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The Promotion Effect of NaCl on the Conversion of Xylose to Furfural

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Chinese Journal of Chemistry 2020年第2期38卷 178-184页

作者： Zheng Li Yiping Luo Zhicheng Jiang qianying fang Changwei Hu Key Laboratory of Green Chemistry and Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengduSichuan 610064China College of Materials and Chemistry&Chemical Engineering Chengdu University of TechnologyChengduSichuan 610059China National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan UniversityChengduSichuan 610065China

Summary of main observation and conclusion In this work,the promotion effect of NaCl on the conversion of xylose to furfural in H2O was *** was found that xylose conversion and furfural yield increased with NaCl *** decreased the pH of the solution providing H+ for the acid catalytic dehydration of *** formation of oligomers was determined by GPC and ESI-MS in the initial stage of reaction,especially at low *** NaCl promoted the formation of humins in the late stage of the *** could also change the decomposition route of formic ***,NaCl had the ability of phase *** these effects with organic solvent during the reaction could inhibit the formation of humins and increase the yield of *** NaCl-H2O-THF biphasic system without other catalyst,the optimal furfural yield of 76.7% and selectivity of 77.6% were achieved at 463 K in 2 h.

关键词： temperature. reaction. conclusion

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六安瓜片冲泡控制图的建立

茶叶科学 2024年第1期44卷 133-148页

作者：赵潇奕陈艾妮姜青赵蕾邱桐方婉昕梁楚韵 Sharipova Alina 戴前颖安徽农业大学茶与食品科技学院安徽合肥230036 安徽农业大学茶树生物学及资源利用国家重点实验室安徽合肥230036

咖啡冲煮控制图在咖啡行业有着广泛的应用。借鉴咖啡评价指标,以六安瓜片为研究对象,将体现风味平衡度和浓度的萃取率(Extraction yield,EY)及总溶解固体(Total dissolved solids,TDS)用作评价茶汤的质量指标。应用生存分析法确定实现... 详细信息

咖啡冲煮控制图在咖啡行业有着广泛的应用。借鉴咖啡评价指标,以六安瓜片为研究对象,将体现风味平衡度和浓度的萃取率(Extraction yield,EY)及总溶解固体(Total dissolved solids,TDS)用作评价茶汤的质量指标。应用生存分析法确定实现六安瓜片茶汤最大消费者接受度的最佳EY范围为2.53%~4.57%,最佳TDS范围为0.14%~0.28%,并以此为“理想”区域建立了六安瓜片冲泡控制图,在消费者层面和专家层面均得到了验证。研究表明,采用茶水比(g∶mL)为1∶30~1∶15,温度在85~100℃时,第一泡茶汤在33 s内调节冲泡时间,第二泡茶汤在15 s内调节冲泡时间,第三泡茶汤在13 s内调节冲泡时间,可以得到“理想”区域的茶汤。本研究为科学地冲泡六安瓜片及其他绿茶提供了理论支持。

关键词：六安瓜片质量指标生存分析法冲泡控制图冲泡参数

表面肌电信号评估神经松动术治疗神经根型颈椎病效果的应用

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现代电生理学杂志 2021年第3期28卷 159-163页

作者：施少云叶国标方倩颖梁杰陈婧姈卢惠苹福州市第二医院康复医学科福建省350007

目的:探讨表面肌电信号评估神经松动术对神经根型颈椎病治疗效果的应用。方法:选取福州市第二医院康复医学科2019年3月至2021年2月收治的神经根型颈椎病患者80例,性别不限,年龄18~70岁,采用随机数字表法分为对照组与观察组,各40例。对... 详细信息

目的:探讨表面肌电信号评估神经松动术对神经根型颈椎病治疗效果的应用。方法:选取福州市第二医院康复医学科2019年3月至2021年2月收治的神经根型颈椎病患者80例,性别不限,年龄18~70岁,采用随机数字表法分为对照组与观察组,各40例。对照组采取常规牵引及针刺治疗,观察组在常规牵引及针刺治疗的基础上,根据疼痛的不同位置,采取不同的神经松动术治疗。采用颈椎病临床评价量表(CASCS)及视觉模拟评分(VAS)评价患者症状改善程度及疼痛程度,并对其尺侧屈腕肌、尺侧伸腕肌进行表面肌电图检查,比较两组积分肌电值(IEMG)、均方根值(RMS)、中位频率值(MF)。结果:治疗后两组CASCS量表各项评分及总分均升高(P<0.05),观察组各项评分及总分较对照组更高(P<0.05)。治疗后两组IEMG、RMS、MF水平明显升高(P<0.05),观察组IEMG、RMS、MF水平较对照组更高(P<0.05)。治疗后2周、4周,观察组VAS评分明显低于对照组(P<0.05)。结论:表面肌电信号应用在神经松动术治疗神经根型颈椎病的效果评估中,能准确反映肌肉功能的改善情况,对于临床诊断和疗效评价有着不可替代的作用。

关键词：肌电描记术颈椎骨椎间盘移位神经根病神经松动术

Dual inhibition of glycolysis and oxidative phosphorylation by aptamer-based artificial enzyme for synergistic cancer therapy

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Nano Research 2022年第7期15卷 6278-6287页

作者： Xiao fang Meng Yuan Junduan Dai qianying Lin Yuhong Lin Wenli Wang Yifan Jiang Haihui Wang fang Zhao Junye Wu Shumeng Bai Chunhua Lu Huanghao Yang MOE Key Laboratory for Analytical Science of Food Safety and Biology Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food SafetyState Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou 350108China College of Biological Science and Engineering Fuzhou UniversityFuzhou 350108China

Dual inhibition of glycolysis and oxidative phosphorylation(OXPHOS)can break the metabolic plasticity of cancer cells to inhibit most energy supply and lead to effective cancer ***,the pharmacokinetic difference among drugs hinders these two inhibitions to realize a uniform temporal and spatial ***,we report an aptamer-based artificial enzyme for simultaneous dual inhibition of glycolysis and OXPHOS,which is constructed by arginine aptamer modified carbon-dots-doped graphitic carbon nitride(AptCCN).AptCCN can circularly capture intracellular arginine attribute to the specific binding ability of arginine aptamers to arginine,and further catalyze the oxidation of enriched arginine to nitric oxide(NO)under red light *** vitro and in vivo experiments showed that arginine depletion and NO stress could inhibit glycolysis and OXPHOS,leading to energy blockage and apoptosis of cancer *** presented aptamer-based artificial enzyme strategy provides a new path for cell pathway regulation and synergistic cancer therapy.

关键词： aptamers artificial enzymes photochemistry energy blockage cancer therapy

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华西医学 2024年第7期39卷 1082-1087页

作者：朱倩莹张凌杨莹莹付平范晴王芳林丽唐雪四川大学华西医院肾脏内科/肾脏病研究所成都610041 雅安市第二人民医院肾脏内科四川雅安625000

目的评估甲磺酸萘莫司他体外抗凝在脓毒症相关急性肾损伤(sepsis-associated acute kidney injury,SA-AKI)患者使用oXiris滤器连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)中的有效性和安全性。方法纳入2021年11月-2023年1月四川大学华西医院接受oXiris滤器-CRRT的伴有高出血风险的SA-AKI患者为研究对象,将应用甲磺酸萘莫司他体外抗凝治疗的患者作为萘莫司他组,同期不使用抗凝剂的患者作为对照组。对比分析两组患者一般情况,CRRT的第1个滤器寿命,第1个滤器使用时间达24、48、72 h例数及百分比情况,治疗前及治疗过程中滤器前和滤器后的活化凝血时间(activated clotting time,ACT),治疗前后实验室检查指标,治疗期间发生不良反应的情况及患者的临床结局。正态分布计量资料采用均数±标准差表示,非正态分布计量资料采用中位数(下四分位数,上四分位)表示。结果共纳入118例患者,其中对照组90例,萘莫司他组28例。两组患者一般情况、治疗前实验室检查指标差异均无统计学意义(P>0.05)。Kaplan-Meier生存分析显示,萘莫司他组第1个滤器寿命长于对照组(风险比=0.524,P=0.001)。萘莫司他组第1个滤器使用时间达24 h百分比高于对照组(60.7%vs.25.7%,P=0.001);第1个滤器治疗时长达48 h及72 h的百分比,两组差异无统计学意义(P>0.05)。CRRT治疗过程中,萘莫司他组滤器后平均ACT长于对照组[(216.7±43.2)vs.(181.6±35.5)s,P0.05)。两组患者临床结局差异无统计学意义(P>0.05)。结论甲磺酸萘莫司他应用于oXiris滤器-CRRT伴有高出血风险的SA-AKI患者,体外抗凝效果优于无抗凝剂模式,其可能是一种有效且安全的抗凝药物。

关键词：甲磺酸萘莫司他脓毒症急性肾损伤 oXiris滤器连续性肾脏替代治疗

Upregulated heme oxygenase-1 expression of mouse mesenchymal stem cells resists to chemotherapy-induced bone marrow suppression

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Chinese Medical Journal 2014年第7期127卷 1310-1316页

作者： Chen Shuya Wang Jishi fang Qin Gao Rui Shi qianying Zhang Hui Zhao Jiangyuan Department of Pharmacy Guiyang Medical College GuiyangGuizhou 550004 China Department of Hematology Affiliated Hospital of Guiyang Medical College Guiyang Guizhou 550004 China Guizhou Province Laboratory of Hematological Disease Diagnostic & Treat Centre Guiyang Guizhou 550004 China Guizhou Province Hematopoietic Stem Cell Transplantation Centre Guiyang Guizhou 550004 China Department of Pharmacy Affiliated Baiyun Hospital of Guiyang Medical College Guiyang Guizhou 550000 China

Background Bone marrow hematopoietic function suppression is one of the most common side effects of *** chemotherapy,the bone marrow structure gets destroyed and the cells died,which might cause the hematopoietic function *** oxygenase-1 （HO-1） is a key enzyme of antioxidative metabolism that associates with cell proliferation and resistance to *** aim of this study was to restore or resist the bone marrow from the damage of chemotherapy by the HO-1 expression of mouse mesenchymal stem cells （mMSCs） homing to the mice which had the chemotherapy-induced bone marrow *** One hundred and sixty female Balb/c mice （6-8-weeks old） were randomly divided into four *** group was performed in 40 *** control group was intraperitoneally injected for 5 days and tail intravenously injected on the 6th day with normal *** chemotherapy-induced bone marrow suppression was established by intraperitoneally injecting cyclophosphamide （CTX） into the mice which performed as the chemotherapy *** mMSCs were tail intravenously injected into 40 chemotherapically damaged mice which served as the mMSCs *** difference between the HO-1 group and the mMSCs group was the injected *** HO-1 group was tail intravenously injected into the mMSCs that highly expressed HO-1 which was stimulated by *** expression of HO-1 was analyzed by Western blotting and *** proliferation was measured using the 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide *** examinations were performed 1 week after *** Compared with the control group,the expression levels of HO-1 mRNA and protein were significantly higher in the HO-1 group （all P ＜0.05）,even obviously than the mMSCs *** treatment induced apoptosis and inhibited *** injected,the white blood cell （WBC）,red blood cell （RBC） and platelet （PLT） declined fast and down to the bottom at the 7th *** bo

关键词： heme oxygenase-1 marrow mesenchymal stem cells hematopoietic function recovery

Comparative study on the weight loss and lipid metabolism by tea polyphenols in diet induced obese C57BL/6J pseudo germ free and conventionalized mice

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Food Science and Human Wellness 2022年第3期11卷 697-710页

作者： Kashif Hussain Yingying Yang Jie Wang Hengjuan Bian Xi Lei Junjie Chen qianying Li Li Wang Qingping Zhong Xiang fang Yutao Wang Hong Wei Yigang Tong Zhenlin Liao College of Food Science South China Agricultural UniversityGuangzhou 510642China Department of Food Science University of GuelphGuelphOntario N1G 2W1Canada College of Life and Geographic Sciences Key Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous RegionKashi UniversityKashi 844000China Institute of Precision Medicine First Affi liated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China College of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China

The role of gut microbiota in terms of host health is becoming increasingly *** this study,the comparative effects of tea polyphenols(TPs)on weight loss and lipid metabolism on conventionalized mice(CVZ)and pseudo germ-free(PGF)mice(treated with antibiotics)were *** findings revealed that high fat(HF)diet considerably increased the body weight,total fat and upsurge lipid indices in CVZ mice but PGF mice were not sensitive to the effect of HF diet as CVZ *** the dietary administration of TP,body weight,perirenal fat and epididymal fat,liver weight,glucose(GLU)level,total chloestrol(TC level),high density lipoprotein-cholesterol(HDL-C)level significantly lowered in PGF mice as compared to CVZ mice ***,the area of fat cells and triglyceride(TG)level were significantly increased in PGF *** CVZ mice,TP intervention resulted in a considerable drop in the Firmicutes/Bacteroides ratio as compared to PGF *** intestinal flora of PGF mice was severely reduced after antibiotic treatment,while TP administration restored intestinal diversity;the abundance of Akkermansia and Lactobacillus increased,whereas the abundance of Enterobacteriaceae and Prevotella ***,we can assume that PGF obese mice administered with TP have less anti-obesity effects compared to obese CVZ mice.

关键词： High fat diet Pseudo germ-free mice Tea polyphenol Obesity Lipid metabolism

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中山地区血小板抗体及特异性分布调查

中国输血杂志 2024年第1期37卷 63-67页

作者：林惠燕吴泳伦孙爱农方育如陈前英李乔王玉珏王红梅杨志钊简晓毅许先国段生宝中山市中心血站广东中山528400 中国科学院苏州生物医学工程技术研究所中山市人民医院中山市博爱医院浙江省血液中心

目的了解广东中山地区无偿献血者及患者血小板抗体发生频率,研究血小板抗体特异性和交叉配型。方法利用固相免疫吸附法(SPIA)对献血者及患者血小板抗体进行筛查,流式细胞术(FCM)进行复查,Pak-Plus酶免法进行抗体特异性鉴定,并采用SPIA... 详细信息

目的了解广东中山地区无偿献血者及患者血小板抗体发生频率,研究血小板抗体特异性和交叉配型。方法利用固相免疫吸附法(SPIA)对献血者及患者血小板抗体进行筛查,流式细胞术(FCM)进行复查,Pak-Plus酶免法进行抗体特异性鉴定,并采用SPIA模拟血小板交叉配型。结果共检测献血者标本1049份,患者标本598份,SPIA筛查阳性分别为6(0.57%)份vs 49(8.19%)份(P<0.05);SPIA检测阳性标本中,献血者FCM、酶免法复查阳性符合率100%,患者FCM复查阳性符合率95%,酶免法阳性符合率88%;献血者初筛阳性标本中,5份为抗-HLAⅠ占83%,1份为抗-CD36占17%(人群发生率为0.10%)。14份酶免阳性患者标本中,2份抗-GPⅡb/Ⅲa,1份抗-GPⅠa/Ⅱa,8份抗-HLAⅠ,3份为混合抗体(HLAⅠ和GPⅡb/Ⅲa、GPⅠa/Ⅱa),按抗体种类计算,HLAⅠ抗体最多,占65%(11/17),其次为与HPA相关的抗-GP占35%(6/17)。血小板抗体阳性配型率低于30%的患者占多数,为71.4%(10/14)。结论中山地区患者血小板抗体阳性率明显高于无偿献血者,多为抗-HLAⅠ、抗-GP,抗-CD36发生率极低,因此应建立已知血小板抗原供者库,同时应开展患者血小板抗体检测及其配型,有助于解决临床血小板输注无效的问题。

关键词：血小板抗体血小板输注无效抗-CD36 无偿献血者血小板交叉配型(PXM)

工作嵌入与护士心理资本及组织承诺和留职意愿相互影响研究

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中华医院管理杂志 2016年第11期32卷 839-842页

作者：钱英方晓眉石燕燕李鲁浙江大学社会医学与全科医学研究所杭州310058 浙江大学医学院附属第一医院呼吸科浙江省人民医院肝胆外科杭州师范大学医学院

目的探讨护士工作嵌入与心理资本、组织承诺、留职意愿及其影响因素间的作用机制。方法通过便利抽样方法，采用护士工作嵌入量表、心理资本量表、组织承诺量表和留职意愿量表，对722名护士进行调查，并用路径分析法对变量间的关系进行... 详细信息

目的探讨护士工作嵌入与心理资本、组织承诺、留职意愿及其影响因素间的作用机制。方法通过便利抽样方法，采用护士工作嵌入量表、心理资本量表、组织承诺量表和留职意愿量表，对722名护士进行调查，并用路径分析法对变量间的关系进行探索。结果夜班间隔对护士心理资本、组织承诺和留职意愿有正性影响；心理资本对工作嵌入既有直接影响，又通过组织承诺有间接影响，对留职意愿仅有间接影响；组织承诺对工作嵌入有较强的直接影响（r=0．494），对留职意愿既有直接影响又有间接影响；工作嵌入对留职意愿有直接影响，r=0．453；模型拟合较好。结论护理管理者可以通过开发心理资本，有效增强护士的组织承诺感；心理资本和组织承诺的改善有助于提高工作嵌入性，最终提高护士的留职意愿。

关键词：护士工作嵌入心理资本组织承诺留职意愿