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食品安全导刊 2024年第27期 18-21页

作者：霍然熊雨姚雪崔倩文杜苗苗周秀娟上海健康医学院健康与公共卫生学院上海201318

凉拌菜作为一种独特的膳食类型,其安全性与食材的加工、制作环境的卫生状况以及安全监管的力度等都有很大的关系。本文分析凉拌菜的安全性问题,阐述凉拌菜的安全监管现状,以期为凉拌菜的食用安全提供建议。

关键词：凉拌菜食品安全食品监管

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HMGB3 is a potential diagnostic marker for early cervical lesion screening

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Genes & Diseases 2023年第6期10卷 2202-2205页

作者： qianwen cui Jiarong Zhao Qingmei Deng Yu Liu Changfang Fu Qiang Wu Qiuyan Sun Haiyan Weng Haiming Dai Wulin Yang Anhui Province Key Laboratory of Medical Physics and Technology Institute of Health and Medical TechnologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch Graduate School of University of Science and Technology of ChinaHefeiAnhui 230026China Medical Pathology Center Hefei Cancer HospitalChinese Academy of SciencesHefeiAnhui 230031China The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Department of Pathology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230601China

Despite the spread of effective vaccination strategies,cervical cancer remains the second leading cause of cancer death among women aged 20 to 39.1 clinical diagnosis of cervical lesions relies on the P16INK4a(P16)marker,but its sensitivity to low-grade cervical intraepithelial neoplasia(CIN)is *** more sensitive and specific molecular markers is still a challenge in cervical lesion *** this study,we found that HMGB3 could effectively label pathological cells in different cervical lesions,especially for early ***,HMGB3 has the potential to be used as a novel marker for the early screening of cervical lesions.

关键词： cervical diagnosis clinical

Hernandezine promotes cancer cell apoptosis and disrupts the lysosomal acidic environment and cathepsin D maturation

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Chinese Journal of Natural Medicines 2024年第5期22卷 387-401页

作者： FENG qianwen SUN Lu Muhammad Jibran Sualeh ZHAO Qingli ZHAO Songji cui Zhengguo INADERA Hidekuni Department of Public Health Graduate School of Medicine and Pharmaceutical SciencesUniversity of ToyamaToyama 930-8501Japan Department of Pediatric Cardiology Heart CenterGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000China Department of Basic Medical Sciences College of MedicineUniversity of SharjahSharjah 57545United Arab Emirates Department of Radiology Graduate School of Medicine and Pharmaceutical SciencesUniversity of ToyamaToyama 930-8501Japan Advanced Clinical Research Center Fukushima Global Medical Science CenterFukushima Medical UniversityFukushima CityFukushima 960-8074Japan Department of Environmental Health School of Medical SciencesUniversity of FukuiFukui 910-8580Japan

Hernandezine(Her),a bisbenzylisoquinoline alkaloid extracted from Thalictrum flavum,is recognized for its range of biological activities inherent to this herbal *** its notable properties,the anti-cancer effects of Her have remained largely *** this study,we elucidated that Her significantly induced cytotoxicity in cancer cells through the activation of apoptosis and necroptosis ***,Her triggered autophagosome formation by activating the AMPK and ATG5 conjugation systems,leading to LC3 *** findings revealed that Her caused damage to the mitochondrial membrane,with the damaged mitochondria undergoing mitophagy,as evidenced by the elevated expression of mitophagy ***,Her disrupted autophagic flux,demonstrated by the upregulation of p62 and accumulation of autolysosomes,as observed in the RFP-GFP-LC3 reporter ***,we determined that Her did not prevent the fusion of autophagosomes and ***,it inhibited the maturation of cathepsin D and increased lysosomal pH,indicating an impairment of lysosomal *** use of the early-stage autophagy inhibitor,3-methyladenine(3-MA),did not suppress LC3II,suggesting that Her also induces noncanonical autophagy in autophagosome *** application of Bafilomycin A1,an inhibitor of noncanonical autophagy,diminished the recruitment of ATG16L1 and the accumulation of LC3II by Her,thereby augmenting Her-induced cell *** observations imply that while autophagy initially plays a protective role,the disruption of the autophagic process by Her promotes programmed cell *** study provides the first evidence of Her’s dual role in inducing apoptosis and necroptosis while also initiating and subsequently impairing autophagy to promote apoptotic cell *** insights contribute to a deeper understanding of the mechanisms underlying programmed cell death,offering potential avenues for enhancing cancer prevention and therapeutic st

关键词： Hernandezine Apoptosis Mitophagy Autophagic flux Lysosome Noncanonical autophagy

Maternal and Perinatal Outcomes of SARS-CoV-2 and Variants in Pregnancy

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Maternal-Fetal Medicine 2023年第2期5卷 104-114页

作者： Qiaoli Feng qianwen cui Zhansong Xiao Zengyou Liu Shangrong Fan Department of Obstetrics and Gynecology Peking University Shenzhen HospitalShenzhen 518036China Department of Obstetrics and Gynecology Huazhong University of Science and Technology Union Shenzhen HospitalShenzhen 518052China Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecological Diseases Shenzhen 518000China.

Pregnancy is a physiological state that predisposes women to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection,a disease that can cause adverse maternal and perinatal *** severity of coronavirus disease 2019 (COVID-19) disease is known to vary by viral strain;however,evidence for the effects of this virus in pregnant women has yet to be fully *** this review,we describe maternal and perinatal outcomes,vaccination,and vertical transmission,among pregnant women infected with the different SARS-CoV-2 variants identified to *** also summarize existing evidence for maternal and perinatal outcomes in pregnant women with specific information relating to SARS-CoV-2 *** analysis showed that Omicron infection was associated with fewer severe maternal and perinatal adverse outcomes while the Delta variant was associated with worse pregnancy *** deaths arising from COVID-19 were found to be rare (<1.0%),irrespective of whether the virus was a wild-type strain or a *** maternal morbidity was more frequent for the Delta variant (10.3%),followed by the Alpha (4.7%),wild-type (4.5%),and Omicron (2.9%) *** rates of stillbirth were 0.8%,4.1%,3.1%,and 2.3%,respectively,in pregnancies infected with the wild-type strain,Alpha,Delta,and Omicron variants,*** birth and admission to neonatal intensive care units were more common for cases with the Delta infection (19.0% and 18.62%,respectively),while risks were similar for those infected with the wild-type (14.7% and 11.2%,respectively),Alpha (14.9% and 13.1%),and Omicron variants (13.2% and 13.8%,respectively).As COVID-19 remains a global pandemic,and new SARS-CoV-2 variants continue to emerge,research relating to the specific impact of new variants on pregnant women needs to be expanded.

关键词： COVID-19 SARS-CoV-2 Variants Pregnancy outcomes Alpha Delta Omicron

IgG4相关甲状腺疾病合并妊娠一例并文献复习

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中华产科急救电子杂志 2024年第1期13卷 33-40页

作者：崔骞文汪燕兰李晴赵平月徐一菲袁知东韩巍张笑薇黄磊樊尚荣北京大学深圳医院产科深圳518035

目的总结分析IgG4相关性疾病(immunoglobulin-G4 related disease,IgG4-RD)的妊娠及产后临床资料、诊治过程及随访结果,以提高产科医生对IgG4-RD的认识水平。方法采用回顾性研究方法对2023年1月18日北京大学深圳医院收治的1例(本例患者)... 详细信息

目的总结分析IgG4相关性疾病(immunoglobulin-G4 related disease,IgG4-RD)的妊娠及产后临床资料、诊治过程及随访结果,以提高产科医生对IgG4-RD的认识水平。方法采用回顾性研究方法对2023年1月18日北京大学深圳医院收治的1例(本例患者)IgG4相关甲状腺疾病成功妊娠的诊疗经过,以及通过数据库检索与妊娠相关的IgG4-RD病例报道进行分析。结果本例患者29岁,发现甲亢4年余、IgG4-RD 7个月、双胎妊娠,孕29周时因"甲亢危象、心功能Ⅳ级、IgG4-RD、子痫前期、新型冠状病毒感染等"于我院经多学科共同诊治,获得良好围产结局。文献检索到IgG4-RD合并妊娠病例报道6篇(共5例患者),包括本例患者在内的6例患者受累器官、临床表现不尽相同,经激素规范治疗后均获得良好围产结局。结论妊娠相关的IgG4-RD表现复杂多样,严重者可致重要脏器功能障碍。IgG4相关甲状腺疾病女性能够成功妊娠但存在较大风险,孕期及产后需持续激素维持治疗、多学科严密监测。

关键词：免疫球蛋白G4相关疾病甲状腺功能亢进症妊娠产后

基于子结构最优传输的跨工况轴承故障诊断方法

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振动与冲击 2023年第7期42卷 273-280,332页

作者：朱良玉崔倩文胡超凡何水龙桂林电子科技大学机电工程学院桂林541004

针对不同工况条件下轴承振动数据分布不一致、源领域与目标领域自适应过程中适配不足或过度适配的难题,提出一种基于子结构最优传输的跨工况轴承故障诊断方法。通过小波变换提取轴承振动数据中的故障特征,构建故障样本集;再对源领域及... 详细信息

针对不同工况条件下轴承振动数据分布不一致、源领域与目标领域自适应过程中适配不足或过度适配的难题,提出一种基于子结构最优传输的跨工况轴承故障诊断方法。通过小波变换提取轴承振动数据中的故障特征,构建故障样本集;再对源领域及目标领域轴承故障样本集进行聚类,生成源领域与目标领域故障样本数据的子结构,并自适应的对源领域数据子结构赋予不同权重,目标领域数据子结构赋予相同权重,完成对源领域数据子结构的映射;利用映射的源领域数据子结构及其所对应的标签,训练支持向量机模型并通过训练后的模型实现对目标工况轴承的故障诊断。将所提方法在机械综合故障模拟试验平台及凯斯西储大学轴承数据集上进行验证,并与传统机器学习及其他迁移学习方法进行对比,试验结果表明该方法的有效性与优越性。

关键词：故障诊断子结构级匹配迁移学习跨工况

Surgical timing and long-term outcomes in patients with severe haemorrhagic spinal cord cavernous malformations

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Stroke & Vascular Neurology 2024年第4期9卷 439-445页

作者： An Tian Ziwei cui Jian Ren Yeqing Ren Ming Ye Guilin Li Chuan He Xiaoyu Li Gao Zeng Peng Hu Yongjie Ma Jiaxing Yu Jingwei Li Lisong Bian Fan Yang qianwen Li Feng Ling Tao Hong Liyong Sun Hongqi Zhang Department of Neurosurgery Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Neurosurgery Beijing Haidian HospitalBeijingChina Department of Neurosurgery United Family HealthcareBeijingChina Department of Radiology Xuanwu Hospital Capital Medical UniversityBeijingChina

Background Surgical resection of the lesions remains the main treatment method for most symptomatic spinal cord cavernous malformations(SCCMs)to eliminate the occupation and associated subsequent lifelong haemorrhagic ***,the timing of surgical intervention remains controversial,especially for patients in the acute stage after severe *** Patients diagnosed with SCCMs who were surgically treated between January 2002 and December 2021 were selected and retrospectively *** Modified McCormick Scale(MMS)was used to evaluate neurological and disability *** medical information was reviewed,and all patients were followed up for at least 6 *** A total of 279 patients were ultimately *** regard to long-term outcomes,110(39.4%)patients improved,159(57.0%)remained unchanged and 10(3.6%)*** patients with an MMS score of 2–5 on admission,in univariate and multivariate analyses,a≤6 weeks period between onset and surgery(adjusted OR 3.211,95%CI 1.504 to 6.856,p=0.003)was a significant predictor of improved *** 69 patients who first presented with severe haemorrhage,undergoing surgery within 6 weeks of the onset of severe haemorrhage(adjusted OR 4.901,95%CI 1.126 to 21.325,p=0.034)was significantly associated with improvement of MMS *** Surgical timing can influence the long-term outcome of *** patients with symptomatic SCCMs,especially those with severe haemorrhage,early surgical intervention within 6 weeks can provide more benefit.

关键词： patients Surgical haemorrhagic

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滚动轴承故障定量诊断方法综述

轴承 2023年第2期 1-11页

作者：朱良玉崔倩文陶林胡超凡何水龙桂林电子科技大学机电工程学院广西桂林541004

将近年来滚动轴承故障定量诊断方法的相关研究归纳为基于双冲击特征提取与轴承动力学建模的定量诊断方法,大数据驱动的智能定量诊断方法以及冲击脉冲法这3大类,分别介绍了3类方法的基本思想、研究进展、适用环境以及优缺点:基于双冲击... 详细信息

将近年来滚动轴承故障定量诊断方法的相关研究归纳为基于双冲击特征提取与轴承动力学建模的定量诊断方法,大数据驱动的智能定量诊断方法以及冲击脉冲法这3大类,分别介绍了3类方法的基本思想、研究进展、适用环境以及优缺点:基于双冲击特征与动力学建模的方法能确定故障尺寸的精确值,但要求诊断人员经验丰富且动力学模型准确;智能定量诊断方法是一种“傻瓜式”的方法,但存在故障尺寸诊断精度不足以及需要历史数据的问题;冲击脉冲法操作简单、效果明显,但诊断过程中需要特定的软硬件。结合研究现状认为,贴近工程实际的研究和各种方法取长补短综合运用以及新技术、新理论的应用将会是轴承故障定量诊断方法未来的发展方向。

关键词：滚动轴承故障诊断定量分析特征提取动力学模型数据驱动冲击脉冲

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水热法合成羟基氧化镓与优化探索

无机盐工业 2013年第2期45卷 15-16页

作者：潘春阳陈武洲张汉辉陈桡莹崔倩文罗晓杏广东工业大学轻工化工学院广东广州510006

羟基氧化镓(GaOOH)是合成氮化镓的重要原料,其微观形态特征对所制备氮化镓的物理性能有着重要影响。以氧化镓、浓盐酸、氨水为原料,用水热法合成出羟基氧化镓,并探讨了浓盐酸用量对羟基氧化镓纯度的影响。对合成产物进行XRD表征,结果表... 详细信息

羟基氧化镓(GaOOH)是合成氮化镓的重要原料,其微观形态特征对所制备氮化镓的物理性能有着重要影响。以氧化镓、浓盐酸、氨水为原料,用水热法合成出羟基氧化镓,并探讨了浓盐酸用量对羟基氧化镓纯度的影响。对合成产物进行XRD表征,结果表明合成产物为羟基氧化镓,且随着浓盐酸用量的增加,羟基氧化镓产品的纯度提高。

关键词：羟基氧化镓水热合成氮化镓

A Review on Metal-and Metal Oxide-Based Nanozymes:Properties,Mechanisms,and Applications

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Nano-Micro Letters 2021年第10期13卷 147-199页

作者： qianwen Liu Amin Zhang Ruhao Wang Qian Zhang Daxiang cui Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong University800 Dongchuan RDShanghai 200240People’s Republic of China Institute of Nano Biomedicine National Engineering Research Center for Nanotechnology28 Jiangchuan EasternroadShanghai 200241People’s Republic of China

Since the ferromagnetic(Fe_(3)O_(4))nanoparticles were firstly reported to exert enzyme-like activity in 2007,extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related *** promising alterna-tives for natural enzymes,nanozymes have broadened the way toward clinical medicine,food safety,environmental monitoring,and chemical *** past decade has witnessed the rapid development of metal-and metal oxide-based nanozymes owing to their remarkable physicochemical proper-ties in parallel with low cost,high stability,and easy *** is widely known that the deep study of catalytic activities and mechanism sheds sig-nificant influence on the applications of *** review digs into the characteristics and intrinsic properties of metal-and metal oxide-based nanozymes,especially emphasizing their catalytic mechanism and recent applications in biological analysis,relieving inflammation,antibacterial,and cancer *** also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

关键词： Metal-and metal oxide-based nanozymes Intrinsic properties Catalytic mechanism Applications