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Role of basophils in the early onset of collagen-induced arthritis mice

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Role of basophils in the early onset of collagen-induced art...

第十届全国免疫学学术大会

作者： qiaofen lan Yanwen Chen Huanjin Liao Pei Tang Tong Xie Huafeng Liu Qingjun Pan Department of Rheumatology and Immunology Affiliated Hospital of Guangdong Medical College Institute of Nephrology Affiliated Hostiptal of Guangdong Medical College

Objective:To investigate the role of basophil in early onset of collagen-induced arthritis in ***:C57BL/6 mice was immunized with chicken collagen typeⅡto induce arthritis(CIA)mouse *** was depleted with MAR-1 antibody,isotype antibody as *** of arthritis index(AI)of mice were *** levels of antibody anti-typeⅡcollagen,IL-4,IL-6 and IFN-γwere detected by *** was analyzed by HE ***:CIA mouse model was successfully *** with the control group and MARR-1 isotype control group,basophiles depleted can significantly reduce arthritis index,decrease serum levels of antibody anti-typeⅡcollagen,IL-4,but not IL-6 and IFN-γ.Meanwhile,basophils depletion significantly improved appearance of the joints and its pathology ***:Basophil depletion can reduce early onset of collagen-induced arthritis in mice,and this may be related to IL-4 and autoantibody production.

关键词： Basophils collagen-induced arthritis anti-Ⅱ collagen antibody IL-4

Role of basophils in the imbalance of Th1/Th2 response in collagen-induced arthritis in mice

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Role of basophils in the imbalance of Th1/Th2 response in co...

第九届全国免疫学学术大会

作者： Qingjun Pan Qiuhua Chen Pei Tang Tong Xie Ping Wu qiaofen lan Huafeng Liu 广东医学院附属医院肾病内科(肾脏疾病研究所)

Objective:To investigate the role ofbasophils in the imbalance of Th1/Th2 response in mouse collagen-induced arthritis ***:Four to six weeks C57/BL6 mice were immunized with collagen at multi-point on back and foot two times to establish mouse model of collagen-induced *** samples were collected before 1immunization and one,three,six and nine weeks after 1immunization,also cells of the lymph node were *** cytometry and ELISA were employed to detect levels ofbasophils and IL-4,and the score of joint swelling was ***:Mouse CIA models were successful *** ratio of IL-4/IFN-γof CIA group was significantly lower than before CIA models induced and control group which indicated a Th2 dominated *** the same time,levels of peripheral basophils counting and percentage of IL-4 positive basophils of CIA group were significantly higher than control ***,the ratio of IL-4/IFN-γof CIA group was significantly higher than control group which indicated a Thl dominated *** the same time,levels of peripheral basophils counting of CIA group were slightly lower than control *** Basophils may participate in the development of mouse CIA model by affecting the imbalance of Thl/Th2 response.

关键词： Basophils Collagen Rrthritis Th1/Th2

Role of Basophils in Rheumatoid Arthritis

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Role of Basophils in Rheumatoid Arthritis

第九届全国免疫学学术大会

作者： Qingjun Pan Pei Tang Qiuhua Chen qiaofen lan Ping Wu Tong Xie Haijuan Yang Ning An Huafeng Liu 广东医学院附属医院肾病内科(肾脏疾病研究所)

Th1/Th2 imbalance plays a crucial role in the development of rheumatoid *** is well known that basophil can affect Th1/Th2 balance by enhancing Th2 response and impairing Thl response then be involved in the development of many *** little is known the role of basophil in rheumatoid *** circulating basophil and Th1response dominated in adult rheumatoid arthritis patients have been reported,while children with juvenile rheumatoid arthritis have been found mainly increased circulating basophil and Th2 response ***,circulating basophil in both of them are activated and associated with disease *** addition,longitudinal study found Th2 response dominatedin the early stage of rheumatoid arthritis,while Thl response dominated in long-term chronic rheumatoid *** finding suggested that basophil maybe involved in the development of rheumatoid arthritis by affect Thl/Th2 balance,especially in the early stage of RA,maybe a new therapeutic strategy in RA and need further investigation.

关键词： Basophil Th1/Th2 Biomarker Rheumatoid arthritis.

Factors affecting the hyperuricemia in IgA nephropathy patients with renal function compensatory phase in western part of Guangdong province

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Factors affecting the hyperuricemia in IgA nephropathy patie...

第十届全国免疫学学术大会

作者： Yanwen Chen qiaofen lan Huanjin Liao Jie Lu Qiuhua Chen Tong Xie Huafeng Liu Qingjun Pan Institute of Nephrology Affiliated Hostiptal of Guangdong Medical College Department of Rheumatology and Immunology Affiliated Hospital of Guangdong Medical College

Objective:To analyze the risk factors of hyperuricemia occurrence in Ig A nephropathy patients with renal function compensatory phase in western part of Guangdong ***:The clinical and pathological data of 328 patients with Ig A nephropathy were selected to investigate the risk factors of ***:The incident of hyperuricemia in Ig A nephropathy was 38.4%.Univariate regression analysis suggested that the risk factors of hyperuricemia in patients with Ig A nephropathy were related to age,serum creatinine,blood urea nitrogen,serum triglyceride,serum total cholesterol,glomerulus sclerosis score,glomerular injury integral,tubular-interstitial injury score,renal small vessel injury score and Lee’s *** regression analysis showed that the independent risk factors for hyperuricemia in patients with Ig A nephropathy were serum triglyceride and renal small vessel injury ***:Among the multiple risk factors of hyperuricemia in Ig A nephropathy with renal function compensatory phase in western part of Guangdong province,the independent risk factors were serum triglyceride and renal small vessel injury *** obtaining therapy strategies with regional characteristics,also provide a reference for other Ig A nephropathy patients with renal function compensatory phase.

关键词： Ig A nephropathy hyperuricemia risk factor

Basophil detection in rheumatoid arthritis patients and its relationship with disease activity and the imbalance of Th1 responses

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Basophil detection in rheumatoid arthritis patients and its ...

第十届全国免疫学学术大会

作者： Yanwen Chen qiaofen lan Huanjin Liao Qiuhua Chen Pei Tang Tong Xie Jie Lu Huafeng Liu Qingjun Pan Institute of Nephrology Affiliated Hostiptal of Guangdong Medical College Department of Rheumatology and Immunology Affiliated Hospital of Guangdong Medical College

Objective:To investigate the activation state of peripheral basophils from RA patients and its mechanism,and the relationship between disease activity and imbalance of Th1/Th2 ***:In this study,flow cytometry was employed to test the ratio of the number of Th1 to Th2 cell and levels ofbasophil and its activation state in peripheral blood mononuclear cells(PBMC)cells from rheumatoid arthritis(RA).ELISA method was used to measure serum levels of IFN-γand *** Blot was employed to detect serum circulating immune complexes containing Ig E(Ig E-CIC).Results:The ratio of the number of Th1 to Th2 cell have a low linear correlation with the DAS28 score;Serum levels of IFN-γin patients with RA was significantly higher than the control group,and correlated with the disease activity,but not IL-4;Levels of basophils of RA patients was significantly reduced compared with the control group,and highly activated(high expression of CD203c and CD62L);The presence of high levels of Ig E-CIC in RA patients,but not in control ***:Peripheral basophil of RA patients was highly activated and significantly reduced,may migrate to secondary lymphoid tissues and sites of inflammation,and against the imbalance of Th1 response,which may provide new clues for the prevention and treatment of RA.

关键词： rheumatoid arthritis Basophil Th1 Th2

Unraveling the therapeutic potential of Calculus Bovis in liver cancer:A novel step for targeted cancer treatment

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World Journal of Gastroenterology 2025年第3期31卷 127-129页

作者： Xing-Yu Chen Xiang lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally,and effective treatments are urgently *** present study aimed to investigate the inhibitory effect of Calculus Bovis(CB)on liver cancer and the underlying *** inhibited M2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway,thereby suppressing the proliferation of liver cancer *** inhibitory effect on liver cancer growth was confirmed by both in vivo and in vitro experiments(detailed by Huang et al).The present study provides a theoretical basis for the application of CB for the treatment of liver cancer,providing new avenues for liver cancer treatment.

关键词： Calculus Bovis Liver cancer M2 tumor-associated macrophage polarization Wnt/β-catenin Pathway Tumor microenvironment

舒张性和收缩性心力衰竭患者的临床表现差异及睡眠情况分析

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世界睡眠医学杂志 2022年第12期9卷 2267-2269页

作者：张旭兰巧芬朱颖郑莹莹霞浦县医院重症医学科霞浦355100 宁德师范学院医学院宁德352106 福鼎市医院检验科福鼎355299

目的:分析舒张性和收缩性心力衰竭患者的临床表现差异及睡眠情况。方法:选取2019年4月至2021年4月我院收治的舒张性和收缩性心力衰竭患者100例作为研究对象,将50例舒张性心力衰竭患者作为观察组,将50例收缩性心力衰竭患者作为对照组,比... 详细信息

目的:分析舒张性和收缩性心力衰竭患者的临床表现差异及睡眠情况。方法:选取2019年4月至2021年4月我院收治的舒张性和收缩性心力衰竭患者100例作为研究对象,将50例舒张性心力衰竭患者作为观察组,将50例收缩性心力衰竭患者作为对照组,比较分析2组患者的临床指标、临床特点以及睡眠情况。结果:观察组患者的收缩压、前白蛋白、血钠、胆固醇、血氯、白蛋白水平均高于对照组;观察组高尿酸症发生率显著高于对照组,观察组中低蛋白血症、肾功能不全、贫血、高脂血症发生率均显著低于对照组,观察组呼吸紊乱指数低于对照组,2组比较差异均有统计学意义(均P<0.05)。结论:舒张性与收缩性心力衰竭患者的临床表现与睡眠情况均存在较大差异,需根据其不同表现采取针对性治疗。

关键词：舒张性心力衰竭收缩性心力衰竭临床表现睡眠情况

轮状病毒-肠道腺病毒荧光纳米颗粒联检试纸检测效能测评

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中华实验和临床病毒学杂志 2015年第4期29卷 368-370页

作者：李琛兰巧芬廖焕金李尚姝叶玲盛慧英潘庆军广东医学院附属医院湛江524001

目的评估轮状病毒-肠道腺病毒抗原荧光纳米颗粒快速联检试纸条的灵敏度和特异性。方法以培养的轮状病毒、肠道腺病毒、以及其他肠道病原体，还有140例具有胃肠道感染症状患者的粪便标本，分别用轮状病毒-肠道腺病毒抗原荧光纳米颗粒快... 详细信息

目的评估轮状病毒-肠道腺病毒抗原荧光纳米颗粒快速联检试纸条的灵敏度和特异性。方法以培养的轮状病毒、肠道腺病毒、以及其他肠道病原体，还有140例具有胃肠道感染症状患者的粪便标本，分别用轮状病毒-肠道腺病毒抗原荧光纳米颗粒快速联检试纸条和轮状病毒-腺病毒抗原二合一彩色微球法检测试纸条检测。结果轮状病毒-肠道腺病毒抗原荧光纳米颗粒快速联检试纸条的灵敏度显著高于轮状病毒-腺病毒抗原二合一彩色微球法检测试纸条；对常见的柯萨奇病毒（A16）、埃可病毒（30型）和肠道病毒（EV71）无交叉反应。结论轮状病毒-肠道腺病毒抗原的荧光纳米颗粒快速联检试纸条灵敏度显著高于彩色微球法快速检测试纸条，特异性良好。

关键词：腺病毒科轮状病毒属荧光纳米颗粒彩色微球敏感性与特异性

Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai Chen Xu Feng Yuan Shi Xin-Lin Li Zheng-Rong Shi Xiang lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report