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Danggui Niantong decoction ameliorates joint inflammation and cardiopulmonary injury in TNF-Tg mice

Acupuncture and Herbal Medicine 2023年第4期3卷 333-342页

作者： Can Yang Tao Chen Mengjiao Ma Qiang li Zhichao liang Hao Xu Youhua Wang Ning li Qianqian liang Longhua Hospital Shanghai University of Traditional Chinese MedicineChina Spine Institute Shanghai University of Traditional Chinese MedicineChina Key Laboratory of theory and therapy of muscles and bones Ministry of EducationChina Jing’an District Center Hospital of Shanghai Fudan UniversityShanghaiChina Department of Cardiology Longhua HospitalChina Guanghua Hospital Shanghai University of Traditional Chinese MedicineChina

Objective:Rheumatoid arthritis(RA)is a common autoimmune disease characterized by multiple joint lesions and systemic *** Niantong decoction(DGNTT)has been clinically used for RA treatment;however,its beneficial effect on cardiopulmonary complications has not been ***:Female tumor necrosis factor-transgenic(TNF-Tg)mice were used to evaluate the therapeutic effects of DGNTT on arthritis and cardiopulmonary ***(MTX)served as a positive *** assessment of the joint sections was performed using hematoxylin and eosin(HE),Alcian Blue/Orange G,and tartrate-resistant acid phosphatase *** mass was assessed by micro-computed tomography,inflammatory infiltrates in the heart and lungs were evaluated by HE staining,cardiopulmonary fibrotic injury was identified by Masson’s trichrome staining,and hypertrophy of mouse cardiomyocytes was measured by wheat germ agglutinin(WGA)***:DGNTT mitigated the inflammation of the ankle joint synovium,decreased the number of osteoclasts,and increased the area of cartilage and bone mass in TNF-Tg *** addition,DGNTT decreased the infiltration of inflammatory cells into the lung and heart tissues,accompanied by a reduction in cardiopulmonary fibrosis and myocardial cell hypertrophy in TNF-Tg *** a positive control drug,MTX attenuated the pathological changes in joints,but had no beneficial effect on cardiopulmonary inflammation and fibrosis in TNF-Tg ***:DGNTT improved joint lesions and alleviated cardiopulmonary complications in TNF-Tg mice.

关键词： Cardiovascular system disease Danggui Niantong decoction Interstitial lung disease Rheumatoid arthritis TNF-Tg mice

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Preliminary analysis of stem cell-like cells in human neuroblastoma

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World Journal of Pediatrics 2015年第1期11卷 54-60页

作者： li-li Xing Yong-liang Sha Ye-Ming Wu Ji-Meng Hu Min Zhang Fan Lv Department of Pediatric Surgery Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

Background:Neuroblastoma is an embryonic neoplasm originating from the neural crest with cellular heterogeneity as one of its oncobiological *** study was undertaken to determine whether human neuroblastoma contains stem ell-like ***:Twenty patients with neuroblastoma who have been treated in our hospital since January 2005 were divided into pre-operative chemotherapy(10 patients)and non-chemotherapy(10)*** specimens of the patients were taken and paraffin sections were *** expressions of stem cell markers CD133,ABCG2,CD117 and nestin were immunohistochemically detected in the *** cells were stained with Hoechst 33342 and *** side population(SP)cells were analyzed by the fluorescence activated cell *** disparity drug resistance to cisplatin(DDP)of SP and non-SP cells was measured with MTT colorimetric *** oncogenicity of SP and non SP cells was identified in nude ***:There was no significant difference in the expression intensity of CD117 and nestin between the two groups of specimens(P>0.05).There was a significant difference between the two groups in terms of the expression intensity of CD133 and ABCG2(Plike cells.

关键词： drug resitance immunohistochemically neuroblastoma oncogenicity side population cells

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An optimized numerical method to pre-researching the performance of solid-phase oxygen control in a non-isothermal lead–bismuth eutectic loop

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Nuclear Science and Techniques 2022年第3期33卷 77-88页

作者： Xiao-Bo li Rui-Xian liang Yi-Feng Wang Hui-Ping Zhu Fang liu Yang liu Cong li Hao Wu Feng-Lei Niu School of Nuclear Science and Engineering North China Electric Power UniversityBeijing 102206China

In the present work,a new transient calculation method for parameters that can be used to evaluate the ability of oxygen control in a non-isothermal lead-bismuth eutectic(LBE)loop with solid-phase oxygen control was *** incorporates the dissolution process of PbO particles and the oxygen mass transfer process,and an optimized method was used for finding out the optimized oxygen mass transfer *** numerical terms,three mass transfer models were simultaneously applied,and comparisons of calculated and experimental results from the CRAFT loop indicated that the optimized calculation method and these new oxygen mass transfer models were correct and applicable to other LBE *** this calculation method,we aimed to optimize prediction of the distribution of oxygen and iron concentrations,time taken to establish the steady state of oxygen,and maximum dissolution/precipitation rates of corrosion products and corrosion depth across the entire LBE *** hope that this work will provide a potential reference for designing a more intelligent oxygen control system in the future.

关键词： LBE Solid-phase oxygen control Operating domain Operating model Corrosion depth Dissolution/precipitation

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Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations

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World Journal of Gastroenterology 2025年第3期31卷 11-28页

作者： Pei-Pei Zhang liang li Hao-Yu Qu Guang-Yu Chen Meng-Zhou Xie Yan-Kun Chen School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Precision Medicine Research and Development Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal ***,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence *** these concerns develop,traditional Chinese medicine(TCM)may have *** is based on the concept of completeness and aims to eliminate pathogens and strengthen the *** has the potential to prevent this condition while also boosting the rate of Helicobacter pylori *** review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关键词： Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body

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Attention and Intervention of Oncologists on Oxaliplatin-induced Adverse Reactions in China' Mainland:A Cross-sectional Internet-based Survey

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Current Medical Science 2022年第6期42卷 1319-1324页

作者： Wei li Lu XIAO Zao-qin YU Min li Xi-min WANG Dong liU Cheng-liang ZHANG Department of Pharmacy Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Rehabilitation Division Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective This cross-sectional study aimed to investigate the current attention and intervention of oncologists on oxaliplatin(OXA)-induced adverse reactions(ADRs).Methods In 31 provinces or administrative regions across China,401 oncologists were surveyed through a self-designed *** survey queried the basic information of respondents,clinical use of OXA,OXA-induced ADRs,and relative ***-square tests and multiple logistic regression were used to explore the sociodemographic factors influencing the safety perception of OXA and the relevant *** The survey showed that the age of respondents was mainly distributed between 30 and 40 years and the working period for most oncologists was no more than 5 *** with long working years were more willing to conduct patient education and inquire about ADRs than those with short working *** rate of ADRs reported by oncologists with intermediate professional titles was significantly higher than that reported by oncologists with junior and senior professional *** Our findings indicate that oncologists in China's Mainland are concerned about OXA-induced ADRs,but the reporting of ADRs still needs to be ***,training and educational programs are urgently needed to improve the risk management of OXA-induced ADRs among oncologists.

关键词： oxaliplatin adverse reaction intervention cross-sectional survey

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POvaStim:An online tool for directing individualized FSH doses in ovarian stimulation

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The Innovation 2023年第5期4卷 23-24页

作者： Huiyu Xu Guoshuang Feng Yong Han Antonio La Marca Rong li Jie qiao Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Beijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China Big Data Center Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Hangzhou Qingguo Medical Technology Co. Ltd.HangzhouZhejiang 310000China Department of Medical and Surgical Sciences for Children and Adults University of Modena and Reggio EmiliaModenaItaly

Individualized controlled ovarian stimulation(COS)is a milestone for treatment of infertility.^(1)The two acknowledged time points for individualized ovarian stim-ulation are,one,the beginning of each new treatment cycle when the starting dose is selected and,two,during a given COS cycle when dose adjustment is performed.A few algorithms for directing the follicle-stimulating hormone(FSH)dose have been *** number of oocytes retrieved(NOR)during ovarian stimulation was used as the outcome variable,and then the outcome variable and independent variables are stratified and a dose suggested by considering their experience.

关键词： stimulation doses starting

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Table-like Large Magnetocaloric Effect in the Misch Metal RSi Compound

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Chinese Physics Letters 2020年第1期37卷 88-91页

作者： Ruo-Shui liu Jun liu li-Chen Wang Zheng-Rui li Xiang Yu Yan Mi qiao-Yan Dong Kai li Dan-li li Chen-Hui Lv li-Feng liu Shu-li He Department of Physics Capital Normal UniversityBeijing 100048 State Key Laboratory for Magnetism Institute of PhysicsChinese Academy of SciencesBeijing 100190 Department of Chemistry Capital Normal UniversityBeijing 100048

Magnetic properties and the magnetocaloric effect(MCE)of the RSi(R=Ce,Pr,Nd)compounds made of Misch metal(MM)are *** transitions are found at 12K and *** variation generated large MCE and two peaks are found in the magnetic entropy change(△S)curves,which correspond to the two transition *** maximum values of the magnetic entropy changes(△S)are found to be-5.1 J/(kg·K)and-9.3 J/(kg·K)for the field ranges of 0-2 T and 0-5 T,*** large AS as well as ultra-low price of MM make(MM)Si a competitive magnetic refrigerant candidate for low temperature in Eriksson cycle.

关键词： entropy magnetic competitive

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日本“印太”战略的生成、演变和发展的新趋势

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东北亚论坛 2022年第4期31卷 47-63,127页

作者：乔亮对外经济贸易大学国际关系学院北京100029

日本作为“印太”战略的实际倡导者与积极推动者,其“印太”战略受到的研究关注相对不够。日本的“印太”战略构想具有其自身独有的特点,该战略的生成背景有着多届日本政府长期的酝酿与构建,并经历了酝酿、定型、巩固到拓展等数个发展... 详细信息

日本作为“印太”战略的实际倡导者与积极推动者,其“印太”战略受到的研究关注相对不够。日本的“印太”战略构想具有其自身独有的特点,该战略的生成背景有着多届日本政府长期的酝酿与构建,并经历了酝酿、定型、巩固到拓展等数个发展阶段的演变,形成了综合领域、价值框架、适切定位的三大特征和海洋安全、价值联盟、经贸竞争、多边机制和国家形象的五层布局,并且近三年内在战略表述、布局和实施上呈现出诸多新的发展趋势。该战略构想的未来发展动向,会对中国海外战略利益产生较大影响,并需要中国积极构建对策。

关键词： “印太” 经贸竞争价值框架多边机制综合战略

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liM1863 is useful to explore collective cancer cell migration,and the group of heterogeneous cells undergoing collective migration behaves like a supracellular unit

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BIOCELL 2023年第12期47卷 2671-2680页

作者： JINSONG WU ZHENG ZHI WENZHONG XU DIANCGENG li QIUBO li YAN HAN JIANMING HE XI liang Department of Radiotherapy Hebei Province Hospital of Chinese MedicineHebei University of Chinese MedicineShijiazhuangChina Department of General Surgery Chongqing General HospitalChongqingChina Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research(Hebei) ShijiazhuangChina

Collective cancer cell migration(CCCM)and epithelial-to-mesenchymal transition(EMT)play key roles in *** study reports that the colorectal carcinoma cell line liM1863 is useful for the study of CCCM and ***:Hematoxylin and eosin staining,scanning electron microscopy,transmission electron microscopy,and western blot analysis were ***:liM1863 automatically grew as spheroids in suspension and had important typical epithelial properties,including several layers of cells arranged around a central lumen,apical-basal polarity,and types of cell-cell *** with a combination of both TGF beta 1 and TNF alpha induced definite and distinct EMT,a spheroid changing phenotype to form a monolayer high-confluent patch without lumen,without *** CCCM occurred in *** EMT cells adhered to the base of a dish,exhibited persistent movement as a cluster of cells,and then shed,resulting in a *** cells from one cluster undergoing CCCM ***,all cells undergoing EMT disappeared and almost all cells located in the cell reservoir survived and ***:liM1863 is an excellent cell line to study CCCM and *** group of heterogeneous cells undergoing CCCM behaves like a supracellular unit.

关键词： Colorectal cancer Epithelial-to-mesenchymal transition Collective cell migration Supracellular migration Metastasis

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Thermal,Rheological and Mechanical Properties of Biodegradable Poly(propylene carbonate)/Epoxidized Soybean Oil Blends

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Chinese Journal of Polymer Science 2021年第12期39卷 1572-1580页

作者： ling Zhao Shi-ling Jia Ze-Peng Wang Yun-Jing Chen Jun-Jia Bian li-Jing Han Hui-liang Zhang li-Song Dong Changchun UniversityofTechnology Changchun 130012China Key Laboratory of Polymer Ecomaterials Chinese Academy of SciencesChangchun Institute of Applied ChemistryChangchun 130022China Sinopec-SK(Wuhan)Petrochemical Company limited Wuhan 430000China

Biodegradable poly(propylene carbonate)(PPC)/epoxidized soybean oil(ESO)blends with different component ratios were prepared by melt blending to improve the performance of *** phase morphology,thermal properties,rheological properties and mechanical properties of the blends were in vestigated in *** exami nation revealed good in terfacial adhesi on betwee n PPC matrix and *** to DSC and DMA,as the content of ESO increased,the glass transition temperature of the PPC component increased,indicating that there was a strong in terfacial in teracti on between the PPC matrix and *** in terfacial in teraction may be caused by rin g-opening reaction between the hydroxyl end groups of PPC and the epoxy groups of ESO,which restricted the chain movement of PPC *** disappearanee of the epoxy groups in FTIR indicated that the in terfacial in teracti on betwee n the two phases was due to the rin g-openi ng reactio n betwee n PPC and *** the addition of ESO,the thermal stabilities were *** the increasing ESO content,the modulus gradually ***,the stre ngth at yield,the strength at break and the elon gation at break were in creased for the PPC/ESO blends,suggest!ng that the enhancement of the strength and toughness of PPC was achieved by the incorporation of *** rheological measurement revealed that the complex viscosity,storage modulus and loss modulus of PPC were in creased with the increasi ng ESO content at low freque ncy,which indicated that the addition of ESO enhanced the melt strength of PPC in stead of plasticizi ng PPC.

关键词： Poly(propylene carbonate) Epoxy soybean oil Compatibility Mechanical properties

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