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Structural effects of sulfonamides on the proliferation dynamics of sulfonamide resistance genes in the sequencing batch reactors and the mechanism

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Journal of Environmental Sciences 2024年第1期135卷 161-173页

作者： Ligui wu Mingyu Wang Lingling Rong Wenbiao Wang Linwei Chen qiaofeng wu Haoyu Sun Xiangfeng Huang Xiaoming Zou College of Environmental Science and Engineering Tongji UniversityShanghai 200092China School of Life Science Jinggangshan UniversityJi’an 343009China Key Laboratory of Organic Compound Pollution Control Engineering(MOE) School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Fuzhou Urban and Rural Construction Group Co.Ltd. Fuzhou 350007China

Antibiotic resistance genes(ARGs)can be easily promoted by antibiotics,however,the structural effects of antibiotics on the proliferation of ARGs dynamic and the associated mechanisms remain obscure in,especially,activated sludge sequencing batch *** the present study,the effects of 9 sulfonamides(SAs)with different structures on the proliferation dynamic of sulfonamide resistance genes(Suls)in the activated sludge sequencing batch reactors and the corresponding mechanisms were determined(30 days),and the results showed that the largest proliferation value(ΔA^(R))of Suls dynamic for SAs(sulfachloropyridazine)was approximately 2.9 times than that of the smallest one(sulfadiazine).The proliferation of Suls was significantly related to the structural features(minHBint6,SssNH,SHBd and SpMax2_Bhm)that represent the biological activity of *** interpret the phenomenon,a mechanistic model was developed and the results indicated that the biodegradation of SAs(T_(1/2))rather than conjugative transfer frequency or mutation frequency tends to be the key process for affecting Suls proliferation.T_(1/2)was proved to be dependent on the interactions between SAs and receptors(E_(binding)),the cleavage mode(bond dissociation energy),and the site of nucleophilic ***,the metagenomic analysis showed that SAs posed significant effect on antibiotic resistome and Tnp31 played a vital role in the proliferation of ***,our findings provide important insight into a theoretical basis for understanding the structural effects of SAs on the proliferation of ARGs in SBR systems.

关键词： Activated sludge Sulfonamides Suls Proliferation Mechanism

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基于转录组学数据探讨针刺“足三里”或“内关”改善溃疡性结肠炎的腧穴功效差异

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世界科学技术-中医药现代化 2024年第1期26卷 119-128页

作者：董龙聪张瑞斌沈缘李虹莹黄琴余曙光吴巧凤成都中医药大学针灸推拿学院成都610075

目的观察针刺“足三里”或“内关”对溃疡性结肠炎(Ulcerative colitis,UC)模型小鼠的干预效应,并利用转录组学分析病变组织结肠和非病变组织心脏在接受针刺干预后基因转录表达的异同之处,以期探讨两个腧穴是否存在功效差异。方法硫酸... 详细信息

目的观察针刺“足三里”或“内关”对溃疡性结肠炎(Ulcerative colitis,UC)模型小鼠的干预效应,并利用转录组学分析病变组织结肠和非病变组织心脏在接受针刺干预后基因转录表达的异同之处,以期探讨两个腧穴是否存在功效差异。方法硫酸葡聚糖钠盐(Dextran sulfate sodium salt,DSS)诱导法建立UC小鼠模型,造模成功后,小鼠被随机分为模型组,足三里组及内关组,每组9只。足三里组及内关组分别于“足三里”、“内关”进行针刺干预,每次30 min,每天1次,连续干预5天,空白组和模型组只捆绑不针刺。观察各组小鼠的一般情况,计算疾病活动指数(Disease activity index,DAI),通过HE染色观察结肠组织形态变化,并利用转录组测序技术,分别对各组小鼠的结肠组织进行测序和生物学分析,从病变组织角度比较研究两个穴位是否存在腧穴功效差异。同时取各组心脏组织进行比较分析,从非病变组织角度探讨两个穴位的效应是否存在差异。结果与空白组相比,模型组DAI评分显著升高(P<0.001),HE染色结果显示伴有明显病理损伤;针刺足三里或内关后,UC小鼠的DAI评分均显著降低(P<0.05),病理损伤明显改善。转录组测序及生物信息学分析结果显示,针刺足三里或内关对病变部位结肠组织的影响涉及多个基因,相似变化的差异基因(co-DEGs)有825个,主要富集到白细胞及趋化因子等通路;只受足三里影响的差异基因(ST36only-DEGs)有168个,富集到胃酸分泌等通路;只受内关影响的差异基因(PC6 only-DEGs)有325个,富集到细胞因子-细胞因子受体相互作用等通路。非病变组织心脏中co-DEGs为95个,主要富集到防御反应的正向调节、对白细胞介素-1的反应等通路;ST36 only-DEGs为28个;PC6 only-DEGs为114个,富集到心血管疾病等通路。结论针刺“足三里”与“内关”均能改善UC小鼠的症状和结肠病理变化。但通过转录组学分析发现,两个穴位对病变部位结肠组织和非病变部位心脏组织的基因转录影响存在一定差异,提示分布部位不同的腧穴在宏观功效上有一定共性,但在微观层面上,存在一定的差异性。

关键词：腧穴转录组学生物信息学溃疡性结肠炎

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Different manual manipulations and electrical parameters exert different therapeutic effects of acupuncture

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Journal of Traditional Chinese Medicine 2014年第6期34卷 754-758页

作者： Zheng Yu Lu Luo Yu Li qiaofeng wu Shufang Deng Shouying Lian Fanrong Liang Department of Preventive Treatment of Disease Pi Xian Hospital of Traditional Chinese medicine College of Acumoxibustion and Tuina Chengdu University ofTraditional Chinese Medicine Department of Endocrinology the Third Teaching Hospital Affiliated to Chengdu University of Traditional Chinese Medicine

Acupuncture is an important component part of Traditional Chinese Medicine(TCM). The therapeutic effects may be influenced by a variety of *** quantity is one of the factors for achieving good therapeutic effects in acupuncture practice. With the development of science and technology, besides the influence of manual manipulations, the parameters adopted for electroacupuncture have become the benchmark of stimulation quantity. This study, by referring to the related literatures, is designed to explore the influence of manual manipulations and electrical parameters on therapeutic effects of acupuncture. The results from the present study show that different manualmanipulations and electrical parameters may exert different therapeutic effects of acupuncture, which are closely related to the characteristics of *** manual manipulations and electrical parameters should be adopted according to syndrome differentiation of TCM. This is very important in acupuncture treatment.

关键词： Acupuncture therapy Electroacupunc-ture Method of reinforcing-reducing Manual ma-nipulation Treatment outcome

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Small molecule interfacial cross-linker for highly efficient two-dimensional perovskite solar cells

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Journal of Energy Chemistry 2022年第5期31卷 35-41页

作者： Hongming Hou Taotao Hu Fu Zhang Rui Liu Jialong He Chang Liu Yue Yu Dong Chen qiaofeng wu Meng Zhang Hua Yu Institute of Photovoltaics Southwest Petroleum UniversityChengdu 610500SichuanChina

The nonradiative recombination of charge carriers at the hole transport layer(HTL)/perovskite interface generally induces remarkable performance loss of the inverted two-dimensional perovskite solar cells(2D PSCs). Herein, a cross-linkable small molecule of 2-mercaptoimidazole(2-MI) was introduced into the nickel oxide(NiO_(x))/2D perovskite interface. Experiments have confirmed the formation of Ni-N covalent bond by N atom in the 2-MI and Ni in the NiO_(x) and the coordinating between S atom of 2-MI and under-coordinated Pb^(2+) near to the NiO_(x)/perovskite interface, which contributes to creating a crosslinking between NiO_(x)/perovskite interface to restrain charge carrier recombination and enhance the extraction of hole carriers at the interface. Besides, the 2-MI modification layer is also beneficial for promoting the crystallinity of 2D perovskite. Consequently, the inverted 2D PSCs with 2-MI modification achieved the best power conversion efficiency of 15%. This paves a route to acquire highly efficient 2D PSCs by constructing a cross-linking at the NiO_(x)HTL/2D perovskite interface.

关键词： 2D perovskite Perovskite solar cells Small molecule Interfacial cross-linking Nickel oxide

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基于数据挖掘分析阳陵泉主治优势病症及配伍规律

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中国中医药图书情报杂志 2024年第2期48卷 85-92页

作者：李思慧刘书庆王玥梅余曙光吴巧凤成都中医药大学针灸推拿学院四川成都610075 成都中医药大学针灸与内稳态研究所四川成都610075

目的运用数据挖掘技术分析阳陵泉现代主治优势病症及腧穴配伍规律。方法检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM)、PubMed、Web of Science及Embase建库至202... 详细信息

目的运用数据挖掘技术分析阳陵泉现代主治优势病症及腧穴配伍规律。方法检索中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、中国生物医学文献数据库(CBM)、PubMed、Web of Science及Embase建库至2022年12月31日收录的阳陵泉相关研究文献。建立阳陵泉单穴、配伍主治病症和配伍腧穴等数据库,利用Gephi0.10.1、SPSS Modeler 18.0、Cytoscape3.9.1、SPSS27.0软件对纳入文献进行复杂网络分析、关联分析和聚类分析。结果纳入文献530篇,阳陵泉单穴主治病症37种,优势病症为肩关节周围炎、落枕、急性胆囊炎及踝关节扭伤等,治疗方式以运动针法为主;配伍主治病症105种,优势病症为膝骨关节炎、腰椎间盘突出症及偏头痛等24种,治疗方式以电针为主。阳陵泉高频配伍特定穴为五输穴、交会穴、下合穴,高频配穴为足三里、血海、三阴交、阴陵泉、犊鼻、内膝眼等17个腧穴,配伍经脉主要为足阳明胃经,聚类分析共得3系4类配伍处方组合。结论阳陵泉主治范围广泛,以运动系统病症为主,单穴、配伍应用各有优势病症。特定穴多重配伍与聚类处方灵活组合,有助于临床精准选穴、科学用穴。

关键词：阳陵泉优势病症腧穴配伍规律数据挖掘

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Ultra-smooth CsPbI_(2)Br film via programmable crystallization process for high-efficiency inorganic perovskite solar cells

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Journal of Materials Science & Technology 2021年第7期66卷 150-156页

作者： Fu Zhang Zhu Ma Taotao Hua Rui Liu qiaofeng wu Yu Yue Hua Zhang Zheng Xiao Meng Zhang Wenfeng Zhang Xin Chen Hua Yu Institute of Photovoltaics Southwest Petroleum UniversityChengdu610500China Center for Computational Chemistry and Molecular Simulation College of Chemistry and Chemical EngineeringSouthwest Petroleum UniversityChengdu610500China

CsPbI_(2)Br is an ideal inorganic perovskite material with a reasonable bandgap for solar cell applications because of its advantage of superior thermal and phase stability. However, the performance of CsPbI2Br based solar cells highly relied on the perovskite crystallization process along with the interfacial contact engineering process between CsPbI_(2)Br perovskite and charge-transporting layers. In this work, a programmable crystallization method is developed to obtain ultra-smooth CsPbI_(2)Br perovskite film with a well-engineered contact interface in perovskite solar cells. This method combines a pre-stand-by process with a programmable gradient thermal engineering process, which mediates the crystal growth dynamics process of CsPbI2Br perovskite by controlling the release of dimethyl sulfoxide(DMSO) from its coordinates with the perovskite film, leading to high-quality CsPbI_(2)Br film with large-scale crystalline grains, reduced surface roughness, and low trap density. Fabricated perovskite devices based on CsPbI_(2)Br film obtained by this method deliver power conversion efficiency of 14.55 %;meanwhile, the encapsulated CsPbI_(2)Br perovskite device achieves a maximum efficiency of 15.07 %. This decent solar conversion efficiency demonstrates the effectiveness of the programmable crystallization method used in this work,which shows great potential as a universal approach in obtaining high-quality CsPbI_(2)Br perovskite films for fabricating high-efficiency inorganic perovskite solar cells.

关键词： CsPbI_(2)Br Ultra-smooth morphology Interface Crystallization Inorganic perovskites

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Symptoms of long-term exposure to moxa smoke in acupuncturists： a correlation analysis

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Journal of Traditional Chinese Medicine 2018年第1期38卷 132-138页

作者： Wang Xiang Yu Chang Tang Yong Chang Shyang Yang Hui Zhang He Jiaozi Zhang Yueyue Jiao Yang Zhuang Zhiqi Yin Haiyan Zhang Chengshun Lu Peng wu qiaofeng Yu Shuguang Acupuncture and Tuina College Chengdu University of Traditional Chinese Medicine Chengdu 610075 China Departmnet of rehabilitation The First Affiliated Hospital of Xi'an Medical University Xi'an 710077 China Department of Electrical Engineering National Tsing Hua University Hsinchu 300 China Taiwan Institute of Acupuncture and Homeostasis Regulation Chengdu 610075 China

OBJECTIVE: To investigate the effects of long-term exposure to moxa smoke on acupuncturists and to consider the association between physical symptoms and gender, age, secondhand smoke(SHS) exposure, and the duration of ***: A self-report, web-based questionnaire was used to evaluate the effects of moxa smoke onacupuncturists. Logistic regression was used to analyze the relationship between physical symptoms and possible correlative ***: A total of 858 questionnaires were analyzed. The data showed that 42.42% of acupuncturists had been exposed to moxa smoke for 5-10 years. The most frequent symptom was tearing(32.98%) and the least frequent symptom was asthma(5.24%). Logistic regression analysis showed that female acupuncturists were slightly more susceptible to cough and tearing than males(cough:OR: 1.583, 95% CI: 1.079, 2.321, P = 0.019; tearing:OR: 1.519, 95% CI: 1.094, 2.108, P = 0.013). Acupuncturists aged over 25 years reported a slightly lower incidence of eye itchiness than those aged under25 years(26-40 years: OR: 0.604, 95% CI: 0.379,0.965, P = 0.035; over 40 years: OR: 0.330, 95% CI:0.114, 0.958, P = 0.042). Ophthalmodynia occurred less in acupuncturists aged 26-40 years(OR: 0.591,95% CI: 0.359, 0.970, P = 0.038) than in those younger than 25 years. The only association between prevalence of symptoms and tobacco use and SHS exposure was that smokers had a lower occurrence of phlegm in the throat(OR: 0.579, 95% CI: 0.392,0.856, P = 0.006). Shortness of breath was less frequent in participants exposed to moxa smoke for more than 5 years(5-10 years: OR: 0.400, 95% CI:0.204, 0.785, P = 0.008; 11-20 years: OR: 0.392, 95%CI: 0.178, 0.864, P = 0.02), but a slightly higher incidence of eye itchiness was found in those with over20 years of moxa exposure(OR: 4.200, 95% CI:1.344, 3.128, P = 0.014).CONCLUSION: The most frequent symptom of moxa smoke exposure in acupuncturists was tear-ing. The association of symptoms with age and duration of e

关键词： Moxibustion Smoking, non-tobacco product Acupuncturists Signs and symptoms Lo- gistic model

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城市人工湖营养盐与抗生素的时空分布特征及生态风险评价

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环境工程 2024年第1期42卷 29-36页

作者：池善庆林财强吴礼贵邹小明黄翔峰张海平谢蓉蓉李家兵吴乔枫刘佳福州市城乡建总集团有限公司福州350001 同济大学环境科学与工程学院上海200092 井冈山大学生命科学学院江西吉安343009 福建师范大学环境科学与工程学院福州350007

对福州市晋安湖不同点位的上覆水及沉积物中营养盐和抗生素开展了一年监测,重点解析了传统污染物与新污染物引起的时空分布差异,对其引起的生态风险进行了评价。研究结果显示,湖体上覆水总氮浓度全年维持在较高水平(1.88~4.96 mg/L),而... 详细信息

对福州市晋安湖不同点位的上覆水及沉积物中营养盐和抗生素开展了一年监测,重点解析了传统污染物与新污染物引起的时空分布差异,对其引起的生态风险进行了评价。研究结果显示,湖体上覆水总氮浓度全年维持在较高水平(1.88~4.96 mg/L),而总磷在夏季表现出较高的浓度水平(0.15~0.55 mg/L),湖体在夏季呈现中度富营养状态(TLI值介于59.92~66.34)。湖体沉积物总氮含量为30.0~1780.0 mg/kg,总磷含量为81.4~2585.0 mg/kg,显示为中度或重度的富营养化污染。上覆水、沉积物中检测到5种抗生素(磺胺甲噁唑、四环素、磺胺多辛、磺胺林、土霉素)的浓度范围分别为0.49~13.03 ng/L、0.23~4.80 ng/g,抗生素的浓度及生态风险在冬季高于其他季节。针对城市人工湖可能同时存在的富营养化风险和生态风险,需要考虑常规污染物与新污染物的时间、空间分布特征,选择更为有效的技术对关键点位存在的复合污染进行针对性治理。

关键词：人工湖上覆水沉积物营养盐抗生素生态风险评价

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基于自主研发ACU&MOX-DATA平台探索腧穴功效特点研究

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中国中医药信息杂志 2024年第2期31卷 64-69页

作者：李思慧刘书庆唐强张瑞斌陈伟洪浩朱冰梅蓝勋王勇余曙光吴巧凤成都中医药大学针灸推拿学院四川成都610075 成都中医药大学针灸与内稳态研究所四川成都610075 成都中医药大学创新研究院四川成都610075 四川大学华西医院四川成都610044 清华大学医学院北京100084 中国科学院数学与系统科学研究院北京100190

目的基于ACU&MOX-DATA平台,初步明确不同腧穴、不同靶器官及不同刺灸法对腧穴功效的影响,并可视化展示相关结果是否存在腧穴功效“特性”“共性”的特点。方法以原创组学数据和公共组学数据整合后获得的多源异构数据作为数据源,经标准... 详细信息

目的基于ACU&MOX-DATA平台,初步明确不同腧穴、不同靶器官及不同刺灸法对腧穴功效的影响,并可视化展示相关结果是否存在腧穴功效“特性”“共性”的特点。方法以原创组学数据和公共组学数据整合后获得的多源异构数据作为数据源,经标准化处理后,利用ACU&MOX-DATA平台中Batch Search、Stimulation Mode等模块对不同腧穴、不同靶器官、不同刺灸法的数据进行差异基因分析、疾病病理网络分析和富集分析。结果在同一疾病状态、同一干预措施下,不同腧穴间存在效应差异;在同一疾病状态、同一腧穴及干预措施下,不同靶器官产生的应答不完全一致;在同一疾病状态、同一腧穴下,不同干预措施间存在效应差异。结论基于ACU&MOX-DATA平台,初步明确腧穴、靶器官、刺灸法是影响腧穴功效的关键因素,上述结果间存在腧穴功效的特异性或共性调节特点。将ACU&MOX-DATA平台应用于针灸学领域关键科学问题的分析和可视化解读,可为深化腧穴认知、指导临床选穴、提高针灸临床疗效等提供参考。

关键词：腧穴功效针灸干预方式靶器官响应多组学数据异源数据分析

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Mammary cell proliferation and catabolism of adipose tissues in nutrition-restricted lactating sows were associated with extracellular high glutamate levels

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Journal of Animal Science and Biotechnology 2019年第1期10卷 172-182页

作者： Heju Zhong Peng Wang Yumo Song Xiaoling Zhang Lianqiang Che Bin Feng Yan Lin Shengyu Xu Jian Li De wu qiaofeng wu Zhengfeng Fang Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education Animal Nutrition InstituteSichuan Agricultural University Acupuncture and Moxibustion College Chengdu University of Traditional Chinese Medicine

Background: Persistent lactation,as the result of mammary cellular anabolism and secreting function,is dependent on substantial mobilization or catabolism of body reserves under nutritional ***,little is known about the biochemical mechanisms for nutrition-restricted lactating animals to simultaneously maintain the anabolism of mammary cells while catabolism of body *** present study,lactating sows with restricted feed allowance(RFA)(n = 6),24% feed restriction compared with the control(CON) group(n = 6),were used as the nutrition-restricted *** and mammary venous cannulas methods were used to monitor postprandial dynamic changes of metabolites in adipose and mammary ***: At lactation d 28,the RFA group showed higher(P 0.05) between ***,piglet performance and milk yield did not differ(P > 0.05) between *** would appear that activation of Notch signaling and adequate supply of glutamate might assist ***: Mammary cell proliferation and catabolism of adipose tissues i

关键词： Glutamate Insulin sensitivity Lipolysis Mammary cell proliferation

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