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pH value monitoring during human albumin purification with near infrared spectroscopy and chemometrics

Journal of Innovative Optical Health Sciences 2018年第3期11卷 28-37页

作者： qiaofeng sun Zhongyu sun Fei Wang Lian Li Ronghua Liu Lei Nie Jiayue Wang Mingyu Wang Hengchang Zang School of Pharmaceutical Sciences Shandong University Wenhuaxi Road 44 Jinan 250012P.R.China School of Basic Medical Sciences Shandong University Wenhuaxi Road 44 Jinan 250012P.R.China Shandong Taibang Biological Products Limited Company No.14 East Hushan Road Taian 271000P.R.China

Human albumin(HA)is a very important blood product which requires strict quality *** precipitation is a key step which has a great effect on the quality of final ***,a new method based on quality by design(QbD)was proposed to investigate thefeasibility of realizing online quality control with the help of near infrared spectroscopy(NIRS)and *** pH value is the critical process parameter(CPP)in acid precipitationprocess,which is used as the end-point *** batches,a total of 74 samples of acidprecipitation process,were simulated in our *** batches were selected randomly as cali-bration set and remaining two batches as validation ***,the analysis based on materialinformation and three dfferent variable selection methods,including interval partial least squaresregression(iPLS),competitive adaptive reweighted sampling(CARS)and correlation coeficient(CC)were compared for eliminating irrelevant variables,Fimally,iPLS was used for *** quantitative model was built up by partial least squares regression(PLSR).Thevalues of determination coeficients(R^(2)_(C) and R^(2)_(P)),root mean squares error of prediction(RMSEP),root mean squares error of calibration(RMSEC)and root mean squared error of crossvalidation(RMSECV)were 0.969,0.953,0.0496,0.0695 and 0.0826,*** paired t test and repeatability test showed that the model had good prediction ability and *** results indicated that PLSR model could give accurate measurement of the pH value.

关键词： Near infrared spectroscopy human albumin acid precipition proces pH value chemometrics

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中国共产党百年历史中坚持问题导向的实践与时代要求

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邓小平研究 2022年第3期 98-109页

作者：陈玉斌孙巧峰南开大学马克思主义学院天津300350 山东农业大学马克思主义学院山东泰安271000

坚持问题导向是辩证唯物主义在现实中的具体运用,是发现问题的哲学工具、分析问题的思维方式和解决问题的工作法宝。回顾党的百年奋斗历程,坚持问题导向贯穿于党领导人民进行革命、建设、改革的全过程:新民主主义革命时期谋求民族独立... 详细信息

坚持问题导向是辩证唯物主义在现实中的具体运用,是发现问题的哲学工具、分析问题的思维方式和解决问题的工作法宝。回顾党的百年奋斗历程,坚持问题导向贯穿于党领导人民进行革命、建设、改革的全过程:新民主主义革命时期谋求民族独立和人民解放,社会主义革命和建设时期独立自主探索社会主义建设道路,改革开放时期建设中国特色社会主义以实现更好的发展,新时代努力实现人民幸福和民族复兴。在新的历史起点上,我们要继续坚持问题导向的思维方法和工作方法,原则问题要旗帜鲜明,发展问题要方向清晰,难点问题要回答明确,实际问题要重点解决,从而确保平稳推进党和国家发展事业和顺利实现民族复兴伟业。

关键词：中国共产党坚持问题导向唯物辩证法党的历史决议

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习近平法治思想融入高校思政课的逻辑与路径

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和田师范专科学校学报 2022年第2期41卷 24-29页

作者：王婵孙巧峰杨晴山东农业大学马克思主义学院山东泰安271000

习近平法治思想是一个内容丰富、系统完备、逻辑严密的科学理论体系,是顺应中华民族伟大复兴时代要求形成的重大理论创新成果。作为实现中华民族伟大复兴事业接班人和践行者的大学生群体,他们肩负着实现伟大中国梦的历史重任,面对国内... 详细信息

习近平法治思想是一个内容丰富、系统完备、逻辑严密的科学理论体系,是顺应中华民族伟大复兴时代要求形成的重大理论创新成果。作为实现中华民族伟大复兴事业接班人和践行者的大学生群体,他们肩负着实现伟大中国梦的历史重任,面对国内外错综复杂的局势,青年大学生既要树立正确的人生观和价值观迎接各种考验,更要坚持用马克思主义的基本立场、观点和方法认识世界、改造世界。习近平法治思想作为马克思主义法治理论中国化的最新成果,立足于中国法治建设实践,引领未来中国的复兴法治发展。在中国特色社会主义法治理论创新的过程中,习近平法治思想也为高校思政课程体系建设指明了方向,高屋建瓴式地对未来高校思政课程改革提出了新要求,对思政教育改革赋予了新的时代使命。对此,在推动新一轮思政课程改革的过程中,我们应将习近平法治思想贯穿于思政教学的全过程。

关键词：习近平法治思想高校思政铸魂育人课程改革

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Engineering nanoparticle structure at synergistic Ru-Na interface for integrated CO2 capture and hydrogenation

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Journal of Energy Chemistry 2025年第1期100卷 779-791页

作者： Hanzi Liu Ling Cen Xinlin Xie Lei Liu Zhao sun Zhiqiang sun Hunan Engineering Research Center of Clean and Low-Carbon Energy Technology School of Energy Science and Engineering Central South University

The development of dual functional material for cyclic CO2capture and hydrogenation is of great significance for converting diluted CO2into valuable fuels,but suffers from kinetic limitation and deactivation of adsorbent and ***,we engineered a series of RuNa/γ-Al2O3materials,varying the size of ruthenium from single atoms to clusters/*** coordination environment and structure sensitivity of ruthenium were quantitatively investigated at atomic *** findings reveal that the reduced Ru nanoparticles,approximately 7.1 nm in diameter with a Ru-Ru coordination number of 5.9,exhibit high methane formation activity and selectivity at 340°*** Ru-Na interfacial sites facilitate CO2migration through a deoxygenation pathway,involving carbonate dissociation,carbonyl formation,and ***-situ experiments and theoretical calculations show that stable carbonyl intermediates on metallic Ru nanoparticles facilitate heterolytic C–O scission and C–H bonding,significantly lowering the energy barrier for activating stored CO2.

关键词： Carbon capture and utilization

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Joint Feature Encoding and Task Alignment Mechanism for Emotion-Cause Pair Extraction

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Computers, Materials & Continua 2025年第1期82卷 1069-1086页

作者： Shi Li Didi sun College of Computer and Control Engineering Northeast Forestry UniversityHarbin150040China

With the rapid expansion of social media,analyzing emotions and their causes in texts has gained significant ***-cause pair extraction enables the identification of causal relationships between emotions and their triggers within a text,facilitating a deeper understanding of expressed sentiments and their underlying *** comprehension is crucial for making informed strategic decisions in various business and societal ***,recent research approaches employing multi-task learning frameworks for modeling often face challenges such as the inability to simultaneouslymodel extracted features and their interactions,or inconsistencies in label prediction between emotion-cause pair extraction and independent assistant tasks like emotion and cause *** address these issues,this study proposes an emotion-cause pair extraction methodology that incorporates joint feature encoding and task alignment *** model consists of two primary components:First,joint feature encoding simultaneously generates features for emotion-cause pairs and clauses,enhancing feature interactions between emotion clauses,cause clauses,and emotion-cause ***,the task alignment technique is applied to reduce the labeling distance between emotion-cause pair extraction and the two assistant tasks,capturing deep semantic information interactions among *** proposed method is evaluated on a Chinese benchmark corpus using 10-fold cross-validation,assessing key performance metrics such as precision,recall,and F1 *** results demonstrate that the model achieves an F1 score of 76.05%,surpassing the state-of-the-art by 1.03%.The proposed model exhibits significant improvements in emotion-cause pair extraction(ECPE)and cause extraction(CE)compared to existing methods,validating its *** research introduces a novel approach based on joint feature encoding and task alignment mechanisms,contributing to advancements in emotion-c

关键词： Emotion-cause pair extraction interactive information enhancement joint feature encoding label consistency task alignment mechanisms

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延续性护理对冠状动脉搭桥术后心功能恢复的影响

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实用临床医药杂志 2018年第22期22卷 114-116,120页

作者：孙巧凤姜宏杨烁欢辽宁省大连市中心医院辽宁大连116033

目的探讨延续性护理对冠状动脉搭桥术患者术后心功能恢复及健康相关行为的影响。方法选取心血管外科行冠状动脉搭桥术的冠心病患者100例,按照入院单双号顺序分为2组,各50例。对照组给予常规出院指导,延续护理组出院后给予延续性护理,持... 详细信息

目的探讨延续性护理对冠状动脉搭桥术患者术后心功能恢复及健康相关行为的影响。方法选取心血管外科行冠状动脉搭桥术的冠心病患者100例,按照入院单双号顺序分为2组,各50例。对照组给予常规出院指导,延续护理组出院后给予延续性护理,持续6个月。比较2组出院前、出院6个月后的心功能指标、健康相关行为评分及再入院率、护理满意度。结果出院6个月后,2组左心室射血分数(LVEF)显著上升,左心室收缩末期容积(LVESVI)、左心室舒张末期容积(LVEDVI)、B型脑钠肽(BNP)显著下降(P 0. 05)。延续护理组护理满意度94. 0%,显著高于对照组72. 0%(P <0. 05)。结论在冠状动脉搭桥术患者出院后实施延续性护理模式,可促进患者恢复心功能、建立健康行为,对患者术后康复具有积极意义。

关键词：延续护理冠状动脉搭桥术超声心动图健康行为健康教育药物管理

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Traffic safety helmet wear detection based on improved YOLOv5 network

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Optoelectronics Letters 2025年第1期21卷 35-42页

作者： GUI Dongdong sun Bo College of Software Southeast University Quanzhou Equipment Research Centre Haixi Institute Chinese Academy of Sciences

Aiming at the problem that the current traffic safety helmet detection model can't balance the accuracy of detection with the size of the model and the poor generalization of the model, a method based on improving you only look once version 5(YOLOv5) is proposed. By incorporating the lightweight Ghost Net module into the YOLOv5 backbone network, we effectively reduce the model size. The addition of the receptive fields block(RFB) module enhances feature extraction and improves the feature acquisition capability of the lightweight model. Subsequently, the high-performance lightweight convolution, GSConv, is integrated into the neck structure for further model size compression. Moreover, the baseline model's loss function is substituted with efficient insertion over union(EIoU), accelerating network convergence and enhancing detection precision. Experimental results corroborate the effectiveness of this improved algorithm in real-world traffic scenarios.

关键词： Traffic control

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Microstructure and Wear/corrosion Resistance of Stainless Steel Laser-alloyed with Mn+W_(2)C, Mn+NiWC and Mn+SiC

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 283-294页

作者： ZHOU Rui DIAO Xiaogang sun Yixin School of Metallurgical Engineering Jiangsu University of Science and TechnologyZhangjiagang 215600China CITIC Heavy Cast Iron Industry Co. Ltd.Luoyang 417039China

In-situ formed high Mn steel coating reinforced by carbides was formed by laser surface alloying(LSA).Laser alloyed layers on 1Cr18Ni9Ti steel with Mn+W_(2)C(specimen A),Mn+NiWC(specimen B)and Mn+SiC(specimen C)powders were fabricated to improve the wear and corrosion behavior of 1Cr18Ni9Ti steel blades in high speed *** evolution,phases,element distribution,microhardness,wear and corrosion behavior of the laser alloyed layers were *** indicated that high Mn steel matrix composites with undissolved W_(2)C,WC and other in-situ formed carbides were formed by LSA with Mn+W_(2)C and Mn+NiWC while SiC totally dissolved into the high Mn matrix when adding Mn+*** as the binding phase in Ni-WC powder decreased the crack sensitivity of the alloyed layer as compared with the addition of W_(2)C *** improvement in average microhardness was achieved in the matrix in specimen A,B and C,with the value of 615,602 and 277 HV_(0.5),while that of the substrate was 212 HV_(0.5).The increase of microhardness,wear and corrosion resistance is highly corelated to microstructure,formed phases,type and content of carbides,micro-hardness and toughness of the alloyed layers.

关键词： laser surface alloying stainless steel carbide type microstructure wear and corrosion resistance

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A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-Ran sun Hao-Ming Yuan Guo-Da Zhang Chao Wang Shu-Juan sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

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CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： TAO sun QINGHUA SONG HUA LIU Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

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