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nterferon alpha （IFNα）-induced TRIM22 interrupts HCV ＇eplication by ubiquitinating NS5A

Cellular & molecular Immunology 2016年第1期13卷 94-102页

作者： Chen yang Xinhao Zhao Dakang Sun Leilei yang Chang Chong Yu Pan Xiumei Chi Yanhang Gao Moli Wang xiaodong Shi Haibo Sun Juan Lv Yuanda Gao Jin Zhong Junqi Niu bing Sun State Key Laboratory of Cell biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China Key Laboratory of molecular Virology and Immunology Institut Pasteur of Shanghai Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China Hepatology Section First Hospital University of Jilin Changchun China Infectious Diseases department Fourth Hospital University of Jilin Changchun China Experiment Center of Clinical Medicine Affiliated Hospital of Binzhou Medical University Binzhou China

TRIM22, a tripartite-motif （TRIM） protein, is upregulated upon interferon alpha （IFNa） administration to hepatitis C virus （HCV）-infected patients. However, the physiological role of TRIM22 upregulation remains unclear. Here, we describe a potential antiviral function of TRI M22＇s targeting of the HCV NSSA protein. NS5A is important for HCV replication and for resistance to I FNa therapy. During the first 24 h following the initiation of I FNa treatment, upregulation of TRIM22 in the peripheral blood mononuclear cells （PBMCs） of HCV patients correlated with a decrease in viral titer. This phenomenon was confirmed in the hepatocyte-derived cell line Huh-7, which is highly permissive for HCV infection. TRIM22 over-expression inhibited HCV replication, and Small interfering RNA （siRNA）-mediated knockdown of TRIM22 diminished IFNα-induced anti-HCV function. Furthermore, we determined that TRIM22 ubiquitinates NS5A in a concentration-dependent manner. In summary, our results suggest that TRIM22 upregulation is associated with HCV decline during IFNα treatment and Dlavs an important role in controlling HCV replication in vitro.

关键词： HCV IFNα NS5A TRIM22 ubiquitin

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Biomarkers of aging

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Science china(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua qiao Xinpei Sun xiaoqiang Tang Jianfang Wang qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-hui xiao lingyan Xu Yingying Xu Haoteng Yan Liang yang Ruici yang Yuanxin yang Yilin Ying Le zhang Weiwei zhang Wenwan zhang Xing zhang Zhuo zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai zhang Hongbo zhang Liang zhang Weiqi zhang Yong zhang Yun-Wu zhang Zhuohua zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

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Cancer metabolism and tumor microenvironment:fostering each other?

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Science china(Life Sciences) 2022年第2期65卷 236-279页

作者： Yiyuan Yuan huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang zhang Weiwei yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng zhang Ping Gao Peng Jiang Shicheng Su bing Sun Shi-Min Zhao Obstetrics&Gynecology Hospital of Fudan university State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200438China State Key Laboratory of Cell biology Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China molecular and Cell biology Lab Institutes of Biomedical Sciences and School of Life SciencesFudan UniversityShanghai 200032China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China West china School of Basic medical Sciences&Forensic Medicine Sichuan Universityand State Key Laboratory of Biotherapy and Cancer CenterWest China Hospitaland Collaborative Innovation Center for BiotherapyChengdu 610041China department of biochemistry and molecular Cell biology Shanghai Key Laboratory of Tumor Microenvironment and InflammationShanghai Jiao Tong University School of MedicineShanghai 200025China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China CAS Centre for Excellence in Cell and molecular biology the CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China School of Medicine Institutes for Life SciencesSouth China University of TechnologyGuangzhou 510006China Tsinghua university School of Life Sciences and Tsinghua-Peking Center for Life SciencesBeijing 100084China

The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells *** reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental *** evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling *** cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor *** cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of *** conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer ***,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer *** metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as *** them,cancer microenvironmental cells are immune cells which exert profound effects on cancer *** of all these processes is a prerequisite for the development of a more effective strategy to contain cancers.

关键词： cancer metabolism cancer microenvironment epigenetics cancer immunology

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Aortic stent graft infection in a patient with Marfan syndrome

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Chinese medical Journal 2007年第10期120卷 935-937页

作者： FU Wei-guo SHI De-bing WANG Yu-qi GUO Da-qiao CHEN Bin SHI Zhen-yu department of Vascular Surgery Institute of Vascular Surgery Zhongshan Hospital Fudan University Shanghai 200032 China

Endovascular repair of raptured abdominal aortic aneurysm （AAA） has been adopted clinically. It is especially suitable for the patients who are at high surgical risk or fulfil the technical requirements for endovascular therapy. The use of endoprostheses, however, may raise the risk of infection, as occurred in our AAA patient with Marfan syndrome who had stent-graft infection as a result of Salmonella choleraesuis.

关键词： blood vessel prosthesis rosthesis-related infections endovascular graft infection endovascular graft complication

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Balloon catheterization for hemostasis during the operation of ruptured femoral artery pseudoaneurysm

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Chinese medical Journal 2007年第21期120卷 1943-1944页

作者： SHI De-bing FU Wei-guo WANG Yu-qi GUO Da-qiao CHEN Bin SHI Zhen-yu department of Vascular Surgery Institute of Vascular Surgery Zhongshan Hospital Fudan University Shanghai 200032 China

Pseudoaneurysms of the femoral artery usually progress and can rupture if left untreated. Therefore,intraoperative hemostasis is of the paramount importance in the management of these emergent situations, especially for the patients with poor general health. We present an efficient method of stopping massive bleeding occurring in this patient by balloon catheter.

关键词： drug abuse aneurysm, false infection balloon catheterization

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南极真菌Penicillium sp. S-2-10次级代谢产物的研究

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中国海洋药物 2017年第3期36卷 18-22页

作者：周玥刘小宇于豪冰卢小玲焦炳华第二军医大学海洋生物医药研究中心上海200433 第二军医大学基础部生物化学与分子生物学教研室上海200433

目的对来源于南极海域海底沉积物真菌Penicilliumsp.S-2-10的次级代谢产物进行研究。方法对菌株进行规模发酵,并对所得发酵液的乙酸乙酯萃取浸膏进行系统分离纯化,据化学指征和生物学活性两方面特点,采用Sephadex LH-20凝胶色谱、正相... 详细信息

目的对来源于南极海域海底沉积物真菌Penicilliumsp.S-2-10的次级代谢产物进行研究。方法对菌株进行规模发酵,并对所得发酵液的乙酸乙酯萃取浸膏进行系统分离纯化,据化学指征和生物学活性两方面特点,采用Sephadex LH-20凝胶色谱、正相硅胶柱色谱、反相ODS柱色谱、高效液相柱层析等色谱分析方法,通过核磁(~1 H-NMR和^(13) C-NMR等)及质谱(MS)等波谱分析方法,并与相关文献比较,鉴定化合物结构。结果分离得到7个单体化合物,经鉴定化合物1~7分别为benzoic acid,2-(2,6-dihydroxybenzoyl)-3-hydroxy-5-(hydroxymethyl)-methyl,methyl ester(1),chrysophanol(2),volemolide(3),ergosta-6,8(14),22-trien-3-ol(4),2-aminophenoxazin-3-one(5),2-benzothiazolol(6),benzoic acid(7)。结论化合物3,4为首次从Penicillium属真菌中获得。

关键词：南极真菌青霉属次级代谢产物

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开窗治疗颌骨囊性病变的专家共识

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口腔疾病防治 2020年第2期28卷 69-72页

作者：陶谦何悦刘冰侯劲松南欣荣张彬张磊涛乔彬中山大学附属口腔医院·光华口腔医学院口腔颌面外科广东广州510055 上海交通大学医学院附属第九人民医院口腔颌面—头颈肿瘤科上海200011 武汉大学口腔医学院口腔颌面外科湖北武汉430072 山西医科大学第一医院口腔颌面外科山西太原030001 中山大学孙逸仙纪念医院口腔颌面外科广东广州510120 南方医科大学南方医院口腔颌面外科广东广州510515 郑州大学第一附属医院口腔颌面外科河南郑州450001

开窗治疗颌骨囊性病变行之有效,具有创伤小、操作简单、减少术后复发,能最大程度地保留周围组织结构和功能等优点;但临床上由于适应证把握不当、操作不规范等原因,开窗治疗存在一定的失败率,文献报道的最高失败率为32.6%。为进一步完善... 详细信息

开窗治疗颌骨囊性病变行之有效,具有创伤小、操作简单、减少术后复发,能最大程度地保留周围组织结构和功能等优点;但临床上由于适应证把握不当、操作不规范等原因,开窗治疗存在一定的失败率,文献报道的最高失败率为32.6%。为进一步完善和规范开窗术临床应用,提高治疗成功率,本文总结国内外文献和汇集部分国内著名专家的诊治经验,形成“开窗治疗颌骨囊性病变的专家共识”。此共识提出开窗术的3个要素为开窗口的建立、囊肿塞维持开窗口以及定期冲洗;开窗术的适用范围包括颌骨囊肿和囊性成釉细胞瘤等;需要规范开窗位置、开窗口大小以及囊肿塞制作与放置等重要操作步骤;对疗效评判采用全景片或锥形束CT观察术前、术后囊腔的变化较为客观;二期手术宜在病灶显著缩小>50%,或远离累及的重要结构5mm左右时实施;对于病灶牙,应根据病灶与牙的关系以及牙的类型,分别予以处理。

关键词：颌骨囊性病变开窗术适应证禁忌证疗效判定二期手术专家共识

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Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

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Protein & Cell 2021年第10期12卷 769-787页

作者： xiaoyan Xu Yaqin Sun Xufeng Cen bing Shan Qingwei Zhao Tingxue Xie Zhe Wang Tingjun Hou Yu Xue Mengmeng zhang Di Peng Qiming Sun Cong Yi Ayaz Najafov Hongguang Xia department of biochemistry&Research Center of Clinical Pharmacy of The First Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China Liangzhu Laboratory Zhejiang University Medical CenterHangzhou 311121China department of Cell biology Harvard Medical SchoolBostonMA 02115USA Interdisciplinary Research Center on biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 201203China College of Pharmaceutical Sciences Hangzhou Institute of innovative MedicineZhejiang UniversityHangzhou 310058China Key Laboratory of molecular Biophysics of Ministry of Education Hubei Bioinformatics and Molecular Imaging Key LaboratoryCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

Chaperone-mediated autophagy(CMA)is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative ***,the mechanisms that regulate CMA are not fully ***,using unbiased drug screening approaches,we discover Metformin,a drug that is commonly the first medication prescribed for type 2 diabetes,can induce *** delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKα/β signaling that leads to phosphorylation of Ser85 of the key mediator of CMA,Hsc70,and its ***,we find that amyloid-beta precursor protein(APP)is a CMA substrate and that it binds to Hsc70 in an IKKα/β-dependent *** inhibition of CMA-mediated degradation of APP enhances its ***,we find that in the APP/PS1 mouse model of Alzheimer's disease(AD),activation of CMA by Hsc70 overexpression or Metformin potently reduces the accumulated brain Aβplaque levels and reverses the molecular and behavioral AD *** study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKα/β-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases,such as AD,where such therapeutic intervention could be beneficial.

关键词： chaperone-mediated autophagy Metformin TAK1 IKKα/β Hsc70 APP Alzheimer’s disease

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Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction

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Journal of Genetics and Genomics 2018年第8期45卷 419-432页

作者： Lu qiao Yajun yang Pengcheng Fu Sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin Yaqun Guan Sijia Wang Shuhua Xu Kun Tang Chinese Academy of Sciences (CAS) Key Laboratory of Computational biology CAS-MPG Partner Institute for Computational Biology (PICB) Shanghai Institutes for Biological Sciences University of Chinese Academy of Sciences CAS Shanghai 200031 China State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology School of Life Sciences Fudan University Shanghai 200433 China Fudan-Taizhou Institute of Health Sciences Taizhou 225300 China department of Neurology The First People's Hospital of Chenzhou Hunan 423000 China Collaborative Innovation Center of Genetics and Development Shanghai 200438 China department of biochemistry and molecular biology Preclinical Medicine College Xinjiang Medical University Urumqi 830011 China Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming 650223 China School of Life Science and Technology ShanghaiTech University Shanghai 201210 China

It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics, Genome-wide associ- ation studies （GWAS） were conducted on a discovery panel of Uyghurs, Six significant loci were iden- tified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios.

关键词： Genome-wide association study Dense 3D facial image Ancestry-divergent phenotypes Face prediction Forensic scenario

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1株北极真菌Eutypella sp.D-1的生物活性成分研究

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中国海洋药物 2020年第2期39卷 38-41页

作者：于豪冰王晓丽胡波张建鹏卢小玲刘小宇焦炳华中国人民解放军海军特色医学中心海洋生物医药与极地医学研究室上海200433 中国人民解放军海军军医大学基础医学院生物化学与分子生物学教研室上海200433

目的对分离自北极高纬度地区的1株真菌Eutypella sp. D-1的抗肿瘤活性成分进行研究。方法运用溶剂分部萃取、硅胶柱色谱、中压ODS柱色谱以及高效液相色谱(HPLC)等多种分离方法对次级代谢产物进行分离纯化;通过运用核磁共振波谱法(NMR)... 详细信息

目的对分离自北极高纬度地区的1株真菌Eutypella sp. D-1的抗肿瘤活性成分进行研究。方法运用溶剂分部萃取、硅胶柱色谱、中压ODS柱色谱以及高效液相色谱(HPLC)等多种分离方法对次级代谢产物进行分离纯化;通过运用核磁共振波谱法(NMR)、质谱分析(MS)等波谱技术,结合文献比对,解析化合物的结构。结果从真菌Eutypella sp. D-1大米培养基萃取物中分得3个化合物,鉴定为cladoacetal C (1)、benzophomopsin A (2)、pestalospirane B (3)。结论化合物1为新化合物,化合物2、3均为首次从该属真菌中分离得到。

关键词：北极真菌 Eutypella sp. 次级代谢产物

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