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Optical Implementation of CMOS/SEED Optoelectronic Integrated Crossbar Interconnection Network

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Chinese Journal of Lasers 1999年第6期 3-5页

作者： LUO Fengguang CAO Mingcui WAN Anjun XU Jun hu qiaoyan (National Lab. of Laser Technology, huazhong University of Science and Technology, Wuhan 430074, China)

An optical implementation of CMOS/SEED optoelectronic integrated crossbar interconnection network is reported. The CMOS/SEED smart pixel arrays with O/E light windows are used as logical controlling switch nodes. High/lower modulating ratio of the output light density is about 1.4. The light beam is supplied by a 0.85 μm semiconductor laser diode. 8×2 spot arrays formed by a computer generated phase grating are used as the pumping light beams for CMOS/SEED light modulators. High precision 2 D optical fiber bundle arrays are used as the I/O access devices. 16×16 optical crossbar interconnection network is realized using our experimental setup. It is easy to couple with CMOS/SEED smart pixel arrays by using 2 D optical fiber bundle arrays as the I/O access devices. Compact in comparison with other optical interconnection systems.

关键词： optical interconnection CMOS/SEED smart pixels 2 D fiber bundle arrays phase computer generated grating

Novel Photonic ATM Switching Architecture Based on Free-Space Optical Interconnect

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Novel Photonic ATM Switching Architecture Based on Free-Spac...

作者： Zhixiang Luo~*, Mingcui Cao, Yuan Li, Jiangdong Wu, qiaoyan hu National Key Lab. of LaPser Technology, huazhong University of Science and Technology, Wuhan, 430074. China

A growable multistage ATM switching architecture based on optical interconnect is presented in this paper. The interconnect stage, core of the 3 stages architecture, is composed of 16×16 CMOS-SEED optoelectronical hybrid ATM switching modules. Since the interconnect stage is memory-less, electronic buffers are provided in the output concentrator stage, and the buffers are partial shared to be used effectively. Optical interconnects between the pair-input expansion stage and the interconnect stage, also the interconnect stage and the output concentrator stage provide high-speed data paths, for example 622Mb/s or 2.4Gb/s. Both the with lower speed control signal and the complicated logical processing are carried out in the electronic devices. With 64 ports of OC-12 interface, the maximum throughput of the prototype system is about 40 gigabits per second, and the packet loss ratio of this ATM switching system is less than 10e-9. Taking advantages of high speed of the optical interconnect and the high density, flexible logical processing of the electronic devices, the ATM switching system has favorable potential to scale easily to very large network size, for example 256 ports of OC-48 interface.

关键词： optical interconnect photonic switching ATM CMOS-SEED multi-stage interconnect

Optical Performance of 4×4 MEMS Optical Switches

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Optical Performance of 4×4 MEMS Optical Switches

Asia-pacific Optical Communications 2004

作者： qiaoyan hu Yuzhou Zhao Xubin Lin Jing Li Baojun Li State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-Sen University Guangzhou China 510275 Email: qiaoyanhu@***

Optical switches made with Micro-electro-mechanical Systems (MEMS) technology bear advantages of both MEMS and traditional optics. It is of very importance to control position misalignments and angula

关键词： optical communications optical switches MEMS

胆囊收缩素A型受体基因序列变异和表达与略阳乌鸡饲料转化率的关联性研究

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中国农业科学 2022年第22期55卷 4539-4549页

作者：王哲鹏周雯馨贺俊锡虎巧燕赵家悦西北农林科技大学动物科技学院

【背景】食欲和饲料转化率的提高构成了现代肉鸡快速生长的生理基础。胆囊收缩素A型受体（CCKAR）是介导胆囊收缩素（CCK）饱食信号和消化调节作用的关键受体。鉴于CCK信号在能量平衡调节中的重要作用，CCKAR的表达水平与鸡的生长性能... 详细信息

【背景】食欲和饲料转化率的提高构成了现代肉鸡快速生长的生理基础。胆囊收缩素A型受体（CCKAR）是介导胆囊收缩素（CCK）饱食信号和消化调节作用的关键受体。鉴于CCK信号在能量平衡调节中的重要作用，CCKAR的表达水平与鸡的生长性能密切相关。然而，CCKAR水平调节鸡生长的确切机制尚不清楚。【目的】通过研究阐明CCKAR基因表达水平和序列变异与鸡饲料转化率的关系，为鸡生长性状遗传调控研究和饲料转化率选育奠定基础。【方法】测定略阳乌鸡12—16周龄料肉比（公鸡n=62，母鸡n=67）和26—30周龄料蛋比（n=150）。用PCR-RFLP法检测CCKAR基因内两个同义突变（g.73206714T>C和g.73209189C>T）的基因型。以性别为固定效应，用双因素方差分析检验g.73206714T>C和g.73209189C>T与料肉比的关联性，用单因素方差分析检验2个SNP与料蛋比的关联性。用JASPAR数据库预测g.73206714T>C对转录因子结合位点产生的影响。以g.73206714T>C为标记，选取10只杂合子（CT）公鸡，用PCR-RFLP法检测CCKAR基因在g.73206714T>C位点等位基因间的表达差异。选取30只带有采食量和料肉比记录的公鸡，用q PCR检测CCKAR基因在下丘脑、脑垂体、胰腺、胆囊和十二指肠中的表达水平，分析CCKAR表达水平与采食量和料肉比的相关性。【结果】性别效应对略阳乌鸡料肉比有显著影响（F=29.44,PC与料肉比显著关联（F=8.44,P=0.0004），其中，TT型的料肉比（5.18±0.63）显著低于CC(6.37±1.1)和CT型（6.17±0.95）。CC型和CT型的料肉比无显著差异。g.73206714T>C与性别的互作效应对料肉比的影响不显著。G.73206714T>C对28个转录因子结合位点有潜在影响。等位基因特异性表达试验显示，T等位基因的转录本丰度显著高于C等位基因，表明CCKAR在等位基因间的表达差异很可能是构成g.73206714T>C与料肉比关联性的遗传基础。略阳乌鸡26—30周龄的平均料蛋比为2.85±0.41。g.73206714T>C和g.73209189C>T的基因型效应对料蛋比的影响均不显著。在5个组织中，CCKAR基因在胰腺中的表达水平最高，且与采食量呈负相关（r=-0.45, P=0.017）。但是，在其他组织中，CCKAR的表达水平与采食量的关联性均不显著。对于料肉比性状，CCKAR基因在胰腺（r=-0.41,P=0.03）和脑垂体（r=-0.57, P=0.0018）中的表达水平越高，料肉比越低。在其他组织中，这种负相关性均不显著。【结论】研究发现CCKAR基因表达水平上调有利于提高鸡的饲料转化率。G.73206714T>C的T等位基因是一个与CCKAR基因高表达活性和高饲料转化率显著关联的分子标记。

关键词：鸡生长 CCKAR 饲料转化率食欲

An optical switch matrix for transparent optical cross-connection

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An optical switch matrix for transparent optical cross-conne...

作者： Wang, Tie Cao. Mingcui hu .qiaoyan Luo. Fengguang The State Key Laboratory. of Laser Technology. huazhong Univ. of Science and Technology. Wuahn 430074. PRC

A 4×4 optical switch performing bi-directional crossbar switching on optical communication signals at 1550 nm is presented and experimented. This switch is expanded from several elementary. 1×2 optical switches. The switch is made of bulk passive components. Operation is totally polarization independent. The proposed free-space architecture has the features of high compactness, reliability and fast response time compared with common switching solutions.

关键词： Free-space optical switches crossbar optical communication systems

光交换系统中二维光纤输入列阵的精密检测实验研究

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激光技术 1999年第4期23卷 228-231页

作者：万安君胡巧燕曹明翠罗风光徐军华中理工大学激光技术国家重点实验室

高速传输的信息网中，需要有高速的信息交换与之相适应。用光交换代替电交换，已是人们的共识且正在致力于这方面的研究。光纤列阵是光交换模块的Ｅ／Ｏ接口，精度要求很高，需要有精密的检测跟踪，才能保证其研制精度。用ＣＣＤ摄像头... 详细信息

高速传输的信息网中，需要有高速的信息交换与之相适应。用光交换代替电交换，已是人们的共识且正在致力于这方面的研究。光纤列阵是光交换模块的Ｅ／Ｏ接口，精度要求很高，需要有精密的检测跟踪，才能保证其研制精度。用ＣＣＤ摄像头成像，送入ＰＩＰ图像板，经计算机软件处理控制进行检测，取代常规的机械检测，精度可达１μｍ，甚至更小，方便适用，能够满足较高精度的科研检测要求。

关键词：光交换模块光纤列阵 CCD摄像仪

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An optoelectronic switching network with 2-D optical fiber bundle array I/O access device

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An optoelectronic switching network with 2-D optical fiber b...

作者： Fengguang Luo~(*a), Mingcui Cao~a. qiaoyan hu~a, Anjun Wan~a, Jun Xu~a, Cong Deng~a, Yuanzhong Xu~b a National Laboratory of Laser Technology, huazhong University of Science & Technology, 1037 Luo Yu Road, Wuhan 430074 P. R. China b Wuhan Research Institute of Posts & Telecommunications, P. R. China

An optoelectronic switching network with 2-D optical fiber bundle arrays I/O access device is presented in this paper. A optoelectronic recirculating Banyan network based on CMOS/SEED smart pixel device is used in this configuration. 32×2 single-mode fiber bundle array and 32×2 mutli-mode fiber bundle array are fabricated respectively based on the features of high density, high precision and array permutation of the C\’OS/SEED optoelectronic integrated devices. The measuring results show that the center to center spacing between adjacent optical fibers in the same layer of the fiber array is 125um. and the spacing between adjacent layers is 500um. Displacing tolerance of the fiber bundle arrays is less than 2um and the angular tilt error is less than 0.02 degree.

关键词： Optical switching. 2-D fiber bundle array. CMOS-SEED smart pixel arrays Optoelectronic integration

Crossover photonic switching network with CMOS/SEED smart pixel device and 2D optical fiber bundle array

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Crossover photonic switching network with CMOS/SEED smart pi...

作者： Fengguang Luo~(*a). Mingcui Cao~a. qiaoyan hu~a. Anjun Wan~a. Jun Xu~a. Cong Deng~a, Deming Liu~b a National Laboratory of Laser Technology. huazhong University of Science & Technology. 1037 Luo Yu Road. Wuhan 430074 P. R. China b Dept, of Optoelectronic Engineering. huazhong University of Science & Technology. 1037 Luo Yu Road. Wuhan 430074 P. R. China

A 16×16 Crossover photonic switching network with hybrid integrated CMOS/SEED smart pixel device and 2D optical fiber bundle array I/O access device is reported in this paper. SEED array devices are used as light receivers and transmitters(modulators), while CMOS devices make efficient logical processing. 4×40 2D multilayer optical fiber bundle arrays are fabricated and are used as I/O access devices in the crossover photonic switching network. The center to center spacing between adjacent optical fibers in the same layer of the fiber array is 125um, and the spacing between adjacent layers is 250um. Displacing tolerance of the fiber bundle arrays is less than 4um and the angular tilt error is less than 0.03 degree. It has the feature of high density,, high precision, array permutation and easy to couple with 2D CMOS/SEED smart pixel device.

关键词： Photonic switching: Crossover interconnection network: CMOS/SEED smart pixel devices: 2D optical fiber bundle array

升麻三萜皂苷对破骨细胞形成分化的影响及机制研究

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中草药 2024年第12期55卷 4032-4044页

作者：宋子乐张奇胡思婧张泉龙徐金龙邱明华张巧艳韩婷秦路平浙江中医药大学药学院浙江杭州310053 中国人民解放军联勤保障部队第九六九医院内蒙古呼和浩特010051 中国科学院昆明植物研究所云南昆明650201 中国人民解放军海军军医大学药学院上海200433

目的探究升麻三萜皂苷(Cimicifuga triterpene saponins)对破骨细胞形成分化和骨吸收功能的影响,并基于网络药理学探讨其作用机制。方法采用CCK-8法测定升麻三萜皂苷阿克特素、升麻环氧醇苷、升麻醇对骨髓巨噬细胞(bone marrow macropha... 详细信息

目的探究升麻三萜皂苷(Cimicifuga triterpene saponins)对破骨细胞形成分化和骨吸收功能的影响,并基于网络药理学探讨其作用机制。方法采用CCK-8法测定升麻三萜皂苷阿克特素、升麻环氧醇苷、升麻醇对骨髓巨噬细胞(bone marrow macrophages,BMMs)增殖活性的影响;抗酒石酸酸性磷酸酶(tartrateresistant acid phosphatase,TRAP)染色测定破骨细胞数目;磷酸苯二钠法测定破骨细胞的TRAP活性;鬼笔环肽染色观察破骨细胞F-actin环的形成;甲苯胺蓝染色检测破骨细胞在牛皮质骨骨片上形成的骨吸收陷窝;Western blotting分析破骨细胞标志基因和蛋白的表达。采用GeneCards和DisGeNET数据库获取破骨细胞功能的靶点,应用Cytoscape 3.7.1软件,采用蛋白互作的方式,筛选升麻三萜皂苷调控破骨细胞功能的核心靶点,并采用DAVID 6.8对核心靶点进行基因本体(gene ontology,GO)功能及京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)通路富集分析。结果升麻三萜皂苷对BMMs增殖无显著影响,升麻三萜皂苷阿克特素、升麻环氧醇苷、升麻醇均可减少破骨细胞的数目,抑制破骨细胞TRAP活性和F-actin环的形成,显著抑制破骨细胞活化T细胞核因子1(nuclear factor of activated T cells 1,NFATc1)、原癌蛋白Fos(oncogene Fos,c-Fos)、基质金属蛋白酶9(matrix metalloproteinase 9,MMP9)和组织蛋白酶(cathepsin K,CTSK)的表达(P<0.05、0.01),减少破骨细胞在骨片上形成的骨吸收陷窝的面积(P<0.01)。网络药理学分析表明升麻三萜皂苷主要通过丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)通路调控破骨细胞的骨吸收功能。结论升麻三萜皂苷通过MAPK通路抑制BMMs诱导的破骨细胞的形成分化和骨吸收,可为抗骨质疏松新药的研发提供先导化合物。

关键词：升麻三萜皂苷阿克特素升麻环氧醇苷升麻醇破骨细胞网络药理学丝裂原活化蛋白激酶通路

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