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Type I interferon pathway in pediatric systemic lupus erythematosus

World Journal of Pediatrics 2024年第7期20卷 653-668页

作者： Yu zhou Hong‑Mei Song Department of Pediatrics Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalBeijingChina

Background The role of type I interferon(IFN-I)signaling in systemic lupus erythematosus(SLE)has been well ***,unanswered questions remain regarding the applicability of these findings to pediatric-onset *** aim of this review is to provide an overview of the novel discoveries on IFN-I signaling in pediatric-onset *** sources A literature search was conducted in the PubMed database using the following keywords:“pediatric systemic lupus erythematosus”and“type I interferon”.Results IFN-I signaling is increased in pediatric SLE,largely due to the presence of plasmacytoid dendritic cells and pathways such as cyclic GMP-AMP synthase–stimulator of interferon genes–TANK-binding kinase 1 and Toll-like receptor(TLR)4/*** extracellular traps and oxidative DNA damage further stimulate IFN-I *** variants in IFN-I-related genes,such as IFN-regulatory factor 5 and tyrosine kinase 2,are linked to SLE susceptibility in pediatric *** addition,type I interferonopathies,characterized by sustained IFN-I activation,can mimic SLE symptoms and are thus important to *** on interferonopathies also contribute to exploring the pathogenesis of *** IFN-I activation is crucial for SLE diagnosis and *** IFNstimulated gene expression and serum IFN-α2 levels are common *** cytometry markers such as CD169 and galectin-9 are promising ***-IFN therapies,such as sifalimumab and anifrolumab,show promise in adult patients with SLE,but their efficacy in pediatric patients requires further *** kinase inhibitors are another treatment option for severe pediatric SLE *** This review presents an overview of the IFN-I pathway in pediatric *** the intricate relationship between IFN-I and pediatric SLE may help to identify potential diagnostic markers and targeted therapies,paving the way for improved patient care and outcomes.

关键词： Interferonopathies Pediatric systemic lupus erythematosus Type I interferon

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Uncharted effects of Fukushima Nuclear Plant Wastewater Discharge on marine life

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Journal of Plant Ecology 2024年第3期17卷 1-4页

作者： Xiaoqi zhou Zhejiang Tiantong Forest Ecosystem National Observation and Research Station School of Ecological and Environmental SciencesEastChina Normal UniversityShanghai 200241China

INTRODUCTION On 24 August 2023,the Japanese government insisted on initiating the discharge of Fukushima nuclearcontaminated water into the sea,causing widespread global concerns regarding marine biological safety,seafood and marine resources(TEPCO 2023).Although the Japanese government has consistently emphasized that the nuclear wastewater has been treated using an Advanced Liquid Processing System(ALPS),resulting in very low concentrations of various nuclear elements,and that the International Atomic Energy Agency(IAEA)has conducted real-time monitoring of the treatment process and discharge fow(IAEA 2023),people around the world still harbor signifcant *** are a few reasons for this ongoing apprehension.

关键词： initiating harbor wastewater

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Miniaturized power detection module operating in millimeter wave band

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Journal of Electronic Science and Technology 2024年第2期22卷 69-76页

作者： Xiang zhou Zhi-Yong Zhong School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

The miniaturized broadband detection module can be embedded into the microwave application system such as the front end of the transmitter to detect the power or other parameters in real *** is highly prospective in military and scientific *** this paper,a broadband power detection module operating at 26.5 GHz-40.0 GHz is designed by using low-barrier Schottky diode as the detector and a comparator for threshold *** module can dynamically detect the power range between-10 dBm and 10 dBm with the detection accuracy of 0.1 ***,the temperature compensation circuit is also applied to improve the measurement *** a result,the resulted error low to±1 dB in the temperature range of -55℃ to +85℃ is *** designed module is encapsulated by a Kovar alloy with a small volume of 9 mm×6 mm×3 *** endows the designed module the advantages of small size,easy integration,and low cost,and even it is applicable to high-reliability environments such as satellites.

关键词： Diode Miniaturization Power detection Temperature compensation

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Nickel-catalyzed enantioselective reductive amination of benzylic ketones in alcohols

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Science China Chemistry 2024年第8期67卷 2566-2570页

作者： Xiuhua Wang Jianrong Steve zhou State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055China

Asymmetric reductive amination directly converts ketones and amines to alkylamines, which are important motifs in *** report that cationic nickel complexes of chiral diphosphines promote enantioselective reductive amination of benzylic ketones with both arylamines and benzhydrazide. Isopropanol was used as a safe and cheap source of hydrogen instead of formic acid. The reaction can be readily applied to a concise synthesis of diarylethylamines, a class of neuroactive substances.

关键词： transfer hydrogenation nickel catalysis chiral alkylamine reductive amination synthetic method

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Multiplexed manipulation of orbital angular momentum and wavelength in metasurfaces based on arbitrary complex-amplitude control

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Light(Science & Applications) 2024年第5期13卷 930-940页

作者： Guoli He Yaqin Zheng Changda zhou Siyang Li Zhonghong Shi Yanhui Deng Zhang-Kai zhou State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-sen UniversityGuangzhou 510275China

Due to its unbounded and orthogonal modes,the orbital angular momentum(OAM)is regarded as a key optical degree of freedom(DoF)for future information processing with ultra-high capacity and *** the manipulation of OAM based on metasurfaces has brought about great achievements in various fields,such manipulation currently remains at single-DoF level,which means the multiplexed manipulation of OAM with other optical DoFs is still lacking,greatly hampering the application of OAM beams and advancement of *** order to overcome this challenge,we propose the idea of multiplexed coherent pixel(MCP)for *** approach enables the manipulation of arbitrary complex-amplitude under incident lights of both plane and OAM waves,on the basis of which we have realized the multiplexed DoF control of OAM and *** a result,the MCP method expands the types of incident lights which can be simultaneously responded by metasurfaces,enriches the information processing capability of metasurfaces,and creates applications of information encryption and OAM *** findings not only provide means for the design of high-security and high-capacity metasurfaces,but also raise the control and application level of OAM,offering great potential for multifunctional nanophotonic devices in the future.

关键词： momentum offering overcome

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Cost-Based Research on Energy Management Strategy of Electric Vehicles Using Hybird Energy Storage System

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Tsinghua Science and Technology 2024年第3期29卷 684-697页

作者： Juanying zhou Jianyou Zhao Lufeng Wang School of Automobile Chang’an UniversityXi’an 710064Chinaand also with College of Automotive Engineering and General AviationShaanxi Vocational and Technical CollegeXi’an 710038China School of Automobile Chang’an UniversityXi’an 710064China College of Automobile Shaanxi College of Communication TechnologyXi’an 710018China

This paper uses the minimization and weighted sum of battery capacity loss and energy consumption under driving cycles as objective functions to improve the economy of Electric Vehicles(EVs)with an hybrid energy storage system composed of power batteries and ***,Dynamic Programming(DP)is employed to determine the objective function values under different weight coefficients,the comprehensive cost consisting of battery aging and power consumption costs,and the relationship between the hybrid power *** also evaluate the real-time fuzzy Energy Management Strategy(EMS),fuzzy control strategies,and a strategy based on DP using the World Light vehicle Test Procedure(WLTP)driving cycle and a synthesis driving cycle derived from New European Driving Cycle(NEDC),WLTP,and Urban Dynamometer Driving Schedule(UDDS)as ***,the proposed strategy is compared with the fuzzy control strategy and the strategy based on *** with fuzzy energy management strategy(namely FZY-EMS),the proposed EMS reduces the battery capacity loss and system energy *** results demonstrate the effectiveness of the proposed EMS in improving EV economy.

关键词： automobile engineering hybrid energy storage Energy Management Strategy(EMS) fuzzy control strategy

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Numerical simulation of the effect of coaxial and cross-axis injection modes on pulverized coal combustion in the raceway of blast furnace tuyere

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PARTICUOLOGY 2024年第10期93卷 154-169页

作者： Wang, Yunpeng Gao, Lei zhou, Xiaolei Kunming Univ Sci & Technol Fac Met & Energy Engn Kunming 650093 Peoples R China

The aim of this study isto investigate the influence of the angle of the pulverized coal (PC) injection lance on the combustion characteristics of fuel in the raceway of blast furnace tuyeres. Using FLUENT software, a Euler-Lagrange three-dimensional numerical model was constructed to analyze the influence of different positions of blast furnace tuyere coal powder injection lance (coaxial and cross-axis) on key parameters such as temperature distribution, gas flow, and combustion efficiency. The results demonstrate that adjusting the angle of the injection lance significantly modifies the average and peak temperatures in the raceway, while the composition of gas components remains relatively stable. When the injection lance angle is 10 degrees, the average temperature and peak temperature in the raceway are 2294 K and 2747 K, respectively. When the injection lance angle is 12 degrees, the combustion efficiency of the PC reaches 80.8%. This study reveals the significant impact of the injection lance angle on the combustion process. Especially at an angle of 12 degrees, the combustion efficiency of the blast furnace significantly improves. With coaxial injection, the combustion rate increases as the distance between the injection lance tip and the tuyere increases. This paper is instructive for the optimization of the blast furnace combustion system, which improve fuel utilization efficiency and reduce environmental emissions. This paper provides practical recommendations for adjusting blast furnace operational parameters, offering insights for achieving more efficient and environmentally friendly industrial production. (c) 2024 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

关键词： Pulverized coal combustion Tuyere raceway Blast furnace CFD simulation GAS FLOWS CFD

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Spatial-temporal patterns and evolution of carbon storage in China's terrestrial ecosystems from 1980 to 2020

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Science China Earth Sciences 2024年第10期67卷 3270-3287页

作者： Shaojian WANG Shijie zhou Chuanglin FANG School of Geography and Planning Sun Yat-sen UniversityGuangzhou 510006China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China

Analyzing the changes in carbon storage in terrestrial ecosystems caused by land use changes is a crucial part of exploring the carbon cycle. In addition, enhancing carbon storage in terrestrial ecosystems is an effective and environmentally friendly measure to sequester anthropogenic carbon emissions, which is significant for achieving carbon neutrality and curbing global climate change. This paper uses land use data and carbon density tables with the In VEST model to obtain a carbon storage distribution map of China. It further applies land use response elasticity coefficients, Theil index multi-stage nested decomposition, and spatial autocorrelation analysis to examine the spatial-temporal patterns, causes of changes, and evolution characteristics of carbon storage in terrestrial ecosystems from 1980 to 2020. The results show that the temporal changes in China's carbon storage generally present an inverted S-curve, with an initial rapid decline followed by a slower decrease. Spatially, it features high levels in the northeast, low levels in the northwest, and a uniform distribution in the central and southern *** disturbance of land use type changes on terrestrial ecosystem carbon storage has been effectively mitigated. The significant reduction in grassland area in the Southwest region is the main source of carbon storage loss during the study period, and the encroachment of construction land on arable land in large urban agglomerations is one of the important causes of carbon storage loss. The Theil index multi-stage nested decomposition results indicate that the overall difference in carbon storage in China has decreased, while differences among cities within provinces and among counties within cities have increased. The influence of natural factors on the distribution of carbon storage is weakening, whereas the impact of human activities is becoming more profound, enhancing its influence on the spatial distribution of carbon storage in China. From 198

关键词： Terrestrial ecosystem carbon storage Carbon density Land use change InVEST model Spatiotemporal pattern

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Dynamics modeling and electromechanical coupling characteristics analysis of cage induction motors

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Science China(Technological Sciences) 2024年第3期67卷 709-724页

作者： zhou ZiWei CHEN ZaiGang ZHAI WanMing State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu 610031China

Induction motors, as typical electromechanical energy conversion devices, have received limited attention in previous studies on electromechanical coupling vibrations, precise modeling, and the use of electromechanical coupling effects for fault diagnosis and condition assessment in motor drive systems. This study proposes a comprehensive model of cage induction motors that integrates the multiple coupled circuit model with a rotor-bearing dynamics model. The model accounts for the linear increase in the magnetomotive force across the slot and incorporates the skidding characteristics of bearings in the rotor-bearing system. By calculating the time-varying mutual inductance parameters based on the air-gap distribution in the vibration environment, the electromechanical coupling vibration of the cage motor is investigated. Furthermore, this study examines the electromechanical coupling vibration characteristics influenced by various factors, including bearing clearances, radial loads, and the vertical excitation frequencies of the stators. The results show that the proposed model improves the excitation inputs for the electrical and mechanical systems of the motor compared with conventional models. Increased bearing clearance and radial load affect the current and torque similarly but have opposite effects on the slip ratio. This study provides a deeper understanding of electromechanical coupling mechanisms and facilitates the use of such phenomena for fault diagnosis and condition assessment in motor-driven systems.

关键词： cage induction motors rotor-bearing dynamics mutual inductance electromechanical testing current signal analysis

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Critical layer in liquid-solid system influencing the remediation of chromium using zeolite-supported sulfide nano zero-valent iron

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Journal of Environmental Sciences 2024年第1期135卷 232-241页

作者： Chundi zhou Caiyun Han Nengsheng Liu Faculty of Material and Environment Guangxi University for NationalitiesNanning 530008China College of Environmental Science and Engineering Tongji UniversityShanghai 200092China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China

Sulfidated nano zero-valent iron particles were immobilized on ZSM-5 zeolite(Z/S-nZⅥ)and used for hexavalent chromium(Cr(Ⅵ))*** performance of Z/S-nZⅥimproved with the increase in Cr(Ⅵ)concentration(0.6).Moreover,the removal mechanisms of Cr(Ⅵ)were elucidated through XRD,transmission electron microscopy(TEM)and XPS *** results demonstrate that the species of chromium in the critical layer changed from Cr(Ⅲ)to Cr(Ⅵ)as the concentration of chromium increased from low to ***,the critical layer was composed of Cr(Ⅵ),Fe(Ⅱ),O and H ***,the experiments of coexisting ions and aging time confirmed that Z/S-nZⅥpossessed high selectivity and stability to ensure efficiency and cost-effectiveness in practical applications.

关键词： Cr(VI) Corrosion Critical layer Selectivity Stability

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