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国际医药卫生导报 2024年第18期30卷 3003-3007页

作者：拓万宝葛郁龙张彦祥梁冠文宋启春宝鸡市人民医院骨二科宝鸡721000 西安交通大学附属第二医院骨一科西安710004

目的探讨改良Y型纳米骨板在多节段脊髓型颈椎病(MCSM)术中的应用效果。方法回顾性分析2020年1月至2023年3月宝鸡市人民医院收治的103例MCSM患者资料,根据内固定材料不同进行分组,对照组51例,研究组52例。对照组男26例,女25例,年龄(54.43... 详细信息

目的探讨改良Y型纳米骨板在多节段脊髓型颈椎病(MCSM)术中的应用效果。方法回顾性分析2020年1月至2023年3月宝鸡市人民医院收治的103例MCSM患者资料,根据内固定材料不同进行分组,对照组51例,研究组52例。对照组男26例,女25例,年龄(54.43±4.12)岁,体重指数(23.28±1.49)kg/m^(2),病变节段:C_(2-7)5例、C_(3-6)7例、C_(3-7)30例、C_(4-7)9例,采用微型钛板内固定联合颈椎单侧肌肉韧带保留治疗;研究组男29例,女23例,年龄(53.01±4.58)岁,体重指数(23.04±1.36)kg/m^(2),病变节段:C_(2-7)6例、C_(3-6)8例、C_(3-7)33例、C_(4-7)5例,采用改良Y型纳米骨板固定联合颈椎单侧肌肉韧带保留治疗。两组患者术后均随访6个月。比较两组手术情况、疼痛情况、颈椎功能、颈椎影像学参数及并发症情况。采用t检验、χ^(2)检验。结果研究组手术时间短于对照组、术中出血量少于对照组[(104.21±15.29)min比(115.98±18.54)min、(131.68±21.01)ml比(145.21±24.16)ml],差异均有统计学意义(t=3.518、P=0.001,t=3.035、P=0.003)。术后3个月,研究组、对照组的视觉模拟评分法(VAS)评分比较[(1.41±0.22)分比(1.47±0.21)分],差异无统计学意义(P>0.05)。术后6个月,研究组的日本骨科协会(JOA)评分高于对照组[(21.98±2.03)分比(21.04±2.28)分],颈部功能障碍指数(NDI)低于对照组[(14.15±2.17)%比(15.26±2.43)%],颈椎前屈、后伸、左屈、右屈活动度均低于对照组[(40.17±3.24)°比(42.01±3.62)°、(39.24±3.43)°比(41.68±3.75)°、(34.84±2.31)°比(36.05±2.74)°、(35.26±2.51)°比(37.01±2.72)°],差异均有统计学意义(t=2.211、2.446、2.719、3.447、2.425、3.394,均P<0.05);两组颈椎侧位生理曲度比较[(10.34±1.43)°比(10.18±1.75)°],差异无统计学意义(t=0.509,P=0.612)。研究组并发症总发生率低于对照组[5.77%(3/52)比21.57%(11/51)],差异有统计学意义(χ^(2)=5.472,P=0.019)。结论与微型钛板内固定相比,改良Y型纳米骨板固定联合颈椎单侧肌肉韧带保留用于MCSM术中,可缩短手术时间,减少出血量,在改善患者颈椎功能方面更具优势,且安全性更高。

关键词：多节段脊髓型颈椎病内固定术 Y型纳米骨板效果

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Same impact momentum causes different degrees of spinal cord injury

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Chinese Science Bulletin 2014年第32期59卷 4298-4303页

作者： Le Ji Xiaoqian Dang Binshang Lan qichun song Dapeng Duan Zhe Ji Yongtao Zhang Lisong Heng Department of Orthopedic Surgery The Second Affiliated Hospital School of Medicine Xi’an Jiaotong University Department of Orthopedic Surgery Shaanxi Provincial People’s Hospital Department of Orthopedic Surgery Xi’an Honghui Hospital

The weight-drop impact is widely used in making animal model of spinal cord injury(SCI).But there has not yet been an appropriate unit for the quantification of the *** this study,we compared the degrees of the spinal cord injury caused by weight-drop impact with the same momentum but different combinations of drop weight and drop height,in order to test whether‘‘momentum’’is capable of being the unit for the quantification of weightdrop *** adult rats were randomly allocated to three groups and were injured with 5 g–10 cm(group A),10 g–2.5 cm(group B)and 15 g–1.11 cm(group C)impacts with the same momentum to the spinal cord,***-field locomotor function was evaluated using the Basso–Beattie–Bresnahan(BBB)locomotor rating *** percentage of spared tissue area(STA)at the epicenter,and 500,1000 and 1500 lm from the epicenter was calculated using serial sections stained by hematoxylin and *** a result,the behavioral recovery(BBB scores)and the STA percentage were similar in group B and group ***,the BBB score in group A was significantly lower than that in groups B and C at the same time point post *** STA percentage was significantly less and the lesion/cavity length was significantlygreater in group A than in groups B and *** suggested that the 5 g–10 cm weight-drop impact,compared with the other two impacts with different weights and heights,caused a greater damage of the spinal cord when the momentum was the ***,these impacts with the same momentum but different weights and drop heights cause different degrees of spinal cord *** alone is inadequate to be the unit for the qualification of weightdrop impact and to be used to predict the extent of injury.

关键词：脊髓损伤运动功能 HE染色 STA 动物模型成年大鼠连续切片跌落高度

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Effects of the local bone renin-angiotensin system on steroid-induced osteoporosis

Effects of the local bone renin-angiotensin system on steroi...

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中华医学会第五次中青年骨质疏松和骨矿盐疾病学术会议

作者： Yongtao Zhang qichun song Kunzheng Wang Chunsheng Wang Second Affiliated Hospital of Xian Jiaotong University Department of Orthopaedics

Purpose Glucocorticoids(GCs) treatment frequently causes osteoporosis,but currently the precise mechanism in the pathogenesis of glucocorticoid-induced osteoporosis(GIOP) is still not fully elucidated. The purpose of ...

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AngiotensinⅡinduces reactive oxygen species in osteoblasts and downstream activates the extracellular signal-regulated kinase and receptor activator of nuclear factor-κB ligand

AngiotensinⅡinduces reactive oxygen species in osteoblasts ...

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中华医学会第五次中青年骨质疏松和骨矿盐疾病学术会议

作者： Yongtao Zhang qichun song Kunzheng Wang Chunsheng Wang Second Affiliated Hospital of Xian Jiaotong University Department of Orthopaedics

Purpose AngiotensinⅡ(AngⅡ) accelerates osteoporosis by activating osteoclasts via receptor activator of nuclear factor- k B ligand(RANKL) ***,the precise mechanism of AngⅡinduction RANKL in osteoblasts is still not be fully *** oxygen species(ROS) is known to modulate the activity of many signal transduction *** of the cytoplasmic kinase pathways

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AngiotensinⅡinduces monocyte chemoattractant protein-1 synthesis in osteoblasts

AngiotensinⅡinduces monocyte chemoattractant protein-1 synt...

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中华医学会第五次中青年骨质疏松和骨矿盐疾病学术会议

作者： Yongtao Zhang qichun song Kunzheng Wang Chunsheng Wang Jianqiang Kou Second Affiliated Hospital of Xian Jiaotong University Department of Orthopaedics

Purpose AngiotensinⅡ(AngⅡ) significantly induced the expression of receptor activator of NF-κB ligand(RANKL) in osteoblasts,leading to the formation of *** chemoattractant protein-1(MCP-1) is a potent stimulator of...

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Panax notoginseng saponins improves osteopenia in steroid-induced osteoporosis in rats and inhibits apoptosis in osteoblasts

Panax notoginseng saponins improves osteopenia in steroid-in...

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中华医学会第五次中青年骨质疏松和骨矿盐疾病学术会议

作者： Yongtao Zhang qichun song Yalong Yang Kunzheng Wang Chunsheng Wang Second Affiliated Hospital of Xian Jiaotong University Department of Orthopaedics

Purpose The aim of the present study was to investigate the effects of panax notoginseng saponins(PNS)which inhibits the apoptosis of neuron on bone loss in steroid-induced osteoporosis in rats and its impact on the apoptosis of cultured primary osteoblasts. Methods 30 adult Sprague-Dawley rats were randomly divided into the following groups with 10

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To investigate the role of local bone renin-angiotensin system in postmenopausal osteoporosis in rats

To investigate the role of local bone renin-angiotensin syst...

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中华医学会第五次中青年骨质疏松和骨矿盐疾病学术会议

作者： Yongtao Zhang qichun song Kunzheng Wang Binqiang Ren Xiaoqian Dang Second Affiliated Hospital of Xian Jiaotong University Department of Orthopaedics

Purpose Angiotensin type 1 receptors(AT1 receptors) blocker and angiotensin converting enzyme inhibitor(ACEI) were shown to improve osteoporotic bone in ovariectomized ***,the explicit role of local bone renin-angiote...

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Hip arthroplasty with intertrochanteric reconstruction technique for intertrochanteric hip frature in the elderly of osteoporosis

Hip arthroplasty with intertrochanteric reconstruction techn...

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中华医学会第五次中青年骨质疏松和骨矿盐疾病学术会议

作者： Yongtao Zhang qichun song Kunzheng Wang Chunsheng Wang Xiaoqian Dang Second Affiliated Hospital of Xian Jiaotong University Department of Orthopaedics

Purpose To evaluate the curative effect of hip arthroplasty with intertrochanteric reconstruction technique for the treatment of intertrochanteric fractures in elderly patients of osteoporosis. Methods 30 senile patients of osteoporosis(32hips) with intertrochanteric fracture between May 2008 and May 2010 were admitted in our *** patients admitted in this study were diagnosed as

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The Role of Sildenafil in Glucocorticoid-Induced Osteoporosis in Rats Through a PKG-Dependent Pathway

The Role of Sildenafil in Glucocorticoid-Induced Osteoporosi...

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中华医学会第五次中青年骨质疏松和骨矿盐疾病学术会议

作者： qichun song Yongtao Zhang Le Ji Xiaoqian Dang Kunzheng Wang Second Affiliated Hospital of Xian Jiaotong University Department of Orthopaedics

Objective Sildenafil,a cyclic guanosine monophosphate(cGMP)-dependent phospodiesterase-5 inhibitor,has been shown to help bone formation and inhibit bone *** study is to evaluate the efficacy of sildenafil in treatmen...

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Advancing Age Results in Reduction of Human Bone Vitamin D Receptor Expression

Advancing Age Results in Reduction of Human Bone Vitamin D R...

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中华医学会第五次中青年骨质疏松和骨矿盐疾病学术会议

作者： qichun song Yongtao Zhang Le Ji Xiaoqian Dang Kunzheng Wang Second Affiliated Hospital of Xian Jiaotong University

Objective We probed the relation between age and 1,25-dihydroxyvitamin D receptor(VDR) expression in freshly removed human bone. Methods We collected biopsy specimens of the femur neck taken at surgery from 25 male patients undergoing total hip arthroplasty and biopsy specimens of the spinous process taken at surgery from 29

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