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Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke cai Youluan Lu Fanpeng Cheng Lijuan Shi Qun Yi Yao Liu Yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Oxygen evolution reaction

微织构衍生切削下的钛合金正交微切削性能分析

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工具技术 2021年第9期55卷 47-53页

作者：刘佳于化东于占江蔡倩倩许金凯李一全长春理工大学跨尺度微纳制造教育部重点实验室长春市130022

针对微织构刀具加工过程中的衍生切削效应,利用正交微切削单元开展了微坑刀具及无织构刀具的钛合金微切削实验,从切屑底面形貌、微坑黏结状态等方面分析了微坑刀具微切削性能;通过ABAQUS软件对微织构刀具微切削钛合金过程进行有限元模拟... 详细信息

针对微织构刀具加工过程中的衍生切削效应,利用正交微切削单元开展了微坑刀具及无织构刀具的钛合金微切削实验,从切屑底面形貌、微坑黏结状态等方面分析了微坑刀具微切削性能;通过ABAQUS软件对微织构刀具微切削钛合金过程进行有限元模拟,分析微坑织构的衍生切削作用对刀-屑接触应力分布及切削力的影响,优化设计微坑边缘过渡区参数并进行切削仿真分析。实验和仿真结果表明,微坑会减小前刀面黏结,存储微屑,减小刀-屑接触应力,提高刀具减摩性能;但微坑与切屑的衍生切削作用会增大瞬时切削力,降低切削过程平稳性。此外,微坑过渡区优化可改善切削过程波动,降低切削力,改变切屑形态,改善切屑在微坑的流入/流出状态,有助于减小微坑织构衍生切削效应,提高织构的减摩效果。

关键词：衍生切削微织构钛合金微切削切削仿真

基于机器学习的胃黏液分泌性腺癌特征基因筛选及免疫浸润分析

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中华实验外科杂志 2023年第5期40卷 939-942页

作者：张原张鹏善罗再徐亦天蔡谦谦黄陈上海交通大学医学院附属第一人民医院胃肠外科上海201620

目的通过机器学习结合生物信息学方法分析胃黏液分泌性腺癌(GMA)的特征基因及特征通路,探索GMA的诊断标志物及其与免疫细胞浸润的关联。方法从癌症基因组图谱(TCGA)数据库中下载胃癌(GC)测序数据,以P<0.05为标准筛选99例GMA与311例胃普... 详细信息

目的通过机器学习结合生物信息学方法分析胃黏液分泌性腺癌(GMA)的特征基因及特征通路,探索GMA的诊断标志物及其与免疫细胞浸润的关联。方法从癌症基因组图谱(TCGA)数据库中下载胃癌(GC)测序数据,以P<0.05为标准筛选99例GMA与311例胃普通型腺癌(GTA)样本差异表达基因(DEGs)。通过功能富集方法分析GMA特征通路和功能途径,进一步通过机器学习算法,使用套索回归(LASSO)结合支持向量机递归特征消除(SVM-RFE)获取23个特征基因,并通过绘制受试者工作特征曲线(ROC)分析DEGs的诊断效能,及其与免疫细胞浸润的相关性。在基因表达谱数据库(GEO)数据集GSE113255中对DEGs的表达和诊断效能进行验证。结果在TCGA数据库中检测到1769个DEGs(P<0.05),其中759个在GMA中上调,而1010个在GTA中上调。这些基因与磷脂酰肌醇3激酶(PI3K)-蛋白激酶B(Akt)信号通路、细胞黏附、细胞外基质、细胞骨架调节等途径显著相关(P<0.01)。GMA组中CMTM8(11.416比17.845,P<0.001)、RTKN(8.456比13.845,P<0.001)、TOMM34(23.219比36.991,P<0.001)平均表达量均低于GTA组,是GMA的诊断标志物。GMA组中M2巨噬细胞(P<0.01)、静息肥大细胞(P<0.001)浸润水平高于GTA组,而激活CD4+T细胞(P<0.01)浸润水平低于GTA组。结论CMTM8、RTKN和TOMM34是GMA的特征基因,与M2巨噬细胞和静息肥大细胞浸润等显著相关。

关键词：胃癌黏液分泌性腺癌机器学习免疫浸润生物标志物

Life-Cycle Bearing Capacity for Pre-Stressed T-beams Based on Full-Scale Destructive Test

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Structural Durability & Health Monitoring 2025年第1期19卷 145-166页

作者： Yushan Ye Tao Gao Liankun Wang Junjie Ma Yingchun cai Heng Liu Xiaoge Liu China Construction Seventh Engineering Division Corp. Ltd.Zhengzhou450004China School of Water Conservancy and Transportation Zhengzhou UniversityZhengzhou450001China

To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete *** on the measurement and ana-lysis of beam deﬂection,strain,and crack development under various loading levels during the research tests,combined with the veriﬁcation coefﬁcient indicators speciﬁed in the codes,the veriﬁcation coefﬁcients of bridges at different stages of damage can be *** results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test *** the complete linear elastic stage,both the deﬂection and bottom strain veriﬁcation coefﬁcients comply with the speciﬁcations,indicating a good structural load-bearing capacity no longer adheres to the code’s *** the non-linear stage,both coefﬁcients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing *** to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s speciﬁed *** strain veriﬁcation coefﬁcient sourced from the compression zone at the bottom of theﬂange is not recommended for assessing the bridge’s load-bearing capacity.

关键词： Pre-stressed T-beams whole process destructive test bearing capacity veriﬁcation coefﬁcient

SensFL:Privacy-Preserving Vertical Federated Learning with Sensitive Regularization

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu Xiangrui Xu Fuqiang Hu Jiao Dai Baigen cai Wei Wang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China Shuohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China Beijing Key Laboratory of Security and Privacy in Intelligent Transportation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Transportation Systems,effective multi-party collaboration is crucial due to concerns over privacy and data *** Federated Learning(VFL)has emerged as a promising approach to facilitate such collaboration,allowing diverse entities to collectively enhance machine learning models without the need to share sensitive training ***,existing works have highlighted VFL’s susceptibility to privacy inference attacks,where an honest but curious server could potentially reconstruct a client’s raw data from embeddings uploaded by the *** vulnerability poses a significant threat to VFL-based intelligent railway transportation *** this paper,we introduce SensFL,a novel privacy-enhancing method to against privacy inference attacks in ***,SensFL integrates regularization of the sensitivity of embeddings to the original data into the model training process,effectively limiting the information contained in shared *** reducing the sensitivity of embeddings to the original data,SensFL can effectively resist reverse privacy attacks and prevent the reconstruction of the original data from the *** experiments were conducted on four distinct datasets and three different models to demonstrate the efficacy of *** results show that SensFL can effectively mitigate privacy inference attacks while maintaining the accuracy of the primary learning *** results underscore SensFL’s potential to advance privacy protection technologies within VFL-based intelligent railway systems,addressing critical security concerns in collaborative learning environments.

关键词： Vertical federated learning privacy defenses

High‑Entropy Electrode Materials:Synthesis,Properties and Outlook

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Nano-Micro Letters 2025年第1期17卷 472-506页

作者： Dongxiao Li Chang Liu Shusheng Tao Jieming cai Biao Zhong Jie Li Wentao Deng Hongshuai Hou Guoqiang Zou Xiaobo Ji College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083People’s Republic of China School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104People’s Republic of China

High-entropy materials represent a new category of high-performance materials,first proposed in 2004 and extensively investigated by researchers over the past two *** definition of high-entropy materials has continuously *** the last ten years,the discovery of an increasing number of high-entropy materials has led to significant advancements in their utilization in energy storage,electrocatalysis,and related domains,accompanied by a rise in techniques for fabricating high-entropy electrode ***,the research emphasis has shifted from solely improving the performance of high-entropy materials toward exploring their reaction mechanisms and adopting cleaner preparation ***,the current definition of high-entropy materials remains relatively vague,and the preparation method of high-entropy materials is based on the preparation method of single metal/low-or medium-entropy *** should be noted that not all methods applicable to single metal/low-or medium-entropy materials can be directly applied to high-entropy *** this review,the definition and development of high-entropy materials are briefly ***,the classification of high-entropy electrode materials is presented,followed by a discussion of their applications in energy storage and catalysis from the perspective of synthesis ***,an evaluation of the advantages and disadvantages of various synthesis methods in the production process of different high-entropy materials is provided,along with a proposal for potential future development directions for high-entropy materials.

关键词： High-entropy Energy storage Electrode materials

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin cai Guangming Wang Min Zhou Luying Peng Yantao Fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

解毒生肌汤雾化熏洗与麻仁软胶囊联用治疗混合痔术后疼痛水肿临床研究

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国际中医中药杂志 2020年第8期42卷 754-757页

作者：许功宇蔡倩倩程凯李明安徽省庐江县人民医院肛肠科合肥231500 安徽省中医院肛肠科合肥230031

目的评价解毒生肌汤雾化熏洗与麻仁软胶囊联用治疗混合痔术后疼痛水肿的临床疗效。方法将符合入选标准的2017年1月-2019年1月安徽省庐江县人民医院110例环状混合痔患者按随机数字表法分为2组,每组55例。2组均行混合痔外剥内扎术,对照组... 详细信息

目的评价解毒生肌汤雾化熏洗与麻仁软胶囊联用治疗混合痔术后疼痛水肿的临床疗效。方法将符合入选标准的2017年1月-2019年1月安徽省庐江县人民医院110例环状混合痔患者按随机数字表法分为2组,每组55例。2组均行混合痔外剥内扎术,对照组于术后给予麻仁软胶囊治疗,研究组在对照组基础上联用解毒生肌汤雾化熏洗。2组均连续治疗14 d。采用VAS量表评价肛门疼痛程度,观察肛门水肿情况并进行评分;采用ELISA法检测血清VEGF、碱性成纤维生长因子(basic fibroblast growth factor,bFGF)及血小板源性生长因子(platelet-derived growth factor,PDGF)水平;观察并记录术后14 d并发症发生情况,评价临床疗效。结果研究组总有效率为92.7%(51/55)、对照组为74.6%(41/55),2组比较差异有统计学意义(χ2=6.643,P<0.01)。研究组VAS评分、肛门水肿评分术后7 d(t值分别为9.144、8.541)、14 d(t值分别为13.720、12.819)均低于对照组(P<0.01);研究组VEGF、bFGF、PDGF水平术后7 d(t值分别为7.491、2.972、5.170)、14 d(t值分别为6.117、3.031、4.599)均高于对照组(P<0.01)。研究组术后并发症发生率为7.3%(4/55),对照组为3.6%(2/55),2组比较差异无统计学意义(χ2=0.705,P=0.401)。结论解毒生肌汤雾化熏洗联合麻仁软胶囊可明显改善混合痔术后疼痛水肿患者的临床症状,加速新生血管形成,促进创面愈合,减少并发症。

关键词：痔痔切除术手术后并发症水肿疼痛熏洗疗法解毒生肌汤麻仁软胶囊

抗β2糖蛋白Ⅰ抗体加速载脂蛋白E基因敲除小鼠动脉粥

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中华心血管病杂志 2017年第1期45卷 44-48页

作者：王晓燕周红朱晓洁夏龙飞何超蔡谦谦王婷江苏大学医学院临床检验与血液研究室镇江212013

目的探讨抗β2糖蛋白Ⅰ（β2GPⅠ）抗体对载脂蛋白E基因敲除（ApoE－/－）小鼠动脉粥样硬化形成的影响。方法SPF级雄性ApoE－/－小鼠24只，6～8周龄，体重20～23 g，分为正常饮食对照组、高脂饮食对照组、高脂饮食＋抗β2GPⅠ抗体组和... 详细信息

目的探讨抗β2糖蛋白Ⅰ（β2GPⅠ）抗体对载脂蛋白E基因敲除（ApoE－/－）小鼠动脉粥样硬化形成的影响。方法SPF级雄性ApoE－/－小鼠24只，6～8周龄，体重20～23 g，分为正常饮食对照组、高脂饮食对照组、高脂饮食＋抗β2GPⅠ抗体组和高脂饮食＋同源对照IgG组，每组6只。饲养期间每2周记录小鼠体重1次，根据分组每周腹腔注射抗β2GPⅠ抗体（100 μg/只）或同源对照IgG （100 μg/只）1次。饲养16周时利用小动物核磁共振（MRI）仪观察颈动脉脂质沉积情况；采集小鼠眼球血，乙二胺四乙酸抗凝后检测血浆总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL－C）和高密度脂蛋白胆固醇（HDL－C）的水平，计算动脉粥样硬化指数（AI）；处死小鼠分离血管，苏木精伊红（HE）染色观察颈动脉近分叉处管腔狭窄情况，并计算其面积。结果（1）各组小鼠体重监测结果：实验过程中，各组小鼠体重均有不同程度增长，至饲养第16周以高脂饮食对照组增长最为明显，与其他各组比较差异均有统计学意义（P均〈0.05），而高脂饮食＋抗β2GPⅠ抗体组和高脂饮食＋同源对照IgG组与正常饮食对照组比较差异均无统计学意义。（2）各组小鼠血脂的检测结果：饲养第16周时，高脂饮食对照组、高脂饮食＋抗β2GPⅠ抗体组和高脂饮食＋同源对照IgG组小鼠血浆TC和LDL－C水平均高于正常饮食对照组（P均〈0.05），而高脂饮食各组间差异均无统计学意义。而HDL－C水平仅高脂饮食对照组高于正常饮食对照组。TG水平各组间差异均无统计学意义。高脂饮食＋抗β2GPⅠ抗体组小鼠AI高于其他各组（P均〈0.05）。（3）各组小鼠颈动脉管腔脂质沉积、管壁厚度、管腔狭窄程度及颈动脉斑块面积的检测结果：饲养16周，MRI可见高脂饮食＋抗β2GPⅠ抗体组小鼠颈动脉管腔周围白色脂质沉积较其余各组明显。同时，小鼠颈动脉切片HE染色发现，高脂饮食＋抗β2GPⅠ抗体组小鼠颈动脉管腔出现狭窄，其斑块面积占整个管腔百分比为（37.545±1.351）%，明显大于正常饮食对照组[（1.235±0.460）%]、高脂饮食对照组[（11.635±2.751）%]和高脂饮食＋同源对照IgG组[（11.815±2.623）%], P均〈0.01。高脂饮食＋抗β2GPⅠ抗体组小鼠颈动脉斑块面积为[（3.121±0.124）×10^4 μm2]，明显大于正常饮食对照组[（0.094±0.015）×10^4 μm2]、高脂饮食对照组[（1.309±0.147）×10^4 μm2]和高脂饮食＋同源对照IgG组[（1.027±0.228）×104 μm2], P均〈0.01。

关键词：动脉粥样硬化抗磷脂综合征 β2糖蛋白Ⅰ