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Changes of gastrointestinal myoelectric activity and bile acid pool size after cholecystectomy in guinea pigs

World Journal of Gastroenterology 2005年第24期11卷 3665-3670页

作者： Xue-MeiZhang LeiDong Li-NaLiu Bi-XiaChang QianHe qianli DepartmentofGastroenterology SecondHospitalofXi'anJiaotongUniversityXi'an710004ShaanxiProvinceChina DepartmentofClinicalLab SecondHospitalofXi'anJiaotongUniversityXi'an710004ShaanxiProvinceChina Centerofultrasonography SecondHospitalofXi'anJiaotongUniversityXi'an710004ShaanxiProvinceChina

AIM: To investigate the bile acid pool size after cholecystectomy whether or not correlated to the gastrointestinal migrating myoeiectric complex (MMC) in guinea pigs. METHODS: Gallbladder motilities were assessed before cholecystectomy. Furthermore, we continuously monitored interdigestive gastrointestinal motilities using bipolar electrodes in conscious guinea pigs before and after surgery at 4 wk in standard diet group and high cholesterol diet (cholesterol gallstone) group. Total bile acid pool sizes were measured by isotope dilution method at meantime. RESULTS: After cholecystectomy, there were parallel falls in duration of phase Ⅰ, Ⅱ, Ⅲ and MMC cycle duration but increase in amplitude in the guinea pigs with normal gallbladder function, and in the guinea pigs with cholesterol stones. However, There were not significantly differences. On the other hand, the bile acid pool was definitely small in the GS guinea pigs compared to normal guinea pigs and became slightly smaller after cholecystectomy. Similarly, bile acid in gallbladder bile, fecal bile acid was slightly increased in GS guinea pigs after cholecystectomy, to the same degree as normal. These differences, however, were not significant. CONCLUSION: It is concluded that in the guinea pigs with normal gallbladder function, and in the guinea pigs with cholesterol stones: (1) Cholecystectomy produce a similar but less marked trend in bile acid pool; and (2) MMC are linked to enterohepatic circulation of bile acids, rather than surgery, which is consistent with changes of the bile acid pool size. As a result, gastrointestinal dyskinesia is not involved in occurrence of postchole cystectomy syndrome.

关键词： Cholecystectomy Enterohepatic circulation of bile acids Bile acid pool Migrating motor complex Gallbladder motility

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Influence of High Relative Humidity on Secondary Organic Carbon: Observations at a Background Site in East China

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Journal of Meteorological Research 2019年第5期33卷 905-913页

作者： Linlin LIANG Guenter ENGLING Yuan CHENG Xiaoye ZHANG Junying SUN Wanyun XU Chang LIU Gen ZHANG Hui XU Xuyan LIU qianli MA State Key Laboratory of Severe Weather&Key Laboratory for Atmospheric Chemistry Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081China State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex Beijing 100084China Division of Atmospheric Sciences Desert Research InstituteRenoNV 89512USA California Air Resources Board CA 91731USA School of Environment Harbin Institute of TechnologyHarbin 150001China National Satellite Meteorological Center China Meteorological AdministrationBeijing 100081China Lin'an Regional Atmosphere Background Station Lin'an 311307China

To investigate the impacts of relative humidity(RH) on secondary organic aerosol(SOA) concentrations and chemical reactions, the carbonaceous aerosol components [i.e., organic carbon(OC) and element carbon(EC)] were quantified in daily PM2.5 samples collected at a background site in East China during summer 2015. Based on the method of EC-tracer, the concentration of secondary organic carbon(SOC) demonstrated an obvious negative relationship with RH higher than 60%. Moreover, the ratio of SOC/EC also exhibited obvious decreasing trends with increasing RH, indicating negative effects for chemical production of SOA under high RH conditions. due to high RH,photochemistry was weakened, gaseous oxidant concentrations was lowered(e.g., significantly decreased O3 levels),and the production rates of SOA were relatively low. On the other hand, because of more water uptake under higher RH conditions, the aerosol droplet acidity was reduced and enhancement of SOA formation by acidity was accordingly absent. In addition, high RH also plays an important role in changing viscosity of pre-existing aerosol coatings,which can affect reactive uptake yield of SOA. Overall, the results from this study imply that SOA production may be more associated with photochemical processes, while aqueous-phase chemistry is not very important for some SOA formation in a moist ambient environment. In the ambient atmosphere, oxidant concentrations, reaction rates,airborne species, etc., are highly variable. How do these factors affect SOA yields under given ambient environment warrants further detailed investigations.

关键词： relative humidity organic aerosol secondary organic carbon(SOC) photochemistry aqueous-phase

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A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2406-2416页

作者： Pedro Martín-Acosta qianli Meng John Klimek Ashok P.Reddy Larry David Stefanie Kaech Petrie Bingbing X.Li Xiangshu Xiao Program in Chemical Biology Department of Chemical Physiology and BiochemistryOregon Health&Science UniversityPortlandOR 97239USA Proteomics Shared Resource Oregon Health&Science UniversityPortlandOR 97239USA Knight Cancer Institute Oregon Health&Science UniversityPortlandOR 97239USA Department of Neurology Oregon Health&Science UniversityPortlandOR 97239USA

Target identification of bioactive compounds is important for understanding their mechanisms of action and provides critical insights into their therapeutic utility. While it remains a challenge,unbiased chemoproteomics strategy using clickable photoaffinity probes is a useful and validated approach for target identification. One major limitation of this approach is the efficient synthesis of appropriately substituted clickable photoaffinity probes. Herein, we describe an efficient and consistent method to prepare such probes. We further employed this method to prepare a highly stereo-congested probe based on naturally occurring triterpenoid betulinic acid. With this photoaffinity probe, we identified tropomyosin as a novel target for betulinic acid that can account for the unique biological phenotype on cellular cytoskeleton induced by betulinic acid.

关键词： Betulinic acid Cancer Diazirine Natural product Photoaffinity probe Tropomyosin

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Investigation of frost heave prevention using permeable subgrade structure

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Research in Cold and Arid Regions 2015年第5期7卷 611-618页

作者： DeGou Cai JianPing Yao HongYe Yan qianli Zhang AiJun Cheng Jie Liu Railway Engineering Research Institute China Academy of Rails Science

This paper set up a series of comprehensive targets based on the concept of＇anti-freeze filler＇, which include reasonable water retention rate, frost heave characteristics, and compaction characteristics of filling material. Then, a type of permeable graded gravel is proposed, suitable for high-speed railway subgrade. A series of in-door water retention, permeability, and frost heave tests were performed under different graded conditions. Water retention, permeability, and frost heave characteristic of dif- ferent graded filling materials can be determined, in order to define the gradation range of permeable graded gravel. Relying on the frost-heave monitoring record of high speed railway in Northeast China, a series of experimental studies were per- formed, which included on-site filler production, compaction test, and the anti-frost effect test, in order to improve the pro- duction and compaction techniques of permeable graded gravel. From the research of this paper, the use of permeable graded gravel subgrade as the anti-frost structure for the high-speed railway subgrade in cold areas is feasible.

关键词： high-speed railway frost-heave prevention structure permeable filling material filling material production compaction control

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bMSC secretion of sRANKL/OPG/M-CSF in response to macrophage-mediated inflammatory response influences osteogenesis on nanostructured Ti surfaces

bMSC secretion of sRANKL/OPG/M-CSF in response to macrophage...

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第十二届全国免疫学学术大会

作者： Ma qianli Chen Lihua Department of immunology school of basic medicinefourth military medical university

Objectives:The interaction among biomaterials,macrophages,and bMSCs play a vital role which contributes to the clinical outcome of *** it has been well reported that bMSC osteogenic differentiation or macrophage osteo... 详细信息

关键词： macrophage bMSCs surface nanostucture cytokines osteoclastic differentiation

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Investigation of insulation layer dynamic characteristics for high-speed railway

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Research in Cold and Arid Regions 2015年第4期7卷 430-437页

作者： HongYe Yan GuoTang Zhao DeGou Cai qianli Zhang JianPing Yao AiJun Cheng Railway Engineering Research Institute China Academy of Railway Sciences China Railway Corporation

Dynamic performance of insulation is one of the key parameters during the insulation application for high-speed railway subgrade. This paper conducted laboratory and field tests for the materials and dynamic load, especially for thermal performance, elastic deformation, and accumulated deformation of insulation materials. Experiment results show that mechanical properties of insulation layer structure are stable, which satisfies the requirements of the high speed railway.

关键词： high-speed railway insulation materials dynamic load elastic deformation accumulated deformation

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A Survey on Low Complexity Detectors for OTFS Systems

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ZTE Communications 2021年第4期19卷 3-15页

作者： ZHANG Zhengquan LIU Heng WANG qianli FAN Pingzhi Key Lab of Information Coding and Transmission Southwest Jiaotong UniversityChengdu 611756China State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an 710071China

The newly emerging orthogonal time frequency space(OTFS)modulation can ob⁃tain delay-Doppler diversity gain to significantly improve the system performance in high mobility wireless communication scenarios such as vehicle-to-everything(V2X),high-speed railway and unmanned aerial vehicles(UAV),by employing inverse symplectic finite Fouri⁃er transform(ISFFT)and symplectic finite Fourier transform(SFFT).However,OTFS modu⁃lation will dramatically increase system complexity,especially at the receiver ***,de⁃signing low complexity OTFS receiver is a key issue for OTFS modulation to be adopted by new-generation wireless communication *** this paper,we review low complexity OTFS detectors and provide some insights on future *** firstly present the OTFS system model and basic principles,followed by an overview of OTFS detector structures,classifications and comparative *** also survey the principles of OTFS detection ***,we discuss the design of hybrid OTFS and orthogonal frequency di⁃vision multiplexing(OFDM)detectors in single user and multi-user multi-waveform commu⁃nication ***,we address the main challenges in designing low complexity OT⁃FS detectors and identify some future research directions.

关键词： high mobility wireless communications OTFS ISFFT SFFT delay-Doppler di⁃versity iterative maximum ratio combining(MRC)detection message passing detection

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Deep brain implantable microelectrode arrays for detection and functional localization of the subthalamic nucleus in rats with Parkinson’s disease

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Bio-Design and Manufacturing 2024年第4期7卷 439-452页

作者： Luyi Jing Zhaojie Xu Penghui Fan Botao Lu Fan Mo Ruilin Hu Wei Xu Jin Shan qianli Jia Yuxin Zhu Yiming duan Mixia Wang Yirong Wu Xinxia Cai State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

The subthalamic nucleus(STN)is considered the best target for deep brain stimulation treatments of Parkinson’s disease(PD).It is difficult to localize the STN due to its small size and deep *** microelectrode arrays(MEAs)can rapidly and precisely locate the STN,which is important for precise *** this paper,16-channel MEAs modified with multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(MWCNT/PEDOT:PSS)nanocomposites were designed and fabricated,and the accurate and rapid identification of the STN in PD rats was performed using detection sites distributed at different brain *** results showed that nuclei in 6-hydroxydopamine hydrobromide(6-OHDA)-lesioned brains discharged more intensely than those in unlesioned *** addition,the MEA simultaneously acquired neural signals from both the STN and the upper or lower boundary nuclei of the ***,higher values of spike firing rate,spike amplitude,local field potential(LFP)power,and beta oscillations were detected in the STN of the 6-OHDA-lesioned brain,and may therefore be biomarkers of STN *** with the STNs of unlesioned brains,the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta band of 6-OHDA-lesioned *** may be a cause of sleep and motor disorders associated with ***,this work describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei.

关键词： Functional localization Implantable microelectrode arrays Parkinson’s disease Subthalamic nucleus

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Study on hepatoprotective effect of peptide S-8300 from shark liver

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World Journal of Gastroenterology 2005年第12期11卷 1809-1812页

作者： Feng-JieHuang Zheng-BingLv qianli Li-JunWei LiangZhang Wu-TongWu SchoolofLifeScienceandTechnology ChinaPharmaceuticalUniversityNanjing210009JiangsuProvinceChina

AIM: To explore the effects of peptide S-8300 from shark liver (S-8300) on liver function as well as in regulating immune functions in experimental injury models. METHODS: Mice were administered with different doses of S-8300 for four consecutive days, followed by mice injected with tetrachloromethane (CCI4) on d 3. The activity of ALT, AST, LDH, SOD and contents of MDA and GSH in the mice liver were tested. And mice were treated with Cy (100 mg/kg) at the beginning of the experiment to induce immunosuppression model. The S-8300 groups were treated with S-8300 seven days after the beginning of Cy administration. The effects of S-8300 on the formulation of serum hemolysin and the content of IL-2 in serum in the immunosuppression mice were observed. RESULTS: S-8300 obviously decreased the level of ALT (52.2±11.0 U/dL vs135.9±6.5 U/dL, Pdulatory and inhibiting of lipid peroxidation activity.

关键词： CCl4 Immunosuppression IL-2 Hepatopratective Serum hemolysin

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对《大明会典》的两种冲突诠释--1668年闵明我与潘国光在广州就祭孔礼仪的争论

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贵州社会科学 2020年第8期 72-82页

作者：梅谦立中山大学哲学系、广州与中外文化交流研究中心广东广州510275

《大明会典》对中国社会产生了深远的影响,因此对于中国历史的研究者们而言,这是一部重要的史料。然而,只有少数学者知道它曾成为天主教传教士在中国礼仪之争期间的重要资源,其中关于祭丁礼仪的部分曾被翻译成拉丁文、西班牙文、法文等... 详细信息

《大明会典》对中国社会产生了深远的影响,因此对于中国历史的研究者们而言,这是一部重要的史料。然而,只有少数学者知道它曾成为天主教传教士在中国礼仪之争期间的重要资源,其中关于祭丁礼仪的部分曾被翻译成拉丁文、西班牙文、法文等等文字。通过对不同译文进行细致的文本分析以及对礼仪之争的神学和哲学背景进行讨论,可以得出这样的结论:中国礼仪之争双方曾在广州对于祭丁礼仪作出两种解释,它们之间张力十足,充满了冲突性。

关键词：礼仪之争祭孔《大明会典》耶稣会闵明我潘国光多明我会广州

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