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Characteristics and geological significance of the stress state of the lithosphere in the Qinghai-Tibetan Plateau and its neighboring areas

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Science China Earth Sciences 2024年第6期67卷 1836-1855页

作者： qianwen zhang Ya XU Wei CHU Shupeng LU Key Lab of Petroleum Resource Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The present-day lithospheric stress state of the Qinghai-Tibetan Plateau and neighboring areas is controlled by both the lithosphere itself and the underlying *** other words,the stress is affected by the gravitational potential energy(GPE)difference caused by the change in the density distribution within the lithosphere and the drag force on the base of the lithosphere caused by mantle *** study of the lithospheric stress state plays an important role in further understanding the dynamic background and mechanism for the evolution of the Qinghai-Tibetan *** this study,the Crust1.0 crustal density model combined with the S40RTS mantle shear wave velocity variation model was used to calculate the *** EGM2008gravity field model was used to calculate the drag force from mantle convection at the base of the *** lithospheric and joint stress fields of the two sources were obtained by solving the force balance under the thin sheet *** way,we could comprehensively analyze the characteristics of the stress state within the *** regions were classified according to the GPE stress field,mantle drag force stress field,the relative magnitude of the two stress fields,and correlation between the two stress fields and surface *** lithospheric stress fields of the Tarim Basin and other stable blocks are mainly controlled by the GPE *** lithospheric stress field in the collision zone between the Indian Plate and the QinghaiTibetan Plateau is predominantly controlled by the deep mantle drag *** lithospheric stress field in the interior of the Plateau is controlled by both GPE and mantle *** correlation between the lithospheric stress field and surface deformation at the southeast margin of the Qinghai-Tibetan Plateau is *** is hypothesized that the presence of lower crustal flow with lower effective viscosity leads to crust-mantle decoupling,and the mantle drag force has a weaker influe

关键词： Qinghai-Tibetan Plateau Gravitational potential energy Mantle convection Lithospheric deviatoric stress field GPS strain rate field

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Revealing the kinetics of ionophore facilitating ion transport across lipid bilayers by surface enhanced infrared absorption spectroscopy

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Chinese Chemical Letters 2020年第2期31卷 479-481页

作者： qianwen zhang Yang Liu Jian Li Xinghua Xia State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Ionophore can prominently improve the ion permeability of cell membrane and disrupt cellular ion *** studies regarding ionophore facilitating ion transmembrane transport focus on artificial liquid-liquid interfaces,which have large difference from the actual environment of cell ***,we construct a supported lipid bilayeron a gold nanoparticles film modified ZnSe prism as an appropriate model of cell membrane to investigate the dynamic of the ion transport facilitated by ionophore using surface enhanced infrared absorption spectroscopy(SEIRAS).We find that the ion transmembrane transport consists of two steps:The ion transmembrane transport starts with the association/disassociation between ion and ionophore at the edge of lipid bilayer;The second step is the transfer of ion-ionophore complex across lipid *** results show that the complex transfer across the lipid bilayer is the rate determining step.

关键词： SEIRAS Ion transmembrane transport Ionophore Kinetics Supported lipid bilayers

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Superplastic Tension Behavior of Dissimilar TC4/SP700 Laminate through Diffusion Bonding

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 353-363页

作者： qianwen zhang Tianle Li Yanbin Han Wei Zheng Xifeng Li Jianjun Wu School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an710072China AVIC Xi’an Aircraft Industry Group Company Ltd Xi’an710089China Institute of Forming Technology and Equipment School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200030China

Superplastic forming is a practical method to manufacture complex-shaped parts of titanium alloys with large *** parts of dissimilar titanium alloys fabricated by superplastic forming can achieve excellent performance by combining the advantages of *** work displays the superplastic tension behavior and microstructural evolution of dissimilar TC4/SP700 laminate prepared by the diffusion bonding *** titanium alloys can achieve metallurgical bonding at parameters of 800℃/1 h/5 *** for dynamic recrystallization and grain growth behaviors upon superplastic tension,stress-induced phase transformation plays an important role inαtoβphase transformation apart from the elevated *** superplastic deformation can be attributed to the grain boundary sliding accommodated multiplex motion of *** addition,the retained strengths of all dissimilar TC4/SP700 laminates after superplastic deformation with different strain rates and temperatures range from 807 to 890 MPa.

关键词： TC4/SP700 laminate Diffusion bonding Microstructure Superplastic tension Strength

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Durable hierarchical phosphorus‐doped biphase MoS_(2)electrocatalysts with enhanced H^(*)adsorption

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Carbon Energy 2024年第4期6卷 104-114页

作者： Yongteng Qian Jianmin Yu Zhiyi Lyu qianwen zhang Tae Hyeong Lee Huan Pang Dae Joon Kang College of Pharmacy Jinhua PolytechnicJinhuaZhejiangChina Department of Physics Sungkyunkwan UniversitySuwonGyeonggi‐doRepublic of Korea International Collaborative Laboratory of 2D Materials for Optoelectronic Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhenGuangdongChina School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhouJiangsuChina

Phase engineering is an efficient strategy for enhancing the kinetics of electrocatalytic ***,phase engineering was employed to prepare high‐performance phosphorous‐doped biphase(1T/2H)MoS_(2)(P‐BMS)nanoflakes for hydrogen evolution reaction(HER).The doping of MoS_(2)with P atoms modifies its electronic structure and optimizes its electrocatalytic reaction kinetics,which significantly enhances its electrical conductivity and structural stability,which are verified by various characterization tools,including X‐ray photoelectron spectroscopy,high‐resolution transmission electron microscopy,X‐ray absorption near‐edge spectroscopy,and extended X‐ray absorption fine ***,the hierarchically formed flakes of P‐BMS provide numerous catalytic surface‐active sites,which remarkably enhance its HER *** optimized P‐BMS electrocatalysts exhibit low overpotentials(60 and 72 mV at 10 mA cm^(−2))in H_(2)SO_(4)(0.5 M)and KOH(1.0 M),*** mechanism of improving the HER activity of the material was systematically studied using density functional theory calculations and various electrochemical characterization *** study has shown that phase engineering is a promising strategy for enhancing the H*adsorption of metal sulfides.

关键词： 1T/2H MoS_(2) density functional theory electrocatalysts phase engineering phosphorous doping

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Electrophysiological Characterization of Substantia Nigra Pars Reticulata in Anesthetized Rats

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Journal of Shanghai Jiaotong university(Science) 2022年第4期27卷 505-511页

作者： Liu Xinrui zhang qianwen Wang Ying Chen Fujun Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai200240China Core Research Facilities Southern University of Science and TechnologyShenzhen518055GuangdongChina Exercise Health and Technology Center Department of Physical EducationShanghai Jiao Tong UniversityShanghai200240China

The substantia nigra pars reticulate(SNr),which plays a pivotal role in motor control,is the key structure in integrating information for cortex,basal ganglia and *** gait and posture deficits can be reversed by SNr deep brain stimulation(DBS)in certain Parkinson’s disease ***,functional characterization of SNr,which is the key for the optimization of DBS effect,remains *** current study,we recorded extracellular single unit in SNr of urethane anesthetized *** have found that urethane can induce slow delta and theta oscillations in SNr local field *** high gamma oscillation observed is positively correlated with the occurrence of action *** putative GABAergic neurons have a mean firing rate of(20.82±2.04)Hz,of which 65.2%display a regular firing pattern and 34.8%show irregular *** results demonstrated the heterogeneous property of SNr and provided possible theoretical basis for promoting the next generation of DBS electrode design and optimization of clinical DBS parameters.

关键词： substantia nigra pars reticulate(SNr) local field potential firing regularity electrophysiology

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Tomato SlRUP is a negative regulator of UV-B photomorphogenesis

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Molecular Horticulture 2021年第1期1卷 108-111页

作者： Chunli zhang qianwen zhang Hongye Guo Xiaohui Yu Wenjing Liang Yinhua Chen Ruohe Yin Li Lin School of Agriculture and Biology Shanghai Jiao Tong University800 Dongchuan RDMinhang DistrictShanghai 200240People’s Republic of China Key Laboratory of Urban Agriculture(Ministry of Agriculture)and Joint Center for Single Cell Biology School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresource Hainan UniversityHaikou 570228People’s Republic of China

Introduction Sunlight is an environmental factor regulating plant growth and *** have evolved a battery of photoreceptors to sense and respond to different wavelengths of light(Jenkins,2017;Liu et al.,2020a).UV-B(280–315 nm)comprises the shortest wavelength of sunlight on the earth *** general,low fluence rate UV-B does not generate damage effects on plants,rather it induces plant photomorphogenic responses(Yin and Ulm,2017).High fluence rate UV-B may damage macromolecules,including nucleic acids,protein and membranes(Hideg et al.,2013).The UV-B photoreceptor UVR8 protein((UV RESISTANCE LOCUS 8)perceives the low dose UV-B and triggers UV-B specific signal transduction.

关键词： photoreceptor development. morphogenesis

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Pepper(Capsicum annuum)xylogen-like arabinogalactan protein(XYLP)1 and XYLP2 promote synthesis of lignin during stem development to cope with stresses

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Vegetable Research 2022年第1期2卷 138-147页

作者： Min zhang qianwen zhang Long Cheng Qianying Li Xinyue He Kaixuan Wang Jianan Liu Feng Li Yingtian Deng Key Laboratory of Horticultural Plant Biology(Ministry of Education) College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China

Pepper stems exhibit a high level of strength and lignin deposition to support plant growth,which direct the cultivation style without binding sticks or ***,regulation of lignin synthesis and accumulation in pepper stem has not been extensively ***,we first investigated the pepper stem developmental process and confirmed that increasing lignin accumulation occurs during stem *** then performed genome-wide identification and characterization of xylogen-like arabinogalactan protein(XYLP)family members and obtained 10,22,and 19 XYLPs in pepper,tomato,and potato *** of the phylogenetic relationship among the identified XYLPs suggested that these proteins are conserved in ***,we analyzed the 10 CanXYLP genes and observed that these genes exhibit differential expressing patterns at different stages of pepper stem *** these genes,two XYLPs,namely CanXYLP1 and CanXYLP2,exhibited an increased expression pattern and a strong correlation with lignin accumulation in pepper *** further found that CanXYLP1 and CanXYLP2 play a role in pepper stem lignification by positively regulating the lignin synthesis pathway genes in pepper,and the CanXYLP1/2-silenced plants displayed a blocked lignification ***,we confirmed that CanXYLP1/2 expression is upregulated in response to some abiotic and biotic signals,suggesting that these two genes enhance the tolerance of pepper stem to unfavorable *** results contribute to our understanding of the molecular mechanism controlling pepper stem lignification,and the relationship between the lignin content of pepper stem and XYLPs.

关键词： fir pepper synthesis

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A novel curcumin-piperlongumine hybrid molecule(CP) induces cell cycle arrest and apoptosis through JNK/c-Jun signaling pathway in lung cancer

A novel curcumin-piperlongumine hybrid molecule(CP) induces ...

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2023年度全国临床药理学学术论坛

作者： qianwen zhang Min Hui Wenzhou Medical University

Lung cancer is the most common *** present,the clinical treatment of lung cancer mainly includes surgery,immunotherapy,chemoradiotherapy and targeted drug *** recent years,the potential application of natural compounds has gradually attracted people's *** and piperine are natural products in the treatment of cancer,and the instability of curcumin structure and the toxic side effects of piperine limit their potential applications in cancer *** overcome these challenges,we designed and synthesized a novel curcumin-piperine hybrid molecule CP using molecular hybridization *** with the parent compound,CP has higher structural stability and *** in vitro and in vivo biological activity screening,CP effectively inhibited cell proliferation,stopped cell cycle in G2/M phase,and induced cell ***,the effect of CP on MAPK family activity in lung cancer is *** addition,we found that CP induced p53-independent apoptosis by regulating the JNK signaling *** look forward to contributing to precision medicine for lung cancer.

关键词： Lung cancer curcumin piperlongine apoptosis JNK pathway

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Induction of cell cycle arrest and apoptosis in drug-resistant lung cancer cells by curcumin-piperlongumine hybrid molecule(CP) through IL6/JAK2/STAT3 signaling pathway

Induction of cell cycle arrest and apoptosis in drug-resista...

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2023年度全国临床药理学学术论坛

作者： Shiyu Wang qianwen zhang Pharmacy School of PharmacyWenzhou Medical University

Lung cancer ranked second in terms of new cases in 2020 and remains th e leading cause of cancer-related ***-small cell lung cancer is the mos t common type of lung *** significant advances in treatment strategi es,the issue of drug resistance has emerged as a consequence of drug *** mechanisms include secondary activating mutations in the EGFR kin ase,MET gene amplification mutations,among others,which contribute to subo ptimal survival outcomes for NSCLC ***,as a natural compound,has shown significant potential therapeu tic value in various diseases in recent years,including inflammatory bowel dise ase,arthritis,pancreatitis,chronic anterior uveitis,and certain types of cancer.I t exhibits notable anti-inflammatory,anti-tumor,and free radical scavenging pro ***,the clinical application of curcumin is significantly limited du e to its high metabolic instability,low bioavailability,and rapid plasma clearan ***,a natural alkaloid,has been proven to possess cytotoxic eff ects against non-small cell lung cancer(NSCLC) cells and enhance the efficacy of standard chemotherapy drugs,showing promising anti-tumor activity and po tential as a lung cancer chemotherapeutic ***,the structural instabil ity of curcumin and the toxic side effects of piperlongumine have limited their potential application in cancer *** order to overcome these challenges,we have utilized a molecular hybridization strategy to design and synthesize a novel curcumin-piperlongumine hybrid molecule,*** to the parent compounds,CP exhibits enhanced structural stability and *** in vitro and in vivo bioactivity screening,CP has been found to effectively inhibit the proliferation of A549-DDPR and PC9-OISR drug-resistant cells,causing cell cycle arrest at the G2/M phase and promoting early apopto *** can induce apoptosis in lung cancer cells by regulating the IL6/JAK2/S TAT3 signaling ***

关键词： curcumin piperlongumine nsclc molecular hybridization

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国际投资中数据的性质判断及保护

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法学 2024年第7期512卷 173-192页

作者：张倩雯西南交通大学法学系

数字企业已成为对外投资的重要主体,如何充分保护数字企业海外投资利益成为国际法和国内法共同探索的议题,“Einarsson诉加拿大案”更是将数据是否为投资的疑问提交至国际投资仲裁庭。依据《华盛顿公约》及国际投资协定的现有规定,数据... 详细信息

数字企业已成为对外投资的重要主体,如何充分保护数字企业海外投资利益成为国际法和国内法共同探索的议题,“Einarsson诉加拿大案”更是将数据是否为投资的疑问提交至国际投资仲裁庭。依据《华盛顿公约》及国际投资协定的现有规定,数据作为一种“投资”在立法上存在模糊性,但结合“Salini标准”和投资应当具有财产属性的要求,以及知识产权作为投资的特征考察,可以推演出数据作为投资有其理论可行性。未来,各国在改革国际投资协定时可通过一般意义的财产权路径和/或知识产权路径强化对数据的保护。在数字投资规则萌芽之际,我国宜把握规则制定先机,在夯实知识产权路径的基础上探索一般意义的财产权路径,同时在国内法中完善数据财产权构建,为加快推动我国数字经济对外投资合作提供法治保障。

关键词：数据投资对外投资保护国际投资协定数据财产权

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