relapse was 14.8% and 17.0%(P=0.800). The 3-year cumulative incidence of nonrelapse mortality was 12.1% and 17.6%(P=0.751). The estimated 3-year disease-free survival was 73.1% and 65.5%(P=0.489). The estimated 3-year overall survival was 74.7% and 74.0%(P=0.946). The data suggested the efficacy and safety of the HLA6/6-and the HLA3/6-matched haplo-HSCT between parents and children are comparable. That HLA-mismatch disparity is not correlated with T-cell-replete haplo-HSCT outcome was substantiated.

关键词： donor human leukocyte antigen hematopoietic stem cell transplantation

Comparison of the clinical outcomes of hematologic malignancies after myeloablative haploidentical transplantation with G-CSF/ATG and posttransplant cyclophosphamide:results from the Chinese Bone Marrow Transplantation Registry Group(CBMTRG)

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Science China(Life Sciences) 2020年第4期63卷 571-581页

作者： Feifei Tang Yajing Xu Huiren Chen Lanping Xu Xiaohui Zhang Yu Wang qifa liu Depei Wu Xiaojun Huang Peking University People’s Hospital Peking University Institute of HematologyBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Xiangya Hospital Central South UniversityChangsha 410008China PLA Army General Hospital Beijing 100700China Nanfang Hospital Southern Medical UniversityGuangzhou 510515China The First Affiliated Hospital of Soochow University Suzhou 215006China Peking-Tsinghua Center for Life Sciences Beijing 100871China

This study compared G-CSF/ATG and PTCy in myeloablative haploidentical hematopoietic stem cell transplantation(haploHSCT)for hematologic malignancies between January 2013 and March 2018 reporting to the Chinese Bone Marrow Transplantation Registry Group(CBMTRG).For each PTCy,G-CSF/ATG subjects(1:4)were selected using the nested case-pair *** total,220 patients including 176 in G-CSF/ATG group and 44 in PTCy group were *** incidences of 30-day neutrophil engraftment(88.6%vs.96.6%,P=0.001),90-day platelet engraftment(84.1%vs.94.2%,P=0.04),the median time to neutrophil engraftment(17 days vs.12 days,P=0.000)and platelet engraftment(22 days vs.17 days,P=0.001)were significantly inferior in PTCy *** incidences of grades 2–4 and 3–4 acute graft-versus-host disease(GVHD),chronic GVHD and severe chronic GVHD were *** G-CSF/ATG and PTCy groups,the 3-year progression-free survival,overall survival,cumulative incidences of nonrelapse mortality and relapse was 74.3%vs.61%(P=0.045),78.3%vs.65.2%(P=0.039),12%vs.27.3%(P=0.008),and 14.9%vs.11.7%(P=0.61),respectively.G-CSF/ATG can achieve better engraftment,PFS and OS,and lower incidence of NRM compared to PTCy in myeloablative haplo-HSCT for hematologic malignancies.

关键词： myeloablative haploidentical transplantation granulocyte colony-stimulating factor antithymocyte globulin posttransplantation cyclophosphamide

Sequential Intensified Conditioning followed by inducing GVL in allo-HSCT for Refractory acute leukemia

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Sequential Intensified Conditioning followed by inducing GVL...

Somatic mutations predict prognosis in myelodysplastic syndrome patients with normal karyotypes

遵循诊疗规范、鼓励临床试验——第八届中国肿瘤内科大会、第三届中国肿瘤医师大会、中国抗癌协会肿瘤临床化疗专业委员会2014年学术年会

作者： qifa liu Department of Hematology Nanfang HospitalSouthern Medical University

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2319-2321页

作者： Xiangzong Zeng Yu Zhang Ke Zhao Lingling Zhou Ya Zhou Li Xuan Rui Cao Jun Xu Min Dai qifa liu Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouChina

Dear Editor,Myelodysplastic syndromes(MDSs)are a group of clonal myeloid stem cell disorders characterized by varying degrees of cytopenias,cytogenetic and molecular genetic abnormalities,and a predisposition to acute myeloid leukemia(AML).The treatments for MDS mainly consist of cytoreductive treatment,such as traditional AML-like chemotherapy,hypomethylating agents(HMAs),allogeneic hematopoietic stem cell transplantation(alio-HSCT)and immunoregulation according to risk stratification.

关键词： dysplastic chemotherapy myeloid

Autologous peripheral hematopoietic stem-cell transplantation in a patient with refractory pemphigus

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Frontiers of Medicine 2008年第2期2卷 191-194页

作者： Ledong SUN Jing SUN Kang ZENG Fanyi MENG Youtao DIAO Dan XU Liang HUANG Jie ZHAO qifa liu Department of Dermatology Nan-fang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Hematology Nan-fang HospitalSouthern Medical UniversityGuangzhou 510515China

The aim of this study is to explore the effective-ness of autologous peripheral hematopoietic stem-cell transplantation in the treatment of refractory pemphigus.A 35-year-old male patient presented with a 4-year history of recurrent bullae on his trunk and *** dia-gnosis of pemphigus was made on the basis of the clinical,histologic and immunofluorescence *** patient had shown resistance to conventional therapy with gluco-corticoid and immunosuppressive *** months before admission,he complained of hip joint pain.X-ray and CT scan revealed aseptic necrosis of the femoral ***-cell mobilization was achieved by treatment with cyclophosphamide,granulocyte colony-stimulating factor(G-CSF)and *** blood stem cells were collected via leukapheresis and cryopreserved for later *** was accomplished by using cyclophospha-mide(200 mg/kg;divided into 50 mg/kg on days-5,-4,-3,and-2),antithymocyte globulin(ATG;10 mg/kg;divided into 2.5 mg/kg on days-6,-5,-4,and-3),and rituximab(1200 mg/d;divided into 600 mg/d on days 0 and 7).Autologous peripheral hematopoietic stem cell transplanta-tion was followed by reconstitution of the immune system which was monitored by flow *** glucocorti-coid was withdrawn immediately after *** pemphigus titer turned negative 6 weeks after transplanta-tion and remained *** patient was in complete drug-free remission with no evidence of residual clinical or serological activity of pemphigus during 1 year of *** patient’s response suggests that autologous peri-pheral hematopoietic stem cell transplantation may be a potential“cure”for refractory ***,fur-ther studies are needed to evaluate the risk-benefit ratio of this approach in patients with pemphigus showing resist-ance to conventional therapy.

关键词： pemphigus hematopoietic stem cells trans-plantation,autologous rituximab

More than two courses of pre-transplant consolidation therapy benefits patients with acute myeloid leukemia in the first complete remission who underwent human leukocyte antigen-matched sibling allografts:a multicenter study

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Chinese Medical Journal 2023年第15期136卷 1855-1863页

作者： Jing liu Depei Wu qifa liu Yingjun Chang Yang Xu Fen Huang Xiaojun Huang Yu Wang Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseResearch Unit of Key Technique for Diagnosis and Treatments of Hematologic MalignanciesBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China First Affiliated Hospital of Soochow University Jiangsu Institute of HematologyInstitute of Blood and Marrow TransplantationSoochow UniversitySuzhouJiangsu 215006China Nanfang Hospital Southern Medical UniversityGuangzhouGuangdong 510515China Collaborative Innovation Center of Hematology Peking UniversityBeijing 100044China Peking-Tsinghua Center for Life Sciences Beijing 100871China

Background:Although the need for consolidation chemotherapy after successful induction therapy is well established in patients with acute myeloid leukemia(AML)in first complete remission(CR1),the value of consolidation chemotherapy before allogeneic hematopoietic stem cell transplantation remains ***:We retrospectively compared the effect of the number of pre-transplant consolidation chemotherapies on outcomes of human leukocyte antigen-matched sibling stem cell transplantation(MSDT)for patients with AML in CR1 in multicenters across *** our study,we analyzed data of 373 AML patients in CR1 from three centers across ***:With a median follow-up of 969 days,patients with≥3 courses of consolidation chemotherapy had higher probabilities of leukemia-free survival(LFS)(85.6%vs.67.0%,P<0.001)and overall survival(89.2%vs.78.5%,P=0.007),and better cumulative incidences of relapse(10.5%vs.19.6%,P=0.020)and non-relapse mortality(4.2%vs.14.9%,P=0.001)than those with≤2 courses of consolidation ***-transplantation minimal residual disease-negative patients with AML in CR1 who received MSDT with≥3 courses of consolidation chemotherapy had a higher probability of LFS(85.9%vs.67.7%,P=0.003)and a lower cumulative incidence of relapse(9.6%vs.23.3%,P=0.013)than those with≤2 ***:Our results indicate that patients with AML in CR1 who received MSDT might benefit from pre-transplant consolidation chemotherapy.

关键词： Acute myeloid leukemia Allogeneic stem cell transplantation Pre-transplant consolidation chemotherapy HLA-matched sibling stem cell transplantation

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我如何管理造血干细胞移植后巨细胞病毒感染

中华血液学杂志 2017年第11期38卷 916-919页

作者：刘启发南方医科大学南方医院广州510515

巨细胞病毒（CMV）为DNA病毒，属于疱疹病毒科，宿主具有种属特异性，感染人类的CMV也称人巨细胞病毒（HCMV）。70％～80％的健康成人有CMV感染史。造血干细胞移植（HSCT）患者由于免疫功能低下，不能有效清除CMV，易发生原发性CMV感染... 详细信息

巨细胞病毒（CMV）为DNA病毒，属于疱疹病毒科，宿主具有种属特异性，感染人类的CMV也称人巨细胞病毒（HCMV）。70％～80％的健康成人有CMV感染史。造血干细胞移植（HSCT）患者由于免疫功能低下，不能有效清除CMV，易发生原发性CMV感染或潜伏的CMV再激活。HSCT患者的CMV感染／再激活发生率达80％，可引起CMV相关发热直至器官累及的系列相关性疾病，具有很高的病死率。笔者以1例重症CMV肺炎为例，介绍HSCT后CMV感染的管理。

关键词：巨细胞病毒感染造血干细胞移植管理移植后 CMV感染人巨细胞病毒免疫功能低下 HSCT