检索结果-南通市图书馆

高浓度低流速对比剂联合低管电压方案行腹部CT血管成像的可行性

在线全文

学校读者我要写书评

暂无评论

中国临床解剖学杂志 2024年第1期42卷 99-103页

作者：周伟石倩倩李盖陈伟彬华北理工大学附属医院CT室河北唐山063000 沧州市中西医结合医院医学影像科河北沧州061001

目的探讨腹主动脉CTA应用高浓度、低流速对比剂注射联合低管电压方案的可行性。方法前瞻性收集430例行腹主动脉CA患者,分为A组(215例)和B组(215例),A组采用碘帕醇(370mgI/mL),剂量400 mgI/kg,流速5 mL/s,管电压120 kV,B组采用碘美普尔(4... 详细信息

目的探讨腹主动脉CTA应用高浓度、低流速对比剂注射联合低管电压方案的可行性。方法前瞻性收集430例行腹主动脉CA患者,分为A组(215例)和B组(215例),A组采用碘帕醇(370mgI/mL),剂量400 mgI/kg,流速5 mL/s,管电压120 kV,B组采用碘美普尔(400 mgI/mL),剂量300 mgI/kg,流速4 mL/s,管电压100 kV。比较两组患者图像质量、腹主动脉及分支的CT值,以及有效辐射剂量等指标。结果与A组比较,B组患者肾动脉显示分级及图像质量评分更优,腹主动脉、腹腔干、肠系膜上下动脉及左右肾动脉CT值更高,辐射剂量明显降低(3.94±0.62)vs(12.25±1.19)mSv,注射碘总量更少,对比剂外渗发生率更低,均P0.05)。结论高浓度低流速对比剂联合低管电压方案可有效降低辐射剂量、注射碘总量及对比剂外渗等风险。

关键词：腹主动脉腹部 CT血管成像对比剂

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

风险投资与企业创新链:作用机理及经济后果

统计研究 2024年第3期41卷 88-99页

作者：杨松令吕紫薇刘亭立石倩倩北京工业大学经济与管理学院

本文将企业创新链分为投入端、产出端和收益端,以2010—2022年新三板企业数据为样本,采用PSM-DID模型研究风险投资(VC)驱动企业创新链的作用机理及其经济后果。研究结果表明,VC介入能够促进企业创新链各端发展。机制分析发现,VC通过在... 详细信息

本文将企业创新链分为投入端、产出端和收益端,以2010—2022年新三板企业数据为样本,采用PSM-DID模型研究风险投资(VC)驱动企业创新链的作用机理及其经济后果。研究结果表明,VC介入能够促进企业创新链各端发展。机制分析发现,VC通过在企业创新链投入端的引智功能促进其产出端的提升,进而推动其收益端的增长;VC的引资功能则表现出显著的行业异质性,在战略性新兴产业中,VC引资能够促进其产出端和收益端增长,而在非战略性新兴产业中存在渠道阻塞。此外,经济政策不确定性在VC介入与企业创新链发展中呈现调节效应。经济后果的分析表明,VC通过驱动企业创新链的发展,推动企业实现“登陆新三板—上市至北京证券交易所—转板至沪深交易所”的发展路径。本文研究对于推动企业科技与资本的结合,助力多层次资本市场发展,优化创新链与产业链具有重要意义。

关键词：风险投资企业创新链战略性新兴产业北京证券交易所

在线全文

学校读者我要写书评

暂无评论

综合能源系统低碳规划与运行研究述评

高电压技术 2024年第3期50卷 1053-1066页

作者：宋晓通师芊芊巨云涛葛怀畅张佳惠卢艺玮于坤禹北方工业大学电气与控制工程学院北京100144 山西省能源互联网研究院太原030000

为提高综合能源系统(integrated energy system, IES)低碳规划及优化运行的技术水平,推进能源结构低碳转型及新型电力系统建设,梳理和总结研究学者在IES的模型构建、系统规划、运行调度等方面的研究成果,该文开展了相关领域的综述研究... 详细信息

为提高综合能源系统(integrated energy system, IES)低碳规划及优化运行的技术水平,推进能源结构低碳转型及新型电力系统建设,梳理和总结研究学者在IES的模型构建、系统规划、运行调度等方面的研究成果,该文开展了相关领域的综述研究。首先,阐述了综合能源系统的典型架构、典型设备及其能流特性。其次,针对IES低碳规划和运行策略及其相关支撑技术,分别论述了多态不确定性模型及功率预测、柔性负荷调控策略、IES参与电力辅助服务及其低碳运营机制、优化模型及其求解算法等方面的技术路线及研究成果;研究表明,规划与运行策略是支撑IES低碳、高效、经济运行水平的关键技术,计及不确定性的高维、非线性、多目标、非凸问题的精确建模和快速求解等难点问题亟待深入研究。最后,展望了人工智能、大数据、电力物联网等新技术在IES低碳规划和运行方面的应用前景,归纳了该领域亟待应对的技术挑战和关键问题。

关键词：综合能源系统低碳规划低碳运行柔性负荷低碳运营机制电力辅助服务

在线全文

学校读者我要写书评

暂无评论

考虑产品绿色度的闭环供应链联盟决策

物流科技 2024年第3期47卷 134-140页

作者：张远芳时倩倩江南大学商学院江苏无锡214122

在闭环供应链中,选择合适的联盟可以帮助制造商更好地从事绿色产品制造活动。针对考虑产品绿色度的供应链联盟问题,文章利用博弈分析技术,分析集中决策(C模型)、分散决策(D模型)、制造商与零售商联盟(MR模型)和制造商与第三方回收商联盟... 详细信息

在闭环供应链中,选择合适的联盟可以帮助制造商更好地从事绿色产品制造活动。针对考虑产品绿色度的供应链联盟问题,文章利用博弈分析技术,分析集中决策(C模型)、分散决策(D模型)、制造商与零售商联盟(MR模型)和制造商与第三方回收商联盟(MC模型)等4种模型下的闭环供应链的最优决策问题,并比较分析不同模型下的最优解。最后,通过算例仿真分析了绿色偏好系数和研发成本投入系数对决策中的最优解的影响。结果发现,集中决策模型下的联盟最优,而制造商与零售商联盟优于与第三方回收商联盟。

关键词：绿色度研发成本投入闭环供应链联盟决策

Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion and metastasis

在线全文

学校读者我要写书评

暂无评论

Frontiers of Medicine 2021年第5期15卷 649-656页

作者： Jingyue Zhang Yawen Song qianqian shi Li Fu Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Breast Cancer Prevention and TherapyTianjin Medical universityMinistry of EducationTianjin 300060China

Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism,which is manifested by increased endogenous fat mobilization,hypertriglyceridemia,and increased fatty acid *** acid synthase(FASN)is a key enzyme for the de novo synthesis of fatty acids,and monoacylglycerol esterase(MGLL)is an important metabolic enzyme that converts triglycerides into free fatty *** enzymes play an important role in lipid metabolism and are associated with tumor-related signaling pathways,the most common of which is the PI3K–AKT signaling *** can also regulate the immune microenvironment,participate in epithelial–mesenchymal transition,and then regulate tumor invasion and *** literature have shown that these two genes are abnormally expressed in many types of tumors and are highly correlated with tumor migration and *** article introduces the structures and functions of FASN and MGLL,their relationship with abnormal lipid metabolism,and the mechanism of the regulation of tumor invasion and metastasis and reviews the research progress of the relationship of FASN and MGLL with tumor invasion and metastasis.

关键词： FASN MGLL lipid metabolism tumor invasion metastasis

Differential function analysis: identifying structure and activation variations in dysregulated pathways

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2017年第1期60卷 116-131页

作者： Chuanchao ZHANG Juan LIU qianqian shi Tao ZENG Luonan CHEN State Key Laboratory of Software Engineering School of Computer Wuhan University Key Laboratory of Systems Biology Innovation Center for Cell Signaling Network Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

Complex diseases are generally caused by the dysregulation of biological functions rather than individual molecules. Hence, a major challenge of the systematical study on complex diseases is how to capture the differentially regulated biological functions, e.g., pathways. The traditional differential expression analysis(DEA) usually considers the changed expression values of genes rather than functions. Meanwhile, the conventional function-based analysis(e.g., PEA: pathway enrichment analysis) mainly considers the varying activation of functions but disregards the structure change of genetic elements of functions. To achieve precision medicine against complex diseases, it is necessary to distinguish both the changes of functions and their elements from heterogeneous dysregulated pathways during the disease development and progression. In this work, in contrast to the traditional DEA, we developed a new computational framework, namely differential function analysis(DFA), to identify the changes of element-structure and expression-activation of biological functions, based on comparative non-negative matrix factorization(cN MF). To validate the effectiveness of our method, we tested DFA on various datasets, which shows that DFA is able to effectively recover the differential element-structure and differential activation-score of pre-set functional groups. In particular, the analysis of DFA on human gastric cancer dataset, not only capture the changed network-structure of pathways associated with gastric cancer, but also detect the differential activations of these pathways(i.e., significantly discriminating normal samples and disease samples), which is more effective than the state-of-the-art methods, such as GSVA and Pathifier. Totally,DFA is a general framework to capture the systematical changes of genes, networks and functions of complex diseases, which not only provides the new insight on the simultaneous alterations of pathway genes and pathway activations, but a

关键词： complex disease biological function non-negative matrix factorization network structure function activation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

人格特质对航线飞行员安全能力影响研究

中国民航飞行学院学报 2024年第3期35卷 48-52页

作者：杜红兵石倩千贾曼中国民航大学安全科学与工程学院天津300300

采用修订后的大五人格量表测量飞行员的人格特质;通过飞行任务分析,将航线飞行员安全能力划分为专业技术、综合管理、安全观念、心理品质4类,并据此设计了航线飞行员安全能力量表。提出了航线飞行员安全能力与人格特质间的假设关系模型... 详细信息

采用修订后的大五人格量表测量飞行员的人格特质;通过飞行任务分析,将航线飞行员安全能力划分为专业技术、综合管理、安全观念、心理品质4类,并据此设计了航线飞行员安全能力量表。提出了航线飞行员安全能力与人格特质间的假设关系模型。然后向航线飞行员发放调查问卷,收集到212份相关自评数据。最后使用AMOS26.0软件计算模型得出宜人性对专业技能的影响最大;神经质对综合技能的影响最大;尽责性对安全观念的影响最大;开放性对心理品质的影响最大。

关键词：航线飞行员人格特质安全能力结构方程模型(SEM)

Transcriptome-wide N6-methyladenosine(m^(6)A)methylation in soybean under Meloidogyne incognita infection

在线全文

学校读者我要写书评

暂无评论

aBIOTECH 2022年第3期3卷 197-211页

作者： Xue Han qianqian shi Ziyi He Wenwen Song Qingshan Chen Zhaoming Qi College of Agriculture Northeast Agricultural UniversityHarbin150030China Shandong Engineering Research Center for Environment-Friendly Agricultural Pest Management College of Plant Health and MedicineQingdao Agricultural UniversityQingdao266109China

N^(6)-methyladenosine(m^(6)A)is a reversible epigenetic modification of mRNA and other RNAs that plays a significant role in regulating gene expression and biological ***,m^(6)A abundance,dynamics,and transcriptional regulatory mechanisms remain unexplored in the context of soybean resistance to Meloidogyne *** this study,we performed a comparative analysis of transcriptome-wide m^(6)A and metabolome profiles of soybean root tissues with and without *** *** m^(6)A hypermethylation was widely induced in response to *** infection and was enriched around the 3′end of coding sequences and in 3′UTR *** were 2069 significantly modified m^(6)A sites,594 differentially expressed genes,and 103 differentially accumulated metabolites between infected and uninfected roots,including coumestrol,psoralidin,and *** 101 m^(6)A-modified DEGs,34 genes were hypomethylated and upregulated,and 39 genes were hypermethylated and downregulated,indicating a highly negative correlation between m^(6)A methylation and gene transcript abundance.A number of these m^(6)A-modified DEGs,including WRKY70,ERF60,POD47 and LRR receptor-like serine/threonine-protein kinases,were involved in plant defense *** study provides new insights into the critical role of m^(6)A modification in early soybean responses to ***.

关键词： m^(6)A methylation Soybean Meloidogyne incognita m^(6)A-seq RNA-seq Metabolome

Comprehensive analysis of antibacterial and anti-hepatoma activity of metabolites from jujube fruit

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Bioscience 2022年第3期47卷 474-483页

作者： qianqian shi Xi Li Dajun Zhu Junjun Jiang Xingang Li College of Forestry Northwest A&F UniversityYangling712100ShaanxiChina Key Comprehensive Laboratory of Forestry of Shaanxi Province Northwest A&F UniversityYangling712100ShaanxiChina Research Center for Jujube Engineering and Technology of State Forestry Administration Northwest A&F UniversityYangling712100ShaanxiChina

Jujube is one of the most produced dried fruits in China,and it is also a traditional Chinese medicine that enhances immunity and has anti-cancer *** fruit is rich in phenolic compounds,but few reports are available on its biological *** evaluate the biological activities of the phenolic compounds in dried jujube fruit,the composition and content of metabolites in dried jujube fruit were determined by metabolomics,and the antibacterial and anticancer activities of the phenolic compounds were analyzed in dried jujube *** results showed that 463 compounds were identified in dried‘Junzao’fruit,including 102 phenolic *** in vitro activity test showed that the jujube phenolic metabolites had extensive antibacterial effects and caused disruption and nuclear sclerosis of hepatocellular carcinoma(HepG2)*** correlation analysis showed that total phenolic content,quercetin-3-rutinose,and procyanidin B1 were the main active antibacterial and anticancer *** study provides data supporting the application of dried jujube fruit in the development of functional foods,pharmaceuticals and cosmetics.

关键词： Anticancer activity HepG2 cell Phenolic metabolites Chinese jujube Pharmaceutical development