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铁死亡相关基因GLS2在泛癌中的预后及免疫价值

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肿瘤防治研究 2024年第3期51卷 169-177页

作者：潘月眉孙之赵倩倩胡雪雪王传玺山东大学济南250021 山东省立医院肿瘤放疗科济南250021 山东第一医科大学附属省立医院医学影像科济南250021 山东第一医科大学附属省立医院肿瘤放疗科济南250021

目的基于生物信息学方法评估铁死亡相关基因GLS2在泛癌中对预后及免疫的相关作用。方法采用癌症基因组图谱(TCGA)、GTEx、癌症细胞系百科全书(CCLE)及国际癌症基因组联盟(ICGC)等在线数据库进行GLS2基因泛癌分析,从基因表达、基因突变... 详细信息

目的基于生物信息学方法评估铁死亡相关基因GLS2在泛癌中对预后及免疫的相关作用。方法采用癌症基因组图谱(TCGA)、GTEx、癌症细胞系百科全书(CCLE)及国际癌症基因组联盟(ICGC)等在线数据库进行GLS2基因泛癌分析,从基因表达、基因突变、生存分析、免疫浸润、免疫检查点相关基因和TMB及MSI等多个方面挖掘GLS2基因在不同肿瘤中的作用。结果GLS2在大多数癌组织与癌旁组织的表达具有显著差异,并且该表达与这些癌症的预后相关。在多种癌症中,GLS2的表达与免疫细胞浸润之间存在正相关关系,并与免疫检查点相关基因有关。GLS2还与TMB、MSI和甲基化呈正相关,其表达与可能的治疗反应具有一定关系。结论通过对铁死亡相关基因GLS2的泛癌分析表明,GLS2的表达可能作为肾透明细胞癌、肾上腺皮质癌、肺腺癌、胰腺癌诊断及预后的重要标志物。

关键词：铁死亡 GLS2 泛癌预后免疫

Predicting complexation performance between cyclodextrins and guest molecules by integrated machine learning and molecular modeling techniques

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Acta Pharmaceutica Sinica B 2019年第6期9卷 1241-1252页

作者： qianqian zhao Zhuyifan Ye Yan Su Defang Ouyang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacaoChina

Most pharmaceutical formulation developments are complex and ideal formulations are generally obtained after extensive *** learning is increasingly advancing many aspects in modern society and has achieved significant success in multiple *** research demonstrated that machine learning can be adopted to build up high-accurate predictive models in drugs/cyclodextrins(CDs)*** descriptors of compounds and experimental conditions were employed as inputs,while complexation free energy as *** showed that the light gradient boosting machine provided significantly improved predictive performance over random forest and deep *** mean absolute error was 1.38 kJ/mol and squared correlation coefficient *** evaluation of relative importance of molecular descriptors further demonstrated the key factors affecting molecular interactions in drugs/CD *** the specific ketoprofen-CD systems,machine learning model showed better predictive performance than molecular modeling calculation,while molecular simulation could provide structural,dynamic and energetic *** integration of machine learning and molecular simulation could produce synergistic effect for interpreting and predicting pharmaceutical *** conclusion,the developed predictive models were able to quickly and accurately predict the solubilizing capacity of CD *** research has taken an important step toward the application of machine learning in pharmaceutical formulation design.

关键词： Machine learning Deep learning LightGBM Random forest Cyclodextrin Binding free energy Molecular modeling Ketoprofen

伏马毒素B_(1)对棉铃虫生长发育、解毒酶系和抗氧化酶系的影响

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中国生物防治学报 2024年第3期40卷 600-607页

作者：肖宏丽杨南赵倩倩庞民好唐博文刘颖超河北农业大学植物保护学院保定071000

玉米耕作模式的转变,使伏马毒素B_(1)成为棉铃虫需要面对的新环境因素。为明确棉铃虫对这种新环境因素的适应机制,本研究测定了饲喂伏马毒素B_(1)后棉铃虫的生长发育情况及体内解毒酶、抗氧化酶活性。自棉铃虫3龄幼虫连续摄入伏马毒素B_... 详细信息

玉米耕作模式的转变,使伏马毒素B_(1)成为棉铃虫需要面对的新环境因素。为明确棉铃虫对这种新环境因素的适应机制,本研究测定了饲喂伏马毒素B_(1)后棉铃虫的生长发育情况及体内解毒酶、抗氧化酶活性。自棉铃虫3龄幼虫连续摄入伏马毒素B_(1)后,幼虫期7 d体质量增长量、产卵量及孵化率较对照组有不同程度的降低,棉铃虫化蛹之前的发育历期较对照组缩短,而蛹期却延长。不同浓度的伏马毒素B_(1)胁迫不同时间后棉铃虫体内酯酶的活性均显著升高,细胞色素P450和谷胱甘肽S-转移酶的活性有不同程度的变化;抗氧化酶系中,过氧化氢酶和超氧化物歧化酶活性在伏马毒素B_(1)胁迫1 d时较对照组均显著升高,过氧化物酶活性仅在高剂量处理5 d时显著升高。棉铃虫伏马毒素B_(1)耐受品系中羧酸酯酶、过氧化氢酶、过氧化物酶活性较敏感品系显著升高,分别上升75.40%、50.74%、117.21%。综上,摄入伏马毒素B_(1)后棉铃虫的生长发育受到影响,棉铃虫通过激活酯酶、过氧化氢酶、过氧化物酶等应对伏马毒素B1的胁迫。

关键词：棉铃虫伏马毒素B_(1) 生长发育解毒酶抗氧化酶

Resveratrol alleviates oxidative stress induced by oxidized soybean oil and improves gut function via changing gut microbiota in weaned piglets

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1639-1660页

作者： Yanan Gao Qingwei Meng Jianwei Qin qianqian zhao Baoming Shi College of Animal Science and Technology Northeast Agricultural UniversityNo.600 Changjiang RoadXiangfang DistrictHarbinChina

Background Oxidized soybean oil(OSO)has been shown to impair growth and exacerbate inflammation,leading to intestinal barrier injury in *** evidence suggests important roles for resveratrol(RES)in the promoting growth performance,antioxidant capacity,anti-inflammatory,and regulate intestinal barriers in ***,The objectives of this study are to investigate the effects of dietary RES(purity 98%)supplementation on the growth performance,antioxidant capacity,inflammatory state,and intestinal function of weaned piglets challenged with *** A total of 28 castrated weaned male piglets with a similar body weight of 10.197 replications per treatment and±0.10 kg were randomly assigned to 4 dietary treatments for 28-d feeding trial with 1 piglet per *** were arranged as a 2×2 factorial with oil type[3%fresh soybean oil(FSO)vs.3%OSO]and dietary RES(0vs.300 mg/kg).Results The results showed that relative to the FSO group,OSO stress tended to decrease the average daily feed intake(ADFI),and decreased the activity levels of lipase,villus/crypt ratio(VCR),the mRNA expression of FABP1,SOD2,IL-10 and ZO-1 in the jejunum,and SOD2,GPX1,occludin and ZO-1 in the colon,the levels of acetic acid in the colonic digesta,whereas up-regulated the mRNA expression of IL-1βand TNF-αin the jejunum(P<0.05).Moreover,dietary supplementation with RES increased ether extract(EE),the activity levels of sucrase,lipase,α-amylase,villus height(VH)and VCR,the mRNA expression of FABP1,SOD2,IL-10 and occludin in the jejunum,and FABP1,PPAR-γ,GPX1,occludin and ZO-1 in the colon,and the abundance of Firmicutes,acetic and propionic acid,but decreased the levels of D-lactic acid in the plasma,the abundance of Bacteroidetes in the colonic digesta of weaned piglets compared to the non-RES group(P<0.05).Meanwhile,in the interaction effect analysis,relative to the OSO group,dietary RES supplementation in the diets supplemented with OSO increased the activity levels of tr

关键词： Inflammation Intestinal barrier Intestinal health Oxidative stress Oxidized soybean oil Piglets Resveratrol

Investigation of molecular aggregation mechanism of glipizide/cyclodextrin complexation by combined experimental and molecular modeling approaches

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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 609-620页

作者： Tianhe Huang qianqian zhao Yan Su Defang Ouyang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences (ICMS) University of Macao

Cyclodextrin complexation is a wise strategy to enhance aqueous solubility of waterinsoluble ***,the aggregation mechanism of drug-cyclodextrin complexes is still *** research aimed to investigate the molecular aggregation mechanism of glipizide/cyclodextrin complexation by the combination of experimental and modeling *** free energies between glipizide and cyclodextrins from modeling calculations were higher than those by the phase solubility diagram *** experimental and modeling results showed that methylated-β-cyclodextrin exhibited the best solubilizing capability to ***-measurement results confirmed the aggregation between glipizide and all four cyclodextrins in high ***/γ-cyclodextrin and glipizide/β-cyclodextrin complexes showed stronger aggregation trend than HP-β-cyclodextrin and methylated-β-*** substituted groups in the rim of HP-β-cyclodextrin and methylated-β-cyclodextrin lead to weak *** research provided us a clear molecular mechanism of glipizide/cyclodextrin complexation and *** research will also benefit the formulation development of cyclodextrin solubilization.

关键词： Glipizide Cyclodextrin Molecular modeling Aggregation Molecular mechanism

铅芯橡胶隔震支座与黏滞阻尼器在某高位连体结构中的应用研究

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建筑结构 2024年第5期54卷 51-57,78页

作者：杜鹏牛四欣王传芳蒋世林高斌赵倩倩同圆设计集团股份有限公司济南250100

一项目两栋塔楼通过高位钢连廊连接为双塔连体结构,该项目采用了铅芯橡胶隔震支座与黏滞阻尼器的柔性支座连接方案。详细介绍了柔性支座连接方案的设计要点,并建立了考虑钢连廊与塔楼相互作用的高位连体结构整体计算模型。采用YJK软件... 详细信息

一项目两栋塔楼通过高位钢连廊连接为双塔连体结构,该项目采用了铅芯橡胶隔震支座与黏滞阻尼器的柔性支座连接方案。详细介绍了柔性支座连接方案的设计要点,并建立了考虑钢连廊与塔楼相互作用的高位连体结构整体计算模型。采用YJK软件对高位连体结构进行了风荷载和小震作用下的计算分析,并采用SAUSAGE分析软件进行了罕遇地震作用下的弹塑性时程分析,分析了铅芯橡胶隔震支座和黏滞阻尼器的非线性地震响应。分析结果表明,在风荷载和小震作用下,铅芯橡胶隔震支座均处于弹性工作状态;在罕遇地震作用下,铅芯橡胶隔震支座产生屈服变形并耗能,最大剪切变形值在规范允许范围内,黏滞阻尼器滞回曲线饱满,出力明显;此外柔性支座连接方案减弱了高位钢连廊对主体结构的影响,按各塔楼进行独立设计并局部采取加强措施能够满足实际工程要求,而且能够降低主体结构设计难度。

关键词：高位钢连廊连体结构柔性连接铅芯橡胶隔震支座黏滞阻尼器动力弹塑性分析

Energy Efficiency in Internet of Things:An Overview

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Computers, Materials & Continua 2020年第5期63卷 787-811页

作者： Wuxiong Zhang Weidong Fang qianqian zhao Xiaohong Ji Guoqing Jia Key Laboratory of Wireless Sensor Network&Communication Shanghai Institute of Micro-System and Information TechnologyChinese Academy of SciencesShanghai201899China Shanghai Research Center for Wireless Communication Shanghai201210China College of Physics and Electronic Information Engineering Qinghai University for NationalitiesXining810007China

Energy efficiency is very important for the Internet of Things(IoT),especially for front-end sensed terminal or *** not only embodies the node’s life,but also reflects the lifetime of the ***,it is also a key indicator of green ***,there is no article on systematic analysis and review for energy efficiency evaluation in *** this paper,we systemically analyze the architecture of IoT,and point out its energy distribution,Furthermore,we summarized the energy consumption model in IoT,analyzed the pros and cons of improving energy efficiency,presented a state of the art the evaluation metrics of energy ***,we conclude the techniques and methods,and carry out a few open research issues and directions in this field.

关键词： Internet of things wireless sensor network energy efficiency energy consumption model

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医用超声探头及耦合剂微生物污染的研究现状

中国当代医药 2024年第15期31卷 194-198页

作者：王金晓王芳赵倩倩赵青青滨州医学院附属医院特需·国际医学部病区山东滨州256603 滨州医学院附属医院消化内科二病区山东滨州256603

随着超声医学技术的发展,超声检查技术被越来越多地应用于临床,在多系统疾病的筛查、诊断和治疗中起到尤为重要的作用。超声技术在急诊超声、重症超声中发展迅速,同时还应用于肺部疾病、妇幼儿科疾病诊疗,颅内压检测、心排血量检测,还... 详细信息

随着超声医学技术的发展,超声检查技术被越来越多地应用于临床,在多系统疾病的筛查、诊断和治疗中起到尤为重要的作用。超声技术在急诊超声、重症超声中发展迅速,同时还应用于肺部疾病、妇幼儿科疾病诊疗,颅内压检测、心排血量检测,还可以改变手术形式,使手术方式更加简便。还与数字剪影血管造影相结合治疗急性脑出血、引导经外周静脉穿刺置管术、肿瘤学中阴道消融术等,在众多系统疾病中广泛应用。在极大程度上减轻了患者痛苦,缩短了患者平均住院日,减轻了患者经济及心理压力。与此同时,超声检查技术的发展也使医学发展面临一定问题。由医学超声检查技术引起的相关院内感染时有发生。超声探头及超声耦合剂的使用成为超声检查相关院内感染发生的重要影响因素。因此,本文对将医用超声探头进行消毒处理、正确选择医用超声耦合剂展开综述。

关键词：医用超声探头医用超声耦合剂微生物污染感染防控

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阿尔茨海默病护理的研究进展

中国当代医药 2024年第12期31卷 190-194页

作者：王金晓赵倩倩赵青青王芳滨州医学院附属医院特需·国际医学部病区山东滨州256603 滨州医学院附属医院消化内科二病区山东滨州256603

随着人口老龄化问题的日趋严重,威胁老年人健康的各种问题也日趋增多。阿尔茨海默病作为老年人健康的一大杀手威胁着老年人的生命安全,且病因未明,患病后难以逆转,这给患者及其家庭带来极大的心理、经济及生活负担。因此,为改善阿尔茨... 详细信息

随着人口老龄化问题的日趋严重,威胁老年人健康的各种问题也日趋增多。阿尔茨海默病作为老年人健康的一大杀手威胁着老年人的生命安全,且病因未明,患病后难以逆转,这给患者及其家庭带来极大的心理、经济及生活负担。因此,为改善阿尔茨海默病患者的生活质量,减轻患者及家属的经济压力,向患者家属提供适宜的生活照护方式,便捷的生活环境,实用的多样化的认知锻炼方式,本文就阿尔茨海默病患者专业化、全面化的评估方法及诊断方法,多样化的认知功能锻炼,安静、舒适、便捷的生活环境,各理论模式、药物性、非药物性及以新型护理技术为基础的护理方式展开综述,以期指导临床护理工作、给予患者家属帮助,更好地护理患者,减轻疾病对患者造成的不良影响。

关键词：阿尔茨海默病康养措施护理措施研究进展