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npj Computational Materials 2022年第1期8卷 2239-2246页

作者： Yu Dai Wenjiang Zhou Hyun-Jung Kim qichen song Xin Qian Te-Huan Liu Ronggui Yang School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhanHubei430074China Peter Grünberg Institut and Institute for Advanced Simulation Forschungszentrum Jülich and JARAD-52425JülichGermany Department of Chemistry and Chemical Biology Harvard UniversityCambridgeMA02138USA

SnTe possesses a single-to double-valley transition in the conduction band minimum when a compressive strain is *** a tight-binding analysis,it is shown that the variation of the band structure is attributed to the strain-induced delocalization of both the Sn-5s orbitals and Te-5p orbitals with different angular *** effect can largely increase the electron density of states near the band edge and thus keep the Fermi level of the compressed SnTe closer to it,where the electrons have lower scattering *** strain-induced double valleys lead to simultaneous increases in the electrical conductivity and the Seebeck coefficient and thereby nearly four times the enhancement of the power factor at the doping concentration of 5×10^(19) cm^(–3).This work suggests a feasible concept that can be employed to promote the power factor of a Dirac semiconductor via manipulating the valley degeneracy in the conduction band minimum.

关键词： conductivity double coefficient

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小议迎随补泻

中华中医药杂志 2023年第11期38卷 5417-5419页

作者：陈松中盐金坛盐化有限责任公司博士后科研工作站常州213200 厦门大学哲学博士后流动站厦门361005 湖北中医药大学针灸骨伤学院武汉430065

“迎随补泻”源于《灵枢·九针十二原》,篇中对“迎随补泻”的操作有所描述,后世多以针向释迎随,并在其基础上延伸出多种迎随补泻方法。通过对“迎随”的语义进行梳理,认为“迎随补泻”不仅表现于具体操作形式上,也蕴含了针刺候气调气... 详细信息

“迎随补泻”源于《灵枢·九针十二原》,篇中对“迎随补泻”的操作有所描述,后世多以针向释迎随,并在其基础上延伸出多种迎随补泻方法。通过对“迎随”的语义进行梳理,认为“迎随补泻”不仅表现于具体操作形式上,也蕴含了针刺候气调气的重要性。人体之气是动态变化的,针刺过程中应根据指下针感体会气的动态变化,随之变换针刺手法,在治神的前提下,知气之往来,意势相合,与之相期。

关键词：针刺迎随补泻气神临床实践

数字经济背景下泰安市现代物流产业发展现状分析

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物流科技 2023年第14期46卷 83-86页

作者：宋其琛贵州大学经济学院贵州贵阳550000

泰安位于山东省中部,地理位置优越,具有良好的区位优势。然而在数字经济背景下,分析泰安市物流产业的发展现状,却发现其存在技术不统一、人才缺乏、创新能力不足等问题。为使其面临的问题得到有效解决,文章在数字经济的大背景下对泰安... 详细信息

泰安位于山东省中部,地理位置优越,具有良好的区位优势。然而在数字经济背景下,分析泰安市物流产业的发展现状,却发现其存在技术不统一、人才缺乏、创新能力不足等问题。为使其面临的问题得到有效解决,文章在数字经济的大背景下对泰安市现代物流产业的发展提出了解决路径和政策建议。

关键词：泰安数字经济现代物流产业发展路径

色彩介入高校校园规划设计的方法探析——以南京大学仙林校区为例

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四川建筑科学研究 2019年第3期45卷 126-130页

作者：赵立志宋启晨李晟凯中国矿业大学(北京)力学与建筑工程学院

现代高校校园的规划设计由于忽视色彩规划导致色彩地域性不足、色彩体系缺失和空间识别性差等问题。本文通过论述色彩的本质和单体设计的意义进而重塑了色彩认知。对南京大学仙林校区的色彩规划进行了调研分析,建构了“色彩策略—色彩... 详细信息

现代高校校园的规划设计由于忽视色彩规划导致色彩地域性不足、色彩体系缺失和空间识别性差等问题。本文通过论述色彩的本质和单体设计的意义进而重塑了色彩认知。对南京大学仙林校区的色彩规划进行了调研分析,建构了“色彩策略—色彩结构—单体细化”的理论架构,提出了系统性建立高校校园建筑色彩设计的方法。

关键词：高校校园建筑色彩系统规划设计方法

Cross-Modal Interaction and Integration Through Stimulus-Specific Adaptation in the Thalamic Reticular Nucleus of Rats

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Neuroscience Bulletin 2022年第7期38卷 785-795页

作者： Yumei Gong Yuying Zhai Xinyu Du Peirun song Haoxuan Xu qichen Zhang Xiongjie Yu Department of Neurology of the Second Affiliated Hospital of Zhejiang University School of MedicineInterdisciplinary Institute of Neuroscience and TechnologyCollege of Biomedical Engineering and Instrument ScienceZhejiang UniversityHangzhou 310029China Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310027China Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal Zhejiang UniversityHangzhou 310027China

Stimulus-specific adaptation(SSA),defined as a decrease in responses to a common stimulus that only partially generalizes to other rare stimuli,is a widespread phenomenon in the brain that is believed to be related to novelty *** cross-modal sensory processing is also a widespread phenomenon,the interaction between the two phenomena is not well *** this study,the thalamic reticular nucleus(TRN),which is regarded as a hub of the attentional system that contains multi-modal neurons,was *** results showed that SSA existed in an interactive oddball stimulation,which mimics stimulation changes from one modality to *** the bimodal integration,SSA to bimodal stimulation was stronger than to visual stimulation alone but similar to auditory stimulation alone,which indicated a limited integrative ***,the present results provide evidence for independent cross-modal processing in bimodal TRN neurons.

关键词： Stimulus-specific adaptation Regularity:Novelty detection Thalamic reticular nucleus Crossmodal

Novel gold nanoparticles targeting somatostatin receptor subtype two with near-infrared light for neuroendocrine tumour therapy

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Nano Research 2022年第10期15卷 9149-9159页

作者： qichen Chen Zilin Li Jiangyuan Yu Qing Xie Haizhen Lu Yiqiao Deng Jinghua Chen Wenjia Zhu Li Huo Yizhou Zhang Wei song Jianqiang Lan Jianqiang Cai Zhen Huang Zixi Wang Hong Zhao Department of Hepatobiliary Surgery State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Gene Editing Screening and R&D of Digestive System Tumor Drugs Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Department of Nuclear Medicine Key Laboratory of Carcinogenesis and Translational ResearchMinistry of EducationPeking University Cancer Hospital&InstituteBeijing 100142China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17Panjiayuan NanliBeijing 100021China Nuclear Medicine Department State Key Laboratory of Complex Severe and Rare DiseasesCenter for Rare Diseases ResearchBeijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear MedicinePeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100005China Department of Biochemistry and Molecular Biology State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Guangdong Research Center of Organoid Engineering and Technology Accurate International Biotechnology Co.Ltd.Guangzhou 510650China

Neuroendocrine tumours(NETs)are rare cancers with positive somatostatin receptor 2(SSTR2)expression,and treatment strategies for NETs are not ***-mediated therapy targeting SSTR2 in NETs is very *** study firstly combined mesoporous silica-coated gold nanorods(AuNRs@mSiO_(2))and targeting-SSTR2 dodecane tetraacetic acidtyrosine3-octreotate(DOTA-TATE)into AuNRs@mSiO_(2)@DOTA-TATE to investigate NETs inhibition under near-infrared ***@mSiO_(2)@DOTA-TATE showed good photothermal conversion *** vitro,under light irradiation,the cell viability significantly decreased with increasing AuNR@mSiO_(2)@DOTA-TATE concentration;in two successfully established neuroendocrine tumour organoids with SSTR2 expression,AuNRs@mSiO_(2)@DOTA-TATE with light inhibited tumours significantly better than AuNRs@mSiO_(2) with *** vivo,the SSTR2-targeting ability and biodistribution of AuNRs@mSiO_(2)@DOTA-TATE were confirmed with AuNRs@mSiO_(2)@64Cu-DOTA-TATE under micro-positron emission tomography/computed tomography(micro-PET/CT);in the AuNRs@mSiO_(2)@DOTA-TATE with laser group,the tumour surface temperature increased rapidly,with tumour volumes similar to those in the octreotide group and significantly lower than those in other *** was no significant difference in mice body weight between the AuNRs@mSiO_(2)@DOTA-TATE with laser group and other *** significant inflammatory lesions or cell necrosis was found in the main *** summary,we presented a feasible strategy to construct AuNRs@mSiO_(2)@DOTA-TATE with good photothermal conversion efficiency,targetingSSTR2 ability,significant antitumour effects,and good biocompatibility,warranting further explorations of AuNRs@mSiO_(2)@DOTA-TATE for NETs therapy applications.

关键词： neuroendocrine tumours somatostatin receptor 2 nanoparticles photothermal therapy

气候变化背景下湖泊有机碳组分对温度和降水格局改变的响应

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生态学报 2024年第10期44卷 4117-4128页

作者：张爽高启晨张戎宋晨珲栗忠飞西南林业大学生态与环境学院昆明650224 中国石油集团安全环保技术研究院有限公司北京102200

湖泊湿地是地球上缓解全球变暖的巨大碳汇系统。在气候变化背景下,随着温度、降水等格局的改变,其碳汇功能存在高度的响应过程。基于135篇文献已发表的557项观测数据,运用meta分析的方法,分析全球尺度上气候及地理因素的相互作用对湖泊... 详细信息

湖泊湿地是地球上缓解全球变暖的巨大碳汇系统。在气候变化背景下,随着温度、降水等格局的改变,其碳汇功能存在高度的响应过程。基于135篇文献已发表的557项观测数据,运用meta分析的方法,分析全球尺度上气候及地理因素的相互作用对湖泊有机碳组分的影响,包括湖泊沉积物有机碳(Sediment Organic Carbon)、湖水中总有机碳(Total Organic Carbon)、湖水溶解有机碳(Dissolved Organic Carbon)和颗粒有机碳(Particulate Organic Carbon)。结果显示:1)在纬度3°49′N—76°24′N和海拔0—4500m范围内,SOC、TOC、POC和DOC的变化范围分别为0.25—15.6 g C/Kg、1.9—25.11 mg C/L、0.026—24 mg C/L、1—115.4 mg C/L;2)地理因素中,海拔与TOC呈显著的负相关(P<0.05),每升高1m,TOC增加0.0077 mg/L;纬度与POC呈显著负相关,与DOC呈显著正相关(P<0.05),每增加1°,POC减少0.136 mg/L,DOC增加1.18 mg/L;3)气候因素中,年均温与SOC和POC呈显著的正相关,与DOC呈显著负相关(P<0.05),每升高1℃,SOC和POC增加0.079 g/kg、0.36 mg/L,DOC下降1.52 mg/L;年均降水量与POC呈显著正相关,与DOC呈显著负相关(P<0.05),每增加100mm,POC增加0.87 mg/L,DOC减少3 mg/L;4)气候和地理因素对SOC、TOC、POC、DOC综合影响的贡献度分别达到16.1%、14%、90%、61.6%;5)最热季度的降水对SOC的影响成正相关,其他季节性气候参数对湖水中TOC和SOC均无显著性影响;最冷季的降水因素是影响POC的主要因素,最潮湿月份、最潮湿季节的降水量和最冷季度的平均温度与POC呈显著正相关关系;最干燥月份、最干旱地区、最热季度和最冷季度的降水量对DOC的影响最显著。

关键词：湖泊有机碳温度与降水海拔与纬度 Meta分析

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Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4637-4652页

作者： Jianqiang Cai Weilong Zhang Yalan Lu Wenjie Liu Haitao Zhou Mei Liu Xinyu Bi Jianmei Liu Jinghua Chen Yanjiang Yin Yiqiao Deng Zhiwen Luo Yi Yang qichen Chen Xiao Chen Zheng Xu Yueyang Zhang Chaoling Wu Qizhao Long Chunyuan Huang Changjian Yan Yan Liu Lei Guo Weihua Li Pei Yuan Yucheng Jiao Wei song Xiaobing Wang Zhen Huang Jianming Ying Hong Zhao Department of Hepatobiliary Surgery State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Gene Editing Screening and R&D of Digestive System Tumor Drugs Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Hematology Lymphoma Research CenterPeking University Third HospitalBeijingChina Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of HealthBeijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina Department of Biochemistry and Molecular Biology State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina Department of Colorectal Surgery State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pathology State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Liver metastasis remains the primary cause of mortality in patients with colon cancer. Identifying specific driver gene mutations that contribute to metastasis may offer viable therapeutic targets. To explore clonal evolution and genetic heterogeneity within the metastasis, we conducted single-cell exome sequencing on 150 single cells isolated from the primary tumor, liver metastasis, and lymphatic metastasis from a stage IV colon cancer patient. The genetic landscape of the tumor samples revealed that both lymphatic and liver metastases originated from the same region of the primary tumor. Notably, the liver metastasis was derived directly from the primary tumor, bypassing the lymph nodes. Comparative analysis of the sequencing data for individual cell pairs within different tumors demonstrated that the genetic heterogeneity of both liver and lymphatic metastases was also greater than that of the primary tumor. This finding indicates that liver and lymphatic metastases arose from clusters of circulating tumor cell (CTC) of a polyclonal origin, rather than from a single cell from the primary tumor. Single-cell transcriptome analysis suggested that higher EMT score and CNV scores were associated with more polyclonal metastasis. Additionally, a mutation in the TRPS1 (Transcriptional repressor GATA binding 1) gene, TRPS1 R544Q, was enriched in the single cells from the liver metastasis. The mutation significantly increased CRC invasion and migration both in vitro and in vivo through the TRPS1R544Q/ZEB1 axis. Further TRPS1 mutations were detected in additional colon cancer cases, correlating with advanced-stage disease and inferior prognosis. These results reveal polyclonal seeding and TRPS1 mutation as potential mechanisms driving the development of liver metastases in colon cancer.

关键词： metastasis colon cancer

特高频信号RSSI统计分析下的变电站空间局部放电定位技术

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高电压技术 2020年第12期46卷 4163-4171页

作者：郁琦琛罗林根贾廷波宋辉盛戈皞江秀臣上海交通大学电气工程系上海200240 国网山东省电力公司日照供电公司日照276800

各类状态监测传感器的物联网化、智能化是目前电力设备状态状态评估技术的发展趋势之一。传统的敞开式变电站设备空间局部放电定位技术主要基于时差法,这种方法对时间同步精度及采样率要求较高。为此,提出了一种基于特高频无线传感器阵... 详细信息

各类状态监测传感器的物联网化、智能化是目前电力设备状态状态评估技术的发展趋势之一。传统的敞开式变电站设备空间局部放电定位技术主要基于时差法,这种方法对时间同步精度及采样率要求较高。为此,提出了一种基于特高频无线传感器阵列和接收信号强度(received signal strength indicator, RSSI)数据统计分析的空间局部放电定位技术。首先,利用高斯过程分类(Gaussian processclassification,GPC)方法来减小数据无线传输中的多径和阴影效应影响;然后,提出了基于特高频RSSI数据极大似然估计(maximum likelihood estimation, MLE)分析的局放源定位方法;最后,为进一步提高局放定位精度,对多次的局放定位结果进行了聚类分析,以充分利用物联网传感器测量数据的优势。实验结果表明:提出的系统及方法的局放定位平均误差为0.378m,定位误差累计概率在0.6 m时为92.78%,满足对具有绝缘缺陷的电力设备或设备部件进行初步定位的要求。相较于传统的到达时间差法,该方法显著降低了装置的采样率及同步精度;而相较于RSSI指纹法,该方法无需预先建立放电指纹图,现场部署方便,易于推广应用。

关键词：局部放电特高频无线传感器阵列 RSSI 高斯过程分类变电站

海外金融冲击的内生传染机制研究——基于开放经济下的DSGE模型分析

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财经科学 2020年第9期 1-13页

作者：刘一楠钟其辰宋晓玲中央国债登记结算有限公司华泰证券(上海)资产管理有限公司北京语言大学商学院

金融全球化背景下海外金融冲击对我国经济的影响逐步凸显,本文将海外金融冲击具象化为海外信贷冲击与汇率冲击,在开放DSGE模型中系统地研究海外金融冲击的内生传染机制:海外信贷冲击内生传染的核心渠道是通过资产价格影响国内流动性水... 详细信息

金融全球化背景下海外金融冲击对我国经济的影响逐步凸显,本文将海外金融冲击具象化为海外信贷冲击与汇率冲击,在开放DSGE模型中系统地研究海外金融冲击的内生传染机制:海外信贷冲击内生传染的核心渠道是通过资产价格影响国内流动性水平、制约国内企业与居民的借贷;汇率冲击的内生传染机制在于资产价格下降与人民币贬值间的内生加速。海外金融冲击传染的内生性说明其对国内经济系统的影响一方面与冲击大小有关,更重要的则取决于海外金融冲击引致的国内经济系统之内在反应。因此,面对海外金融冲击我们不仅需被动监测,更要主动防范,提升金融市场抵御风险的能力,着力点包括资本账户宏观审慎监管、避免汇率大幅波动、维持国内资产价格稳定等。

关键词：海外金融冲击内生传染机制信贷抵押约束 DSGE