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First-principles study on the heterogeneous formation of environmentally persistent free radicals(EPFRs)overα-Fe2O3(0001)surface:Effect of oxygen vacancy

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Journal of Environmental Sciences 2024年第8期142卷 279-289页

作者： Wenxiao Pan Shuming He qiao xue Xian Liu Jianjie Fu Kang Xiao Aiqian Zhang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of Environment Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310012China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Beijing Yanshan Earth Critical Zone National Research Station University of Chinese Academy of SciencesBeijing 101408China

Metal oxides with oxygen vacancies have a significant impact on catalytic activity for the transformation of organic pollutants in waste-to-energy(WtE)incineration *** study aims to investigate the influence of hematite surface oxygen point defects on the formation of environmentally persistent free radicals(EPFRs)from phenolic compounds based on the first-principles *** oxygen-deficient conditions were considered:oxygen vacancies at the top surface and on the *** simulations indicate that the adsorption strength of phenol on theα-Fe_(2)O_(3)(0001)surface is enhanced by the presence of oxygen ***,the presence of oxygen vacancies has a negative impact on the dissociation of the phenol molecule,particularly for the surface with a defective point at the top ***-kinetic parameters were established over a temperature range of300-1000 K,and lower reaction rate constants were observed for the scission of phenolic O-H bonds over the oxygen-deficient surfaces compared to the pristine *** negative effects caused by the oxygen-deficient conditions could be attributed to the local reduction of FeⅢto FeⅡ,which lower the oxidizing ability of surface reaction *** findings of this study provide us a promising approach to regulate the formation of EPFRs.

关键词： EPFR formation Phenol dissociation Oxygen-vacancy impact Hematite surface First-principles calculation

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Parotid metastasis of rare lung adenocarcinoma:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1182-1189页

作者： Ru-Xi Yan Lin-Bo Dou Zi-Jia Wang xue qiao Hong-Hai Ji Yan-Cong Zhang School of Stomatology Weifang Medical UniversityWeifang 261000Shandong ProvinceChina Department of Stomatology Dezhou People’s HospitalDezhou 253000Shandong ProvinceChina Department of Stomatology Dezhou Women and Children's HospitalDezhou 253000Shandong ProvinceChina

BACKGROUND Lung cancer(LC)is the leading cause of malignancy-related deaths *** most common sites of metastasis include the nervous system,bone,liver,respiratory system,and adrenal *** metastasis in the parotid gland is very rare,and its diagnosis presents a ***,we report a case of parotid metastasis in primary *** SUMMARY The patient was a 74-year-old male who was discovered to have bilateral facial asymmetry inadvertently two years *** right earlobe was slightly swollen and without pain or *** tomography(CT)examination showed bilateral lung space-occupying *** biopsy was performed and revealed adenocarcinoma(right-upper-lung nodule tissue).Positron emission tomography-CT examination showed:(1)Two hypermetabolic nodules in the right upper lobe of the lung,enlarged hy-permetabolic lymph nodes in the right hilar and mediastinum,and malignant space-occupying lesion in the right upper lobe of the lung and possible metastasis to the right hilar and mediastinal lymph nodes;and(2)multiple hypermetabolic nodules in bilateral parotid *** puncture biopsy was performed considering lung adenocarcinoma *** detection of lung biopsy specimens revealed an EGFR gene 21 exon L858R *** This case report highlights the challenging diagnosis of parotid metastasis in LC given its rare *** lesions should be differentiated from primary tumors of the parotid *** radiological imaging is unreliable,and puncture biopsy is needed for final diagnosis of this condition.

关键词： Lung cancer Metastasis Parotid gland Pathology Positron emission tomography/computed tomography Case report

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Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation

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Journal of Pharmaceutical Analysis 2024年第1期14卷 115-127页

作者： Yang Yi Wenzhe Li Kefang Liu Heng xue Rong Yu Meng Zhang Yang-Oujie Bao Xinyuan Lai Jingjing Fan Yuxi Huang Jing Wang Xiaomeng Shi Junhua Li Hongping Wei Kuanhui Xiang Linjie Li Rong Zhang Xin Zhao xue qiao Hang Yang Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing100191China Yunnan Baiyao International Medical Research Center Peking UniversityBeijing100191China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterPeking UniversityBeijing100191China Hubei Jiangxia Laboratory Wuhan430000China Shenzhen Children's Hospital ShenzhenGuangdong518036China

Currently,human health due to corona virus disease 2019(COVID-19)pandemic has been seriously *** coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)spike(S)protein plays a crucial role in virus transmission and several S-based therapeutic approaches have been approved for the treatment of ***,the efficacy is compromised by the SARS-CoV-2 evolvement and *** we report the SARS-CoV-2 S protein receptor-binding domain(RBD)inhibitor licorice-saponin A3(A3)could widely inhibit RBD of SARS-CoV-2 variants,including Beta,Delta,and Omicron BA.1,XBB and ***,A3 could potently inhibit SARS-CoV-2 Omicron virus in Vero E6 cells,with EC50 of 1.016μ*** mechanism was related to binding with Y453 of RBD determined by hydrogen-deuterium exchange mass spectrometry(HDX-MS)analysis combined with quantum mechanics/molecular mechanics(QM/MM)***,phosphoproteomics analysis and multi fluorescent immunohistochemistry(mIHC)respectively indicated that A3 also inhibits host inflammation by directly modulating the JNK and p38 mitogen-activated protein kinase(MAPK)pathways and rebalancing the corresponding immune *** work supports A3 as a promising broad-spectrum small molecule drug candidate for COVID-19.

关键词： COVID-19 Inflammation Licorice-saponin A3 Receptor-binding domain(RBD) SARS-CoV-2

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Network Pharmacology-Based Dissection of the Bioactive Compounds and Pharmacological Mechanisms of Yiqi Fumai Lyophilized Injection for the Treatment of Heart Failure

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 75-82页

作者： Yu-Xi Huang Jing-Jing Fan Lu-Lu Xu Rong Yu Yi Kuang Yue Chai Rui Zheng Xiao-Yu Zhang Hong-Cai Shang xue qiao Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina Key Laboratory of Chinese Internal Medicine of Ministry of Education Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina Yunnan Baiyao International Medical Research Center Peking UniversityBeijingChina Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Peking UniversityBeijingChina

Objective:Yiqi Fumai Lyophilized Injection(YQFM),a Chinese medicine injection,has been widely used for the treatment of cardiovascular diseases,especially heart failure(HF).However,bioactive compounds and underlying mechanisms of YQFM in treating HF remain poorly *** and Methods:Network pharmacology was employed to investigate the bioactive compounds and mechanisms of YQFM.A compound-target network was constructed to screen bioactive compounds based on contribution index ***,an adriamycin-induced HF rat model was established to evaluate the cardio-protective effects of YQFM by hematoxylin and eosin staining and enzyme-linked immunosorbent ***:Network pharmacology indicated that YQFM may alleviate HF through 36 compounds and 109 ***,ginsenosides Rb1,Rg1,Re,Rf,Rb2,Rh1,schisandrin,and ginsenoside Rc were indicated as the top contributors of YQFM in treating *** was predicted to act on multiple targets such as vascular endothelial growth factor A,interleukin-2(IL-2),IL-6,and IL-1β,as well as to regulate signaling pathways such as hypoxia-inducible factor 1,tumor necrosis factor,VEGF,and *** pharmacological study suggested that YQFM could attenuate cardiac injury and up-regulate plasma concentrations of VEGFR-1 and NO in HF *** Rb1,as the major contributor from network pharmacology analysis,also showed a cardioprotective effect and up-regulation of VEGFR-1 in ***:Ginsenosides and schisandrin were predicted as the most important contributors to the cardioprotective effect of *** Rb1 was proved to alleviate HF and increase the plasma concentration of VEGFR-1.

关键词： Contribution index heart failure network pharmacology traditional Chinese medicine yiqi fumai lyophilized injection

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低压静电场辅助解冻对牛肉品质的影响

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食品工业科技 2024年第17期45卷 48-56页

作者：乔雪乔雅洁付慧鑫孟新涛张婷新疆农副产品精深加工工程技术中心新疆农业大学食品科学与药学学院新疆农业科学院农产品贮藏加工研究所

为筛选冷冻牛肉适宜的解冻方式，更好地维持其解冻后食用品质。本文以-20 ℃冷冻的牛背最长肌为研究对象，以自然解冻为对照组（CK），以与低压静电场发生板隔距分别为20、30、40 cm（LVEFT20、LVEFT30、LVEFT40）为处理组，2 ℃为解冻... 详细信息

为筛选冷冻牛肉适宜的解冻方式，更好地维持其解冻后食用品质。本文以-20 ℃冷冻的牛背最长肌为研究对象，以自然解冻为对照组（CK），以与低压静电场发生板隔距分别为20、30、40 cm（LVEFT20、LVEFT30、LVEFT40）为处理组，2 ℃为解冻终温，采用常规品质检测结合气相色谱-离子迁移谱（gas chromatography-ion mobility spectroscopy，GC-IMS）技术，对比分析不同低压静电场发生板隔距解冻对牛肉品质和挥发性化合物变化的影响。结果表明：与CK相比，低压静电场辅助解冻处理可缩短牛肉的解冻时间，降低牛肉解冻汁液流失率和蒸煮损失，抑制其微生物的生长，使其保持较好的色泽和剪切力。其中，LVEFT30处理较好，其解冻时间较CK缩短7 h，解冻后牛肉的解冻汁液流失率、解冻汁液中蛋白质量分数、蒸煮损失率分别降低了45.79%、21.32%和27.48%，剪切力仅为66.99 N，挥发性盐基氮（TVB-N）、菌落总数、色泽、挥发性化合物种类及相对含量接近新鲜牛肉。可见，静电板隔距为30 cm适于牛肉解冻，可使其保持较好的品质，该结果为生产中冷冻牛肉的解冻提供科学依据和技术指导。

关键词：低压静电场解冻牛肉品质

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不同相对湿度处理对牛肉解冻效果的影响

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食品科技 2024年第4期49卷 133-142页

作者：付慧鑫乔雪乔雅洁孟新涛张婷潘俨新疆农业大学食品科学与药学学院新疆乌鲁木齐830052 新疆农业科学院农产品贮藏加工研究所新疆主要农副产品精深加工工程研究中心新疆乌鲁木齐830091

为筛选适于生产中冷冻牛肉解冻的相对湿度,维持其解冻后感官和食用品质,以冷冻牛肉为试材,以传统解冻方式(4℃,相对湿度(Relative humidity,RH)65%~73%)为对照(CK),分别以RH80%、85%、90%、95%4个条件解冻为处理组,分析不同RH处理对牛... 详细信息

为筛选适于生产中冷冻牛肉解冻的相对湿度,维持其解冻后感官和食用品质,以冷冻牛肉为试材,以传统解冻方式(4℃,相对湿度(Relative humidity,RH)65%~73%)为对照(CK),分别以RH80%、85%、90%、95%4个条件解冻为处理组,分析不同RH处理对牛肉解冻效果的影响。结果表明,RH80%、85%、90%和95%4个条件处理对冷冻牛肉解冻均有一定的效果,可一定程度上缩短其解冻时间,降低解冻后牛肉汁液流失率和蒸煮损失率,使其挥发性盐基氮含量和菌落总数维持在较低的水平,肉品保持较好的色泽、新鲜度和风味。综合效果分析显示,RH90%解冻效果较好,解冻时间为4.17 h,与CK相比,缩短了1.33 h,汁液流失率和蒸煮损失率分别降低了21.96%和11.20%,剪切力值为17.21 N,牛肉色泽、新鲜度和风味更接近鲜样,食用安全。该结果为生产中牛肉解冻提供了新方法,为其应用推广提供了科学依据和技术支持。

关键词：牛肉相对湿度解冻品质风味

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激光联合干扰素治疗对阴道上皮内瘤变患者阴道微生态、炎症因子及预后的影响

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中国实用医药 2024年第3期19卷 108-111页

作者：薛巧梅青岛大学附属威海市立第二医院妇科 264200

目的分析激光联合干扰素对阴道上皮内瘤变(VAIN)患者的阴道微生态、炎症因子以及预后的影响。方法60例VAIN患者,按随机数字表法分为对照组和研究组,每组30例。对照组患者通过二氧化碳(CO_(2))激光治疗,研究组患者通过CO_(2)激光联合干... 详细信息

目的分析激光联合干扰素对阴道上皮内瘤变(VAIN)患者的阴道微生态、炎症因子以及预后的影响。方法60例VAIN患者,按随机数字表法分为对照组和研究组,每组30例。对照组患者通过二氧化碳(CO_(2))激光治疗,研究组患者通过CO_(2)激光联合干扰素治疗。比较两组患者临床治疗效果;并发症发生情况;治疗前后炎症因子指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)、Toll样受体2(TLR2)];生存素(Survivin)、增殖细胞核抗原(Ki-67)阳性表达情况。结果研究组患者的临床治疗总有效率96.67%高于对照组的73.33%,差异有统计学意义(P0.05)。结论针对VAIN患者给予VAIN患者激光联合干扰素治疗的临床效果更佳,能够有效改善炎症因子指标及Survivin、Ki-67表达情况,减少患者并发症的发生,值得推广应用。

关键词：激光干扰素阴道上皮内瘤变阴道微生态炎症因子

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乡村振兴中的乡村语言现代化

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黑龙江工业学院学报（综合版） 2024年第2期24卷 66-70页

作者：马冬薛巧齐齐哈尔大学公共外语教研部黑龙江齐齐哈尔161006 齐齐哈尔大学外国语学院黑龙江齐齐哈尔161006

乡村振兴离不开乡村语言的发展。乡村语言作为乡村生活的重要组成部分,蕴含着独特的文化价值、经济价值和社会价值。作为特殊的资源,乡村语言的发展与乡村振兴息息相关。试通过探讨乡村语言的价值,分析乡村语言现代化的实践路径,旨在以... 详细信息

乡村振兴离不开乡村语言的发展。乡村语言作为乡村生活的重要组成部分,蕴含着独特的文化价值、经济价值和社会价值。作为特殊的资源,乡村语言的发展与乡村振兴息息相关。试通过探讨乡村语言的价值,分析乡村语言现代化的实践路径,旨在以语言为原点,以其自身价值为辐射半径,深化乡村语言现代化对乡村振兴影响的进一步研究。

关键词：乡村振兴战略乡村语言语言现代化

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Mean estimation over numeric data with personalized local differential privacy

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Frontiers of Computer Science 2022年第3期16卷 183-192页

作者： qiao xue Youwen ZHU Jian WANG College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Guangxi Key Laboratory of Trusted Software Guilin University of Electronic TechnologyGuilin 541004China School of Cyber Security Gansu University of Political Science and LawLanzhou 730070China

The fast development of the Internet and mobile devices results in a crowdsensing business model,where individuals(users)are willing to contribute their data to help the institution(data collector)analyze and release useful ***,the reveal of personal data will bring huge privacy threats to users,which will impede the wide application of the crowdsensing *** settle the problem,the definition of local differential privacy(LDP)is ***,to respond to the varied privacy preference of users,resear-chers propose a new model,i.e.,personalized local differential privacy(PLDP),which allow users to specify their own privacy *** this paper,we focus on a basic task of calculating the mean value over a single numeric attribute with *** on the previous schemes for mean estimation under LDP,we employ PLDP model to design novel schemes(LAP,DCP,PWP)to provide personalized privacy for each *** then theoretically analysis the worst-case variance of three proposed schemes and conduct experiments on synthetic and real datasets to evaluate the performance of three *** theoretical and experimental results show the optimality of PWP in the low privacy regime and a slight advantage of DCP in the high privacy regime.

关键词： personalized local differential privacy mean estimation crowdsensing model

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金银花总黄酮低共熔溶剂提取工艺优化

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中成药 2024年第5期46卷 1465-1470页

作者：赵惠茹张硕王晴靖会乔雪婷西安医学院药学院陕西西安710021

目的优化金银花总黄酮低共熔溶剂提取工艺。方法在单因素试验基础上,以1,3-丁二醇与氯化胆碱比例、液料比、超声时间为影响因素,总黄酮得率为评价指标,响应面法和BP神经网络优化提取工艺。结果BP神经网络优化总黄酮得率高于响应面法优... 详细信息

目的优化金银花总黄酮低共熔溶剂提取工艺。方法在单因素试验基础上,以1,3-丁二醇与氯化胆碱比例、液料比、超声时间为影响因素,总黄酮得率为评价指标,响应面法和BP神经网络优化提取工艺。结果BP神经网络优化总黄酮得率高于响应面法优化。最优条件为1,3-丁二醇与氯化胆碱比例2.7∶1,液料比27∶1,超声时间29 min,总黄酮得率为7.85%。结论该方法稳定可靠,可用于低共熔溶剂提取金银花总黄酮。

关键词：金银花总黄酮低共熔溶剂提取工艺响应面法 BP神经网络

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