检索结果-南通市图书馆

Methyl tertiary-butyl ether inhibits THP-1 macrophage cholesterol efflux in vitro and accelerates atherosclerosis in ApoE-deficient mice in vivo

引用

Journal of Environmental Sciences 2021年第3期33卷 236-247页

作者： qidong ren Xinni Xie Yue Tang Qing Hu Yuguo Du State Key Laboratory of Environmental Chemistry and Eco-Toxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

The biosafety of methyl tertiary-butyl ether(MTBE),mainly used as a gasoline additive,has long been a contentious topic.In addition to its routine toxicities,MTBE has been demonstrated to disrupt glucose and lipid metabolism and contribute to the development of type2 diabetes as well as obesity.As one of the morbidities related to dyslipidemia,atherosclerosis is worthy of being investigated under MTBE exposure.Since foam cells derived from macrophages play pivotal roles during atherosclerosis development,we studied the effects of MTBE on macrophages in vitro and assessed the effect of MTBE on atherosclerosis plaque formation with the ApoE^(-/-)mouse model in uiuo for the first time.Our results demonstrated that exposure to MTBE at environmentally relevant concentrations decreased the expression of ABCA1 and ABCG1,which are responsible for macrophage cholesterol efflux,at both mRNA and protein levels in THP-1 macrophages.Consequently,treatment with MTBE inhibited the transport of cholesterol from macrophages to High-density lipoprotein.ApoE^(-/-)mice exposed to MTBE at environmentally relevant concentrations(100,1000μg/kg)displayed significant increases in lesion area in the aorta and aortic root compared to vehicletreated ones.Further analysis indicated that MTBE exposure enhanced the macrophagespecific marker Mac-2 contents within plaques in the aortic root,implying that MTBE could promote macrophage-derived foam cell formation and thus accelerate atherosclerosis plaque formation.We for the first time demonstrated the pro-atherogenic effect of MTBE via eliciting disruption of macrophage cholesterol efflux and accelerating foam cell formation and atherosclerosis plaque development.

关键词： Methyl tertiary–butyl ether(MTBE) macrophage cholesterol efflux ApoE^(-/-)mouse Atherosclerosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of methyl tert-butyl ether on adipogenesis and glucose metabolism in vitro and in vivo

引用

Journal of Environmental Sciences 2019年第11期31卷 208-219页

作者： Yue Tang qidong ren Qing Wen Caixia Yu Xinni Xie Qing Hu Yuguo Du State Key Laboratory of Environmental Chemistry and Eco-toxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China School of Chemical Sciences University of Chinese Academy of Sciences Beijing 100049 China School of Environmental Science and Engineering Southern University of Science and Technology Shenzhen 518055 China

Methyl tert-butyl ether (MTBE),as a widely used gasoline additive,is suspected of being environmentally toxic.MTBE accumulates mainly in adipose tissue,but its effect on obesity or obesity-related metabolic disorders has not been well understood yet.Therefore,we examined the effect of MTBE on the adipose function and the related metabolic processes with both 3T3-L1 cell line and C57BL/6J mice model.We found that exposure to MTBE at the environmental relevant concentration (100 μmol/L) could significantly induce differentiation of preadipocyte and disturb insulin-stimulated glucose uptake of mature adipocyte.The in vivo observation in male mice showed a positive correlation of visceral white adipose tissue (vWAT) expansion and cell size increase with MTBE treatment in 14 weeks.Glucose tolerance and insulin sensitivity tests demonstrated that MTBE at 1000 μg/(kg·day) disturbed the systemic glucose metabolism in a gender-specific manner,which might be partly attributed to the alterations of gut microbiota community at genus level with respect to Akkermansia,Clostridium XIVb,and Megamonas.In summary,our study characterized the effect of MTBE on adipose tissue function and glucose homeostasis in vitro and in vivo,and revealed that systemic disorders of the glucose metabolism might be modulated by the related gut microbiota.

关键词： MTBE Adipogenesis Glucose metabolism Metabolic disorder Gut microbiota

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

华北克拉通东北缘改造:来自吉林辉南地区构造热事件的古地磁记录

引用

地质通报 2024年第2期43卷 289-301页

作者：金继浩任收麦王胜建刘永江侯啓东刘一珉王浩中国石化胜利油田分公司孤东采油厂山东东营257237 中国地质调查局北京100037 中国地质调查局油气资源调查中心北京100083 中国海洋大学海洋地球科学学院山东青岛266100 中国地质大学(北京)地球科学与资源学院北京100083 中国科学院地质与地球物理研究所岩石圈演化国家重点实验室北京100029

华北克拉通东北缘处于构造运动活跃地区,古地磁研究可为构造演化和岩浆热事件提供依据。笔者在吉林辉南地区中寒武统32个采点共采集246块样品进行了岩石学、岩石磁学及系统热退磁实验。古地磁实验表明,徐庄组砂质泥岩主要磁性矿物是赤... 详细信息

华北克拉通东北缘处于构造运动活跃地区,古地磁研究可为构造演化和岩浆热事件提供依据。笔者在吉林辉南地区中寒武统32个采点共采集246块样品进行了岩石学、岩石磁学及系统热退磁实验。古地磁实验表明,徐庄组砂质泥岩主要磁性矿物是赤铁矿和磁铁矿,张夏组灰岩主要磁性矿物是颗粒较小的磁铁矿和黄铁矿,且均发生了重磁化,并记录了稳定的中温分量,前者中温分量地理坐标平均方向为D/I=10.9°/50.8°,α_(95)=11.7°,对应的极位置为76°N,264.6°E,A_(95)=13°,与早白垩世岩浆活动记录的古地磁极位置一致;后者中温分量地理坐标平均方向为D/I=29.1°/59.0°,α_(95)=6.5°,对应的极位置为68°N,213.7°E,A_(95)=8.4°,与第四纪火山岩记录的古地磁极位置一致。综合区域地质背景分析,早白垩世—第四纪,吉林辉南及邻区古地磁记录的2次较为强烈的构造热事件,以及因敦化-密山断裂带左旋走滑运动造成的北向运移形成的古纬度差,一定程度上对华北克拉通东北缘起到双重改造作用。

关键词：华北克拉通东北缘中寒武世重磁化构造热事件

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characterization of the CpsQ Regulon Reveals Its Role in the Transcription of Type Ⅵ Secretion System 2 Genes in Vibrio parahaemolyticus

引用

Biomedical and Environmental Sciences 2024年第4期37卷 436-439页

作者： LUO Xi LI Xue ZHANG Miao Miao HUANG Qing Lian ZHANG Yi Quan JI Shen Jie LU ren Fei Department of Clinical Laboratory Affiliated Nantong Hospital 3 of Nantong UniversityNantong Third People’s HospitalNantong 226006JiangsuChina Department of Clinical Laboratory Qidong People’s HospitalQidong 226200JiangsuChina

Vibrio parahaemolyticus,a gram-negative halophilic bacterium that naturally inhabits coastal waters,causes gastroenteritis,skin infections,and septicemia in human beings[1].This bacterium produces multiple virulence factors,including thermostable direct hemolysin(TDH),TDH-related hemolysin(TRH),type Ⅲ secretion system 1(T3SS1),T3SS2,type Ⅵ secretion system 1(T6SS1),and T6SS2[1].Furthermore,Ⅴ.parahaemolyticus forms biofilms on the surface,which help it in adapting to unfavorable conditions[2].Mature biofilm formation requires special structures,including lateral and polar flagella,exopolysaccharide(EPS),and type Ⅳ pili[2].

关键词： coastal system T3SS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi-scaling hierarchical structure analysis on the sequence of E.coli complete genome

引用

Chinese Science Bulletin 2001年第23期46卷 1988-1992页

作者： WANG Jin ZHANG qidong ren Kui SHE Zhensu State Key Laboratory of Pharmaceutical Biotechnology School of Life ScienceNanjing UniversityNanjing 210093China State Key Laboratory for Studies of Turbulence and Complex Systems Department of Mechanics and Engineering SciencePeking UniversityBeijing 100871China Department of Geophysics Peking UniversityBeijing 100871China

We have applied the newly developed hierarchical structure theory for complex systems to analyze the multi-scaling structures of the nucleotide density distribution along a linear DNA sequence from the complete Escherichia coli genome. The hierarchical symmetry in the nucleotide density distribution was demonstrated. In particular, we have shown that the G, C density distribution that represents a strong H-bonding between the two DNA chains is more coherent with smaller similarity parameter compared to that of A, T density distribution, indicating a better organized multi-scaling fluctuation field for G, C density distributionalong the genome sequence. The biological significance of these findings is under investigation.

关键词： complexity hierarchical structure genome nucleotide Escherichia coli.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Graphene oxide-decorated Fe2（MoO4）3 microflowers as a promising anode for lithium and sodium storage

引用

Nano Research 2018年第3期11卷 1285-1293页

作者： Chunhua Han Xiaoji ren qidong Li Wen Luo Lei Huang Liang Zhou Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Luoshi Road122 Wuhan 430070 China Laboratoire de Chimie et Physique: Approche Multiechelles des Milieux Complexes Institut Jean Barriol Universite de Lorraine57070 Metz France

Mixed transition metal oxides （MTMOs） have received intensive attention as promising anode materials for lithium-ion batteries （LIBs） and sodium-ion batteries （SIBs）. In this work, we demonstrate a facile one-step water-bath method for the preparation of graphene oxide （GO） decorated Fe2（MoO4）3 （FMO） microflower composite （FMO/GO）, in which the FMO is constructed by numerous nanosheets. The resulting FMO/GO exhibits excellent electrochemical performances in both LIBs and SIBs. As the anode material for LIBs, the FMO/GO delivers a high capacity of 1,220 mAh·g^-1 at 200 mA·g^-1 after 50 cycles and a capacity of 685 mAh·g^-1 at a high current density of 10 A·g^-1. As the anode material for SIBs, the FMO/GO shows an initial discharge capacity of 571 mAh·g^-1 at 100 mA·g^-1, maintaining a discharge capacity of 307 mAh·g^-1 after 100 cycles. The promising performance is attributed to the good electrical transport from the intimate contact between FMO and graphene oxide. This work indicates that the FMO/GO composite is a promising anode for high-performance lithium and sodium storage.

关键词： Fe2（MoO4）3 microflowers,anode,lithium and sodium storage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Q460NH耐候钢药芯焊丝焊接接头力学性能与组织研究

引用

热加工工艺 2024年第1期53卷 63-67,74页

作者：任军陈晨郑乔伍光凤江苏大西洋焊接材料有限责任公司江苏启东226200 重庆理工大学材料科学与工程学院重庆400054 四川大西洋焊接材料股份有限公司四川自贡643000

Q460NH是低合金高强度耐候钢,采用自制的CHT81W2药芯焊丝进行焊接,得到组织合理、力学性能良好的焊接接头。焊缝金相组织主要为先共析铁素体、板条铁素体、针状铁素体以及粒状贝氏体;热影响区组织主要有板条贝氏体和粒状贝氏体;焊缝、... 详细信息

Q460NH是低合金高强度耐候钢,采用自制的CHT81W2药芯焊丝进行焊接,得到组织合理、力学性能良好的焊接接头。焊缝金相组织主要为先共析铁素体、板条铁素体、针状铁素体以及粒状贝氏体;热影响区组织主要有板条贝氏体和粒状贝氏体;焊缝、热影响区、母材的显微硬度呈梯度分布,并且依次下降。焊接接头各区的低温冲击韧性均达到标准规定的要求,具有良好的冲击性能;母材的断裂方式以延性断裂为主,断口微观形貌主要是韧窝;焊缝及热影响区的断口微观形貌为韧窝+准解理形貌。

关键词： Q460NH钢药芯焊丝力学性能金相组织

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于强化学习的再入飞行器“新质”走廊在线生成技术

引用

航空学报 2022年第9期43卷 615-627页

作者：惠俊鹏汪韧俞启东中国运载火箭技术研究院研究发展部北京100076

人工智能技术的突破性进展为飞行器再入制导技术的研究提供了新的技术途径。无论是基于标称轨迹的制导还是预测校正制导,都需要基于人工经验设计飞行走廊参数。本文旨在突破传统制导方法中普遍存在的“锥形”飞行轨迹包络的约束,利用强... 详细信息

人工智能技术的突破性进展为飞行器再入制导技术的研究提供了新的技术途径。无论是基于标称轨迹的制导还是预测校正制导,都需要基于人工经验设计飞行走廊参数。本文旨在突破传统制导方法中普遍存在的“锥形”飞行轨迹包络的约束,利用强化学习技术在智能决策方面的天然优势,在满足动力学方程和热流率、过载、动压等硬条件的前提下,通过飞行器与环境的大量交互“试错”:一方面,借鉴人类基于反馈来调整学习策略的思想,设置有效的奖励(反馈)引导;另一方面,利用强化学习中近端策略优化(PPO)算法训练飞行器倾侧角制导模型,基于实时的状态信息在线决策倾侧角指令,探索出完全不同于传统制导方法的“新质”飞行走廊。Monte Carlo仿真分析验证了基于强化学习的智能制导技术能够充分发挥飞行器的宽域飞行优势,进一步拓展飞行剖面。

关键词：智能制导 “新质”飞行走廊强化学习 PPO算法人工智能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Differential expression of a cDNA clone in human liverversus hepatic cancer-highly homologous to aryl-dialkyl-phosphatase

引用

Cell Research 1997年第1期7卷 79-90页

作者： WANG KAN KAN DA FANG WAN XIAO KUN QIU PEI XIN LU JIAN ren GU(National La6oratory for Oncogenes and Related Genes Shanghai Cancer Institute, Shanghai 200032)(qidong Cancer Institute, Jiangsu 226200) National Laboratory for Oneogenes and Related Genes Shanghai Cancer Institute Shanghai qidong Cancer Institute diangsu

We applied the technique of mRNA differential display to normal liver tissue and hepatoma cell line Hep3B. One of the isolated cDNA clones was expressed in human normal liver tissue but not in the human hepatocarcinoma cell line. Northern Blot analysis confirmed that high level of mRNA was expressed in human normal liver tissue but the level was decreased in non-cancerous liver tissue from hepatoma patients. Low level or no expression was observed in human hepatoma tissue. One of these transcripts was about 1.8 kb in length. Southern Blot analysis showed that it was a single copy gene. We obtained a full length cDNA clone of 2,395 bp by screening human liver 5'-stretch plus cDNA library. Nucleotide sequence indicated that this clone was highly homologous to aryldialkyl-phosphatase and possessed two polymorphic sites. Aryl-dialkyl--phosphatase which has a prominent role in the metabolism of several toxic, synthetic compounds, may be potentially related to human hepatocarcinoma susceptibility. The biological significance of its differential expression in normal versus malignant tissue is discussed.

关键词： Hepatocarcinoma mRNA DD aryl-dialkyl-phosphatase

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

BiPO_4@Ag_3PO_4核/壳异质结的制备及光催化性能

引用

高等学校化学学报 2014年第11期35卷 2435-2441页

作者：任延琳李新勇肇启东大连理工大学环境学院大连116024

采用简单的水热法结合离子交换法制备了BiPO4@Ag3PO4核/壳异质结光催化剂,采用场发射扫描电子显微镜(FE-SEM)、透射电子显微镜(TEM)、紫外-可见漫反射光谱仪(DRS)和X射线光电子能谱仪(XPS)等对催化剂的形貌、组成、晶型和光物理性质等... 详细信息

采用简单的水热法结合离子交换法制备了BiPO4@Ag3PO4核/壳异质结光催化剂,采用场发射扫描电子显微镜(FE-SEM)、透射电子显微镜(TEM)、紫外-可见漫反射光谱仪(DRS)和X射线光电子能谱仪(XPS)等对催化剂的形貌、组成、晶型和光物理性质等进行了研究,用罗丹明B(RhB)为模拟水体中有机污染物分别在可见光和模拟太阳光照条件下对催化剂的催化活性进行了测试.结果表明,负载Ag3PO4的BiPO4微米棒具有较高的可见光响应,其核/壳异质结结构有利于光生电子-空穴对的有效分离和提高对RhB的光催化降解效率,在可见光和模拟太阳光照射条件下分别在60和40 min可使RhB完全脱色降解.活性物种检测实验结果证明,该催化剂在污染物降解过程中主要的机理是光生空穴的直接氧化.

关键词： BiPO4@Ag3PO4 核/壳结构异质结空穴氧化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：