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Research 2024年第1期6卷 687-706页

作者： qianqian huang Chaoqing Jiang Xue Xia Yufan Wang Chenxing Yan Xiaorong Wang Ting Lei Xiaotong Yang Wenqin Yang Guo Cheng Huile Gao Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041P.R.China Laboratory of Molecular Translational Medicine Center for Translational MedicineKey Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Ministry of EducationDepartment of PediatricsWest China Second University HospitalSichuan UniversityChengdu 610041P.R.China

Inflammatory responses,manifested in excessive oxidative stress and microglia overactivation,together with metal ion-triggered amyloid-beta(Aβ)deposition,are critical hallmarks of Alzheimer’s disease(AD).The intricate pathogenesis causes severe impairment of neurons,which,in turn,exacerbates Aβaggregation and facilitates AD progression.Herein,multifunctional melanin-like metal ion chelators and neuroinflammation regulators(named PDA@K)were constructed for targeted treatment of AD.In this platform,intrinsically bioactive material polydopamine nanoparticles(PDA)with potent metal ion chelating and ROS scavenging effects were decorated with the KLVFF peptide,endowing the system with the capacity of enhanced pathological blood–brain barrier(BBB)crossing and lesion site accumulation via Aβhitchhiking.In vitro and in vivo experiment revealed that PDA@K had high affinity toward Aβand were able to hitch a ride on Aβto achieve increased pathological BBB crossing.The engineered PDA@K effectively mitigated Aβaggregate and alleviated neuroinflammation.

关键词： oxidative aggregation chelating

A novel negative quantum capacitance field-effect transistor with molybdenum disulfide integrated gate stack and steep subthreshold swing for ultra-low power applications

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Science China(Information Sciences) 2023年第6期66卷 71-77页

作者： Liang CHEN Huimin WANG qianqian huang Ru huang School of Integrated Circuits Peking University Beijing Advanced Innovation Center for Integrated Circuits

Various steep-slope devices based on novel structures and mechanisms garnered considerable attention for their potential in ultra-low power logic applications. In this work, a novel steep-slope negative quantum capacitance field-effect transistor(NQCFET)with molybdenum disulfide(MoS2)-integrated gate stack was realized by theoretical analysis and experimental evaluation. By combining the MoS+2 equivalent capacitance model calibrated with experimental results, the NQCFET device model is further established.The results demonstrated that the optimized MoS2-integrated NQCFET can achieve a subthreshold swing(SS)of sub-60 mV/dec over a current range of 5 decades, with the minimum SS reaching 29 mV/dec,indicating the remarkable potential of MoS2-integrated NQCFETs for ultra-low power applications.

关键词： negative quantum capacitance molybdenum disulfide field-effect transistor subthreshold swing ultra-low power device

Carbon dots derived from Poria cocos polysaccharide as an effective“on-off”fluorescence sensor for chromium(Ⅵ)detection

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Journal of Pharmaceutical Analysis 2022年第1期12卷 104-112页

作者： qianqian huang qianqian Bao Chengyuan Wu Mengru Hu Yunna Chen Lei Wang Weidong Chen Anhui Province Key Laboratory of Chinese Medicinal Formula Anhui University of Chinese MedicineHefei230012China

Chromium is a harmful contaminant showing mutagenicity and carcinogenicity.Therefore,detection of chromium requires the development of low-cost and high-sensitivity sensors.Herein,blue-fluorescent carbon quantum dots were synthesized by one-step hydrothermal method from alkali-soluble Poria cocos polysaccharide,which is green source,cheap and easy to obtain,and has no pharmacological activity due to low water solubility.These carbon quantum dots exhibit good fluorescence stability,water solubility,anti-interference and low cytotoxicity,and can be specifically combined with the detection of Cr(Ⅵ)to form a non-fluorescent complex that causes fluorescence quenching,so they can be used as a label-free nanosensor.High-sensitivity detection of Cr(Ⅵ)was achieved through internal filtering and static quenching effects.The fluorescence quenching degree of carbon dots fluorescent probe showed a good linear relationship with Cr(Ⅵ)concentration in the range of 1-100μM.The linear equation was F;/F=0.9942+0.01472[Cr(Ⅵ)](R;=0.9922),and the detection limit can be as low as 0.25μM(S/N=3),which has been successfully applied to Cr(Ⅵ)detection in actual water samples herein.

关键词： Carbon dots Alkali-soluble Poria cocos polysaccharide Cr(Ⅵ)detection Internal filtering effect Static quenching effect

Surface repair of wide-bandgap perovskites for high-performance all-perovskite tandem solar cells

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Journal of Energy Chemistry 2024年第6期93卷 64-70,I0003页

作者： Xiaojing Lv Weisheng Li Jin Zhang Yujie Yang Xuefei Jia Yitong Ji qianqian Lin Wenchao huang Tongle Bu Zhiwei Ren Canglang Yao Fuzhi huang Yi-Bing Cheng Jinhui Tong State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070HubeiChina Key Lab of Artificial Micro-and Nano-Structures of Ministry of Education of China School of Physics and TechnologyWuhan UniversityWuhan 430072HubeiChina Department of Electrical and Electronic Engineering Photonics Research Institute(PRI)Research Institute for Intelligent Wearable Systems(iWEAR)The Hong Kong Polytechnic University999077Hong KongChina Laboratory of Advanced Materials Fudan UniversityShanghai 200438China Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Foshan 528200GuangdongChina

Wide-bandgap(WBG)perovskite solar cells(PSCs)play a fundamental role in perovskite-based tandem solar cells.However,the efficiency of WBG PSCs is limited by significant open-circuit voltage losses,which are primarily caused by surface defects.In this study,we present a novel method for modifying surfaces using the multifunctional S-ethylisothiourea hydrobromide(SEBr),which can passivate both Pb^(-1)and FA^(-1)terminated surfaces,Moreover,the SEBr upshifted the Fermi level at the perovskite interface,thereby promoting carrier collection.This proposed method was effective for both 1.67 and 1.77 eV WBG PSCs,achieving power conversion efficiencies(PCEs)of 22.47%and 19.90%,respectively,with V_(OC)values of 1.28 and 1.33 V,along with improved film and device stability.With this advancement,we were able to fabricate monolithic all-perovskite tandem solar cells with a champion PCE of 27.10%,This research offers valuable insights for passivating the surface trap states of WBG perovskite through rational multifunctional molecular engineering.

关键词： Wide-bandgap perovskite Surface defect Multifunctional molecule All-perovskite tandem solar cells

Physical investigation of subthreshold swing degradation behavior in negative capacitance FET

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Science China(Information Sciences) 2022年第6期65卷 241-246页

作者： Mengxuan YANG qianqian huang Kaifeng WANG Chang SU Liang CHEN Yangyuan WANG Ru huang Key Laboratory of Microelectronic Devices and Circuits (MOE) Institute of MicroelectronicsPeking University Beijing Laboratory of Future IC Technology and Science Peking University

Power consumption has become one of the bottlenecks limiting the future development of integrated circuits. Tunnel FETs(TFETs) and negative capacitance FETs(NCFETs) can break the subthreshold swing limitation(60 mV/dec at room temperature) of conventional metal-oxide-semiconductor field-effect transistor(MOSFET) to reduce the operating voltage and thus power consumption. However, induced by the band-to-band tunneling mechanism, TFETs have a subthreshold swing degradation issue and relatively low ON current. Although NCFETs with ferroelectric/dielectric gate stack can theoretically maintain a high ON current comparable to conventional MOSFET, the physical origin of sub-60 SS is controversial and the mechanism of switching behavior in NCFET is still not clear. In this work, by experimentally investigating the whole negative differential capacitance process and its gate voltage amplification coefficient, an intrinsic issue of SS degradation with increased gate voltage is also found in NCFET for the first time. Based on the physical investigation and simulation results, it is shown that the intrinsic SS degradation in NCFET is resulting from the instant dielectric polarization response. Both the decrease of dielectric thickness and the increase of dielectric constant may lead to the severer SS degradation, which is not favorable for scaled NCFETs.

关键词： ferroelectric negative differential capacitance effect polarization low power voltage amplification

Gold nanoparticles combat enveloped RNA virus by affecting organelle dynamics

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4244-4251页

作者： Fangzhou Li qianqian huang Ziran Zhou Qiongge Guan Fei Ye Baoying huang Weisheng Guo Xing-Jie Liang CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaNo.11First North RoadZhongguancun100190 BeijingP.R.China University of Chinese Academy of Sciences 100049 BeijingP.R.China MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChina CDCBeijingChina Department of Minimally Invasive Interventional Radiology the State Key Laboratory of Respiratory DiseaseSchool of Biomedical Engineering&The Second Affiliated HospitalGuangzhou Medical University510260 GuangzhouP.R.China

Enveloped RNA viruses are a group of viruses with an outer membrane derived from a host cell and a genome consisting of ribonucleic acid(RNA).These viruses rely on host cell machinery and organelles to replicate and assemble new virus particles.However,the interaction between viruses and host organelles may be disrupted by nanomaterials,such as gold nanoparticles(AuNPs)with unique physical and chemical properties.In this study,we investigated the effects of AuNPs with different surface charge properties on the subcellular structure and function of mammalian cells,and their effects on two representative enveloped RNA viruses:lentivirus and human coronavirus OC43(HCoV-OC43)antiviral potential.By comparing the subcellular effects of AuNPs with different surface charge properties,we found that treatment with AuNPs with positive surface charges induced more significant disruption of subcellular structures than neutrally charged AuNPs and negatively charged AuNPs,mainly manifested in lysosomes and Cytoskeletal disorders.The antiviral effect of the surface positively charged AuNPs was further evaluated using lentivirus and HCoV-OC43.The results showed that AuNPs had a significant inhibitory effect on both lentivirus and HCoV-OC43 without obvious side effects.In conclusion,our study provides insights into the mechanism of action and biocompatibility of AuNP in biological systems,while supporting the potential of targeting organelle dynamics against enveloped RNA viruses.

关键词： properties particles envelope

Metamaterial electromagnetic wave absorbers and devices:Design and 3D microarchitecture

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Journal of Materials Science & Technology 2022年第13期108卷 90-101页

作者： qianqian huang Gehuan Wang Ming Zhou Jing Zheng Shaolong Tang Guangbin Ji College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Chemistry and Materials Science College of ScienceNanjing Forestry UniversityNanjing 210037China National Laboratory of Solid State Microstructures Nanjing UniversityNanjing 210093China

Metamaterials refer to a class of artificial composite structures with supernormal physical properties that natural materials do not have.The emergence of metamaterials has opened up new research directions for classical electromagnetic theory and made it possible to manipulate electromagnetic waves effectively.One of most important applications of metamaterials is metamaterial absorbers(MMAs).The properties of MMAs depend on the material composition,cell size and structure,which could often achieve"perfect"absorption through reasonable design.This review starts with the development of MMAs and describes the status of this absorber,then mainly focuses on bionic design and new artificial design.Specifically,it is to draw inspiration from natural plants and animals,design novel structures to get better absorbing properties.Furthermore,the artificial design can achieve the optimize absorption capacity as well as absorption bandwidth.What’s more,this review summarizes the 3D printing technology to prepare MMAs that are different from traditional printed circuit board technology.The MMAs produced by 3D printing technology can prepare more complex shapes,and has light weight and better absorbing properties.

关键词： Electromagnetic waves absorption Metamaterial Bionic design Artificial design 3D printing

Safety and efficacy of Compound huangdai Tablets combined with all-trans retinoic acid for treatment of acute promyelocytic leukemia:Clinical evidence and potential mechanisms

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Chinese Herbal Medicines 2022年第1期14卷 154-165页

作者： qianqian huang Tao Wang Yan Xiong Liping Qu Qiaozhi Yin Wenjun Zou College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China School of Medical and Life Sciences Chengdu University of Traditional Chinese MedicineChengdu 610041China

Objective:To evaluate the safety and efficacy of Compound huangdai Tablets(Realgar-Indigo Naturalis formula,RIF)combined with all-trans retinoic acid(ATRA)to treat acute promyelocytic leukemia(APL).Methods:This study was registered in PROSPERO(CRD42018108118).The relevant literatures on RIF treatment of APL were systematically searched in the following databases:China National Knowledge Infrastructure,Wanfang,VIP Medical Information System,Chinese Biomedical Database,EMBASE,Cochrane Library,and PubMed.The quality of the included studies was evaluated and Review Manager 5.3 software and Stata 13.0 software were used to perform the Meta-analysis.In addition,this study used the method of network pharmacology to conduct a preliminary exploration of the mechanism of RIF on APL.Results:The study included 12 studies involving 775 APL patients.The Meta-analysis showed that there was no significant difference(P>0.05)between the RIF group and the arsenic trioxide(ATO)group for primary outcomes,secondary outcomes apart from liver dysfunction.The incidence of liver dysfunction(P=0.006)in the RIF group were significantly lower than those in the ATO group.In addition,the cost of maintenance therapy in the RIF group was significantly lower(P<0.05)than the ATO group.Besides,the active ingredients in RIF mainly act on targets proteins such as ACHE,NCOA2,RXRA,and then play a role in the treatment of APL through regulating multiple molecular mechanisms,such as TP53 regulates transcription of cell cycle genes,nuclear receptor transcription pathway.Conclusion:There was no significant difference in efficacy of oral RIF combined with ATRA compared with intravenous ATO combined with ATRA for the treatment of APL.The oral RIF exposed patients to less risk,offered more convenience and had lower prices.RIF can treat APL by multi-target and multipathway interventions that inducing apoptosis of APL cells and inhibiting the proliferation of APL cells,and so on.Therefore,oral RIF in the treatment of APL is worthy of further research and develo

关键词： acute promyelocytic leukemia all-trans retinoic acid network pharmacology Realgar-Indigo Naturalis formula

Improved electromagnetic dissipation of Fe doping LaCoO_(3)toward broadband microwave absorption

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Journal of Materials Science & Technology 2022年第10期105卷 92-100页

作者： Fan Wang Weihua Gu Jiabin Chen qianqian huang Mingyang Han Gehuan Wang Guangbin Ji College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Perovskite LaCoO_(3)is of great potential in electromagnetic wave absorption considering its outstanding dielectric loss as well as the existing magnetic response with the magnetic doping.However,the dissipation mechanism of the magnetic doping on the microwave absorption is lack of sufficient investigated.In this paper,LaCo_(1-x)Fe_(x)O_(3)(x=0,0.05,0.1,0.15,0.2,0.25,0.3,LCFOs)perovskites with different Fe doping amounts were prepared successfully by the sol-gel method and subsequent heat treatment in the air atmosphere.The structure characterization carried out by the frst-principles calculations shows the effect of Fe doping on the dielectric and magnetic properties of LCFOs and the strong hybridization of Co/Fe-3d with O-2p in the LCFOs system was successfully demonstrated.Particularly,when x=0.1 and the thickness is only 1.95 mm,the LaCo_(0.9)Fe_(0.1)O_(3)exhibits the best microwave absorption performance with the minimum reflection loss(RL)value of about-41 dB.The typical samples achieve a broad effective absorption bandwidth(EAB)of 5.16 GHz(7.92-13.08 GHz),which covers the total X band(8-12 GHz).Considering that,the especial Fe doping perovskite is promising to be a candidate as efficient microwave absorbers.

关键词： Perovskites LaCoO_(3) Magnetic doping First-principles Electromagnetic wave absorption Broad bandwidth

Experimental investigation of the gate voltage range of negative differential capacitance in ferroelectric transistors

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Science China(Information Sciences) 2022年第6期65卷 277-278页

作者： Mengxuan YANG qianqian huang Chang SU Liang CHEN Yangyuan WANG Ru huang Key Laboratory of Microelectronic Devices and Circuits (MOE) Institute of MicroelectronicsPeking University Beijing Laboratory of Future IC Technology and Science Peking University

Dear editor,Recently, ferroelectric(FE)-based negative capacitance FET(NCFET) with ferroelectric/dielectric(FE/DE) gate stack has attracted extensive attention due to its capability of sub-60 mV/dec subthreshold swing... 详细信息

关键词： Ferroelectric Negative differential capacitance effect Polarization Low power Subthreshold swing