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YOLOv5-LR:一种遥感影像旋转目标检测模型

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红外技术 2024年第1期46卷 43-51页

作者：高明明李沅洲马雷南敬昌周芊邑辽宁工程技术大学电子与信息工程学院辽宁葫芦岛125105 中国科学院自动化研究所北京100190 辽宁工程技术大学电气与控制工程学院辽宁葫芦岛125105

真实遥感图像中,目标呈现任意方向分布的特点,原始YOLOv5网络存在难以准确表达目标的位置和范围、以及检测速度一般的问题。针对上述问题,提出一种遥感影像旋转目标检测模型YOLOv5-Left-Rotation,首先利用Transformer自注意力机制,让模... 详细信息

真实遥感图像中,目标呈现任意方向分布的特点,原始YOLOv5网络存在难以准确表达目标的位置和范围、以及检测速度一般的问题。针对上述问题,提出一种遥感影像旋转目标检测模型YOLOv5-Left-Rotation,首先利用Transformer自注意力机制,让模型更加注意感兴趣的目标,并且在图像预处理过程中采用Mosaic数据增强,对后处理过程使用改进后的非极大值抑制算法Non-Maximum Suppression。其次,引入角度损失函数,增加网络的输出维度,得到旋转矩形的预测框。最后,在网络模型的浅层阶段,增加滑动窗口分支,来提高大尺寸遥感稀疏目标的检测效率。实验数据集为自制飞机数据集CASIA-plane78和公开的舰船数据集HRSC2016,结果表明,改进旋转目标检测算法相比于原始YOLOv5网络的平均精度提升了3.175%,在吉林一号某星推扫出的大尺寸多光谱影像中推理速度提升了13.6%,能够尽可能地减少冗余背景信息,更加准确检测出光学遥感图像中排列密集、分布无规律的感兴趣目标的区域。

关键词：遥感图像滑动窗口注意力机制旋转目标检测 YOLOv5

海藻酸钠/聚乙烯醇pH指示水凝胶的制备及其对鲜切哈密瓜的新鲜度指示

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食品与发酵工业 2024年第16期50卷 185-192页

作者：黄霜霜王涛周倩怡王红雨罗国荣伍柯翰吴习宇任丹徐丹西南大学食品科学学院西南大学食品贮藏与物流研究中心

为制备能稳定且灵敏指示鲜切果蔬新鲜度的指示器，该研究以海藻酸钠和聚乙烯醇为基材，复配甲基红和溴百里酚蓝为指示剂，制备pH显色水凝胶。首先以指示剂添加量、交联剂浓度以及交联时间为影响因素进行单因素试验，以水凝胶的变色灵敏... 详细信息

为制备能稳定且灵敏指示鲜切果蔬新鲜度的指示器，该研究以海藻酸钠和聚乙烯醇为基材，复配甲基红和溴百里酚蓝为指示剂，制备pH显色水凝胶。首先以指示剂添加量、交联剂浓度以及交联时间为影响因素进行单因素试验，以水凝胶的变色灵敏度和力学性能为指标，对水凝胶制备工艺进行优化；然后，对最优工艺制备的水凝胶进行结构表征和性能测定；最后，将其用于鲜切哈密瓜的新鲜度监测。结果表明，指示剂添加量为5%,交联剂质量浓度为7 g/L,交联时间为18 h的条件下制备的水凝胶结构完整，内部呈多孔结构，具有较好的硬度和弹性，在pH 3～11内有良好的颜色响应。将其应用到鲜切哈密瓜的新鲜度指示中发现，在4℃贮藏3 d时，哈密瓜从新鲜转变为次新鲜，此时水凝胶从黄绿色变为橙色。因此，该研究所制备的水凝胶在鲜切果蔬的新鲜度指示中具有较好的应用前景，有助于提高鲜切果蔬的安全性和消费者体验。

关键词：海藻酸钠聚乙烯醇水凝胶新鲜度指示鲜切哈密瓜

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Realize ultralow-energy-consumption photo-synaptic device based on a single(Al,Ga)N nanowire for neuromorphic computing

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Nano Research 2024年第3期17卷 1933-1941页

作者： Xiushuo Gu Min zhou Yukun Zhao qianyi Zhang Jianya Zhang Yonglin Huang Shulong Lu College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China Key Lab of Nanodevices and Applications Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)Suzhou 215123China School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China Jiangsu Key Laboratory of Micro and Nano Heat Fluid Flow Technology and Energy Application School of Physical Science and TechnologySuzhou University of Science and TechnologySuzhou 215009China

The rapid development of artificial intelligence poses an urgent need for low-energy-consumption and small-sized artificial photonic ***,it is pretty novel to demonstrate a light-stimulated synaptic device based on a single(Al,Ga)N nanowire *** to the presence of vacancy defects in the single nanowire,the artificial synaptic device can simulate multiple functions of biological synapses under stimulation of both 310 and 365 nm light photons,including paired-pulse facilitation,spike timing dependent plasticity,and memory learning *** energy consumption of artificial synaptic device can be reduced as little as 5.58×10^(-13) J,which is close to that of the biological synapse in human ***,the synaptic device is demonstrated to have the high stability for both long-time stimulation and long-time *** on the experimental conductance of long-term potentiation and long-term depression,the simulated three-layer neural network can achieve a high recognition rate of 92%after only 10 training *** a brain-like behavior,the single-nanowire-based synaptic devices can promote the development of visual neuromorphic computing technology and artificial intelligence systems requiring ultralow energy consumption.

关键词： single(Al Ga)N nanowire light-stimulated synaptic device low-energy-consumption neural network

TGF-β-regulated different iron metabolism processes in the development and cisplatin resistance of ovarian cancer

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Oncology Research 2024年第2期32卷 373-391页

作者： JIANFA WU qianyi LIAO LI ZHANG SUQIN WU zhou LIU Department of Gynecology Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghaiChina Department of Gynecology Shanghai University of Medicine&Health SciencesShanghaiChina Department of Gynecology Gongshan People’s HospitalNujiang Lisu Autonomous PrefectureChina

The impact of different iron metabolism processes(DIMP)on ovarian cancer remains *** this study,we employed various gene chips and databases to investigate the role of DIMP in the initiation and development of ovarian *** was used to determine mutations in DIMP-associated genes in ovarian ***-Meier plotter was used to examine the influence of DIMP on the prognosis of ovarian *** analyzing 1669 serous ovarian cancer cases,we identified a range of mutations in iron metabolism genes,notably in those coding for the transferrin receptor(19%),melanotransferrin(19%),and ceruloplasmin(10%)in the iron import process,and glucose-6-phosphate isomerase(9%),hepcidin antimicrobial peptide(9%),metal regulatory transcription factor 1(8%),and bone morphogenetic protein 6(8%)in the iron regulation *** to the unaltered group,the group with gene alterations exhibited a higher tumor mutation burden count(43 vs.54)and more advanced histologic grade(78.19%vs.87.90%).Compared to the normal ovarian counterparts,a reduction in expression was observed in 9 out of the 14 genes involved in iron utilization and 4 out of the 5 genes involved in iron export in ovarian cancer;in contrast,an increase in expression was observed in 2 out of the 3 genes involved in iron storage in ovarian ***,in cisplatin-resistant cells compared to cisplatin-sensitive ones,the expression of all genes in iron storage and 13 out of 14 genes in iron import was decreased,while that of 8 out of the 10 genes in iron utilization was *** addition,survival curve analysis indicated that a higher expression in the majority of genes in the iron import process(12/21),or a reduced expression in most genes in the iron export process(4/5)correlated with poor progression-free ***,TGF-βcould regulate the expression of most iron metabolism-associated genes;particularly,expression of genes involved in the iron storage process(2/2)was inhibited aft

关键词： Chemoresistance Cisplatin Iron Ovarian neoplasms TGF-β

CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1889-1900页

作者： Qiong Yuan Yunwei Sun Fan Yang Dan Yan Meihua Shen Zhigang Jin Lin Zhan Guangqi Liu Ling Yang qianyi zhou Zhijun Yu Xiangyu zhou Yang Yu Yong Xu Qingming Wu Jianfang Luo Xiamin Hu Chunxiang Zhang Department of Cardiology the Affiliated Hospital of Southwest Medical University and Key Laboratory of Medical ElectrophysiologyMinistry of EducationInstitute of Cardiovascular Research and Institute of Metabolic DiseasesSouthwest Medical UniversityLuzhou 646000China College of Medicine Wuhan University of Science and TechnologyWuhan 430065China Department of Emergency and Critical Care Medicine Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China China Resource&WISCO General Hospital Wuhan University of Science and TechnologyWuhan 430065China Department of Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of Coronary Heart Disease PreventionGuangdong General HospitalGuangzhouChina College of Pharmacy Shanghai University of Medicine and Health SciencesShanghai 210000China

In this study,we identified that a conserved circular RNA(circRNA)DICAR,which was downregulated in diabetic mouse *** had an inhibitory effect on diabetic cardiomyopathy(DCM),as the spontaneous cardiac dysfunction,cardiac cell hypertrophy,and cardiac fibrosis occurred in DICAR deficiency(DICAR+/−)mice,whereas the DCM was alleviated in DICARoverexpressed DICARTg *** the cellular level,we found that overexpression of DICAR inhibited,but knockdown of DICAR enhanced the diabetic cardiomyocyte *** the molecular level,we identified that DICAR-VCP-Med12 degradation could be the underlying molecular mechanism in DICAR-mediated *** synthesized DICAR junction part(DICAR-JP)exhibited a similar effect to the entire *** addition,the expression of DICAR in circulating blood cells and plasma from diabetic patients was lower than that from health controls,which was consistent with the decreased DICAR expression in diabetic *** and the synthesized DICAR-JP may be drug candidates for DCM.

关键词： diabetic endogenous cardiomyopathy

Correction of a CADASIL point mutation using adenine base editors in hiPsCsandbloodvessel organoids

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Journal of Genetics and Genomics 2024年第2期51卷 197-207页

作者： Jingwen Wang Lei Zhang Guanglan Wu Jinni Wu Xinyao zhou Xiaolin Chen Yongxia Niu Yiren Jiao qianyi Liu Puping Liang Guang Shi Xueqing Wu Junjiu Huang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Key Laboratory of Reproductive Medicine of Guangdong Province The First Affiliated Hospital and School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Center of Reproductive Medicine Children's Hospital of Shanxi and Women Health Center of ShanxiTaiyuanShanxi 030013China

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic small vessel disease caused by mutations in the NOTCH3 gene. However, the pathogenesis of CADASIL remains unclear, and patients have limited treatment options. Here, we use human induced pluripotent stem cells (hiPSCs) generated from the peripheral blood mononuclear cells of a patient with CADASIL carrying a heterozygous NOTCH3 mutation (c.1261C>T, p.R421C) to develop a disease model. The correction efficiency of different adenine base editors (ABEs) is tested using the HEK293T-NOTCH3 reporter cell line. ABEmax is selected based on its higher efficiency and minimization of predicted off-target effects. Vascular smooth muscle cells (VSMCs) differentiated from CADASIL hiPSCs show NOTCH3 deposition and abnormal actin cytoskeleton structure, and the abnormalities are recovered in corrected hiPSC-derived VSMCs. Furthermore, CADASIL blood vessel organoids generated for in vivo modeling show altered expression of genes related to disease phenotypes, including the downregulation of cell adhesion, extracellular matrix organization, and vessel development. The dual adeno-associated virus (AAV) split-ABEmax system is applied to the genome editing of vascular organoids with an average editing efficiency of 8.82%. Collectively, we present potential genetic therapeutic strategies for patients with CADASIL using blood vessel organoids and the dual AAV split-ABEmax system.

关键词： CADASIL Induced pluripotent stem cells Adenine base editors AAV Blood vessel Organoid

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干旱胁迫下大蒜叶绿素合成基因家族鉴定分析

植物资源与环境学报 2022年第3期31卷 54-64,74页

作者：王紫彤周倩怡田洁青海大学农林科学院青海省蔬菜遗传与生理重点实验室青海西宁810016 青海大学省部共建三江源生态与高原农牧业国家重点实验室青海西宁810016

为探究干旱胁迫对大蒜(Allium sativum Linn.)叶绿素合成的影响,本研究基于大蒜转录组测序数据,筛选出响应干旱胁迫的大蒜叶绿素合成基因家族成员,利用实时荧光定量PCR(qRT-PCR)技术验证其表达情况后,采用生物信息学方法鉴定其序列属性... 详细信息

为探究干旱胁迫对大蒜(Allium sativum Linn.)叶绿素合成的影响,本研究基于大蒜转录组测序数据,筛选出响应干旱胁迫的大蒜叶绿素合成基因家族成员,利用实时荧光定量PCR(qRT-PCR)技术验证其表达情况后,采用生物信息学方法鉴定其序列属性。结果表明:从大蒜转录组数据中搜索得到的17个叶绿素合成基因家族中,筛选出6个积极响应干旱胁迫的大蒜叶绿素合成基因家族,即AsHEMA、AsHEMB、AsGSA、AsCHLD、AsCHLI和AsCAO。qRT-PCR和RNA-Seq结果显示:干旱胁迫6 d,AsHEMA、AsHEMB、AsGSA、AsCHLD、AsCHLI和AsCAO基因家族成员的表达量总体上显著增加。生物信息学分析结果显示:大蒜上述6个基因家族32个unigenes编码序列的氨基酸残基数为104~773,理论相对分子质量为11978~84411,理论等电点为pI 4.78至pI 9.86,不稳定指数为24.66~60.13,脂溶系数为80.04~104.59;除AsGSA家族外,其余5个家族成员的总平均亲水性为负值,即AsGSA家族成员为亲水蛋白,其余5个家族成员为疏水蛋白。保守基序分析结果表明:大蒜这6个叶绿素合成基因家族成员编码的氨基酸序列具有较高的保守性和相似性,其中,AsHEMA、AsGSA和AsCHLD家族高度保守;AsHEMB、AsCHLI和AsCAO家族保守性也较高,仅个别家族成员存在差异。进化树结果显示:大蒜同一叶绿素合成基因家族成员聚在一起,说明各基因家族的成员在进化上具有较高的保守性和相似性;AsHEMA、AsHEMB、AsCHLD、AsCHLI和AsCAO基因家族与单子叶植物小麦(Triticum aestivum Linn.)、石刁柏(Asparagus officinalis Linn.)和玉簪〔Hosta plantaginea(Lam.)Aschers.〕相关基因的同源性较高。上述研究结果显示:AsHEMA、AsHEMB、AsGSA、AsCHLD、AsCHLI和AsCAO基因家族的保守性和相似性较高,在大蒜响应干旱胁迫中发挥重要作用。

关键词：大蒜干旱胁迫叶绿素合成基因生物信息学分析

Total Synthesis of C-α-Mannosyl Tryptophan via Palladium-Catalyzed C-H Glycosylation

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CCS Chemistry 2021年第6期3卷 1729-1736页

作者： Quanquan Wang Yue Fu Wanjun Zhu Shuang An qianyi zhou Shou-Fei Zhu Gang He Peng Liu Gong Chen State Key Laboratory and Institute of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin 300071 Department of Chemistry University of PittsburghPittsburghPA 15260

The C2-α-mannosyl-tryptophan amino acid is produced by a unique posttranslational modification(PTM)of proteins and poses a significant synthetic challenge.A new strategy based on Pd-catalyzed auxiliary-directed remote C-H glycosylation of tryptophan was developed,which generates the C2-α-mannopyranose(Man)-Trp unit in a highly efficient and stereoselective *** functional theory(DFT)computational studies support a concerted oxidative addition mechanism for the stereospecific functionalization of a Pd(II)palladacycle intermediate with anα-mannosyl chloride *** utility of this method was demonstrated in the first total synthesis of insect C-glycopeptide hormone Cam-HrTH-I.

关键词： C-glycoside C−H glycosylation palladium auxiliary adipokinetic hormone

Cerebral autoregulation-directed optimal blood pressure management reduced the risk of delirium in patients with septic shock

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Journal of Intensive Medicine 2024年第3期4卷 376-383页

作者： qianyi Peng Xia Liu Meilin Ai Li Huang Li Li Wei Liu Chunguang Zhao Chenghuan Hu Lina Zhang Department of Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunanChina Hunan Provincial Clinical Research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunanChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunanChina

Background When resuscitating patients with septic shock,cerebrovascular reactivity parameters are calculated by monitoring regional cerebral oxygen saturation(rSO_(2))using near-infrared spectroscopy to determine the optimal blood ***,we aimed to analyze the impact of cerebral autoregulation-directed optimal blood pressure management on the incidence of delirium and the prognosis of patients with septic *** This prospective randomized controlled clinical study was conducted in the Xiangya Hospital of Central South University,***-one patients with septic shock(December 2020–May 2022)were enrolled and randomly allocated to the experimental(n=26)or control group(n=25).Using the ICM+software,we monitored the dynamic changes in rSO_(2) and mean arterial pressure(MAP)and calculated the cerebrovascular reactivity parameter tissue oxygen reactivity index to determine the optimal blood pressure to maintain normal cerebral autoregulation function during resuscitation in the experimental *** control group was treated according to the Surviving Sepsis Campaign *** in the incidence of delirium and 28-day mortality between the two groups were compared,and the risk factors were *** The 51 patients,including 39 male and 12 female,had a mean age of(57.0±14.9)*** incidence of delirium was 40.1%(23/51),and the 28-day mortality rate was 29.4%(15/51).The mean MAP during the first 24 h of intensive care unit(ICU)admission was higher([84.5±12.2]mmHg vs.[77.4±11.8]mmHg,P=0.040),and the incidence of delirium was lower(30.8%vs.60.0%,P=0.036)in the experimental group than in the control *** use of cerebral autoregulation-directed optimal blood pressure(odds ratio[OR]=0.090,95%confidence interval[CI]:0.009 to 0.923,P=0.043)and length of ICU stay(OR=1.473,95%CI:1.093 to 1.985,P=0.011)were risk factors for delirium during septic *** drug dose(OR=8.445,95%CI:1.26 to 56.576,P=0.028)and partial pressure of o

关键词： Septic shock Cerebral regional oxygen saturation Optimal blood pressure Delirium Mortality