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Journal of Molecular Cell Biology 2022年第6期14卷 47-56页

作者： Runqiang Chen hui Xie Sahba Khorsandzadeh Madison Smith Namir Shaabani qidong hu Xiaoxuan Lyu hua Wang Wan-lin Lim Haotian Sun Henry Ji Brian Cooley Russell Ross David M.Francis Sorrento Therapeutics Inc.San DiegoCA 92121USA Sofusa a Division of Sorrento TherapeuticsAtlantaGA 30350USA

The exploration and identification of safe and effective vaccines for the SARS-CoV-2 pandemic have captured the world's attention and remains an ongoing issue due to concerns of balancing protection against emerging variants of concern while also generating long-lasting immunity. Here, we report the synthesis of a novel messenger ribonucleic acid encoding the spike protein in a lipid nanoparticle formulation (STI-7264) that generates robust humoral and cellular immunity following immunization of C57Bl6 mice. In an effort to improve immunity, a clinically focused lymphatic drug delivery device (MuVaxx) was engineered to modulate immune cells at the injection site (epidermis and dermis) and draining lymph node (LN) and tested to measure adaptive immunity. Using MuVaxx, immune responses were elicited and maintained at a 10-fold dose reduction compared to traditional intramuscular (IM) administration as measured by anti-spike antibodies, cytokine-producing CD8 T cells, neutralizing antibodies against the Washington (wild type) strain and South African (Beta) variants, and LN-resident spike-specific memory B cells. Remarkably, a 4-fold-elevated T cell response was observed in MuVaxx-administered vaccination compared to that of IM-administered vaccination. Thus, these data support further investigation into STI-7264 and lymphatic-mediated delivery using MuVaxx for SARS-CoV-2 and VoC vaccines.

关键词： COVID-19 lymph nodes lymphatics vaccines drug delivery

Using distinguishable dissolution curve to select the optimal preparation technique of generic riociguat tablets

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Using distinguishable dissolution curve to select the optima...

2018年第十二届中国药物制剂大会

作者：张雨 qidong hu Jiang Li Xueying huang Jing Gao Aiping Zheng State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and Toxicology

＜正＞Objective:Riociguat is a soluble guanosine cyclase（sGC）agonist to treat pulmonary arterial hypertension（PAH）clinically.It’s an insoluble BCSII Drug.In this study,we constructed four dissolution curves in different mediums and select a critical dissolution condition to find the optimal preparation technique of riociguat generic tablets.

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AI技术在铁路视频会议通信的应用研究

铁道通信信号 2023年第3期59卷 50-55页

作者：胡启东北京铁路通信技术中心北京100038

视频会议系统是当今办公必不可少的通信系统,在铁路中尤为重要。通过对现有铁路视频会议系统现状进行分析,结合AI技术特点,研究智能语音助手、语音与文字转化、智能语音追踪技术,以及人脸识别在铁路视频会议系统中的应用,提出AI技术在... 详细信息

视频会议系统是当今办公必不可少的通信系统,在铁路中尤为重要。通过对现有铁路视频会议系统现状进行分析,结合AI技术特点,研究智能语音助手、语音与文字转化、智能语音追踪技术,以及人脸识别在铁路视频会议系统中的应用,提出AI技术在铁路视频会议中的应用建议,以便更好地服务于铁路日常工作。

关键词：通信铁路视频会议系统人工智能语音识别技术人脸识别技术

Triplex-structure based DNA circuits with ultra-low leakage and high signal-to-noise ratio

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Chinese Chemical Letters 2024年第1期35卷 465-470页

作者： huan Liu Zhihao Ming Yuanpeng Zhang qidong Xia Hao hu Ruijie Liu Yuheng Liao Yizhou Liu Xiao Liu Xiaoping Zhang Longjie Li Shaogang Wang Xianjin Xiao Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department and Institute of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department and Institute of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Life Science and Technology Wuhan Polytechnic UniversityWuhan 430030China Department of Laboratory Medicine Tongji hospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

DNA circuits are powerful tools in various applications such as logical computation,molecular diagnosis and synthetic biology.Leakage is a major problem in constructing complex DNA circuits.It directly affects the output signal and harms the circuit’s performance significantly.In the traditional DNA circuits,the gate complex is a duplex structure.There are insufficient energy barriers to prevent spontaneous detachment of strands,resulting in a leak prone.Herein,we have developed triplex-structure based DNA circuit with ultra-low leakage and high signal-to-noise ratio(SNR).The triplex structure improves the stability in the absence of input.At the same time,the driving force of the strand displacement cascades reduces the influence of the triplex structure on the desired reaction.The SNR of the DNA circuit was increased to 695,while the desired reaction rate remained 90%of the conventional translator circuit.The triplex-structure mediated leakage prevention strategy was further tested at different temperatures and in DNA translator and seesaw circuits.We also constructed modular basic logic gates with a high efficiency and low leakage.On this basis,we further constructed triplex-structure based tertiary DNA logic circuits,and the SNR reached 295,which,to the best of our knowledge,was among the highest of the field.We believe that our scheme provides a novel,valid,and general tool for reducing leakages,and we anticipate that it will be widely adopted in DNA nanotechnology.

关键词： Leakage DNA strand displacement cascades Triplex DNA circuits Molecular programming

PIPE ROUTING DESIGN AND ASSEMBLY PLANNING TECHNOLOGY IN VIRTUAL ENVIRONMENT

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PIPE ROUTING DESIGN AND ASSEMBLY PLANNING TECHNOLOGY IN VIRT...

International Technology and Innovation Conference 2009

作者： Jianhua Liu * Ruxin Ning qidong hu School of Mechanical Engineering Beijing Institute of Technology Beijing 100081 China

Pipe routing design and assembly planning for complicated products are time-consuming and difficult, and Virtual Reality （VR） technology provides engineers a new and efficiency way. Based on the analysis of pipeline’s characteristic, a pipe modeling method based on control points model in virtual environment is introduced, and the pipe are built though recognizing and organizing those control points. The process of pipeline layout was introduced. Some rules are applied in the process of pipeline layout. The outcome of the pipeline layout is used for pipe assembly simulation in virtual environment directly. The unreasonable outcome can be found earlier through pipe assembly simulation. This paper focuses on the key realization techniques of pipeline layout and assembly simulation in virtual environment, including digital model of pipeline, pipeline layout technique, real-time collision detection in the process of pipe assembly simulation. Eventually, a prototype is developed and has illustrated the feasibility of the proposed above methods and algorithms.

关键词： Pipe routing design Pipe assembly planning Virtual assembly Control point Arc fitting

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肾透明细胞癌根治术后胰腺转移2例报告

中华泌尿外科杂志 2024年第2期45卷 146-147页

作者：夏启东王敏王少刚胡嘏华中科技大学同济医学院附属同济医院泌尿外科武汉430030 华中科技大学同济医学院附属同济医院胆胰外科武汉430030

肾透明细胞癌根治术后胰腺转移临床罕见。本文报道2例患者的临床资料。例1,男,64岁,因体检发现胰腺肿物1周就诊。例2,女,62岁,因上腹部疼痛7个月余就诊。2例既往均因肾透明细胞癌行腹腔镜根治性肾切除术。2例均行腹腔镜胰腺中段切除术/... 详细信息

肾透明细胞癌根治术后胰腺转移临床罕见。本文报道2例患者的临床资料。例1,男,64岁,因体检发现胰腺肿物1周就诊。例2,女,62岁,因上腹部疼痛7个月余就诊。2例既往均因肾透明细胞癌行腹腔镜根治性肾切除术。2例均行腹腔镜胰腺中段切除术/全胰十二指肠切除术,术后病理检查均提示胰腺透明细胞癌,符合肾癌转移。术后2例未行肿瘤免疫或靶向治疗,随访1年,均无复发和其他器官受累。

关键词：肾透明细胞癌胰腺转移临床特征外科治疗预后

In situ carbon coating for enhanced chemical stability of copper nanowires

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International Journal of Minerals,Metallurgy and Materials 2022年第3期29卷 557-562页

作者： Xiaolan Tong Hao hu Xingzhong Zhao qidong Tai School of Physics and Technology Wuhan UniversityWuhan 430072China Institute of Technological Sciences Wuhan UniversityWuhan 430072China

Copper nanowires(CuNWs)are promising electrode materials,especially for used in flexible and transparent electrodes,due to their advantages of earth-abundant,low-cost,high conductivity and flexibility.However,the poor stability of CuNWs against oxidation and chemic-al corrosion seriously hinders their practical applications.Herein,we propose a facile strategy to improve the chemical stability of CuNWs by in situ coating of carbon protective layer on top of them through hydrothermal carbonization method.The influential factors on the growth of carbon film including the concentration of the glucose precursor(carbon source),hydrothermal temperature,and hydrothermal time are sys-tematically studied.By tailoring these factors,carbon layers with thickness of 3-8 nm can be uniformly grown on CuNWs with appropriate glucose concentration around 80 mg·mL−1,hydrothermal temperature of 160-170°C,and hydrothermal time of 1-3 h.The as-prepared carbon-coated CuNWs show excellent resistance against corrosion and oxidation,and are of great potential to use broadly in various optoelectronic devices.

关键词： electrode material copper nanowire in situ carbon coating stability

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启东市近年来环境空气质量变化趋势分析

污染防治技术 2012年第5期25卷 16-18,80页

作者：茅文湖启东市环境监测站江苏启东226200

文中以2004-2011年启东市环境空气监测数据为依据,统计、分析了主要污染物的变化特征及趋势,探讨了影响启东市环境空气质量的主要因素,提出了进一步改善环境空气质量的对策措施。

关键词：空气质量变化趋势影响因素对策措施

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浅议环境监测部门仪器设备的档案管理工作

污染防治技术 2013年第1期26卷 65-66页

作者：茅文湖启东市环境监测站江苏启东226200

文中针对环境监测部门仪器设备档案管理中普遍存在的问题,提出了加强仪器设备档案管理的措施,为仪器设备的准确可靠提供有力保障。

关键词：环境监测仪器设备档案管理准确可靠

橄榄油市场行情及其与其他植物油的脂肪酸组成和微量营养成分比较

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中国油脂 2024年第3期49卷 27-31,40页

作者：孙玉萍杨亚黄国栋刘启东龚俊伊军胡金华中粮(东莞)粮油工业有限公司广东东莞523145 湖北润邦农业科技有限公司湖北黄冈435300

旨在更全面、深入地了解橄榄油,对2010—2021年世界橄榄油的产量和消费量以及2015—2019年中国橄榄油的进口量进行了统计分析,测定不同品牌和不同等级市售橄榄油(特级初榨橄榄油、混合橄榄油和混合油橄榄果渣油)与9种其他植物油的脂肪... 详细信息

旨在更全面、深入地了解橄榄油,对2010—2021年世界橄榄油的产量和消费量以及2015—2019年中国橄榄油的进口量进行了统计分析,测定不同品牌和不同等级市售橄榄油(特级初榨橄榄油、混合橄榄油和混合油橄榄果渣油)与9种其他植物油的脂肪酸组成和微量营养成分,并分析比较其差异。结果显示:世界橄榄油的产量和消费量常年维持在300万t左右,其中欧盟占比最大,分别为58.71%~76.68%和48.73%~62.15%;2015—2019年中国橄榄油产量仅在0.5万~0.7万t,而消费量和进口量分别达到了3.9万~5.75万t和3.86万~5.37万t;不同品牌和不同等级市售橄榄油的脂肪酸组成整体差异不大,但微量营养成分存在明显差异,其中特级初榨橄榄油的角鲨烯、多酚含量明显高于混合橄榄油和混合油橄榄果渣油,而混合油橄榄果渣油的甾醇和总生育酚含量最高;与一级菜籽油、一级玉米油、一级葵花籽油、一级大豆油和亚麻籽油等其他植物油比较,特级初榨橄榄油的油酸、角鲨烯和多酚含量最高,而甾醇和总生育酚含量偏低。

关键词：橄榄油市场行情脂肪酸组成微量营养成分