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Untethered Micro/Nanorobots for Remote Sensing:Toward Intelligent Platform

Nano-Micro Letters 2024年第2期16卷 450-483页

作者： qianqian wang Shihao Yang Li Zhang Jiangsu Key Laboratory for Design and Manufacture of Micro‑Nano Biomedical Instruments School of Mechanical EngineeringSoutheast UniversityNanjing 211189People’s Republic of China Department of Mechanical and Automation Engineering The Chinese University of Hong KongShatinHong Kong 999077People’s Republic of China Chow Yuk Ho Technology Centre for Innovative Medicine The Chinese University of Hong KongShatinHong Kong 999077People’s Republic of China T Stone Robotics Institute The Chinese University of Hong KongShatinHong Kong 999077People’s Republic of China Department of Surgery The Chinese University of Hong KongShatinHong Kong 999077People’s Republic of China

Untethered micro/nanorobots that can wirelessly control their motion and deformation state have gained enormous interest in remote sensing applications due to their unique motion characteristics in various media and diverse functionalities.Researchers are developing micro/nanorobots as innovative tools to improve sensing performance and miniaturize sensing systems,enabling in situ detection of substances that traditional sensing methods struggle to achieve.Over the past decade of development,significant research progress has been made in designing sensing strategies based on micro/nanorobots,employing various coordinated control and sensing approaches.This review summarizes the latest developments on micro/nanorobots for remote sensing applications by utilizing the self-generated signals of the robots,robot behavior,microrobotic manipulation,and robot-environment interactions.Providing recent studies and relevant applications in remote sensing,we also discuss the challenges and future perspectives facing micro/nanorobots-based intelligent sensing platforms to achieve sensing in complex environments,translating lab research achievements into widespread real applications.

关键词： Micro/nanorobot Remote sensing Wireless control Self-propulsion Actuation at small scales

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Exploring the potential of olivine-containing copper-nickel slag for carbon dioxide mineralization in cementitious materials

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 562-573页

作者： qianqian wang Zequn Yao Lijie Guo Xiaodong Shen College of Materials Science and Engineering Nanjing Tech UniversityNanjing 211816China State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing 211816China BGRIMM Technology Group Beijing 100160China

Water-quenched copper-nickel metallurgical slag enriched with olivine minerals exhibits promising potential for the production of CO_(2)-mineralized cementitious materials.In this work,copper-nickel slag-based cementitious material(CNCM)was synthesized by using different chemical activation methods to enhance its hydration reactivity and CO_(2) mineralization capacity.Different water curing ages and carbonation conditions were explored related to their carbonation and mechanical properties development.Meanwhile,thermogravimetry differential scanning calorimetry and X-ray diffraction methods were applied to evaluate the CO_(2) adsorption amount and carbonation products of CNCM.Microstructure development of carbonated CNCM blocks was examined by backscattered electron imaging(BSE)with energy-dispersive X-ray spectrometry.Results showed that among the studied samples,the CNCM sample that was subjected to water curing for 3 d exhibited the highest CO_(2) sequestration amount of 8.51wt%at 80℃and 72 h while presenting the compressive strength of 39.07 MPa.This result indicated that 1 t of this CNCM can sequester 85.1 kg of CO_(2) and exhibit high compressive strength.Although the addition of citric acid did not improve strength development,it was beneficial to increase the CO_(2) diffusion and adsorption amount under the same carbonation conditions from BSE results.This work provides guidance for synthesizing CO_(2)-mineralized cementitious materials using large amounts of metallurgical slags containing olivine minerals.

关键词： copper-nickel slag fayalite CO_(2)sequestration cementitious material admixtures carbonation conditions

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Abiotic stress treatment reveals expansin like A gene OfEXLA1 improving salt and drought tolerance of Osmanthus fragrans by responding to abscisic acid

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Horticultural Plant Journal 2024年第2期10卷 573-585页

作者： Bin Dong qianqian wang Dan Zhou Yiguang wang Yunfeng Miao Shiwei Zhong Qiu Fang Liyuan Yang Zhen Xiao Hongbo Zhao School of Landscape Architecture Zhejiang Agriculture and Forestry UniversityHangzhouZhejiang 311300China Zhejiang Provincial Key Laboratory of Germplasm Innovation and Utilization for Garden Plants HangzhouZhejiang 311300China Key Laboratory of National Forestry and Grassland Administration on Germplasm Innovation and Utilization for Southern Garden Plants HangzhouZhejiang 311300China

Sweet osmanthus(Osmanthus fragrans) is a having general approval aromatic tree in China that is widely applied to landscaping and gardening. However, the evergreen tree adaptability is limited by many environmental stresses. Currently, limited information is available regarding the genetic analysis and functional identification of expansin genes in response to abiotic stress in sweet osmanthus. In this study, a total of 29 expansin genes were identified and divided into four groups by genome-wide analysis from the sweet osmanthus genome. Transcriptome and quantitative Real-time PCR analysis showed that the cell wall-localized protein expansin-like A(OfEXLA1) gene was significantly induced by salt and drought treatment. Histochemical GUS staining of transgenic Arabidopsis lines in which GUS activity was driven with the OfEXLA1 promoter, GUS activity was significantly induced by salt, drought, and exogenous abscisic acid(ABA). In yeast, we found OfEXLA1overexpression significantly improved the population of cells compared with wild-type strains after NaCl and polyethylene glycol(PEG)treatment. Additionally, OfEXLA1 overexpression not only promoted plant growth, but also improved the salt and drought tolerance in Arabidopsis. To gain insight into the role of ABA signaling in the regulation of OfEXLA1 improving abiotic tolerance in sweet osmanthus, four differentially expressed ABA Insensitive 5(ABI5)-like genes(OfABL4, OfABL5, OfABL7, and OfABL8) were identified from transcriptome, and dualluciferase(dual-LUC) and yeast one hybrid(Y1H) assay showed that OfABL4 and OfABL5 might bind to OfEXLA1 promoter to accumulate the OfEXLA1 expression by responding to ABA signaling to improve abiotic tolerance in sweet osmanthus. These results provide the information for understanding the molecular functions of expansin-like A gene and molecular breeding of sweet osmanthus in future.

关键词： Osmanthus fragrans Abiotic tolerance Expansin Abscisic acid

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Substitutions of stem-loop subdomains in internal ribosome entry site of Senecavirus A:Impacts on rescue of sequence-modifying viruses

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Journal of Integrative Agriculture 2024年第7期23卷 2391-2406页

作者： qianqian wang Jie wang Lei Zhang Xiaoxiao Duan Lijie Zhu Youming Zhang Yan Li Fuxiao Liu College of Veterinary Medicine Qingdao Agricultural UniversityQingdao 266109China College of Veterinary Medicine Inner Mongolia Agricultural UniversityHuhhot 010018China Shandong New Hope Liuhe Group Co. Ltd.Qingdao 266100China Qingdao Center for Animal Disease Control&Prevention Qingdao 266199China State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China

Senecavirus A(SVA)has a positive-sense,single-stranded RNA genome.Its 5´untranslated region harbors an internal ribosome entry site(IRES),comprising 10 larger or smaller stem-loop structures(including a pseudoknot)that have been demonstrated to be well conserved.However,it is still unclear whether each stem-loop subdomain,such as a single stem or loop,is also highly conserved.To clarify this issue in the present study,a set of 29 SVA cDNA clones were constructed by site-directed mutagenesis(SDM)on the IRES.The SDM-modified scenarios included:(1)stem-formed complementary sequences exchanging with each other;(2)loop transversion;(3)loop transition;and(4)point mutations.All cDNA clones were separately transfected into cells for rescuing viable viruses,whereas only four SVAs of interest could be recovered,and were genetically stable during 20 passages.One progeny grew significantly slower than the other three did.The dual-luciferase reporter assay showed that none of the SDM-modified IRESes significantly inhibited the IRES activity.Our previous study indicated that a single motif from any of the ten stem structures,if completely mutated,would cause the failure of virus recovery.Interestingly,our present study revealed three stem structures,whose individual complementary sequences could exchange with each other to rescue sequence-modifying SVAs.Moreover,one apical loop was demonstrated to have the ability to tolerate its own full-length transition,also having no impact on the recovery of sequence-modifying SVA.The present study suggested that not every stem-loop structure was strictly conserved in its conformation,while the full-length IRES itself was well conserved.This provides a new research direction on interaction between the IRES and many factors.

关键词： SVA HCV IRES HCV-like IRES stem-loop structure cDNA clone virus rescue mutation

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Strong electron correlation-induced Mott-insulating electrides of Ae_(5)X_(3)(Ae=Ca,Sr,and Ba;X=As and Sb)

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Matter and Radiation at Extremes 2024年第3期9卷 74-82页

作者： Ya Xu Lu Zheng Yunkun Zhang Zhuangfei Zhang qianqian wang Yuewen Zhang Liangchao Chen Chao Fang Biao Wan Huiyang Gou Key Laboratory of Material Physics of Ministry of Education School of Physics and Laboratory of Zhongyuan LightZhengzhou UniversityZhengzhou 450052China School of Mechanical and Equipment Engineering Hebei University of EngineeringHandan 056038China Center for High Pressure Science and Technology Advanced Research Beijing 100094China

The presence of interstitial electrons in electrides endows them with interesting attributes,such as low work function,high carrier concentration,and unique magnetic properties.Thorough knowledge and understanding of electrides are thus of both scientific and technological significance.Here,we employ first-principles calculations to investigate Mott-insulating Ae_(5)X_(3)(Ae=Ca,Sr,and Ba;X=As and Sb)electrides with Mn_(5)Si_(3)-type structure,in which half-filled interstitial electrons serve as ions and are spin-polarized.The Mott-insulating property is induced by strong electron correlation between the nearest interstitial electrons,resulting in spin splitting and a separation between occupied and unoccupied states.The half-filled antiferromagnetic configuration and localization of the interstitial electrons are critical for the Mott-insulating properties of these materials.Compared with that in intermetallic electrides,the orbital hybridization between the half-filled interstitial electrons and the surrounding atoms is weak,leading to highly localized magnetic centers and pronounced correlation effects.Therefore,the Mott-insulating electrides Ae_(5)X_(3)have very large indirect bandgaps(0.30 eV).In addition,high pressure is found to strengthen the strong correlation effects and enlarge the bandgap.The present results provide a deeper understanding of the formation mechanism of Mott-insulating electrides and provide guidance for the search for new strongly correlated electrides.

关键词： intermetallic filled occupied

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CARD11 serves as a therapeutic biomarker for the drug therapies of ccRCC

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BIOCELL 2024年第5期48卷 817-834页

作者： KAIWEN TIAN HANZHONG CHEN qianqian wang FENGLIAN JIANG CHUNXIANG FENG TENG LI XIAOYONG PU YANLIN TANG JIUMIN LIU Department of Urology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510080China

Background:The incidence of clear cell renal cell carcinoma(ccRCC)is globally high;however,despite the introduction of innovative drug therapies,there remains a lack of effective biomarkers for evaluating treatment response.Recently,Caspase recruiting domain-containing protein 11(CARD11)has garnered attention due to its significant association with tumor development and the immune system.Methods:The expression of CARD11 mRNA and protein in ccRCC were analyzed by public database and immunohistochemistry.The focus of this study is on the epigenomic modifications of CARD11,its expression of ccRCC immunophenotype,and its correlation with response to immunotherapy and targeted therapy.Furthermore,to investigate the mechanism of this molecule’s influence on different biological behaviors of cells,cell tests in vitro have been conducted to observe the impact of its expression level.Results:CARD11 expression was upregulated which may be mainly modified by body methylation and was correlated with poor prognosis in ccRCC.In the tumor microenvironment of ccRCC,CARD11 expression was positively correlated with increased T lymphocyte infiltration and increased expression of inhibitory immune checkpoints.Moreover,ccRCC patients with high CARD11 expression had a better response to immunotherapy and targeted therapy.The knockdown of CARD11 ultimately suppressed the proliferation,migration,and invasion capabilities of ccRCC cells while simultaneously enhancing tumor cell apoptosis.Conclusion:We identified CARD11 as a novel therapeutic biomarker for immunotherapy and targeted therapy in ccRCC.

关键词： Clear cell renal cell carcinoma Tumor microenvironment CARD11 Immune checkpoint inhibitor Tyrosine kinase inhibitor

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Notum protects against myocardial infarction-induced heart dysfunction by alleviating cardiac fibrosis

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Frigid Zone Medicine 2024年第1期4卷 41-50页

作者： Tongzhu Jin Zhen Ye Ruonan Fang Yue Li Wei Su qianqian wang Tianyu Li Hongli Shan Yanjie Lu Haihai Liang Laboratory of Frigid Zone Cardiovascular Diseases(SKLFZCD) Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China Department of Pharmacy Suqian First HospitalSuqian 223800China Research Unit of Noninfectious Chronic Diseases in Frigid Zone(2019RU070) Chinese Academy of Medical SciencesHarbin 150081China

Background and Objective:Cardiac fibrosis is a pathological reparative process that follows myocardial infarctionand is associated with compromised cardiac systolic and reduced cardiac compliance.The Wnt signaling pathway is closely implicated in organ fibrosis,and Notum,a highly conserved secreted inhibitor,modulates Wnt signaling.The objective of this study was to explore the role and mechanism of Notum in cardiac fibrosis.Methods:A mouse model of cardiac remodeling was established through left coronary artery ligation surgery,with the addition of Notum injection following myocardial infarction surgery.The protective effect of Notum on myocardial infarction was assessed by evaluating cardiac function,including survival rate,echocardiographic assessment,and cardiac contraction analyses.Inflammatory cell necrosis and infiltration were confirmed through H&E and Masson staining.The expression of fibrosis-related genes andβ-catenin pathway markers was detected using Western blot quantificational RT-PCR(qRT-PCR).Additionally,EdU,wound healing,and immunofluorescence staining analyses were performed to detect the effect of Notum's in transforming growth factor beta-1(TGF-β1)induced myofibroblast transformation.Results:The administration of Notum treatment resulted in enhanced survival rates,improved cardiac function,and decreased necrosis and infiltration of inflammatory cells in mice subjected to left coronary artery ligation.Furthermore,Notum effectively impeded the senescence of cardiac fibroblasts and hindered their pathological transformation into cardiac fibroblasts.Additionally,it significantly reduced collagen production and attenuated the activation of the Wnt/β-catenin pathway.Our preliminary investigations successfully demonstrated the therapeutic potential of Notum in both fibroblasts in vitro and in a mouse model of myocardial infarction-induced cardiac fibrosis in vivo.Conclusion:Notum inhibition of the Wnt/β-catenin signaling pathway and cardiac fibroblast senescence ultimately hampers the onset of cardi

关键词： cardiac fibrosis Notum Wnt/β-catenin senescence myocardial infarction

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Enhanced high-temperature strength of HfNbTaTiZrV refractory high-entropy alloy via Al_(2)O_(3)reinforcement

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Journal of Materials Science & Technology 2022年第28期123卷 191-200页

作者： Bingjie wang qianqian wang Nan Lu Xiubing Liang Baolong Shen School of Materials Science and Engineering Jiangsu Key Laboratory for Advanced Metallic MaterialsSoutheast UniversityNanjing 211189China School of Materials Science and Engineering Jiangsu Key Laboratory of Advanced Structural Materials and Application TechnologyNanjing Institute of TechnologyNanjing 211167China Defense Innovation Institute Academy of Military ScienceBeijing 100071China

Novel composites of HfNbTaTiZrV refractory high-entropy alloy(RHEA)reinforced with 0–4 vol.%Al_(2)O_(3)particles have been synthesized by vacuum arc melting.The microstructure evolution,compressive mechanical properties at room and elevated temperatures,as well as strengthening mechanism of the composites were analyzed.The HfNbTaTiZrV RHEA reinforced with 4 vol.%Al_(2)O_(3)displayed excellent phase stability at elevated temperatures.A superior compressive yield strength of 2700 MPa at room temperature,1392 MPa at 800°C,and 693 MPa at 1000°C was obtained for this composite.The improved yield strength resulted from multiple strengthening mechanisms caused by Al_(2)O_(3)addition,including solution strengthening,interstitial strengthening,grain boundary strengthening,and dispersion strengthening.Besides,the effects of interstitial strengthening increased with temperature and was the main strengthening mechanism at elevated temperatures.These findings not only promote the development of oxidereinforced RHEAs for challenging engineering applications but also provide guidelines for the design of light refractory materials with multiple strengthening mechanisms.

关键词： Al_(2)O_(3)-reinforcement HfNbTaTiZrV Refractory high-entropy alloy Interstitial strengthening

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Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage, inhibiting ATM/SOG1-mediated DNA damage response,and antagonizing global DNA hypermethylation

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Journal of Integrative Plant Biology 2022年第1期64卷 87-104页

作者： qianqian wang Yumei La Huihui Xia Shaoxia Zhou Zhaoyu Zhai Honggui La College of Life Sciences Nanjing Agricultural UniversityNanjig 210095China College of Plant Protection Nanjing Agricultural UniversityNanjig 210095China College of Artificial Intelligence Nanjing Agricultural UniversityNanjig 210095China

Arabidopsis methylation elevated mutant 1(mem1)mutants have elevated levels of global DNA methylation. In this study, such mutant alleles showed increased sensitivity to methyl methanesulfonate(MMS). In mem1 mutants, an assortment of genes engaged in DNA damage response(DDR), especially DNA-repair-associated genes, were largely upregulated without MMS treatment, suggestive of activation of the DDR pathway in them. Following MMS treatment, expression levels of multiple DNArepair-associated genes in mem1 mutants were generally lower than in Col-0 plants, whichaccounted for the MMS-sensitive phenotype of the mem1 mutants. A group of DNA methylation pathway genes were upregulated in mem1 mutants under non-MMS-treated conditions, causing elevated global DNA methylation, especially in RNAdirected DNA methylation(Rd DM)-targeted regions.Moreover, MEM1 seemed to help ATAXIATELANGIECTASIA MUTATED(ATM) and/or SUPPRESSOR OF GAMMA RESPONSE 1(SOG1) to fully activate/suppress transcription of a subset of genes regulated simultaneously by MEM1 and ATM and/or SOG1, because expression of such genes decreased/increased consistently in mem1 and atm and/or sog1 mutants, but the decreases/increases in the mem1 mutants were not as dramatic as in the atm and/or sog1 mutants. Thus, our studies reveals roles of MEM1 in safeguarding genome, and interrelationships among DNA damage, activation of DDR, DNA methylation/demethylation, and DNA repair.

关键词： ATM cell death DDR DNA demethylation DNA methylation DNA repair MEM1 MMS SOG1 ROS1

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Nitride-reinforced HfNbTaTiV high-entropy alloy with excellent room and elevated-temperature mechanical properties

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Journal of Materials Science & Technology 2023年第18期149卷 31-41页

作者： Bingjie wang qianqian wang Bo Sun Jinyong Mo Yangbin Guo Xiubing Liang Baolong Shen School of Materials Science and Engineering Jiangsu Key Laboratory for Advanced Metallic MaterialsSoutheast UniversityNanjing 211189China School of Materials Science and Engineering Jiangsu Key Laboratory of Advanced Structural Materials and Application TechnologyNanjing Institute of TechnologyNanjing 211167China Defense Innovation Institute Academy of Military ScienceBeijing 100071China

Nitride-reinforced(HfNbTaTiV)_(90)N_(10) high-entropy alloy aiming at high-temperature applications is de-signed in this paper.Abundant FCC nitride phases are formed in situ in theBCC matrix by arc melt-ing technique,without complex deformation or heat treatment.The(HfNbTaTiV)_(90)N_(10) alloy exhibits a remarkable yield strength of 2716 MPa and ultimate compressive strength of 2833 MPa with a plas-tic strain of 10%at room temperature.Besides,the alloy remains a high yield strength of 279 MPa at 1400℃.The nitride phases play an essential role in maintaining the excellent strength-ductility com-bination at room temperature and enhancing the high-temperature softening resistance.Alternating BCC and FCC phases possess the semi-coherent interface,which not only strengthens the BCC matrix but also promotes the compatible deformation of the duplex microstructure.The lattice coherency structure of the semi-coherent interface is conducive to the slip transfer of partial dislocations through the interface,which facilitates the accommodation of plastic deformation.The cross-slip of the screw dislocations ef-fectively eliminates stress concentration and leads to good ductility of the dual-phase alloy.The results demonstrate that the nitride phases achieve coordinate deformation with the matrix without deteriorat-ing the ductility of the(HfNbTaTiV)_(90)N_(10) alloy.

关键词： Nitride-reinforced High-entropy alloy Softening resistance Strength-ductility balance Semi-coherent interface

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