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Journal of Rare Earths 2024年第1期42卷 36-45,I0002页

作者： Xiaoli Luo qichen chen Hongbo Guo Heng Zhang Xiaowei He Wu Zhao School of Mathematics and Computer Science Ningxia Normal UniversityGuyuan756099China School of Information Science and Technology Northwest UniversityXi'an710127China

Fluorescence imaging techniques represent essential tools in in vitro,preclinical,and clinical *** this study,an improved one-step hydrothermal method to synthesize citric acid(CA)modifiedα-NaYbF_(4):2%Er^(3+)nanocrystals was *** introduction of various doping ions into NaYbF_(4):2%Er^(3+)and the different valence states of the same ions affect both the crystal size and upconversion luminesce *** fore,we investigated the upconversion luminesce nce enha ncement of NaYbF_(4):2%Er^(3+)by ion doping and find that the upconversion luminescence intensity of the upconversion nanoparticles(UCNPs)co-doped with 5 mol%Fe^(2+)ions shows the greatest enhancement,especially for red emission at654 ***,HeLa cells incubated with UCNPs allow for imaging with strong red upconversion emission detectio *** laser scanning microscope(CLSM)fluorescent images of HeLa cells indicate that NaYbF_(4):2%Er/5%Fe^(2+)leads to a clear outline and improves visualization of the cell *** addition,the CA coated NaYbF_(4):2%Er^(3+)/5%Fe^(2+)nanoparticles and NaYbF_(4):2%Er^(3+)/5%Fe^(2+)show low cytotoxicity in HeLa *** imaging reveals the efficiency of these UCNPs to analyze the lungs,liver,and ***,these results indicate that the Cit-NaYbF_(4):2%Er^(3+)/5%Fe^(2+)UCNPs are efficient nanoprobes for fluorescence molecular to mography.

关键词： Hydrothermal method Fe^(2+)ion doping Tuning size Nanoprobes Fluorescence imaging Rare earths

Novel gold nanoparticles targeting somatostatin receptor subtype two with near-infrared light for neuroendocrine tumour therapy

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Nano Research 2022年第10期15卷 9149-9159页

作者： qichen chen Zilin Li Jiangyuan Yu Qing Xie Haizhen Lu Yiqiao Deng Jinghua chen Wenjia Zhu Li Huo Yizhou Zhang Wei Song Jianqiang Lan Jianqiang Cai Zhen Huang Zixi Wang Hong Zhao Department of Hepatobiliary Surgery State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Gene Editing Screening and R&D of Digestive System Tumor Drugs Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Department of Nuclear Medicine Key Laboratory of Carcinogenesis and Translational ResearchMinistry of EducationPeking University Cancer Hospital&InstituteBeijing 100142China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17Panjiayuan NanliBeijing 100021China Nuclear Medicine Department State Key Laboratory of Complex Severe and Rare DiseasesCenter for Rare Diseases ResearchBeijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear MedicinePeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100005China Department of Biochemistry and Molecular Biology State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Guangdong Research Center of Organoid Engineering and Technology Accurate International Biotechnology Co.Ltd.Guangzhou 510650China

Neuroendocrine tumours(NETs)are rare cancers with positive somatostatin receptor 2(SSTR2)expression,and treatment strategies for NETs are not ***-mediated therapy targeting SSTR2 in NETs is very *** study firstly combined mesoporous silica-coated gold nanorods(AuNRs@mSiO_(2))and targeting-SSTR2 dodecane tetraacetic acidtyrosine3-octreotate(DOTA-TATE)into AuNRs@mSiO_(2)@DOTA-TATE to investigate NETs inhibition under near-infrared ***@mSiO_(2)@DOTA-TATE showed good photothermal conversion *** vitro,under light irradiation,the cell viability significantly decreased with increasing AuNR@mSiO_(2)@DOTA-TATE concentration;in two successfully established neuroendocrine tumour organoids with SSTR2 expression,AuNRs@mSiO_(2)@DOTA-TATE with light inhibited tumours significantly better than AuNRs@mSiO_(2) with *** vivo,the SSTR2-targeting ability and biodistribution of AuNRs@mSiO_(2)@DOTA-TATE were confirmed with AuNRs@mSiO_(2)@64Cu-DOTA-TATE under micro-positron emission tomography/computed tomography(micro-PET/CT);in the AuNRs@mSiO_(2)@DOTA-TATE with laser group,the tumour surface temperature increased rapidly,with tumour volumes similar to those in the octreotide group and significantly lower than those in other *** was no significant difference in mice body weight between the AuNRs@mSiO_(2)@DOTA-TATE with laser group and other *** significant inflammatory lesions or cell necrosis was found in the main *** summary,we presented a feasible strategy to construct AuNRs@mSiO_(2)@DOTA-TATE with good photothermal conversion efficiency,targetingSSTR2 ability,significant antitumour effects,and good biocompatibility,warranting further explorations of AuNRs@mSiO_(2)@DOTA-TATE for NETs therapy applications.

关键词： neuroendocrine tumours somatostatin receptor 2 nanoparticles photothermal therapy

RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2555-2567页

作者： Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu qichen chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao chen Jinjie Yao Hanjie Hu Xiaowen cheng Yufeng Wan Xinyan chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao Department of Biochemistry and Molecular Biology State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Hepatobiliary Surgery State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Gene Editing Screening and R&D of Digestive System Tumor Drugs Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of HealthBeijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116China Department of Pathology State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Clinical Laboratory the First Affiliated HospitalAnhui Medical UniversityHefei 230022China Wellcome Centre for Anti-Infectives Research(WCAIR) Division of Biological Chemistry and Drug DiscoverySchool of Life SciencesUniversity of DundeeDundee DD15EHUK

Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling ***,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage ***138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic ***,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)*** importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB *** the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor ***,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation.

关键词： malignancy sustained finger

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人才强校战略之思考

湖南广播电视大学学报 2008年第1期 13-14页

作者：陈祺琛长沙广播电视大学

实施人才强校战略的途径主要是通过观念创新树立科学的人才观,通过制度创新建立健全有利于人才队伍建设的各种机制,通过方法创新建立适合高校自身特点的工作方法。

关键词：人才人才强校战略

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浅议文明进步带动建筑发展

安徽建筑 2010年第3期17卷 10-10,13页

作者：陈琦琛沈阳建筑大学建筑与规划学院辽宁沈阳110168

探讨人类的文明与建筑发展的关系。方法:以中外建筑历史的沿革为主线,从建筑物质技术构成,建筑与人的物质、精神活动需求,建筑的民族和地域特征,建筑的历史和时代特征,建筑的文化艺术性等方面进行一些尝试性的讨论。结论:人类文明的进... 详细信息

探讨人类的文明与建筑发展的关系。方法:以中外建筑历史的沿革为主线,从建筑物质技术构成,建筑与人的物质、精神活动需求,建筑的民族和地域特征,建筑的历史和时代特征,建筑的文化艺术性等方面进行一些尝试性的讨论。结论:人类文明的进步带动了建筑的发展。

关键词：人类文明建筑物质技术构成建筑与人民族和地域特征建筑发展

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启动压力影响下注采井间有效驱替规律

深圳大学学报（理工版） 2017年第1期34卷 91-97页

作者：陈民锋王兆琪张琪琛陈璐中国石油大学(北京)石油工程学院北京102249

低渗透储层具有明显的启动压力梯度,导致注采井间的渗流场分布与常规条件存在一定差异.基于典型注采条件下的渗流特点和驱替过程分析,在产量方程中引入启动压力梯度,构建出考虑启动压力影响下一注一采定产渗流模型.通过推导得出注采井... 详细信息

低渗透储层具有明显的启动压力梯度,导致注采井间的渗流场分布与常规条件存在一定差异.基于典型注采条件下的渗流特点和驱替过程分析,在产量方程中引入启动压力梯度,构建出考虑启动压力影响下一注一采定产渗流模型.通过推导得出注采井间压力场、速度场分布的数学表达式,并建立计算注采井间有效驱替面积、有效注采井距的方法,得到不同开发条件下井间渗流场分布和注采单元中有效驱替范围变化的规律.结合典型低渗透油藏参数进行的研究表明,根据有效驱替要求确定有效注采井距,并以此为基础部署开发井网,能在更大程度上有效驱动注采单元内的流体,进而提高低渗透油藏的开发效果.

关键词：油田开发低渗透启动压力梯度渗流场有效驱替注采井距

医疗建筑的有机生长——以中国医科大学附属第一医院浑南院区为例

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建筑技艺 2022年第S2期28卷 68-75页

作者：陈琦琛李强中国建筑东北设计研究院有限公司第一(广州)设计院

以中国医科大学附属第一医院浑南院区为例,对医疗建筑设计的有机生长理论进行探讨和研究,从院区规划和医疗设计两个方面来进行分析和解读。项目设计过程以有机生长理论作为指导思想,同时结合医疗技术、建筑技术及当地人文环境。

关键词：有机生长理论大专科、小综合人车分流下沉庭院

广州市越秀区2016—2020年学生肺结核流行特征及筛查情况分析

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广州医药 2021年第6期52卷 101-107页

作者：林晓珊陈其琛广州市胸科医院广州510095

目的本文通过对越秀区2016—2020年学生肺结核流行特征和筛查情况分析,为学校制定针对性防控措施提供参考依据,最大限度地做好学校结核病防控工作。方法在“国家结核病管理信息系统”专网中,导出2016—2020年常住在越秀区的学生肺结核... 详细信息

目的本文通过对越秀区2016—2020年学生肺结核流行特征和筛查情况分析,为学校制定针对性防控措施提供参考依据,最大限度地做好学校结核病防控工作。方法在“国家结核病管理信息系统”专网中,导出2016—2020年常住在越秀区的学生肺结核患者的病案信息到EXCLE表,进行逻辑核对和补漏;将患者每次所做的密切接触者筛查资料统一并录入到一个EXCLE汇总表,将信息表转换成FoxPro 6.0数据库进行统计,分析本地居住学生肺结核登记发病率、新发与复发构成比,人群分布特征、发现方式、就诊和确诊延误、耐药情况、密切接触者筛查情况。结果共登记学生肺结核191例,登记发病率为3.25/10万,不同年份登记发病率未见统计学差异(χ^(2)=7.84.P=0.0973),但学生患者占比从2016年的2.52%上升到2020年的7.74%,上升了3.07倍。学生患者均为新发,男女性别比为1.27:1,以15~24岁年龄段的高中生和大学生构成为主,分别占45.55%和39.79%,两者合计85.34%。发现方式主要以转诊、追踪到位和因症到结防机构直接就诊为主,分别为44.50%、25.13%、23.56%,其中转诊比例最高,占了44.50%;各年的发现方式构成比差异未见统计学意义(χ^(2)=12.057,P=0.4411)。共登记涂阳患者45例,就诊延误10例,延误率22.22%,确诊延误2例,延误率4.44%;共登记涂阴患者146例,就诊延误29例,延误率19.86%,确诊延误3例,延误率2.05%。共登记培养阳性(涂阳培阳45例,涂阴培阳6例),对一线抗结核药物(HRZES)全敏感42例,全敏感率82.35%;单耐药9例,耐药率17.65%,其中单耐药率最高的为异烟肼和链霉素,不同年份的全敏感率未见统计学差异(χ^(2)=3.81 P=0.432)。需开展筛查的学生肺结核患者178例,已开展筛查的患者169例,筛查率94.94%。需筛查的密切接触者7954例,实际接受筛查(开展了PPD或胸片筛查1项或以上)者7898例,筛查率99.30%,发现活动性肺结核13例,检出率0.16%。密切接触者筛查方式:胸片筛查6317人,发现胸片异常42人,异常率0.66%;PPD筛查7897人,强阳性493人,强阳性率6.24%;症状筛查7897人,自诉有症状64人,症状阳性率0.81%。结论2016—2020年,广州市越秀区学生肺结核疫情较轻,患者以高中和大学生首次发病为主,男女差别不大,但就诊延误和确诊延误仍较普遍。其次,对学生患者及其密切接触者的筛查工作做得较好,及时发现了较多现症患者及近期感染者。因此,继续加强高中以上学校的结核病防治知识宣传工作和做好应筛必筛工作,是今后学校疫情控制的侧重点。

关键词：结核肺流行特征筛查

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浅谈客车涂装制造过程的工艺改进

当代化工研究 2017年第6期 112-113页

作者：雷育玲陈祺琛福田汽车股份有限公司南海汽车厂广东528200

本文主要从客车行业内焊缝密封胶涂胶工艺方法、公交车橡胶铰链电泳漆防护方法、彩条喷涂工艺方法、原子灰落地后清理方法、集中供漆系统的应用五方面研究,辅以新材料的使用,最终找到了更优化的工艺作业方法,提高了客车的整车质量,降低... 详细信息

本文主要从客车行业内焊缝密封胶涂胶工艺方法、公交车橡胶铰链电泳漆防护方法、彩条喷涂工艺方法、原子灰落地后清理方法、集中供漆系统的应用五方面研究,辅以新材料的使用,最终找到了更优化的工艺作业方法,提高了客车的整车质量,降低了辅料成本,改善了员工的作业环境。

关键词：电泳漆渣焊缝密封腻子渣彩条套色集中供漆系统

响应面法优化马克斯克鲁维酵母干燥保护剂的研究

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中国饲料 2020年第22期 37-40页

作者：周樱王绍云陈祺琛陈新伟詹志春吕红复旦大学生命科学学院上海200433 武汉新华扬生物股份有限公司湖北武汉430206

研究干燥保护剂,提高马克斯克鲁维酵母在热风干燥过程中的存活率,实现高活菌数的活性干酵母的制备。以马克斯克鲁维酵母CGMCC 10621为试验菌株,干酵母活菌数为评价指标,采用响应面法对3种保护剂(司盘60、吐温80和海藻糖)的最佳添加量进... 详细信息

研究干燥保护剂,提高马克斯克鲁维酵母在热风干燥过程中的存活率,实现高活菌数的活性干酵母的制备。以马克斯克鲁维酵母CGMCC 10621为试验菌株,干酵母活菌数为评价指标,采用响应面法对3种保护剂(司盘60、吐温80和海藻糖)的最佳添加量进行优化。通过响应面试验和分析得到最优复合保护剂为司盘601.45%,吐温801.05%,海藻糖1.0%。在此条件下制备得到马克斯克鲁维干酵母活菌数可达3.2×1010 CFU/g,与实际试验结果相符,表明该模型具有应用意义,对马克斯克鲁维活性干酵母的工业化生产具有指导作用。

关键词：马克斯克鲁维酵母保护剂响应面法优化活性干酵母