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Phanerozoic Tectonic Evolution,Metallogenesis and Formation of Mineral Systems in China

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 819-842页

作者： chen Xuanhua HAN Lele DING Weicui XU Shenglin TONG Ying ZHANG Yiping LI Bing ZHOU Qi WANG Ye SinoProbe Laboratory Chinese Academy of Geological SciencesBeijing 100037China Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China

The continental Asia is mainly composed of three major tectonic regimes,the Tethys,Paleo Asian Ocean,and West *** underwent multi-stage plate convergences,ocean-continent transformations,and subductions,collisions and/or collages,and post collisional(orogenic)extensions in *** evolution of the Asia brings up a unique fault system and tectonic geomorphological features in the China's ***,it provides a geodynamic background for the formation and evolution of metallogeneses and mineral systems,resulting in nonuniform distribution of tectono-metallogenic systems and metallogenic *** spatiotemporal distribution of mineral deposits in China and adjacent areas exhibits periodic variation under controlling of the full life Wilson cycle and tectonic evolution,forming the plate convergence-related mineral system in East *** Cu deposits are mainly related to compressional systems in Paleozoic and early Mesozoic,and more closely related to post-collision extensional settings in late Mesozoic and *** Au deposits mainly formed in post-orogeny extensional *** rock related rare earth element deposits formed mainly at margins of the North China and Yangtze ***-pegmatite Li and other rare metal deposits formed mainly in early Mesozoic,related to Indosinian post-orogeny ***-metallogenic systems provide important basis for the prospecting of mineral resources.

关键词： tectonic evolution geodynamic system post-orogenic extension metallogenesis tectono-metallogenic system East Asia

Surface ozone in global cities:A synthesis of basic features,exposure risk,and leading meteorological driving factors

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Geography and Sustainability 2024年第1期5卷 64-76页

作者： Jinmian Ni Jiming Jin Yanwen Wang Bin Li Qian Wu Yanfei chen Shenwen Du Yilin Li Chao He College of Resources and Environment Yangtze UniversityWuhan 430100China Hubei Key Laboratory of Petroleum Geochemistry and Environment Yangtze UniversityWuhan 430100China School of Resource and Environmental Science Wuhan UniversityWuhan 430079China Economics and Management College China University of GeosciencesWuhan 430074China

Long-term exposure to high surface ozone(O_(3))concentrations,a complex oxidative atmospheric pollutant,can adversely impact human *** on O_(3)monitoring data from 261 cities worldwide in 2020,generalized additive model(GAM)and spatial data analysis(SDA)methods were applied in this study to quantitatively evaluate the spatiotemporal distribution of O_(3)concentration,exposure risk,and dominant meteorological *** indicated that over 40%of the cities worldwide were exposed to harmful O_(3)concentration ranges(40-60μg/m^(3)),with most cities distributed in China and ***,significant seasonal variations in global O_(3)concentrations were observed,presenting as summer(45.6μg/m^(3))>spring(47.3μg/m^(3))>autumn(38.0μg/m^(3))>winter(33.6μg/m^(3)).Exposure analysis revealed that approximately 12.2%of the population in 261 cities were exposed to an environment with high O_(3)concentrations(80-160μg/m^(3)),with about 36.32 million people in major ***,the persistent increase in high O_(3)levels worldwide is a critical factor contributing to threats to human ***,GAM results indicated temperature,relative humidity,and wind speed as primary determinants of O_(3)*** synergy of meteorological factors is critical for understanding O_(3)*** findings are important for enforcing robust air quality policies and mitigating public risk.

关键词： Ozone pollution Spatiotemporal variation Exposure risk GAM Meteorological factors

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli Si Naijia Xue Yi Liu Ran Zheng Ying chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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试论清宫“紫金琍玛”的技术内涵

中国科技史杂志 2024年第2期45卷 223-231页

作者：陈璐曲亮刘建宇尹航陈坤龙北京科技大学科技史与文化遗产研究院故宫博物院

紫金琍玛是反映明清时期汉藏手工艺交流的典型例证。本文对“紫金琍玛”的相关研究进行了梳理，明确了清宫“紫金琍玛”实际含义为制作佛像所用的材料而非佛像本身。通过对造办处档案所见紫金琍玛配方的辨析，并结合紫金琍玛实物的初步... 详细信息

紫金琍玛是反映明清时期汉藏手工艺交流的典型例证。本文对“紫金琍玛”的相关研究进行了梳理，明确了清宫“紫金琍玛”实际含义为制作佛像所用的材料而非佛像本身。通过对造办处档案所见紫金琍玛配方的辨析，并结合紫金琍玛实物的初步检测分析，指出文献记载的配方可能并非仿制过程的真实记录，导致清宫“紫金琍玛”表面特殊效果的技术本质是特殊的合金成分与表面处理工艺的组合。

关键词：紫金琍玛清宫造办处合金配方表面处理

Production and characterization of monoclonal antibodies against grass carp CD4-1 and CD4-2

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Aquaculture and Fisheries 2024年第2期9卷 154-163页

作者： Bangjie Wang Yuting Qin Zhaosheng Sun Xiaozhen Zhu Zhao Jia Kangyong chen Danjie Liu Junya Wang Jun Zou Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationShanghai Ocean UniversityShanghai201306China International Research Center for Marine Biosciences at Shanghai Ocean University Ministry of Science and TechnologyShanghai201306China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai201306China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and TechnologyQingdao266071China

CD4 T helper cells are an important group of cells in the immune system of vertebrates and express CD4 receptor on the cell *** mammals,the CD4 receptor is encoded by a single copy gene,whilst in fish,two copies of cd4 genes,namely cd4-1 and cd4-2,are *** this study,the ectodomains of grass carp(Ctenopharyngodon idella,Ci)CD4-1 and CD4-2 were expressed in the *** cells and used to generate monoclonal antibodies in *** blotting,confocal microscopy and flow cytometry were performed to characterize the monoclonal *** has been shown that the CiCD4-1 and CiCD4-2 monoclonal antibodies had good specificity to react with the recombinant ectodomains of CiCD4-1 and CiCD4-2 expressed in the CHO-S cells and the native CD4 molecules of grass *** CiCD4-1 monoclonal antibody did not recognize CiCD4-2 and verse *** addition,the CD4-1 and CD4-2 monoclonal antibodies specifically recognized the CD4-1 and CD4-2 receptors expressed in the HEK293 cells and native molecules of fish ***,the percentages of lymphocytes in immune tissues of healthy fish were analyzed by flow *** was found that 17.6%of lymphocytes were CD4-1^(+)cells and 22.5%were CD4-2^(+)in the head *** the spleen,13.1%of lymphocytes were CD4-1^(+)and 18.6%were CD4-2^(+)while 7.3%of blood lymphocytes were CD4-1^(+)cells and 8.8%were CD4-2^(+)*** availability of the CD4-1 and CD4-2 monoclonal antibodies provides antibody-based tools for further elucidation of the functions of CD4 T cells in grass carp.

关键词： Grass carp CD4 Monoclonal antibodies Flow cytometry Confocal microscopy

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簇状分布的刚性双层植被明渠紊流特性分析

水利水电科技进展 2024年第3期44卷 8-12,33页

作者：吕升奇陈俊舟陈红陈界仁河海大学水利水电学院江苏南京210098 河海大学水科学研究院江苏南京210098

采用RNG k-ε紊流模型,对簇状分布的刚性双层植被明渠水流进行了模拟和分析;根据时间及空间的双平均方法对植被明渠水流的流速及紊动参数进行了统计。结果表明:簇状分布的植被明渠水流可以分为植物区、间隙区及主流区,不同区域时均流速... 详细信息

采用RNG k-ε紊流模型,对簇状分布的刚性双层植被明渠水流进行了模拟和分析;根据时间及空间的双平均方法对植被明渠水流的流速及紊动参数进行了统计。结果表明:簇状分布的植被明渠水流可以分为植物区、间隙区及主流区,不同区域时均流速的大小和分布各异;双层植被明渠水流中,时均流速垂线分布在近床面、低植物顶部附近及高植物顶部附近均出现拐点,脉动强度和紊动能的最大值出现在高植物顶部附近。

关键词：双层植被簇状分布植被明渠水流紊流特性紊动能

Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy

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Chinese Journal of Natural Medicines 2024年第6期22卷 515-529页

作者： SU Lili GUO Pengli GUO Xiangjuan HE Zhongmei ZHAO Yan ZONG Ying LI Jianming chen Weijia DU Rui College of Chinese Medicinal Materials Jilin Agricultural UniversityChangchun 130118China Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer Changchun 130118China Key Laboratory of Animal Production and Product Quality and Security Ministry of EducationMinistry of National EducationChangchun 130118China

Depression ranks among the most common neuropsychiatric disorders *** studies examining the roles of inflammation and mitochondrial autophagy in the antidepressant efficacy of paeoniflorin(PF)are *** study aimed to elucidate PF’s antidepressant mechanism by promoting autophagy and inhibiting NLRP3 inflammasome activation using chronic unpredictable mild stimulation(CUMS)-induced C57BL/6 mouse models in vivo and corticosterone(CORT)-induced HT22 cell models in *** demonstrated that PF enhanced the viability of HT22 cells following CORT exposure,restored mitochondrial membrane poten-tial(MMP),reduced reactive oxygen species accumulation,increased LC3 fluorescence intensity,and suppressed inflammatory cy-tokine secretion and inflammation ***,PF ameliorated depressive behaviors induced by CUMS and improved damage in hippocampal *** also reduced the expression of NLRP3,ASC,Caspase-1,IL-1β,and the assembly of the NLRP3 ***,PF upregulated the expression of autophagy-related proteins in the hippocampus,facilitating the clearance of damaged mitochondria and enhancing *** role of autophagy in PF’s antidepressant effects was further confirmed through the use of the autophagy inhibitor 3-methyladenine(3-MA),which reduced the efficacy of *** conclusion,PF effectively improved depressive behaviors in CUMS-induced mice and reduced NLRP3-mediated inflammation both in vivo and in vitro,likely via the in-duction of autophagy.

关键词： Paeoniflorin Depression Autophagy NLRP3 inflammasome

Stercoral perforation of the cecum:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1189-1194页

作者： Hung-Chun Yu Ta-Wei Pu Jung-cheng Kang Chao-Yang chen Je-Ming Hu Ruei-Yu Su Department of Surgery Taichung Armed Forces General HospitalTaichung 411228Taiwan Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 325Taiwan

BACKGROUND With less than 90 reported cases to date,stercoral perforation of the colon is a rare *** ulceration is thought to occur due to ischemic pressure necrosis of the bowel wall,which is caused by the presence of a stercoraceous *** underscore this urgent surgical situation concerning clinical presentation,surgical treatment,and results,we present the case of a 66-year-old man with a stercoral *** SUMMARY A 66-year-old man with a history of hypertension,hyperlipidemia,and gout presented at the emergency department with lower abdominal pain and a low-grade fever lasting for a few *** computed tomography indicated a suspected bezoar(approximately 7.6 cm)in the dilated cecum,accompanied by pericolic fat stranding,mild proximal dilatation of the ileum,pneumoperitoneum,and minimal ***,feculent peritonitis with isolated cecal perforation were ***,a right hemicolectomy with peritoneal lavage was performed.A histopathological examination supported the intraoperative *** In stercoral perforations,a diagnosis should be diligently pursued,especially in older adults,and prompt surgical intervention should be implemented.

关键词： Acute abdomen Colectomy Peritoneal lavage Pneumoperitoneum Bezoars Case report

Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3432-3456页

作者： Xueqiang Peng Jianjun Fang Chuyuan Lou Liang Yang Shaobo Shan Zixian Wang Yutong chen Hangyu Li Xuexin Li Department of General Surgery The Fourth Affiliated HospitalChina Medical UniversityShenyang 110032China Department of Ophthalmology Xi’an People’s Hospital(Xi’an Fourth Hospital)Xi’an 710004China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 10050China Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangzhou 510060China Department of Pathology Medical CollegeJinan UniversityGuangzhou 510632China Department of Physiology and Pharmacology Karolinska InstitutetStockholm SE-17177Sweden

The advent of cancer immunotherapy has imparted a transformative impact on cancer treatment paradigms by harnessing the power of the immune ***,the challenge of practical and precise targeting of malignant cells *** address this,engineered nanoparticles(NPs)have emerged as a promising solution for enhancing targeted drug delivery in immunotherapeutic interventions,owing to their small size,low immunogenicity,and ease of surface *** comprehensive review delves into contemporary research at the nexus of NP engineering and immunotherapy,encompassing an extensive spectrum of NP morphologies and strategies tailored toward optimizing tumor targeting and augmenting therapeutic ***,it underscores the mechanisms that NPs leverage to bypass the numerous obstacles encountered in immunotherapeutic regimens and probes into the combined potential of NPs when co-administered with both established and novel immunotherapeutic ***,the review evaluates the existing limitations of NPs as drug delivery platforms in immunotherapy,which could shape the path for future advancements in this promising field.

关键词： Engineered nanoparticles Cancer immunotherapy Drug delivery Bloodebrain barrier Tumor-barrier Nanomedicine Nanomaterial Cancer