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Structural optimization of a settler via CFD simulation in a mixer-settler

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Chinese Journal of Chemical Engineering 2020年第4期28卷 995-1015页

作者： Sishi Ye qiao Tang Yundong Wang Weiyang fei The State Key Laboratory of Chemical Engineering.Department of Chemical Engineering Tsinghua UniversityBeijing 100084China SINOPEC Research Institute of Petroleum Processing Beijing 100083China

This work is aimed at optimizing a settler structure in a *** different aspects have been ***,the flowcharacteristics of a settler have been examined by computational fluid dynamics(CFD)simulation with various agitation speeds of the mixer,as well as organic phase volume fractions ranging from 0.075 to *** aqueous and organic phase turbulent flow fields were measured by particle image velocimetry(PIV)technique to verify the CFD *** organic phases with different physical properties were assessed in the CFD simulation to simulate the liquid-liquid systems related to rare earth element extraction,i.e.,0.072 mol·L^-1 P507/kerosene and 1.8 mol·L^-1 P507/***,the CFD simulation was carried out in a settler equipped with *** effects of number and location of the baffle in the settler on flow features and entrainments of the aqueous and organic outlet were ***,different settler/mixer volume ratios were also *** analyses and comparisons,an optimal design for settler was *** can provide a significant guidance to better mixer-settler design.

关键词： Settler Liquid-liquid CFD RANS equations Optimization

Study on tidal gravity observations obtained at stations Zhongshan and Changcheng, Antarctic

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Acta Seismologica Sinica(English Edition) 2001年第3期14卷 325-332页

作者： xu Jian-qiao Laboratory of Dynamic Geodesy Institute of Geodesy and Geophysics Chinese Academy of Sciences

Based on the international tidal gravity reference values at station Wuhan, the tidal gravity parameters, including the amplitude factors and phase differences are determined accurately by using the observations with three La-Coste-Romberg (LCR) gravimeters (G-589, ET-20 and ET-21) at stations Zhongshan and Changcheng in the Antarctic, respectively. The standard deviations of the determined amplitude factors of the main tidal waves are better than 0.5%. The amplitude of each tidal wave observed at station Zhongshan is much less than that of the same wave at station Changcheng. The differences of amplitude factors in the diurnal band (O1) at these two stations are less than 7% while those in the semi-diurnal band (M2) are larger than 40%. The influences of meteorology factors, such as atmospheric pressure and temperature, on the tidal gravity observations are very obvious. The oceanic loading effects on the tidal gravity are also very prominent. It is found that the amplitude of the final residual vector of every tidal wave reduces significantly after oceanic correction based on the Schwiderski's global co-tides. However, because the local oceanic loading is not taken into account, the discrepancies of amplitude factors of wave O1 observed at Zhongshan from the corresponding values of theoretical tidal model are about 4%, and 9% at Changcheng.

关键词： stations Zhongshan and Changcheng Antarctic tidal gravity observations international tidal gravity reference values theoretical tidal model P223.9

Pruning-aware Sparse Regularization for Network Pruning

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Machine Intelligence Research 2023年第1期20卷 109-120页

作者： Nan-fei Jiang xu Zhao Chao-Yang Zhao Yong-Qi An Ming Tang Jin-qiao Wang School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Institute of Automation Chinese Academy of SciencesBeijing 100049China

Structural neural network pruning aims to remove the redundant channels in the deep convolutional neural networks(CNNs)by pruning the filters of less importance to the final output *** reduce the degradation of performance after pruning,many methods utilize the loss with sparse regularization to produce structured *** this paper,we analyze these sparsity-training-based methods and find that the regularization of unpruned channels is ***,it restricts the network′s capacity,which leads to *** solve this problem,we propose a novel pruning method,named Mask Sparsity,with pruning-aware sparse *** Sparsity imposes the fine-grained sparse regularization on the specific filters selected by a pruning mask,rather than all the filters of the *** the fine-grained sparse regularization of Mask Sparity,we can use many methods to get the pruning mask,such as running the global sparse *** Sparsity achieves a 63.03%float point operations(FLOPs)reduction on Res Net-110 by removing 60.34%of the parameters,with no top-1 accuracy loss on *** ILSVRC-2012,Mask Sparsity reduces more than 51.07%FLOPs on Res Net-50,with only a loss of 0.76%in the top-1 *** code of this paper is released at https://***/CASIA-IVA-Lab/Mask *** have also integrated the code into a self-developed Py Torch pruning toolkit,named Easy Pruner,at https://***/casia_iva_engineer/easypruner.

关键词： Deep learning convolutional neural network(CNN) model compression and acceleration network pruning regula rization

A naive optimization method for multi-line systems with alternative machines

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Frontiers of Mechanical Engineering 2019年第4期14卷 377-392页

作者： Weichang KONG fei qiao Qidi WU School of Electronics and Information Engineering Tongji UniversityShanghai 201804China

The scheduling of parallel machines and the optimization of multi-line systems are two hotspots in the field of complex manufacturing *** the two problems are considered simultaneously,the resulting problem is much more complex than either of *** sufficient training data for conventional data-based optimization approaches is difficult because of the high diversity of system ***,optimization of multi-line systems with alternative machines requires a simple mechanism and must be minimally dependent on historical *** define a general multi-line system with alternative machines,this study introduces the capability vector and matrix and the distribution vector and matrix.A naive optimization method is proposed in accordance with classic feedback control theory,and its key approaches are *** a reasonable target value is provided,the proposed method can realize closed-loop optimization to the selected objective *** studies are performed on a real 5/6-inch semiconductor wafer manufacturing facility and a simulated multi-line system constructed on the basis of the MiniFAB *** show that the proposed method can effectively and efficiently optimize various objective *** method demonstrates a potential for utilization in multi-objective optimization.

关键词： multi-line systems alternative machines feedback control closed-loop optimization

The cutting-edge progress of immune-checkpoint blockade in lung cancer

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Cellular & Molecular Immunology 2021年第2期18卷 279-293页

作者： fei Zhou Meng qiao Caicun Zhou Department of Medical Oncology Shanghai Pulmonary HospitalThoracic Cancer InstituteTongji University School of MedicineShanghaiChina

Great advances in immune checkpoint blockade have resulted in a paradigm shift in patients with lung ***-checkpoint inhibitor(ICI)treatment,either as monotherapy or combination therapy,has been established as the standard of care for patients with locally advanced/metastatic non-small cell lung cancer without EGFR/ALK alterations or extensive-stage small cell lung *** increasing number of clinical trials are also ongoing to further investigate the role of ICIs in patients with early-stage lung cancer as neoadjuvant or adjuvant *** PD-L1 expression and tumor mutational burden have been widely studied for patient selection,both of these biomarkers are *** to the complex cancer-immune interactions among tumor cells,the tumor microenvironment and host immunity,collaborative efforts are needed to establish a multidimensional immunogram to integrate complementary predictive biomarkers for personalized ***,as a result of the wide use of ICIs,managing acquired resistance to ICI treatment remains an inevitable challenge.A deeper understanding of the underlying biological mechanisms of acquired resistance to ICIs is helpful to overcome these *** this review,we describe the cutting-edge progress made in patients with lung cancer,the optimal duration of ICI treatment,ICIs in some special populations,the unique response patterns during ICI treatment,the emerging predictive biomarkers,and our understanding of primary and acquired resistance mechanisms to ICI treatment.

关键词： lung cancer immune-checkpoint inhibitor predictive biomarker acquired resistance

Accelerated Deterioration Mechanism and Reliability Evaluation of Concrete in Saline Soil Area

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Journal of Wuhan University of Technology(Materials Science) 2023年第3期38卷 582-590页

作者：付勇乔宏霞 HAKUZWEYEZU Theogene qiao Guobin GUO fei School of Civil Engineering Lanzhou University of TechnologyLanzhou 730050China Western Civil Engineering Disaster Prevention and Mitigation Engineering Research Center Ministry of EducationLanzhou University of TechnologyLanzhou 730050China

To reveal the deterioration mechanism and service life of concrete durability in the western saline soil area,the indoor accelerated test of the concrete specimen was simulated in the coupled environment of salt erosion and dry-wet cycles in the west saline soil area of *** deterioration mechanism of concrete durability was revealed through the relative dynamic elastic modulus,relative quality evaluation parameters,SEM,and XRD evaluation *** Wiener distribution function was used for modeling life *** results show that the relative dynamic elastic modulus evaluation parameter as an evaluation index of concrete durability under various environmental coupling effects is more reliable than the relative quality,there were holes and cracks in the concrete,and needle-like and layered crystals grow from the internal *** corrosion products include ettringite,gypsum and other expansive crystals and non-gelling Mg(OH)_(2);the expansion stress caused by physical,chemical reaction,and temperature change under the action of drywet cycle aggravates the formation and development of *** random Wiener distribution function can describe the degradation process of concrete specimen durability,and the established concrete reliability function can intuitively reflect the service life of concrete specimens.

关键词： concrete saline soil area service prediction random wiener durability deterioration mechanism

Involvement of T-complex protein 1-ring complex/chaperonin containing T-complex protein 1(TRiC/CCT) in retrograde axonal transport through tau phosphorylation

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Neural Regeneration Research 2019年第4期14卷 588-590页

作者： xu-qiao Chen Department of Neurosciences University of California San Diego

The cytosolic chaperonin T-complex protein 1-ring complex(TRiC)or chaperonin containing T-complex protein 1(CCT)is essential in de novo folding of approximately 10%of the eukaryotic,newly translated polypeptides as well as misfolded *** is a close link between the TRiC/CCT cytosolic chaperonin and neurodegenerative diseases(Lopez et al.,2015).A lot of research suggests that CCT plays neuroprotective roles in neurodegenerative diseases including Huntington’s disease(Lopez et al.,2015).Either overexpression of a single or all eight subunits(CCT1-8)or treatment of the substrate-binding apical domain of yeast CCT1(ApiCCT1)prevented mutant Huntingtin aggregation and improved cellular and neuronal functions(Zhao et al.,2016).Importantly,our recent study has demonstrated that both CCT and ApiCCT could reduce mutant Huntingtin level and enhance both anterograde and retrograde axonal transport of brain-derived neurotrophic *** results led to restoration of the trophic status of striatal neurons from a bacterial artificial chromosome transgenic mouse model of Huntington’s disease(Zhao et al.,2016).Axonal transport is regulated by many factors including microtubule-associated protein tau,which promotes tubulin polymerization and stabilizes *** interaction between tau and microtubules plays a vital role in the pathogenesis of multiple neurodegenerative diseases(Wang and Mandelkow,2016).Interestingly,tau phosphorylation is also observed in brains of several Huntington’s disease mouse models and Huntington’s disease patients(Gratuze et al.,2016).In a recent study,we explored if CCT subunit has any effect on axonal transport in a tau-dependent pathway(Chen et al.,2018b).We focused on the retrograde axonal transport of brain-derived neurotrophic factor,as neurotrophic factor-mediated signaling in the form of signaling endosome is essential in both the developing and the mature nervous system and dysregulation of trafficking of neurotrophic fact

关键词： T-complex protein 1-ring complex(TRiC) chaperonin containing T-complex protein 1(CCT) Involvemen

A kinetic study and factor analysis of solar thermochemical membrane reactors for syngas production

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Science China Technological Sciences 2025年第1期 207-221页

作者： Jiaxin XING Chao xu Xiangyu SUN Xin XIA fei JIN Qiongqiong JIANG Jiale GAO Key Laboratory of Power Station Energy Transfer Conversion and System of MOE School of Energy Power and Mechanical EngineeringNorth China Electric Power University Department of Chemistry University College London School of Chemistry and Chemical Engineering Ningxia Key Laboratory of Solar Chemical Conversion TechnologyState Ethnic Affairs CommissionNorth Minzu University

Solar thermochemical conversion technologies are promising for effectively utilizing solar energy by capturing the full spectrum of solar radiation. To overcome the challenges of low energy conversion efficiency and intermittency faced by solar thermochemical conversion, these technologies can be effectively integrated with membrane reactor technology. Although the performance of solar thermochemical membrane reactors has been experimentally tested, the chemical reactions and oxygen transport mechanisms during the energy conversion process remain poorly understood. This study introduces a resistance network model to elucidate the interactions between interfacial reactions and bulk diffusion during simultaneous oxidationreduction reactions on both sides of the membrane. We analyzed the oxygen flux of the membrane reactor under various operating conditions using this model to identify the reaction/transport-limiting side of the overall process. The most effective solar membrane reactor configuration utilizes natural gas and CO2, facilitating clean conversion of fossil fuels with significant advantages in fuel production and energy efficiency. Introducing CH4lowers the overall reaction temperature, maintains low oxygen partial pressure on the sweep side, and produces a synthesis gas with a 2:1 H2/CO molar ratio. Finally, a sensitivity analysis was used to explore the relationship between overall fuel production performance and operational parameters,highlighting the critical role of this research in enhancing the reaction and transport performance of membrane reactors and advancing the development of solar-driven thermochemical fuel production technologies.

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Improved local amplification factor transport equation for stationary crossflow instability in subsonic and transonic flows

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Chinese Journal of Aeronautics 2020年第12期33卷 3073-3081页

作者： Jiakuan xu Lei qiao Junqiang BAI School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China Department of Mathematics Imperial College LondonLondon SW72AZUnited Kingdom

Transition prediction is a hot research topic of fluid *** subsonic and transonic aerodynamic flows,e^(N) method based on Linear Stability Theory(LST)is usually adopted reliably to predict *** 2013,Coder and Maughmer established a transport equation for Tollmien-Schlichting(T-S)instability so that the e^(N) method can be applied to general Reynolds-Average-Navier-Stokes(RANS)solvers ***,this equation focuses on T-S instability,and is invalid for crossflow instability induced transition which plays a crucial role in flow instability of three-dimensional boundary ***,a transport equation for crossflow instability was developed in 2016,which is restricted to wing-like ***,in 2019,this model was extended to arbitrarily shaped geometries based on local ***,there are too many tedious functions and parameters in this version,and it can only be used for incompressible ***,in this paper,after a large amount of LST analyses and parameter optimization,an improved version for subsonic and transonic boundary layers is *** present improved model is more robust and more concise,and it can be applied widely in aeronautical flows,which has great engineering application value and *** extensive validation study for this improved transition model will be performed.

关键词： Boundary layer transition Crossflow instability Linear stability theory Transition Model Transonic flows