检索结果-南通市图书馆

oxLDL/β2GPI/抗β2GPI抗体复合物促进A7r5细胞钙化及炎症因子表达

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

细胞与分子免疫学杂志 2019年第12期35卷 1069-1075页

作者：姚雨叶蔡谦谦周红何超张鹏吴倩倩张贵婷匡铭陈芋丹江苏大学医学院血液研究所江苏镇江212013 海军军医大学附属长征医院实验诊断科上海200003

目的探讨氧化低密度脂蛋白/β2糖蛋白I/抗β2糖蛋白I抗体(oxLDL/β2GPI/抗β2GPI抗体)复合物对大鼠血管平滑肌A7r5细胞钙化、炎症因子表达的影响以及Toll样受体4(TLR4)在其中的作用。方法分别用oxLDL、oxLDL/β2GPI复合物、β2GPI/抗β2... 详细信息

目的探讨氧化低密度脂蛋白/β2糖蛋白I/抗β2糖蛋白I抗体(oxLDL/β2GPI/抗β2GPI抗体)复合物对大鼠血管平滑肌A7r5细胞钙化、炎症因子表达的影响以及Toll样受体4(TLR4)在其中的作用。方法分别用oxLDL、oxLDL/β2GPI复合物、β2GPI/抗β2GPI抗体复合物、oxLDL/抗β2GPI抗体复合物、oxLDL/β2GPI/抗β2GPI抗体复合物干预刺激大鼠A7r5细胞系不同时间,采用或不采用TLR4抑制剂TAK-242处理。茜素红染色观察细胞钙化结节,实时荧光定量PCR和Western blot法检测平滑肌蛋白22α(SM22α)和RUNX家族转录因子2(RUNX2)的mRNA和蛋白水平,ELISA检测细胞培养上清中肿瘤坏死因子α(TNF-α)水平;A7r5细胞给予TNF-α刺激后,进一步检测SM22α和RUNX2 mRNA和蛋白水平的变化。结果oxLDL/β2GPI/抗β2GPI抗体复合物能够促进A7r5细胞钙化结节增多,SM22α表达减少而RUNX2明显上升,促进炎症因子TNF-α的表达,TLR4抑制剂能够缓解这一现象;外加不同浓度的TNF-α能够使A7r5细胞SM22α表达下降,RUNX2表达增加。结论oxLDL/β2GPI/抗β2GPI抗体复合物促使A7r5细胞表达炎症因子TNF-α增加,并由此促进细胞发生钙化,同时使细胞由收缩表型向成骨表型发生转变,TLR4参与这一过程。

关键词： oxLDL/β2GPI/抗β2GPI抗体复合物血管平滑肌细胞肿瘤坏死因子(TNF-α) 血管钙化

胸腹部肿瘤患者放射治疗依从性对摆位误差的影响分析

在线全文

学校读者我要写书评

暂无评论

现代肿瘤医学 2023年第21期31卷 4034-4038页

作者：徐金济蔡倩倩居玲玲成俊李伟南通市第三人民医院南通大学附属南通第三医院放疗中心江苏南通226006

目的:分析胸腹部肿瘤患者放射治疗依从性的影响因素及对摆位误差的影响。方法:利用自制依从性评分表对我院2021年03月至2022年06月放疗的胸腹部肿瘤患者进行调查,根据评分分为A组(依从得分≥12分)、B组(依从得分0.05);随着治疗时间推进,... 详细信息

目的:分析胸腹部肿瘤患者放射治疗依从性的影响因素及对摆位误差的影响。方法:利用自制依从性评分表对我院2021年03月至2022年06月放疗的胸腹部肿瘤患者进行调查,根据评分分为A组(依从得分≥12分)、B组(依从得分0.05);随着治疗时间推进,B组在三个方向上误差呈减小趋势(P0.05)。结论:胸腹部肿瘤患者放射治疗依从性越好摆位误差越小,依从性差摆位误差较大的患者随着治疗时间推进误差逐渐减小,其值接近依从性好的患者。为了提高胸腹部肿瘤患者放射治疗效果,临床应采取相应措施,提升治疗依从性,减少摆位误差。

关键词：肿瘤放射治疗依从性摆位误差

基于SII和TSP的Ⅱ、Ⅲ期胃腺癌术后患者预后相关列线图模型的构建与验证

在线全文

学校读者我要写书评

暂无评论

现代肿瘤医学 2022年第23期30卷 4277-4284页

作者：杨彦程非池邱佳辉蔡谦谦黄陈蚌埠医学院研究生院安徽蚌埠233000 上海交通大学附属第一人民医院胃肠外科上海200080

目的:探索术前系统性免疫炎症指标(systemic immune-inflammation index,SII)、病理特征肿瘤间质百分比(tumor stroma percentage,TSP)对Ⅱ、Ⅲ期胃腺癌术后患者预后的评估价值,构建并验证基于SII及TSP的预后相关列线图模型。方法:回顾... 详细信息

目的:探索术前系统性免疫炎症指标(systemic immune-inflammation index,SII)、病理特征肿瘤间质百分比(tumor stroma percentage,TSP)对Ⅱ、Ⅲ期胃腺癌术后患者预后的评估价值,构建并验证基于SII及TSP的预后相关列线图模型。方法:回顾性分析我院行胃癌根治术的Ⅱ、Ⅲ期胃腺癌术后患者380例临床病理资料,并对SII和病理特征TSP分组,比较不同分组下临床病理资料与生化指标的差异。生存分析采用乘积极限法(Kaplan-Meier),并进行对数秩检验(Log-rank test)。Cox比例风险回归模型进行单因素和多因素分析,以确定对预后有影响的因素。分别绘制术前SII、TSP、pTNM分期及联合预测患者预后的受试者工作特征曲线(receiver operating characteristic curve,ROC),并计算曲线下面积(area under the curve,AUC)以比较预测效能。采用R软件(版本4.0.5)构建预后列线图,并进行内部验证。结果:共入组380例Ⅱ、Ⅲ期胃腺癌患者。男女比例为2.8∶1。发病年龄≥60岁(80.26%)、低分化(61.58%)占比较高。Ⅱ、Ⅲ期占比分别为36.32%、63.68%。大部分患者(82.37%)伴淋巴结转移。神经侵犯达61.58%,脉管癌栓达64.74%。将入组患者的SII高、低分组与其他临床病理资料比较分析,发现高、低SII两组间各临床病理特征差异无统计学意义(均P>0.05)。高TSP组200例(52.63%),低TSP组180例(47.37%)。与低TSP组相比,高TSP组中pTNM分期较晚,近端胃、淋巴结转移、神经侵犯、脉管癌栓比例较高,差异具有统计学意义(均P0.05)。低SII组总体生存率显著高于高SII组(P=0.0297),低TSP组总体生存率显著高于高TSP组(P<0.001)。pTNM分期、神经侵犯、TSP、SII是影响入组患者总体生存的独立预后因素(均P<0.05)。ROC曲线结果显示,联合SII、TSP、pTNM分期较单一因素可更为有效预测Ⅱ、Ⅲ期胃腺癌患者的预后。列线图模型C指数为0.6867(95%CI:0.6445~0.7290),AIC为1832,校准预测曲线与理想曲线贴合良好。结论:高SII、高TSP是Ⅱ、Ⅲ期胃腺癌术后患者预后不良的独立危险因素。基于SII和TSP的列线图模型预测准确性较好,有助于对Ⅱ、Ⅲ期胃腺癌术后患者的预后评估。

关键词：胃腺癌系统性免疫炎症指标肿瘤间质百分比肿瘤微环境

在线全文

学校读者我要写书评

暂无评论

基于机器视觉的机器人分拣技术发展研究

现代制造技术与装备 2018年第8期54卷 9-11,14页

作者：蔡倩倩宁祎王雷河南工业大学机器人研究所郑州450007

在工业生产中,完全人工分拣作业很难实现生产目标,而传统机器人分拣还存在系统稳定性较差、精度较低等缺点。针对这些问题,在传统分拣机器人中引入机器视觉,完成对工件、食品以及其它产品的分拣工作,不仅能够满足生产需求,而且能够提高... 详细信息

在工业生产中,完全人工分拣作业很难实现生产目标,而传统机器人分拣还存在系统稳定性较差、精度较低等缺点。针对这些问题,在传统分拣机器人中引入机器视觉,完成对工件、食品以及其它产品的分拣工作,不仅能够满足生产需求,而且能够提高生产效率。基与此,重点分析目标识别、目标跟踪以及视觉伺服等关键技术的研究现状以及在工业、食品以及其它领域的应用现状,并对未来的发展趋势进行展望。

关键词：机器视觉分拣机器目标跟踪目标识别视觉伺服

在线全文

学校读者我要写书评

暂无评论

基于改进粒子群算法的微电网能量管理模型

电器与能效管理技术 2016年第4期 51-57页

作者：蔡乾乾刘西强段善旭蔡涛张威华中科技大学电气与电子工程学院湖北武汉430074 陕西省电子信息产品监督检验院陕西西安710004

为了实现微电网运行的可靠性和经济性,对其进行能量优化管理是微电网运行的关键。提出一种基于改进粒子群算法的微电网能量管理模型,改进算法重点在于提出一种寻找可行解方法,将可行解作为粒子群初始位置,并使用步长加速法对部分可行解... 详细信息

为了实现微电网运行的可靠性和经济性,对其进行能量优化管理是微电网运行的关键。提出一种基于改进粒子群算法的微电网能量管理模型,改进算法重点在于提出一种寻找可行解方法,将可行解作为粒子群初始位置,并使用步长加速法对部分可行解进一步搜索得到更优解。通过一个直流微电网验证了所提模型的有效性,算例运行结果表明,所提模型在不同能量管理策略下实现了微电网运行的可靠性和经济性。

关键词：微电网能量管理粒子群算法可行解步长加速法

A Cross Attention Transformer-Mixed Feedback Video Recommendation Algorithm Based on DIEN

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 977-996页

作者： Jianwei Zhang Zhishang Zhao Zengyu cai Yuan Feng Liang Zhu Yahui Sun College of Software Engineering Zhengzhou University of Light IndustryZhengzhou450000China Faculty of Information Engineering Xuchang Vocational Technical CollegeXuchang461000China College of Computer Science and Technology Zhengzhou University of Light IndustryZhengzhou450000China College of Electronics and Information Zhengzhou University of Light IndustryZhengzhou450000China

The rapid development of short video platforms poses new challenges for traditional recommendation *** systems typically depend on two types of user behavior feedback to construct user interest profiles:explicit feedback(interactive behavior),which significantly influences users’short-term interests,and implicit feedback(viewing time),which substantially affects their long-term ***,the previous model fails to distinguish between these two feedback methods,leading it to predict only the overall preferences of users based on extensive historical behavior ***,it cannot differentiate between users’long-term and shortterm interests,resulting in low accuracy in describing users’interest states and predicting the evolution of their *** paper introduces a video recommendationmodel calledCAT-MFRec(CrossAttention Transformer-Mixed Feedback Recommendation)designed to differentiate between explicit and implicit user feedback within the DIEN(Deep Interest Evolution Network)*** study emphasizes the separate learning of the two types of behavioral feedback,effectively integrating them through the cross-attention ***,it leverages the long sequence dependence capabilities of Transformer technology to accurately construct user interest profiles and predict the evolution of user *** results indicate that CAT-MF Rec significantly outperforms existing recommendation methods across various performance *** advancement offers new theoretical and practical insights for the development of video recommendations,particularly in addressing complex and dynamic user behavior patterns.

关键词： Video recommendation user interest cross-attention transformer

商务园区安全生产监管体系的构建——以北京恒通商务园为例

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

安全与环境工程 2017年第2期24卷 132-136页

作者：姜智旭刘倩倩蔡敏京东方科技集团股份有限公司北京100015

为实现商务园区的安全生产及正常运行,保障生产经营活动持续稳定好转,在严格遵守国家法律法规的前提下,从北京恒通商务园安全生产监管的实际工作出发,提出安全生产基础管理和现场管理相结合的管理方法,并通过提炼管理过程中的主要规章... 详细信息

为实现商务园区的安全生产及正常运行,保障生产经营活动持续稳定好转,在严格遵守国家法律法规的前提下,从北京恒通商务园安全生产监管的实际工作出发,提出安全生产基础管理和现场管理相结合的管理方法,并通过提炼管理过程中的主要规章制度及工作流程,逐步完善了商务园区安全生产监管体系,最终构建了适合商务园区的制度化、系统化、标准化、专业化的安全生产监管体系。

关键词：商务园区安全生产监管体系基础管理

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie Lu Ying Han Yanning cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

Long noncoding RNA LINC01106 promotes lung adenocarcinoma progression via upregulation of autophagy

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 171-184页

作者： GENGYUN SUN YIPING ZHENG JIANFENG cai JIE GAO LIE DONG XIANGBIN ZHANG YINGHUI HUANG Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Respiratory and Critical Care Medicine Nanping First Hospital Affiliated to Fujian Medical UniversityNanping353006China

Background:Long noncoding RNA,LINC01106 exhibits high expression in lung adenocarcinoma(LUAD)tumor tissues,but its functional role and regulatory mechanism in LUAD cells remain ***:LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was *** cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor *** downstream transcription factors and molecular mechanism were determined using the Human transcription factor database(TFDB)database and Gene Expression Profiling Interactive Analysis(GEPIA)***,the impact of linc01106 on autophagy was analyzed by determining the expression of autophagy-related genes(ATGs)in LUAD ***:Our results showed that LINC01106 exhibited upregulation in both LUAD tissues and cell *** silencing of LINC01106 demonstrated a suppressive effect on tumorigenesis in a xenograft mouse model of ***,LINC01106 was found to recruit TATA-binding protein-associated factor 15(TAF15),an RNA-binding protein,thereby enhancing the mRNA stability of TEA domain transcription factor 4(TEAD4).In turn,TEAD4 served as a transcription factor that bound to the LINC01106 promoter and regulated its *** assays indicated that LINC01106 promoted autophagy in LUAD cells by upregulating the expression of autophagy-related genes(ATGs).The silencing of LINC01106 in LUAD cells inhibited autophagy,and cell proliferation,and promoted apoptosis,which all were effectively reversed by ATG5 ***:Overall,LINC01106,transcriptionally activated by TEAD4,interacts with TAF15 to promote the stability of TEAD4 and upregulates the expression of ATGs,promoting malignancy of LUAD cells.

关键词： LINC01106 TAF15 TEAD4 ATG5 Lung adenocarcinoma(LUAD) Non-small cell lung cancer(NSCLC)