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Susceptibility gene for stroke or cerebral infarction in the Han population in Hunan Province of China

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Neural Regeneration Research 2013年第16期8卷 1519-1527页

作者： Danheng Mo Hongwei Xu Wensheng Zhou Qiming yang Jianwen yang Bo Xiao qidong yang Department of Neurology Hunan Provincial Mawangdui Hospital Department of Neurology Xiangya Hospital Central South University

The scavenger receptor class B type I gene can protect against atherosclerosis; a mononucleotide polymorphism is associated with differences in blood lipid metabolism, postprandial serum lipid levels, insulin resistance, coronary artery disease and familial hyperlipidemia. In this study, the scavenger receptor class B type I gene exon 1 G4A gene polymorphism in atherosclerotic cerebral infarction patients, cerebral hemorrhage patients and normal controls was detected using the polymerase chain reaction-restriction fragment length polymorphism method. The results showed that the GA ＋ AA genotype frequency of scavenger receptor class B type I gene G4A in atherosclerotic cerebral infarction patients was similar to that in cerebral hemorrhage patients and normal controls; however, the A allele frequency was significantly lower than that in normal controls. The serum level of high-density lipoprotein cholesterol in patients with the scavenger receptor class B type I gene G4A GA ＋ AA genotype was significantly higher, while the serum level of low-density lipoprotein cholesterol was significantly lower than that in patients with the GG genotype, in both the atherosclerotic cerebral infarction and cerebral hemorrhage groups. The serum level of high-density lipoprotein cholesterol in patients with the scavenger receptor class B type I gene G4A GA ＋ AA genotype was significantly higher, while the serum levels of low-density lipoprotein cholesterol and total cholesterol were significantly lower than those in normal controls with the GG genotype. Our experimental results suggest that the G4A polymorphism of the scavenger receptor class B type I gene is a possible predisposing risk factor for atherosclerotic cerebral infarction, and that it has no association with cerebral hemorrhage in the Hart population in Hunan province of China. The A allele is possibly associated with the metabolism of high-density and low-density lipoprotein cholesterol.

关键词： neural regeneration scavenger receptor class B type I stroke atherosclerotic cerebral infarction cerebral hemorrhage genetic polymorphism cholesterol neuroregeneration

In-situ X-ray computed tomography tensile tests and analysis of damage mechanism and mechanical properties in laser powder b e d fused Invar 36 alloy

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Journal of Materials Science & Technology 2024年第8期175卷 29-46页

作者： qidong yang Shuo yang Shiyu Ma Junhan Zhou Ye Zhou Rongzheng Huang Kai Wei Zhaoliang Qu Xujing yang Key Laboratory of Advanced Design and Simulation Techniques for Special Equipment Ministry of EducationHunan UniversityChangsha 410082China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China

Laser powder bed fusion(LPBF)is a potential additive manufacturing process to manufacture Invar 36 alloy components with complicated *** it inevitably introduces specific microstructures and pore defects,which will further influence the mechanical ***,aiming at exploring the LPBF process-related microstructures and pore defects,and especially their influences on the damage mechanism and mechanical properties,Invar 36 alloy was manufactured by LPBF under designed different laser scanning *** microstructure observations reveal that higher scanning speeds lead to equiaxed and short columnar grains with higher dislocation density,while lower scanning speeds result in elongated columnar grains with lower dislocation *** pore defects analyzed by X-ray computed tomography(XCT)suggest that the high laser scanning speed gives rise to numerous lamellar and large lack-of-fusion(LOF)pores,and the excessively low laser scanning speed produces relatively small keyhole pores with high ***,the insitu XCT tensile tests were originally performed to evaluate the damage evolution and failure ***,high laser scanning speed causes brittle fracture due to the rapid growth and coalescence of initial lamellar LOF pores along the scan-ning *** laser scanning speed induces ductile fracture originating from unstable depressions in the surfaces,while metallurgical and keyhole pores have little impact on damage ***,the process-structure-property correlation is *** presence of high volume fraction of lamel-lar LOF pores,resulting from high scanning speed,leads to inferior yield strength and ***,specimens without LOF pores exhibit larger grain sizes and lower dislocation density at decreased scanning speeds,slightly reducing yield strength while slightly enhancing *** understanding lays the foundation for widespread applications of LPBF-processed Invar 36 alloy

关键词： Invar 36 alloy Laser powder bed fusion Microstructure Pore defects Mechanical property X-ray tomography in-situ tensile test

Electrical fields and the promotion of endogenous angiogenesis in a rat spinal cord injury model

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Neural Regeneration Research 2010年第14期5卷 1091-1095页

作者： yang Shao Bo Xiao Haihan Ma Jie Gao qidong yang Min Zhao Department of Neurology Xiangya Hospital Central South University Changsha 410008 Hunan Province China State Key Laboratory of Trauma Burns and Combined Injury Institute of Surgery Research Daping Hospital Third Military Medical University Chongqing 400042 China School of Medical Sciences University of Aberdeen Aberdeen AB25 2ZD UK

BACKGROUND： Previous studies have shown that direct current electrical fields affect development and growth of human microvascular endothelial cells, but the role of electrical fields on promoting angiogenesis in tissues following spinal cord injury remains poorly understood. OBJECTIVE： To determine the effects of electrical fields on angiogenesis and spinal cord repair following traumatic spinal cord injury in rats. DESIGN, TIME AND SETTING： A randomized, controlled, animal experiment was performed at the Chongqing Key Laboratory of Neurology, Affiliated Hospital of Chongqing Medical University, China from September 2007 to August 2008. MATERIALS： Hydrogen blood flow detector （Soochow University Medical Instrument, China）, Power Lab System （AD Instruments, Colorado Springs, CO, USA） and mouse anti-vascular endothelial growth factor （VEGF） monoclonal antibody （Sigma-Aldrich, St. Louis, MO, USA） were used in this study. METHODS： A total of 60 healthy, adult, Sprague Dawley rats were equally and randomly assigned to sham-surgery, model, and electrical field groups. The Allen＇s weight-drop method was used to induce complete spinal cord injury in the model and electrical field groups. Rats in the electrical field group were implanted with silver needles and electrical fields （350 V/m） were applied following traumatic injury. MAIN OUTCOME MEASURES： Latency of somatosensory-evoked potential was detected and spinal cord blood flow was measured by hydrogen blood flow detector. Microvascular density was determined by histological analysis. VEGF expression in the spinal cord was observed by immunohistochemical staining. RESULTS： Recovery of spinal cord blood flow was significantly increased in the electrical field group （at 1, 2, 4, 8, and 24 days after injury） compared with the model group （P 〈 0.05 or P 〈 0.01）. Latency of P1 waves in somatosensory-evoked potential of electrical field group （at 1,2, 4, 8, and 24 days after injury） was significantly shorter than the

关键词： angiogenesis electric fields spinal cord injury spinal cord blood flow vascular endothelial growth factor neural regeneration

Neuroprotective role of edaravone and the effects of endoplasmic reticulum stress in an adult rat model of focal cerebral ischemia/reperfusion

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Neural Regeneration Research 2010年第3期5卷 197-204页

作者： Xiangmin Shen Liming Tan Yunhai Liu Hainan Zhang Chunyu Wang qidong yang QingHuang Lin Zhou Zhenyu Tang Department of Neurology Xiangya Hospital Central South University Changsha 410008 Hunan Province China Department of Neurology Second Xiangya Hospital Central South University Changsha 410011 Hunan Province China

BACKGROUND： Endoplasmic reticulum （ER） stress impairs ER functions and leads to the accumulation of unfolded or misfolded proteins in the ER lumen. ER stress-induced cell death plays an important role in cerebral ischemia. Edaravon （3-methyl-1-phenyl-2-pyrazolin-5-one） is a potent and novel scavenger of free radicals that inhibit delayed neuronal death, as demonstrated by in vitro and animal studies. However, its effect on ER stress and induced neuronal apoptosis in a rat model of brief middle cerebral artery occlusion remains unclear. OBJECTIVE： To explore the effects of edaravone on the expression of ER stress-related factors and neuronal apoptosis, based on the hypothesis that edaravone influences ER stress in a rat model of cerebral ischemia/reperfusion. DESIGN, TIME AND SETTING： A randomized, controlled, animal study was performed at the Laboratory of Department of Neurology, Xiangya Hospital and the Department of Laboratory Animals, Xiangya Medical College, Central South University in China from June 2005 to May 2006. MATERIALS： Edaravone was purchased from Simcere Pharmaceutical Group, China. METHODS： A total of 216 adult, male, Sprague Dawley rats were randomly assigned to sham-surgery, model and edaravone groups, with 72 rats in each group, Brief middle cerebral artery occlusion was established in the model and edaravone groups. In addition, the edaravone group rats were injected with 3 mg/kg edaravone through the tail vein. MAIN OUTCOME MEASURES： RNA-dependent protein kinase-like endoplasmic reticulum eukaryotic translation initiation factor 2a kinase （PERK） and C/EBP homology protein （CHOP） mRNA expression in the ischemic parietal cortex was determined by reverse transcriptionpolymerase chain reaction; phosphorylated PERK and CHOP protein expression was detected by immunohistochemistry; neuronal apoptosis was detected by TdT-mediated-dUTP nick end labeling. RESULTS： Neurological deficit scores were significantly reduced in the edaravone group compared to

关键词： edaravone cerebral ischemia/reperfusion endoplasmic reticulum stress RNA-dependent protein kinase-like endoplasmic reticulum elF2a kinase C/EBP homology protein brain injury neural regeneration

Traffic Prediction Method for GEO Satellites Combining ARIMA Model and Grey Model

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Journal of Shanghai Jiaotong university(Science) 2020年第1期25卷 65-69页

作者： ZHOU Jian yang qidong ZHANG Xiaofei HAN Chong SUN Lijuan College of Computer Jiangsu High Technology Research Key Laboratory for Wireless Sensor NetworksNanjing University of Posts and TelecommunicationsNanjing 210023China

An accurate traffle prediction on various service is of great importance to the channel resource management of geostationary earth orbit(GEO)***,a traffic prediction method for GEO satellites combining autoregressive integrated moving average(ARIMA)model and grey model is ***,the traffle prediction methods based on ARIMA model and grey model are introduced ***,a combined model is given,in which according to the results of the historical prediction of ARIMA model and grey model,those two models are combined with different ***,the combined model is applied to a multi-service access and the access probability of each kind of service is calculated based on the prediction ***,the simulation experiments indicate that the combined model has better prediction stability and higher average prediction accuracy than either of the separated ***,the proposed access strategy based on the combined model performs better than other similar strategies.

关键词： traffic prediction ARIMA model grey model access GEO satellites

Chloride molten salt derived attapulgite with ground-breaking electrochemical performance

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Chinese Chemical Letters 2024年第10期35卷 437-441页

作者： Kailong Zhang Chao Zhang Luanhui Wu qidong yang Jiadong Zhang Guang Hu Liang Song Gaoran Li Wenlong Cai School of Chemical Engineering Huaiyin Institute of TechnologyHuaian 223003China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China

The existence of adsorbed water and structural water in the crystal structure of attapulgite(ATP)endows it with poor capability to store lithium ***,the chloride molten salt method was developed to function ATP materials based on theoretical calculations,which exhibit ground-breaking electrochemical *** the modification process,the metal ions in chloride molten salt occupy the vertices of the Mg-O octahedral structure from the liberation of structural water and hydroxyl groups in ATP,forming MaMgbAlcSixOy(M=Li,Na,or K).Using Li Cl molten salt-modified ATP(Li-ATP)as a proof-of-concept,the detailed phase transition,physicochemical properties,and lithium storage capacity were *** to the original ATP,Li-ATP achieves a nearly 7-fold increase in lithium storage capacity(498mAh/g),featuring a promising low-cost polyanionic type anode material.

关键词： Molten salt modification Attapulgite Phasetransition Electrochemical performance Anode

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高压氧对脑出血大鼠脑内血管新生的影响

中国康复医学杂志 2014年第12期29卷 1113-1118页

作者：彭争荣杨阿莉杨期东中南大学湘雅医院高压氧科长沙410008 中南大学湘雅医院神经病学研究所

目的:探讨高压氧对脑出血大鼠脑内血管新生的作用机制。方法:将120只SD大鼠随机分为假手术组、脑出血组和高压氧组。采用组织切片HE染色显微镜下观察各组大鼠血肿周围脑组织新生血管形成情况;采用免疫组织化学分析方法检测各组大鼠脑内... 详细信息

目的:探讨高压氧对脑出血大鼠脑内血管新生的作用机制。方法:将120只SD大鼠随机分为假手术组、脑出血组和高压氧组。采用组织切片HE染色显微镜下观察各组大鼠血肿周围脑组织新生血管形成情况;采用免疫组织化学分析方法检测各组大鼠脑内缺氧诱导因子(HIF)1-α、血管内皮生长因子(VEGF)的蛋白表达含量;采用荧光定量RT-PCR方法测定各组大鼠脑组织HIF1-αm RNA、VEGF m RNA的表达水平。结果:血肿周围脑组织切片经HE染色后光镜下观察可见,随着出血后时间延长,高压氧组血肿已基本吸收,较脑出血组可见大量分布的血管样结构和微血管,新生血管数目明显增多,假手术组未见明显血肿及新生血管的病理改变。脑出血组和高压氧组HIF1-α和VEGF蛋白表达在第14、21、28天比较差异均有显著性意义(P<0.01)。三组(假手术组、脑出血组、高压氧组)比较,高压氧组HIF1-αm RNA、VEGF m RNA表达值分别高于脑出血组和假手术组,HIF1-αm RNA在第14、21、28天时三组比较差异均有显著性意义(P<0.05);VEGF m RNA在第21、28天时三组比较差异均有显著性意义(P<0.05)。结论:高压氧能增加脑出血大鼠脑内HIF1-α、VEGF蛋白和m RNA表达水平,促进新生血管形成,加快血肿吸收,改善脑出血大鼠损伤神经功能,促进其康复。

关键词：脑出血高压氧血管新生

嗜中性粒细胞胞质因子1基因C923T多态性与长沙市汉族人群脑出血的相关性研究

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中南大学学报（医学版） 2011年第4期36卷 301-306页

作者：黄晓松杨期东湖南省脑科医院神经内科长沙410007 中南大学湘雅医院神经内科长沙410008

目的:探讨嗜中性粒细胞胞质因子1(NCF1)基因第10外显子C923T(A la308Val)多态性与湖南省长沙市汉族人群脑出血的关系。方法:采用PCR-单链构象多态技术和DNA直接测序法检测湖南省长沙市汉族人群脑出血患者110例、10个脑出血家系成员110... 详细信息

目的:探讨嗜中性粒细胞胞质因子1(NCF1)基因第10外显子C923T(A la308Val)多态性与湖南省长沙市汉族人群脑出血的关系。方法:采用PCR-单链构象多态技术和DNA直接测序法检测湖南省长沙市汉族人群脑出血患者110例、10个脑出血家系成员110例和健康对照者100名的NCF1基因第10外显子C923T多态性;同时检测各组血脂水平。结果:湖南省长沙市汉族人群NCF1基因第10外显子C923T多态存在CC,CT,TT 3种基因型,脑出血组及其各亚型组C923T(A la308Val)多态基因频率分布与对照组比较,差异无统计学意义(P>0.05);脑出血家系组中患病组和未患病组及脑出血组的C923T多态分布与对照组比较,差异无统计学意义(P>0.05);脑出血组中各基因型血脂水平与对照组比较,差异无统计学意义(P>0.05)。结论:湖南省长沙市汉族人群NCF1基因C923T多态性可能与脑出血的易患性无关。

关键词：脑出血嗜中性粒细胞胞质因子1 基因多态性血脂

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济阳拗陷上古生界煤成气储层非均质性研究

西南石油大学学报（自然科学版） 2015年第1期37卷 25-32页

作者：门岳峰郑雪杨其栋中化地质矿山总局山东地质勘查院山东济南250013 山东省沉积成矿作用与沉积矿产重点实验室.山东科技大学山东青岛266590

济阳拗陷上古生界是重要的煤成气储层,储层非均质性是影响地下煤成气运移重要因素,同时也是认识煤成气藏的基础,因此,对煤成气储层的非均质性研究水平将直接影响到对储层中煤成气的分布规律的认识和开发效果的好坏。根据所掌握的资料,... 详细信息

济阳拗陷上古生界是重要的煤成气储层,储层非均质性是影响地下煤成气运移重要因素,同时也是认识煤成气藏的基础,因此,对煤成气储层的非均质性研究水平将直接影响到对储层中煤成气的分布规律的认识和开发效果的好坏。根据所掌握的资料,运用统计学方法和洛伦兹曲线法,分别从平面、层间、层内3个方面对济阳拗陷上古生界煤成气储层的非均质性进行研究,并根据研究结果做出评价。结果表明,济阳拗陷沾化凹陷孤北地区砂体渗透率大致呈西高东低、北高南低的趋势。储层层间非均质性严重的井区有德古2、王古1、孤北古1、孤北古2、孤北古3等,层内非均质性严重的井区有德古2、孤北古1、孤北古2等,这些对济阳拗陷煤成气的勘探有指导意义。

关键词：济阳拗陷上古生界煤成气储层非均质性