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The cytochrome P4501A1(CYP1A1)inhibitor bergamottin enhances host tolerance to multidrug-resistant Vibrio vulnificus infection

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Chinese Journal of Traumatology 2024年第5期27卷 295-304页

作者： Ruo-bai qiao Wei-Hong Dai Wei Li Xue Yang Dong-Mei He Rui Gao Yin-Qin Cui Ri-Xing Wang Xiao-Yuan Ma Fang-Jie Wang Hua-Ping Liang The College of Emergency and Trauma Hainan Medical UniversityHaikou571199China The First Research Department State Key Laboratory of Trauma and Chemical PoisoningArmy Medical Center(Daping Hospital)Army Medical UniversityChongqing400042China Emergency Department The Second Affiliated HospitalHainan Medical UniversityHaikou570311China

Purpose:Vibrio vulnificus (V. Vulnificus) infection is characterized by rapid onset, aggressive progression, and challenging treatment. Bacterial resistance poses a significant challenge for clinical anti-infection treatment and is thus the subject of research. Enhancing host infection tolerance represents a novel infection prevention strategy to improve patient survival. Our team initially identified cytochrome P4501A1 (CYP1A1) as an important target owing to its negative modulation of the body''s infection tolerance. This study explored the superior effects of the CYP1A1 inhibitor bergamottin compared to antibiotic combination therapy on the survival of mice infected with multidrug-resistantV. Vulnificus and the protection of their vital ***:An increasing concentration gradient method was used to induce multidrug-resistantV. Vulnificus development. We established a lethal infection model in C57BL/6J male mice and evaluated the effect of bergamottin on mouse survival. A mild infection model was established in C57BL/6J male mice, and the serum levels of creatinine, urea nitrogen, aspartate aminotransferase, and alanine aminotransferase were determined using enzyme-linked immunosorbent assay to evaluate the effect of bergamottin on liver and kidney function. The morphological changes induced in the presence of bergamottin in mouse organs were evaluated by hematoxylin and eosin staining of liver and kidney tissues. The bacterial growth curve and organ load determination were used to evaluate whether bergamottin has a direct antibacterial effect on multidrug-resistantV. Vulnificus. Quantification of inflammatory factors in serum by enzyme-linked immunosorbent assay and the expression levels of inflammatory factors in liver and kidney tissues by real-time quantitative polymerase chain reaction were performed to evaluate the effect of bergamottin on inflammatory factor levels. Western blot analysis of IκBα, phosphorylated IκBα, p65, and phosphorylated p65 prot

关键词： Multidrug-resistant Vibrio vulnificus Bergamottin CYP1A1 inhibitors Infection tolerance

Structural characteristics and geochronology of migmatites in the North Dabie Complex unit: Timing of post-collisional deformation

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Science China Earth Sciences 2018年第7期61卷 887-902页

作者： Yongsheng WANG qiao bai Bingfei YANG School of Resources and Environmental Engineering Hefei University of Technology

Extensive migmatization and large-scale post-collisional intrusions occurred in the Dabie orogen, east-central China,during the Early Cretaceous, characterized by distinct deformation preserved in migmatites in the North Dabie Complex *** North Dabie Complex unit can be subdivided into three areas based on detailed field observations： the north of the Tiantangzhai pluton, the Luotian area and the Yuexi area. Banded migmatites crop out in the north of the Tiantangzhai pluton while anisotropically deformed migmatites occur in the Luotian area, and both types coexist in the Yuexi area. Microscopy reveals similar micro-structures are in migmatites from the north of the Tiantangzhai pluton, the Yuexi area and border of the Luotian area, while static recrystallization appears in migmatites from the core of the Luotian area. The Lattice-Preferred Orientation of dynamically recrystallized quartz grains in the migmatites are measured using electron backscattered diffraction,revealing prism slip or slip in migmatite from the north of the Tiantangzhai pluton and the Yuexi area and in one sample from the Luotian area. A Type I crossed girdle is developed in another sample from the Luotian area, indicating top-to-the-SE shearing that developed under greenschist facies conditions. Zircon U-Pb dates from four migmatites reveal that mainly Early Cretaceous ages are from the north of the Tiantangzhai pluton, only four Early Cretaceous ages are from the Luotian area, and all zircons from the Yuexi area record Indosinian metamorphic ages. Although zircon U-Pb results show multiple migmatization events, all samples record a migmatization age of about 132 Ma, suggesting an orogen-scale event at that time. The subsolidus deformation in migmatites indicates that deformation were soon after migmatization. Overall, this study shows that deformation in migmatites of the North Dabie Complex unit occurred somewhat later than the migmatization（132 Ma） at about 131 Ma. The most likely mecha

关键词： The North Dabie Complex unit Migmatite Structural evidence Zircon U-Pb dating

Detrital zircon U-Pb dating in the southern Hefei Basin: Evidence for exhumation of HP-UHP rocks of the Dabie Orogen

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Science China Earth Sciences 2020年第7期63卷 954-968页

作者： Yongsheng WANG qiao bai Ziqiang TIAN Hui DU School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China

The Hefei Basin of eastern China developed in response to uplift of the Dabie Orogen,and zircon dating can be used to assess the exhumation history of the *** were collected from samples of the Lower Jurassic Fanghushan Formation and Middle Jurassic Sanjianpu Formation in the southern Hefei Basin,and mica-quartz schist and biotite granite gneiss from the Susong Complex of the Dabie *** zircon U-Pb dating was undertaken using laser ablation-inductively coupled plasma-mass *** detrital zircons from conglomerates of the Fanghushan Formation and from clasts within the conglomerates have age-frequency distributions with the main clusters between 2.0 and 1.8 Ga,similar to age data of the Susong *** the other hand,the zircons of the Fanghushan Formation do not show the age cluster at 1000–900 Ma that characterizes zircons in the underlying metasediments of the lower Paleozoic Foziling Group.A cluster of Triassic zircon ages also appears in the arkosic sandstones of the Fanghushan *** data indicate that the provenance of the Fanghushan Formation was a mixture of high-pressure(HP)and ultrahigh-pressure(UHP)Triassic metamorphic rocks,Paleozoic magmatic rocks,and the Susong Complex,but not the lower Paleozoic Foziling Group even though it directly underlies the sediments of the Hefei *** samples from the Sanjianpu Formation show zircon age clusters at 797 and 791 Ma(middle Neoproterozoic)and 226 Ma(Triassic),and again,these are markedly different from the age clusters that characterize the Foziling *** seems,therefore,that despite the Foziling Group being at the surface in the underwater depositional area of the Hefei Basin,it was not exposed in the source area of the Hefei basinal sediments during the Jurassic,and there are two possible reasons for ***,the exhumation of the Dabie Orogen was directed partly towards the north,in the process of which some of the Foziling Group was ***,the Susong Compl

关键词： Dabie Orogen Exhumation of HP-UHP rocks Hefei Basin Lower-Middle Jurassic Zircon dating

芒柄花黄素通过DRP1-NLRP3信号通路缓解过敏性哮喘的作用机制

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中国药理学通报 2024年第3期40卷 529-536页

作者：陈牧白巧云宋艺兰陈娇金永德延光海吉林省过敏性常见疾病免疫与靶向研究重点实验室吉林延吉133002 延边大学附属医院耳鼻咽喉科吉林延吉133002 延边大学医学院解剖学教研室吉林延吉133002

目的本研究旨在探讨芒柄花黄素(formononetin,FN)通过干预ROS的生成抑制线粒体动力相关蛋白1(dynamic-related protein 1,DRP1)-NLRP3轴减轻过敏性气道炎症的有关机制。方法为建立过敏性哮喘小鼠模型,50只8周龄的BALB/c小鼠通过卵清蛋白... 详细信息

目的本研究旨在探讨芒柄花黄素(formononetin,FN)通过干预ROS的生成抑制线粒体动力相关蛋白1(dynamic-related protein 1,DRP1)-NLRP3轴减轻过敏性气道炎症的有关机制。方法为建立过敏性哮喘小鼠模型,50只8周龄的BALB/c小鼠通过卵清蛋白(ovalbumin,OVA)诱导后分为对照组、模型组、FN治疗组及地塞米松组。采用HE和Masson染色检测气道炎症和胶原沉积,ELISA测定支气管肺泡灌洗液(BALF)中Th2型细胞因子和超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、丙二醛(MDA)以及IgE水平,DCFH-DA染色评估BEAS-2B细胞中ROS,免疫组织化学和免疫荧光检测肺组织和BEAS-2B细胞中DRP1表达,免疫印迹分析DRP1-NLRP3途径。结果FN治疗可有效改善哮喘小鼠模型的症状,包括减少嗜酸性粒细胞聚集、气道胶原沉积,降低Th2细胞因子和IgE水平,减少ROS和MDA生成,提高SOD和CAT活性,并调节DRP1-NLRP3途径相关蛋白表达,从而缓解炎症。结论FN通过调节DRP1-NLRP3途径改善哮喘气道炎症。

关键词：哮喘芒柄花黄素 ROS DRP1 NLRP3 炎症

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压缩剪切平面应变试样的应力状态响应

塑性工程学报 2024年第7期31卷 188-194页

作者：赵宁许镱巍赵小松白峭峰王琛赵春江太原科技大学机械工程学院山西太原030024 山西电子科技学院智能制造产业学院山西临汾041000

为模拟金属塑性变形过程中的压缩剪切应力状态的平面应变特征,构建了平面压缩剪切试样。通过数字图像相关(DIC)技术和有限元模拟表征变形区Y方向的应力状态分布特征及压缩断裂过程。DIC结果显示,在压缩实验过程中,变形区的应变场分布与... 详细信息

为模拟金属塑性变形过程中的压缩剪切应力状态的平面应变特征,构建了平面压缩剪切试样。通过数字图像相关(DIC)技术和有限元模拟表征变形区Y方向的应力状态分布特征及压缩断裂过程。DIC结果显示,在压缩实验过程中,变形区的应变场分布与有限元结果吻合良好,有限元结果可靠。有限元结果表明,通过改变试样的缺口倾角,可以定量控制应力三轴度的大小,并且主应变方向与缺口倾角方向一致。在变形区Y方向发生压缩剪切的平面应变,同时试样边缘位置相对于中心位置具有更低的Lode角参数,具有双向压缩加载特征,使得静水压力增大,应力三轴度进一步降低至-0.823。

关键词：应力状态平面应变压缩剪切数字图像相关

一种超市搬运机器人结构设计及底盘静力学分析

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机械工程与自动化 2024年第2期 20-22页

作者：柴玮锋郭森白峭峰太原科技大学机械工程学院山西太原030024

针对超市货品整理搬运效率低的问题,基于Inventor设计了一款智能化的超市货品搬运机器人。完成了机器人的整体结构设计,分析了执行机构和底盘的结构组成及工作原理,并针对底盘关键部件进行了静力学分析,分别研究了车轮轴、车轮支架、车... 详细信息

针对超市货品整理搬运效率低的问题,基于Inventor设计了一款智能化的超市货品搬运机器人。完成了机器人的整体结构设计,分析了执行机构和底盘的结构组成及工作原理,并针对底盘关键部件进行了静力学分析,分别研究了车轮轴、车轮支架、车轮轮毂及底盘的变形、应力及应变情况,可为解决超市货品整理工作的相关搬运机器人的设计提供参考。

关键词：搬运机器人结构设计底盘静力学分析

Double-Cable Conjugated Polymers with Fullerene Pendant for Single-Component Organic Solar Cells

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Chinese Journal of Polymer Science 2022年第8期40卷 898-904,I0007页

作者： bai-qiao Liu Yun-Hua Xu Feng Liu Cheng-Cheng Xie Shi-Jie Liang qiao-Mei Chen Wei-Wei Li Department of Chemistry School of ScienceBeijing Jiaotong UniversityBeijing100044China Beijing Advanced Innovation Center for Soft Matter Science and Engineering&State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China

In this work,the“functionalization-polymerization”(FP)method has been used to construct fullerene-contained double-cable conjugated polymers with“donor-acceptor”*** was realized via synthesizing a fullerene-contained monomer and performing Stille *** this method,a series of double-cable conjugated polymers with different fullerene contents were developed and applied into single-component organic solar *** power conversion efficiencies(PCEs)based on these polymers increased from 0.71%to 1.71%with the enhanced fullerene *** relatively low PCEs might be originated from the poor microstructure in these *** new conjugated polymers with molecular heterojunction would show potential application in organic electronic devices.

关键词： Double-cable conjugated polymers Single-component organic solar cells Fullerene “Donor-acceptor”conjugated polymers Microphase separation

Experimental study on propagation characteristics of rotating detonation wave with kerosene fuel-rich gas

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Defence Technology（防务技术） 2022年第8期18卷 1498-1512页

作者： Jia-xiang Han qiao-dong bai Shi-jian Zhang Fang Wang Chun-sheng Weng National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing210094China

In this study, kerosene fuel-rich gas produced by the combustion in the gas generator was used as the fuel and oxygen-rich air was used as the oxidant to investigate the propagation characteristics of the rotating detonation wave (RDW). The initiation of the kerosene fuel-rich gas and propagation process of the RDW were analyzed. The influences of the oxygen content in the oxidizer, kerosene mass flow rate of the gas generator, and temperature of the kerosene fuel-rich gas on the propagation process of the RDW were studied. The experimental results revealed that the propagation velocity of the RDW could be improved by increasing the three parameters mentioned above with the kerosene mass flow rate as the strongest factor. The minimum oxygen content that could successfully initiate and maintain the stable propagation of the RDW was 32%, achieving the RDW velocity of 1141.9 m/s. The RDW mainly propagated as two-counter rotating waves and a single wave when the equivalent ratios were 0.62–0.79 and 0.85–0.87, respectively. The highest RDW velocity of 1637.2 m/s was obtained when the kerosene mass flow rate, oxygen content, and equivalent ratio were 74.6 g/s, 44%, and 0.87, respectively.

关键词： Rotating detonation wave Kerosene fuel-rich gas Initiation process Propagation mode

Effects of total pressures and equivalence ratios on kerosene/air rotating detonation engines using a paralleling CE/SE method

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Defence Technology（防务技术） 2021年第6期17卷 1805-1816页

作者： Fang Wang Chun-sheng Weng Yu-wen Wu qiao-dong bai Quan Zheng Han Xu National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing210094China

In this paper,the kerosene/air rotating detonation engines(RDE)are numerically investigated,and the emphasis is laid on the effects of total pressures and equivalence ratios on the operation characteristics of RDE including the initiation,instabilities,and propulsive performance.A hybrid MPI t OpenMP parallel computing model is applied and it is proved to be able to obtain a more effective parallel performance on high performance computing(HPC)systems.A series of cases with the total pressure of 1 MPa,1.5 MPa,2 MPa,and the equivalence ratio of 0.9,1,1.4 are *** one hand,the total pressure shows a significant impact on the instabilities of rotating detonation *** instability phenomenon is observed in cases with low total pressure(1 MPa)and weakened with the increase of the total *** total pressure has a small impact on the detonation wave velocity and the specific *** the other hand,the equivalence ratio shows a negligible influence on the instabilities,while it affects the ignition process and accounts for the detonation velocity *** is more difficult to initiate rotating detonation waves directly in the lean fuel operation *** difference was observed in the thrust with different equivalence ratios of 0.9,1,and *** highest specific impulse was obtained in the lean fuel cases,which is around 2700 *** findings could provide insights into the understanding of the operation characteristics of kerosene/air RDE.

关键词： Kerosene/air rotating detonation waves Total pressure Equivalence ratio Instabilities MPItOpenMP