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Biomarkers for predicting efficacy of chimeric antigen receptor T cell therapy and their detection methods

iLABMED 2024年第1期2卷 14-26页

作者： Bo Zou Yanzhou Song Ning Li Zhongyi Fan Jie Li Yuanzheng Peng Wanshan Wei Yuzi Zhang Yinan Su Xianmin Meng Hongzhou Lu Xingding Zhang Xiaohua Tan qibin liao Department of Oncology and Bio-Therapeutic Center Shenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina Molecular Cancer Research Center School of MedicineShenzhen Campus of Sun Yat-Sen UniversitySun Yat-Sen UniversityShenzhenChina Department of Hepato-Biliary Surgery Shenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina Institute for Hepatology National Clinical Research Centre for Infectious DiseasesShenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina Kidney Transplant Department(Liver Transplant Department) Transplant CenterNational Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated HospitalSouthern University of Science and TechnologyShenzhenChina Institute of Translational Medicine First Affiliated Hospital of Shenzhen UniversityShenzhen Second People's HospitalShenzhenGuangdongChina BASIS International School HuizhouGuangdongChina Department of Pharmacy Shenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina

Cancer immunotherapy has emerged as the fourth most prevalent approach to tumor treatment,alongside surgery,radiotherapy,and *** several decades of development,chimeric antigen receptor T(CAR-T)cell therapy,a promising branch of adoptive T-cell therapy,has demonstrated superior efficacy and safety in comparison to other cell therapies in the treatment of *** present,CAR-T cells are predominantly used to treat hematological malignancies,although their application in solid tumors is being readily *** numerous studies have examined the biomarkers associated with the safety of CAR-T cell therapy,few have evaluated predictors of CAR-T cell therapeutic ***,the primary objective of this review article was to provide a comprehensive overview of the factors predicting the efficacy of CAR-T cell therapy,with a particular focus on biomarkers and their detection methods.

关键词： biomarkers cancer immunotherapy CAR-T cell detection methods therapeutic efficacy

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Freeze-Drying Formulations Increased the Adenovirus and Poxvirus Vaccine Storage Times and Antigen Stabilities

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Virologica Sinica 2021年第3期36卷 365-372页

作者： Ye Chen qibin liao Tianyue Chen Yuchao Zhang Weien Yuan Jianqing Xu Xiaoyan Zhang Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences Fudan UniversityShanghai 201508China Engineering Research Center of Cell and Therapeutic Antibody Ministry of Educationand School of PharmacyShanghai Jiao Tong UniversityShanghai 200000China

Successful vaccines induce specific immune responses and protect against various viral and bacterial infections. Noninactivated vaccines, especially viral vector vaccines such as adenovirus and poxvirus vaccines, dominate the vaccine market because their viral particles are able to replicate and proliferate in vivo and produce lasting immunity in a manner similar to natural infection. One challenge of human and livestock vaccination is vaccine stability related to the antigenicity and infectivity. Freeze-drying is the typical method to maintain virus vaccine stability, while cold chain transportation is required for temperatures about 2 °C–8 °C. The financial and technological resource requirements hinder vaccine distribution in underdeveloped areas. In this study, we developed a freeze-drying formula consisting of bovine serum albumin(BSA), L-glutamic acid(L-Glu), polyethylene glycol(PEG), and dextran(DEX) to improve the thermal stability and activity of viral vaccines, including vaccinia recombinant vaccine(rTTV-OVA) and adenovirus vaccine(Ad5-ENV). We compared a panel of five different formulations(PEG: DEX: BSA: L-GLU = 50:9:0:0(#1), 50:5:4:0(#2), 50:10:9:0(#3),50:0:0:9(#4), and 50:1:0:8(#5), respectively) and optimized the freeze-drying formula for rTTV-OVA and Ad5-ENV. We found that the freeze-drying formulations #2 and #3 could maintain rTTV-OVA infectivity at temperatures of 4 °C and25 °C and that r TTV-OVA immunogenicity was retained during lyophilization. However, formulations #4 and #5 maintained Ad5-ENV infectivity under the same conditions, and Ad5-ENV immunogenicity had maximum retention with freeze-drying formulation #4. In summary, we developed new freeze-drying formulations that increased virus vaccine storage times and retained immunogenicity at an ambient temperature.

关键词： Adenovirus vaccine Poxvirus vaccine Freeze-drying formulation Stability Immunogenicity

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海洋微藻脂肪酸的气相色谱分析

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海洋通报 2000年第6期19卷 66-71页

作者：廖启斌李文权陈清花郑爱榕厦门大学海洋系亚热带海洋研究所厦门361005

以正十九酸（Ｃ１９：０）作内标，藻体经超声萃取、浓缩吹干，进行抽提酯化后采用毛细管气相色谱法分析测定。该方法重现性好，相对偏差为０．５３％～５．４９％，回收率较高，为９５．１％～１０２．５％，检测限为０．００７２ μ ｇ。

关键词：海洋微藻脂肪酸气相色谱分析 PUFA 试验测定

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大亚湾颗粒有机物生化组成研究

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海洋科学 1999年第2期23卷 60-63页

作者：崔淑芬李文权蔡阿根王宪陈清花郑爱榕廖启斌深圳职业技术学院 518055 厦门大学海洋系 361005

对大亚湾海域颗粒有机物（ＰＯＭ）的生化组成与环境因子的关系进行了研究。现场采样调查分别于１９９５年５月和１１月进行。研究结果表明，环境因子对ＰＯＭ生化组成有很大的影响。核电站的运作使大亚湾海域有局部升温现象。温度升... 详细信息

对大亚湾海域颗粒有机物（ＰＯＭ）的生化组成与环境因子的关系进行了研究。现场采样调查分别于１９９５年５月和１１月进行。研究结果表明，环境因子对ＰＯＭ生化组成有很大的影响。核电站的运作使大亚湾海域有局部升温现象。温度升高，使脂类含量升高。蛋白质含量受无机氮盐含量影响显著。由于大亚湾ＰＯＭ中蛋白质的含量不高，而且大亚湾水域呈贫氮特征，适当增加该海区无机氮的含量对于提高大亚湾ＰＯＭ的生物营养性具有现实意义。

关键词：颗粒有机物生化组成环境因子大亚湾水样

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Broadband tunable instantaneous frequency measurement system based on stimulated Brillouin scattering

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Optoelectronics Letters 2023年第3期19卷 174-178页

作者： liao Weijie ZHANG Jiahong CAI qibin Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming 650500China

A broadband tunable instantaneous frequency measurement(IFM)system is designed based on the stimulated Brillouin scattering effect of the highly nonlinear fiber in which the carrier suppressed single sideband modulated signal of the Brillouin frequency shift acts as pump *** amplitude comparison function(ACF)is constructed by the power radio of the two paths in the *** frequency measurement range and measurement accuracy can be tuned by changing the frequency difference of the two phase modulation *** tunable frequency measurement ranges of 2—5 GHz,2—10 GHz,2—15 GHz,2—20 GHz,and 2—24 GHz are realized,and the corresponding measurement accuracies are 3.64 d B/GHz,2.17 d B/GHz,1.87 d B/GHz,1.22 d B/GHz,and 0.77 d B/GHz,respectively.

关键词： tunable scattering pump

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嵌合抗原受体修饰T细胞疗法:过去、现在和未来

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生命的化学 2022年第5期42卷 837-848页

作者：廖启彬肖雯王敏卢洪洲谭晓华深圳市第三人民医院生物治疗中心深圳518112 深圳市第三人民医院肿瘤内科深圳518112 深圳市第三人民医院肝病研究所国家感染性疾病临床医学研究中心深圳518112

嵌合抗原受体修饰T细胞(chimeric antigen receptor-modified T cells,CAR-T)疗法经过30多年的发展已日趋成熟为一种新型治疗方式,特别是CAR-T细胞在血液瘤治疗中取得了巨大成功。目前已经有8款CAR-T产品获得美国食品药品监督管理局(FDA... 详细信息

嵌合抗原受体修饰T细胞(chimeric antigen receptor-modified T cells,CAR-T)疗法经过30多年的发展已日趋成熟为一种新型治疗方式,特别是CAR-T细胞在血液瘤治疗中取得了巨大成功。目前已经有8款CAR-T产品获得美国食品药品监督管理局(FDA)批准用于血液肿瘤的治疗。除了在血液肿瘤中的应用,CAR-T细胞在实体瘤治疗中的研究更是在如火如荼地进行,但是目前的临床疗效仍不尽如人意,亟待开发出新一代CAR-T细胞疗法。此外,CAR-T细胞疗法的应用也在不断拓展,不仅涵盖了恶性肿瘤治疗,也延伸至感染性疾病、自身免疫性疾病、器官移植排斥、衰老、纤维化等非肿瘤疾病的治疗。本文将主要综述CAR-T细胞疗法的发展历程和近年来的研究进展,特别是CAR-T细胞疗法在实体瘤中的应用,并对该疗法的未来发展作一展望。

关键词：嵌合抗原受体细胞疗法恶性肿瘤非肿瘤疾病

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烟用香料配制的气相色谱法质量控制研究

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福建分析测试 2002年第3期11卷 1602-1604页

作者：刘江生刘加增廖启斌刘泽春龙岩卷烟厂技术中心福建龙岩364000

采用气相色谱法对香料房卷烟用料液中的溶剂及水分进行检测,分析测定其中的水分、乙醇、丙二醇、山梨醇等的含量,通过对香料房每批配制料液的抽检,可以跟踪料液配制的准确性,保证卷烟产品质量,该方法操作简单、准确性高、重现性好。

关键词：气相色谱法烟用香料配制溶剂含量水分含量

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卷烟焦油检测误差来源的试验研究

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福建分析测试 2001年第3期10卷 1462-1466页

作者：廖启斌赖伟玲林艳蔡国华刘加增龙岩卷烟厂技术中心福建龙岩364000

应用两种牌号30条卷烟样品,对影响卷烟焦油检测结果的各相关因素进行试验研究,分析探讨吸烟机稳定性、环境温湿度。样品均一性等各因素对卷烟焦油检测的影响。

关键词：卷烟焦油检测误差来源

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酸模根际解淀粉芽胞杆菌SH-53发酵条件优化及其生防作用

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植物保护学报 2024年第4期51卷 817-829页

作者：王楠廖永琴申云鑫赵江源陈齐斌杨佩文云南农业大学植物保护学院昆明650201 云南省农业科学院农业环境资源研究所昆明650200 云南省微生物研究所昆明650091

为探索解淀粉芽胞杆菌Bacillus amyloliquefaciens SH-53的优化发酵条件及其生防作用,以发酵液OD_(600nm)值和抑菌率为指标,设计单因素试验和响应面试验优化发酵条件,以室内盆栽试验检测优化发酵液对番茄枯萎病防效、番茄苗促生效果及... 详细信息

为探索解淀粉芽胞杆菌Bacillus amyloliquefaciens SH-53的优化发酵条件及其生防作用,以发酵液OD_(600nm)值和抑菌率为指标,设计单因素试验和响应面试验优化发酵条件,以室内盆栽试验检测优化发酵液对番茄枯萎病防效、番茄苗促生效果及根系防御酶活的影响,并测定菌株SH-53在番茄根系的定殖能力。结果显示:菌株SH-53优化后的发酵条件为蔗糖15.00 g/L、硝酸钠15.00 g/L、磷酸氢二钠5.25 g/L、酵母浸粉5.00 g/L、pH 7.5、温度30℃、转速200 r/min,装液量200 mL培养24 h;优化后SH-53发酵液OD_(600nm)值及抑菌率分别较优化前显著提升183.01%和14.06%;在保护试验和治疗试验中防效分别为84.44%和64.86%,能显著提高番茄苗株高、茎粗和根长等农艺性状,可增强番茄根系过氧化物酶、过氧化氢酶、多酚氧化酶和超氧化物歧化酶活性。菌株SH-53在番茄苗根系表面定殖量为1.25×10^(8) CFU/mm。表明解淀粉芽胞杆菌SH-53优化发酵后对番茄枯萎病防治效果良好,可在番茄植株根系定殖,促进植株生长。

关键词：解淀粉芽胞杆菌发酵条件优化番茄枯萎病根系定殖根系防御酶

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A Localization Method of High Energy Transients for All-sky Gamma-ray Monitor

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Research in Astronomy and Astrophysics 2024年第10期24卷 25-35页

作者： Yi Zhao Wangchen Xue Shaolin Xiong Qi Luo Yuanhao Wang Jiacong Liu Heng Yu Xiaoyun Zhao Yue Huang Jinyuan liao Jianchao Sun Xiaobo Li qibin Yi Ce Cai Shuo Xiao Shenglun Xie Chao Zheng Yanqiu Zhang Chenwei Wang Wenjun Tan Zhiwei Guo Chaoyang Li Zhenghua An Gang Chen Yanqi Du Min Gao Ke Gong Dongya Guo Jiang He Jianjian He Bing Li Gang Li Xinqiao Li Jing Liang Xiaohua Liang Yaqing Liu Xiang Ma Rui Qiao Liming Song Xinying Song Xilei Sun Jin Wang Ping Wang Xiangyang Wen Hong Wu Yanbing Xu Sheng Yang Dali Zhang Fan Zhang Hongmei Zhang Peng Zhang Shu Zhang Zhen Zhang Shijie Zheng Keke Zhang Xingbo Han Haiyan Wu Hu Tai Hao Geng Gaopeng Lu Wei Xu Fanchao Lyu Hongbo Zhang Fangjun Lu Shuangnan Zhang Department of Astronomy Beijing Normal UniversityBeijing 100875China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China College of Physics Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China Institute of Astrophysics Central China Normal UniversityWuhan 430079China College of physics Sciences Technology Hebei UniversityBaoding 071002China Physics and Space Science College China West Normal UniversityNanchong 637002China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China College of Electronic and information Engineering Tongji UniversityShanghai 201804China Innovation Academy for Microsatellites of Chinese Academy of Sciences Shanghai 201304China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Electronic Information School Wuhan UniversityWuhan 430072China Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing Joint Institute for Atmospheric SciencesNanjing 210000China Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

Fast and reliable localization of high-energy transients is crucial for characterizing the burst properties and guiding the follow-up *** based on the relative counts of different detectors has been widely used for all-sky gamma-ray *** are two major methods for this count distribution localization:χ^(2)minimization method and the Bayesian *** we propose a modified Bayesian method that could take advantage of both the accuracy of the Bayesian method and the simplicity of the χ^(2)*** comprehensive simulations,we find that our Bayesian method with Poisson likelihood is generally more applicable for various bursts than the χ^(2)method,especially for weak *** further proposed a location-spectrum iteration approach based on the Bayesian inference,which could alleviate the problems caused by the spectral difference between the burst and location *** method is very suitable for scenarios with limited computation resources or timesensitive applications,such as in-flight localization software,and low-latency localization for rapidly follow-up observations.

关键词： methods:data analysis methods:analytical (stars:)gamma-ray burst:general

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