检索结果-南通市图书馆

Vaccination against coronavirus disease 2019 in patients with pulmonary hypertension:A national prospective cohort study

引用

Chinese Medical Journal 2024年第6期137卷 669-675页

作者： Xiaohan Wu Jingyi Li Jieling Ma qianqian liu Lan Wang Yongjian Zhu Yue Cui Anyi Wang Cenjin Wen Luhong Qiu Yinjian Yang Dan Lu Xiqi Xu Xijie Zhu Chunyan Cheng Duolao Wang Zhicheng Jing Department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Echocardiography National Center for Cardiovascular DiseasesFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Pulmonary Circulation Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200433China Department of Cardiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Clinical Sciences Liverpool School of Tropical MedicineLiverpoolUnited Kingdom

Background:Coronavirus disease 2019(COVID-19)has potential risks for both clinically worsening pulmonary hypertension(PH)and increasing mortality.However,the data regarding the protective role of vaccination in this population are still lacking.This study aimed to assess the safety of approved vaccination for patients with PH.Methods:In this national prospective cohort study,patients diagnosed with PH(World Health Organization[WHO]groups 1 and 4)were enrolled from October 2021 to April 2022.The primary outcome was the composite of PH-related major adverse events.We used an inverse probability weighting(IPW)approach to control for possible confounding factors in the baseline characteristics of patients.Results:In total,706 patients with PH participated in this study(mean age,40.3 years;mean duration after diagnosis of PH,8.2 years).All patients received standardized treatment for PH in accordance with guidelines for the diagnosis and treatment of PH in China.Among them,278 patients did not receive vaccination,whereas 428 patients completed the vaccination series.None of the participants were infected with COVID-19 during our study period.Overall,398 patients received inactivated severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccine,whereas 30 received recombinant protein subunit vaccine.After adjusting for baseline covariates using the IPW approach,the odds of any adverse events due to PH in the vaccinated group did not statistically significantly increase(27/428[6.3%]vs.24/278[8.6%],odds ratio=0.72,P=0.302).Approximately half of the vaccinated patients reported at least one post-vaccination side effects,most of which were mild,including pain at the injection site(159/428,37.1%),fever(11/428,2.6%),and fatigue(26/428,6.1%).Conclusions:COVID-19 vaccination did not significantly augment the PH-related major adverse events for patients with WHO groups 1 and 4 PH,although there were some tolerable side effects.A large-scale randomized controlled trial is warranted to confirm this finding.The final approval

关键词： Coronavirus disease COVID-19 Pulmonary hypertension Vaccination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiple isotopes reveal the driving mechanism of high NO_(3)^(-) level and key processes of nitrogen cycling in the lower reaches of Yellow River

引用

Journal of Environmental Sciences 2024年第4期138卷 597-606页

作者： qianqian Zhang Huiwei Wang Lu liu Tianlun Zhai Xueqing Zhang Hebei and China Geological Survey Key Laboratory of Groundwater Remediation Institute of Hydrogeology and Environmental GeologyChinese Academy of Geological SciencesHebei 050061China Geo-Environmental Monitoring Institute of Hebei Province Hebei 050011China Hebei Provincial Laboratory of Water Environmental Science Hebei 050037China Hebei Provincial Academy of Ecological Environmental Science Hebei 050037China

The continuous increase of nitrate(NO_(3)^(-))level in rivers is a hot issue in the world.However,the driving mechanism of high NO_(3)^(-)level in large rivers is still lacking,which has limited the use of river water and increased the cost of water treatment.In this study,multiple isotopes and source resolution models are applied to identify the driving mechanism of high NO_(3)^(-)level and key processes of nitrogen cycling in the lower reaches of the Yellow River(LRYR).The major sources of NO_(3)^(-)were sewage and manure(SAM)in the low-flow season and soil nitrogen(SN)and chemical fertilizer(CF)in the high-flow season.Nitrification was the most key process of nitrogen cycling in the LRYR.However,in the biological removal processes,denitrification may not occur significantly.The temporal variation of contributions of NO_(3)^(-)sources were estimated by a source resolution model in the LRYR.The proportional contributions of SAM and CF to NO_(3)^(-)in the low-flow and high-flow season were 32.5%-52.3%,44.2%-46.2%and 36.0%-40.8%,54.9%-56.9%,respectively.The driving mechanisms of high NO_(3)^(-)level were unreasonable sewage discharge,intensity rainfall runoff,nitrification and lack of nitrate removal capacity.To control the NO_(3)^(-)concentration,targeted measures should be implemented to improve the capacity of sewage and wastewater treatment,increase the utilization efficiency of nitrogen fertilizer and construct ecological engineering.This study deepens the understanding of the driving mechanism of high nitrate level and provides a vital reference for nitrogen pollution control in rivers to other area of the world.

关键词： Nitrate Driving mechanism Nitrogen cycle Source apportionment Transformation Yellow River

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Boron nitride nanofibers enhanced composite PEO-based solid-state polymer electrolytes for lithium metal batteries

引用

Chinese Chemical Letters 2024年第6期35卷 216-221页

作者： qianqian Song Yunting Zhang Jianli Liang Si liu Jian Zhu Xingbin Yan School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275China College of Physics and Materials Science Tianjin Normal UniversityTianjin 300387China Department of Chemistry&Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong KongHong Kong 999077China Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology School of Physics and Optoelectronic EngineeringFoshan UniversityFoshan 528225China

Polyethylene oxide(PEO)-based solid-state polymer electrolytes(SPEs)are limited by their poor cyclic stability and inferior ionic conductivity for applicating in high-safety,long-cycling and high-energy-density lithium metal batteries.Herein,porous boron nitride nanofibers(BNNFs)are filled into PEO-based SPE,which significantly suppresses Li dendrites growth and enhances the electrochemical performance of Li metal battery.BNNFs with high porosity have more active sites to connect with PEO,which can effectively reduce the crystallinity of the PEO matrix and enhance its ionic conductivity.Moreover,owing to the hardness and good stability of BNNFs,BNNFs/PEO/Li TFSI electrolyte exhibits a wider electrochemical window,better mechanical property and higher thermal stability compared with PEO/Li TFSI electrolyte.Consequently,the Li symmetric cell composed of 1%BNNFs/PEO/Li TFSI performs good cyclic stability(>1800 h),and the Li||1%BNNFs/PEO/Li TFSI||LFP full battery shows obviously improved performances in charge-discharge polarization voltage,discharge specific capacity,rate performance and cyclic stability than the Li||PEO/Li TFSI||LFP battery.

关键词： Solid-state polymer electrolyte Boron nitride nanofibers Lithium metal battery Ionic conductivity Li dendrite

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-radical activation of persulfate with Bi_(2)O_(3)/BiO_(1.3)I_(0.4)for efficient degradation of propranolol under visible light

引用

Journal of Environmental Sciences 2024年第8期142卷 57-68页

作者： Yuehua Deng qianqian Che Yani Li Jiating Luo Xiang Gao Yan He Yiling liu Tong liu Xiaolong Zhao Xiaobin Hu Wei Zhao College of Geology and Environment Xi’an University of Science and TechnologyXi’an 710054China Shaanxi Provincial Key Laboratory of Geological Support for Coal Green Exploitation Xi’an 710054China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China School of Life Science Huzhou UniversityHuzhou 313000China School of Materials Engineering Changshu Institute of TechnologyChangshu 215500China

Non-radical activation of persulfate(PS)by photocatalysts is an effective approach for removing organic pollutants from aqueous environments.In this study,a novel Bi_(2)O_(3)/BiO_(1.3)I_(0.4)heterojunction was synthesized using a facile solvothermal approach and used for the first time for non-radical activation of PS to degrade propranolol(PRO)in the presence of visible light.The findings found that the degradation rate of PRO in the Bi_(2)O_(3)/BiO_(1.3)I_(0.4)/PS system was significantly increased from 19%to more than 90%within 90 min compared to the Bi_(2)O_(3)/BiO_(1.3)I_(0.4)system.This indicated that the composite system exerted an excellent synergistic effect between the photocatalyst and the persulfate-based oxygenation.Quenching tests and electron paramagnetic resonance demonstrated that the non-radical pathway with singlet oxygen as the active species played a major role in the photocatalytic process.The existence of photo-generated holes during the reaction could also be directly involved in the oxidation of pollutants.Meanwhile,a possible PRO degradation pathway was also proposed.Furthermore,the impacts of pH,humic acid and common anions on the PRO degradation by the Bi_(2)O_(3)/BiO_(1.3)I_(0.4)/PS were explored,and the system’s stability and reusability were also studied.This study exhibits a highly productive catalyst for PS activation via a non-radical pathway and provides a new idea for the degradation of PRO.

关键词： Iodine deficiency Heterojunction Persulfate(PS) Propranolol(PRO) Photocatalytic degradation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

3D bioprinting of in vitro porous hepatoma models:establishment,evaluation,and anticancer drug testing

引用

Bio-Design and Manufacturing 2024年第2期7卷 137-152页

作者： Xiaoyuan Wang Zixian liu qianqian Duan Boye Zhang Yanyan Cao Zhizhong Shen Meng Li Yanfeng Xi Jianming Wang Shengbo Sang Shanxi Key Laboratory of Micro Nano Sensors and Artificial Intelligence Perception College of Electronic Information and Optical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education Taiyuan University of TechnologyTaiyuan 030024China Shanxi Institute of 6D Artificial Intelligence Biomedical Science Taiyuan 030031China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China Department of Pathology Shanxi Provincial Cancer HospitalTaiyuan 030024China General Hospital of Taiyuan Iron and Steel Company Taiyuan 030809China

Traditional tumor models do not tend to accurately simulate tumor growth in vitro or enable personalized treatment and are particularly unable to discover more beneficial targeted drugs.To address this,this study describes the use of threedimensional(3D)bioprinting technology to construct a 3D model with human hepatocarcinoma SMMC-7721 cells(3DP-7721)by combining gelatin methacrylate(GelMA)and poly(ethylene oxide)(PEO)as two immiscible aqueous phases to form a bioink and innovatively applying fluorescent carbon quantum dots for long-term tracking of cells.The GelMA(10%,mass fraction)and PEO(1.6%,mass fraction)hydrogel with 3:1 volume ratio offered distinct pore-forming characteristics,satisfactorymechanical properties,and biocompatibility for the creation of the 3DP-7721 model.Immunofluorescence analysis and quantitative real-time fluorescence polymerase chain reaction(PCR)were used to evaluate the biological properties of the model.Compared with the two-dimensional culture cell model(2D-7721)and the 3D mixed culture cell model(3DM-7721),3DP-7721 significantly improved the proliferation of cells and expression of tumor-related proteins and genes.Moreover,we evaluated the differences between the three culture models and the effectiveness of antitumor drugs in the three models and discovered that the efficacy of antitumor drugs varied because of significant differences in resistance proteins and genes between the three models.In addition,the comparison of tumor formation in the three models found that the cells cultured by the 3DP-7721 model had strong tumorigenicity in nude mice.Immunohistochemical evaluation of the levels of biochemical indicators related to the formation of solid tumors showed that the 3DP-7721 model group exhibited pathological characteristics of malignant tumors,the generated solid tumors were similar to actual tumors,and the deterioration was higher.This research therefore acts as a foundation for the application of 3DP-7721 models in drug development research.

关键词： 3D bioprinting Hepatoma tumor models Drug screening Antitumor drug development

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metadata as a Methodological Commons:From Aboutness Description to Cognitive Modeling

引用

Data Intelligence 2023年第1期5卷 289-302页

作者： Wei liu Yaming Fu qianqian liu Shanghai Library(Institute of Scientific and Technical Information of Shanghai) No.1555 Huaihai Middle Road Xuhui DistrictShanghai 200031China School of Information Management at Nanjing University No.163 Xianlin AvenueNanjingJiangsu 210093China

Metadata is data about data,which is generated mainly for resources organization and description,facilitating finding,identifying,selecting and obtaining information.With the advancement of technologies,the acquisition of metadata has gradually become a critical step in data modeling and function operation,which leads to the formation of its methodological commons.A series of general operations has been developed to achieve structured description,semantic encoding and machine-understandable information,including entity definition,relation description,object analysis,attribute extraction,ontology modeling,data cleaning,disambiguation,alignment,mapping,relating,enriching,importing,exporting,service implementation,registry and discovery,monitoring etc.Those operations are not only necessary elements in semantic technologies(including linked data)and knowledge graph technology,but has also developed into the common operation and primary strategy in building independent and knowledge-based information systems.In this paper,a series of metadata-related methods are collectively referred to as'metadata methodological commons',which has a lot of best practices reflected in the various standard specifications of the Semantic Web.In the future construction of a multi-modal metaverse based on Web 3.0,it shall play an important role,for example,in building digital twins through adopting knowledge models,or supporting the modeling of the entire virtual world,etc.Manual-based description and coding obviously cannot adapted to the UGC(User Generated Contents)and AIGC(AI Generated Contents)-based content production in the metaverse era.The automatic processing of semantic formalization must be considered as a sure way to adapt metadata methodological commons to meet the future needs of Al era.

关键词： Metadata Methodological Commons Content Architecture Data Modeling Ontology Semantic Web Semantic Formalization Web3.0 Metaverse

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantum properties of fermionic fields in multi-event horizon spacetime

引用

Science China(Physics,Mechanics & Astronomy) 2023年第12期66卷 56-62页

作者： qianqian liu Shu-Min Wu Cuihong Wen Jieci Wang Department of Physics Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of EducationSynergetic Innovation Center for Quantum Effects and ApplicationHunan Normal UniversityChangsha 410081China Department of Physics Liaoning Normal UniversityDalian 116029China

We investigated the properties of quantum entanglement and mutual information in the multi-event horizon Schwarzschild-de Sitter(Sd S)spacetime for massless Dirac fields.For the first time,we obtained the expression for the evolutions of the quantum state near the black hole event horizon(BEH)and cosmological event horizon(CEH)in the Sd S spacetime.Under the Nariai limit,the physically accessible entanglement and mutual information are maximized,and the physically inaccessible correlations are zero.With the increase in temperature of either horizon,the physically accessible correlations experience degradation.Notably,the initial state remains entangled and can be utilized in entanglement-based quantum information processing tasks,which differs from the scalar field case.Furthermore,the degradation of physically accessible correlations is more pronounced for small-mass black holes.In contrast,the physically inaccessible correlations separated by the CEH monotonically increase with the radiation temperature,and such correlations are not decisively influenced by the effect of particle creation at the BEH.Moreover,a similar phenomenon is observed for the inaccessible correlations separated by the BEH.This result differs from the single event spacetime,in which the physically inaccessible entanglement is a monotonic function of the Hawking temperature.

关键词： multi-event horizon spacetime Dirac field SdS spacetime quantum entanglement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Alteration of the health effects of bioaerosols by chemical modification in the atmosphere:A review

引用

Fundamental Research 2024年第3期4卷 463-470页

作者： Ailin Li Xinghua Qiu Xing Jiang Xiaodi Shi Jinming liu Zhen Cheng qianqian Chai Tong Zhu State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China

Bioaerosols are a subset of important airborne particulates that present a substantial human health hazard due to their allergenicity and infectivity.Chemical reactions in atmospheric processes can significantly influence the health hazard presented by bioaerosols;however,few studies have summarized such alterations to bioaerosols and the mechanisms involved.In this paper,we systematically review the chemical modifications of bioaerosols and the impact on their health effects,mainly focusing on the exacerbation of allergic diseases such as asthma,rhinitis,and bronchitis.Oxidation,nitration,and oligomerization induced by hydroxyl radicals,ozone,and nitrogen dioxide are the major chemical modifications affecting bioaerosols,all of which can aggravate allergenicity mainly through immunoglobulin E pathways.Such processes can even interact with climate change including the greenhouse effect,suggesting the importance of bioaerosols in the future implementation of carbon neutralization strategies.In summary,the chemical modification of bioaerosols and the subsequent impact on health hazards indicate that the combined management of both chemical and biological components is required to mitigate the health hazards of particulate air pollution.

关键词： Bioaerosols Allergenicity Chemical modification Airpollution Climate change

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cryo-EM structure of cannabinoid receptor CB1-β-arrestincomplex

引用

Protein & Cell 2024年第3期15卷 230-234页

作者： Yuxia Wang Lijie Wu Tian Wang Junlin liu Fei Li Longquan Jiang Zhongbo Fan Yanan Yu Na Chen qianqian Sun Qiwen Tan Tian Hua Zhi-Jie liu iHuman Institute ShanghaiTech UniversityShanghai 201210China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Institute of Molecular and Clinical Medicine Kunming Medical UniversityKunming 650500China

Dear Editor,G protein-coupled receptors(GPCRs)play a vital role in regulating almost every aspect of human physiology,making up more than one-third of marketed drug targets(Santos et al.,2017).GPCRs orchestrate their signalling through interactions with three distinct downstream protein families:G proteins,G protein-coupled receptor kinases(GRKs),and arrestins(Santos et al.,2017).While G protein-mediated signalling is initiated upon GPCR stimulation,activated GPCRs return to their basal levels through a GRK-and arrestin-regulated desensitization process(Santos et al.,2017).In addition to modulating receptor desensitization,β-arrestin also regulates downstream events that are distinct from classical G protein signalling(Ahn et al.,2020).

关键词： stimulation return

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparative pharmacokinetics of six components in normal and rheumatoid arthritis rats after intragastrical administration of Qianghuo Shengshi Decoction granules by LC-MS/MS

引用

Chinese Herbal Medicines 2024年第3期16卷 457-465页

作者： Xin Li Min Wang Yuhong Zhong qianqian Yin Zheming Hu Wenli Tian Zhongyan liu Zhidong liu Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique Ministry of EducationTianjin University of Traditional Chinese Medicine State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese Medicine Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine

Objective:To investigate the plasma pharmacokinetics of six representative components(nodakenin,osthole,5-0-methylvisammioside,ferulic acid,liquiritigenin,and liquiritin),which were the ingredients of Qianghuo Shengshi Decoction(QSD) granules,in normal and rheumatoid arthritis(RA) rats administrated QSD granules intragastrically.Methods:A rapid and accurate ultra-high performance liquid chromatography-tandem mass spectrometry(LC-MS/MS) method was developed for the simultaneous determination of six components in plasma,and it showed a good specificity,linearity,intra-day and inter-day precision,intra-day and inter-day accuracy,extraction recovery,stability,and the less matrix effect.Results:The validated LC-MS/MS method was successfully used to compare the plasma pharmacokinetics of six ingredients between normal and RA rats after intragastrical administration of QSD granules and differences in the pharmacokinetics were found in two types of rats.The absorption rate in the RA rats was lower for nodakenin,osthole,5-0-methylvisammioside,liquiritigenin and liquiritin than in the normal group,while the absorption rate of ferulic acid remained constant in two groups.In comparison with the normal rats,the exposure concentration of nodakenin was higher and that of other five components except for nodakenin was lower under pathological conditions.Additionally,the absorptive amount of nodakenin,osthole,5-0-methylvisammioside and liquiritin was increased and that of ferulic acid and liquiritigenin was reduced in the RA rats than in the normal rats.Compared with the normal rats,the retention time of nodakenin,ferulic acid and liquiritin was reduced in vivo,whereas the retention time of osthole,5-0-methylvisammioside and liquiritigenin was raised in the body for the RA rats.In contrast to the normal rats,the data demonstrated an increase in the elimination velocity of nodakenin and a decrease in the elimination velocity of the other five components except for nodakenin in the pathological state.Conclusion:This study showed th

关键词： LC-MS/MS pharmacokinetics Qianghuo Shengshi Decoction granules rheumatoid arthritis

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：