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配糟对清香型白酒发酵中环境因子及微生物群落的影响

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微生物学通报 2024年第2期51卷 554-572页

作者：唐洁阮松林斌陈前锦杜栋夏金阳江威杨生智杨强陈申习劲牌有限公司劲牌研究院中药保健食品质量与安全湖北省重点实验室湖北黄石435100

【背景】环境因子是影响微生物生长代谢的重要因素,解析半开放条件下酿造过程中环境因子对微生物群落演替的作用对于清香型白酒生产调控具有重要意义。配糟在白酒发酵过程中起着调节发酵速度的作用,其对微生物群落组成变化的影响尚不明... 详细信息

【背景】环境因子是影响微生物生长代谢的重要因素,解析半开放条件下酿造过程中环境因子对微生物群落演替的作用对于清香型白酒生产调控具有重要意义。配糟在白酒发酵过程中起着调节发酵速度的作用,其对微生物群落组成变化的影响尚不明确。【目的】揭示使用不同发酵周期配糟对清香型白酒发酵过程中环境因子及微生物群落演替的影响。【方法】采用PacBio测序平台和多元统计分析比较使用2种配糟酒醅中微生物群落结构组成,结合蒙特卡洛置换检验明确环境因子对微生物群落的影响。【结果】与使用正常发酵周期配糟酒醅相比,使用延长发酵周期配糟酒醅水分较低,而酸度、氨基酸态氮、总游离氨基酸、还原糖和残余淀粉较高;微生物多样性和丰富度分析发现,使用延长发酵周期配糟酒醅中细菌α多样性极显著高于使用正常发酵周期配糟酒醅(P<0.001),而真菌α多样性显著/极显著低于使用正常发酵周期配糟酒醅(P<0.05, P<0.001);通过组间差异性分析发现,细菌群落共产生28个差异指示种,而真菌群落共产生15个差异指示种;水分、酸度、氨基酸态氮、还原糖、残余淀粉和总游离氨基酸对微生物群落结构的影响显著(P<0.05),其中水分、酸度、氨基酸态氮和总游离氨基酸与使用延长发酵周期配糟酒醅微生物群落密切相关,还原糖和残余淀粉是使用正常发酵周期配糟酒醅微生物群落演替的主要驱动因素。【结论】本研究揭示了使用不同发酵周期配糟的清香型白酒发酵过程中环境因子对微生物群落组装的驱动作用,为清香型白酒的可控发酵提供了理论基础。

关键词：清香型白酒配糟环境因子高通量测序微生物群落

Surface facets dependent oxygen evolution reaction of single Cu_(2)O nanoparticles

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Chinese Chemical Letters 2022年第12期33卷 5158-5161页

作者： Yun Shan Xiaoli Deng Xiaoxi Lu Cong Gao Yingjian Li qianjin chen State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China

Understanding and establishing the structure-activity relation of nanoparticles is a prerequisite for rational design of high-performance ***_(2)O nanoparticles enclosed with different crystal facets,namely,o-Cu_(2)O NPs with{111}facets,c-Cu_(2)O NPs with{100}facets are prepared and their electrocatalytic properties for oxygen evolution reaction(OER)in alkaline condition are evaluated at single nanoparticle level with a combination of scanning electrochemical cell microscopy and scanning electron *** is found that the o-Cu_(2)O NPs have significantly superior OER electrocatalytic activity compared to c-Cu_(2)O,which is almost *** estimated turnover frequency(TOF)at 1.97 V *** on{111}facet increases from 4 s^(-1) to 115 s^(-1) with the octahedron edge length decreasing from 1.3μm to 100 *** of carbon on c-Cu_(2)O surface barely promotes the activity,suggesting the inherent poor electric conductivity within the nanocrystal is most likely the reason for low *** work provides direct probing to single transition metal oxide crystals with dramatically different activity.

关键词： Oxygen evolution reaction Cu_(2)O nanoparticle Facets Scanning electrochemical cell microscopy Single-particle analysis

具有聚集诱导发光性质的铂(Ⅱ)金属大环的合成

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合成化学 2024年第4期32卷 345-351页

作者：彭宇陈茂文刘森坤陈前进张灯青东华大学化学与化工学院上海201620

含有四苯乙烯(TPE)基团的铂(Ⅱ)金属大环化合物具有良好的聚集诱导发光(AIE)性质,在构建人工光捕获体系中具有潜在的应用价值。为了获得一种具有良好AIE性质的新型铂(Ⅱ)金属大环化合物,以4,4-二溴四苯乙烯为原料,经硝化反应得到化合物2... 详细信息

含有四苯乙烯(TPE)基团的铂(Ⅱ)金属大环化合物具有良好的聚集诱导发光(AIE)性质,在构建人工光捕获体系中具有潜在的应用价值。为了获得一种具有良好AIE性质的新型铂(Ⅱ)金属大环化合物,以4,4-二溴四苯乙烯为原料,经硝化反应得到化合物2,再将化合物2中硝基还原得到化合物3,化合物3与十二烷基酰氯发生缩合反应得到化合物4,化合物4与4-乙炔基吡啶盐酸盐发生Sonogashira偶联反应得到四苯乙烯衍生物5。5与铂(Ⅱ)配体6进行[3+3]配位驱动自组装合成六边形铂(Ⅱ)金属大环化合物7,其结构经核磁、质谱和紫外可见吸收光谱表征。结果表明:紫外可见吸收光谱显示化合物7的最大吸收波长在302 nm;荧光光谱显示化合物7在水含量低于20%(体积分数,下同)的二甲基亚砜(DMSO)/水(H_(2)O)混合溶液中,荧光强度极低,当水含量增加到30%时,荧光强度大幅增加,表现出优异的AIE性质。

关键词：配位驱动自组装四苯乙烯铂(Ⅱ)金属大环聚集诱导发光合成

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元大都织帽匠何失生平及交游考

民族文学研究 2023年第6期41卷 155-167页

作者：陈前进北京师范大学文学院

元代中期的社会生态塑造出了何失“织帽匠”“老征夫”“诗人”“隐士”的四重形象。由于科举在元代的长期缺失,使得大量“贾服儒行”的普通文人在元代社会的身份转化中更具张力,他们一生游离于官、隐、商、儒等身份之间,上可以以布衣... 详细信息

元代中期的社会生态塑造出了何失“织帽匠”“老征夫”“诗人”“隐士”的四重形象。由于科举在元代的长期缺失,使得大量“贾服儒行”的普通文人在元代社会的身份转化中更具张力,他们一生游离于官、隐、商、儒等身份之间,上可以以布衣取卿相,下可以以生事避红尘。在科举未兴、荐举盛行的元代中期政治生态背景下,何失的影响力所反映的应是当时荐举制下有举荐权力的上层官员所产生的一种潜在影响力。作为北上的南人,即使是后来的文坛盟主如虞集、揭傒斯等在初入大都时也不得不通过荐举制来依附于李孟、王约、吴元珪等这样的朝中大臣。同时,何失的交友圈也是在当时多元文化和多族士人圈互动背景下所构建起来的,彼时官、隐、商、儒等各种身份的文化个体在相对平等的多元氛围中上下流转,积极交游,并借助诗、酒、书、画等文化活动积极地进行族群互动、阶层互动和文化互动。

关键词：何失织帽匠李孟虞集揭傒斯

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《清平调》新解——兼论李白被“赐金放还”

杜甫研究学刊 2023年第3期 80-92,120页

作者：陈前进北京师范大学文学院 100875

《清平调》三首诗之间有严密的逻辑关系,第一首写玄宗与杨妃未见时,第二首写两人初见时,第三首写其长相守。就三首诗的主旨而言,李白在此并无讥刺之意,而当以褒为主,李白是借三首诗在奉迎“礼同皇后”的杨妃。李白被“赐金放还”当与李... 详细信息

《清平调》三首诗之间有严密的逻辑关系,第一首写玄宗与杨妃未见时,第二首写两人初见时,第三首写其长相守。就三首诗的主旨而言,李白在此并无讥刺之意,而当以褒为主,李白是借三首诗在奉迎“礼同皇后”的杨妃。李白被“赐金放还”当与李白“不拘细行”的性格和玄宗极为重视礼法的态度有很大关系,同时无论是李白被招入长安还是后来被逐出长安,都与玄宗对道教的态度有关。

关键词：李白《清平调》赐金放还

上博简《孔子诗论》留白简简序新排——兼谈《孔子诗论》整体分章问题

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宿州教育学院学报 2022年第2期25卷 81-85页

作者：陈前进北京师范大学文学院北京100875

《孔子诗论》简的简序编排问题一直争议较大,目前至少已有15种不同的编连方案。从简制和文意两个方面入手,可以对第1-7简的留白简的顺序进行重新考查。在所有29枚简中,第1简所在位置争议最大,而通过对文义和文例两个方面的分析,将第1简... 详细信息

《孔子诗论》简的简序编排问题一直争议较大,目前至少已有15种不同的编连方案。从简制和文意两个方面入手,可以对第1-7简的留白简的顺序进行重新考查。在所有29枚简中,第1简所在位置争议最大,而通过对文义和文例两个方面的分析,将第1简排在第3简之后较为合适,同时根据“墨节符”的位置可以把所有29枚简的内容分成三个大的章节。

关键词：上博简《孔子诗论》简序

国内外特殊儿童个别化教育计划研究热点比较及启示

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教育与教学研究 2022年第4期36卷 100-116页

作者：陈秋珠陈芊锦陕西师范大学教育学部陕西师范大学陕西西安710062

个别化教育计划(IEP)是将全纳理想付诸实践的工具之一,是融合教育有效实施的关键。文章采用文献计量与质性分析相结合的方法,运用CiteSpace软件对2004—2021年国内外IEP研究的热点进行梳理与比较,以期对我国IEP的有效实施有所启示,进而... 详细信息

个别化教育计划(IEP)是将全纳理想付诸实践的工具之一,是融合教育有效实施的关键。文章采用文献计量与质性分析相结合的方法,运用CiteSpace软件对2004—2021年国内外IEP研究的热点进行梳理与比较,以期对我国IEP的有效实施有所启示,进而提升随班就读的实施质量。研究发现,国内IEP研究热点聚焦于对国外有关IEP研究的梳理与分析、IEP对7~18岁学龄期智障儿童发展的影响以及学校在IEP实施中的干预作用;国外IEP研究聚焦于IEP实施的运作机制、IEP对0~21岁各年龄段特殊儿童的影响以及教师和家长对IEP实施的干预作用。对国内外IEP研究热点比较分析发现,国内的研究范式以经验—分析范式为主,国外以科学实证研究范式为主;国内研究的对象聚焦于7~18岁学龄期的特殊儿童,国外研究涵盖0~21岁全年龄段的特殊儿童;国内研究的支持体系以学校参与为主,国外研究以家庭参与为主。未来我国应在扎根本土的基础上借鉴国际先进经验、重视IEP服务对象的多样性以及促进家长和学生参加IEP会议。

关键词：特殊儿童个别化教育计划研究热点

Visualizing the Electrochemical H2 Bubble Nucleation at Pt Surface and its Heterogeneous Junctions

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Visualizing the Electrochemical H2 Bubble Nucleation at Pt S...

Efficacy and safety of CM310 in moderate-to-severe atopic dermatitis:A multicenter,randomized,double-blind,placebo-controlled phase 2b trial

中国化学会第二十次全国电化学大会

作者： qianjin chen Yulong Liu cheng Jin College of Chemistry Chemical Engineering and Biotechnology Donghua University

Electrolytic gas evolution is a significant phenomenon in many electrochemical technologies from water splitting, chlor-alkali process to fuel cells. Although it is known that gas evolution may substantially affect the ohmic resistance and mass/ion transfer, the study focusing on the electrochemistry of individual bubbles has not been much explored. Here we develop a single-entity approach to study individual gas bubbles on polycrystalline Pt and Au substrate via scanning electro-chemical cell microscopy. Due to the confinement effect of micropipette, well defined peak-shaped voltammetry featuring single bubble nucleation and growth is consistently observed. This technique is further employed to visualize bubble nuclea-tion at heterogeneous Pt/Au surface and significantly less activation energy barrier is found for bubble nucleation at a 30 nm thick Au film from sputtering. Furthermore, Pt surface with different surface nanostructures shows very different xxxx for bubble nucleation. In combination with material structure characterization, this study has provided unique understand-ing to the gas involved electrode process and proven SECCM a promising general technique for nanoscale electrocatalysis.

关键词：

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Chinese Medical Journal 2024年第2期137卷 200-208页

作者： Yan Zhao Jianzhong Zhang Bin Yang Jingyi Li Yangfeng Ding Liming Wu Litao Zhang Jinyan Wang Xiaohong Zhu Furen Zhang Xiaohua Tao Yumei Li Chunlei Zhang Linfeng Li Jianyun Lu Qingchun Diao qianjin Lu Xiaoyong Man Fuqiu Li Xiujuan Xia Hao cheng Yingmin Jia Guoqing Zhao Jinchun Yan Bo chen Department of Dermatology Peking University People’s HospitalBeijing 100044China Department of Dermatology Dermatology HospitalSouthern Medical UniversityGuangzhouGuangdong 510091China Department of Dermatology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Dermatology Shanghai Skin Disease HospitalInstitute of PsoriasisTongji University School of MedicineShanghai 200443China Department of Dermatology Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China Department of Dermatology Ningbo No.2 HospitalNingboZhejiang 315010China Department of Dermatology The Wuxi Second Affiliated Hospital of Nanjing Medical UniversityWuxiJiangsu 214002China Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Veneorology Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250022China Center for Plastic&Reconstructive Surgery Department of DermatologyZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)HangzhouZhejiang 310014China Department of Dermatology Affiliated Hospital of Jiangsu UniversityZhenjiangJiangsu 212001China Department of Dermatology Peking University Third HospitalBeijing 100191China Department of Dermatology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Dermatology The Third Xiangya Hospital of Central South UniversityChangshaHunan 410013China Department of Dermatology Chongqing Traditional Chinese Medicine HospitalChongqing 400011China Hunan Key Laboratory of Medical Epigenomics Department of DermatologyThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Dermatology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Departme

Background:Atopic dermatitis(AD)affects approximately 10%of adults ***310 is a humanized monoclonal antibody targeting interleukin-4 receptor alpha that blocks interleukin-4 and interleukin-13 *** trial aimed to evaluate the efficacy and safety of CM310 in Chinese adults with moderate-to-severe ***:This multicenter,randomized,double-blind,placebo-controlled,phase 2b trial was conducted in 21 medical institutions in China from February to November *** 120 eligible patients were enrolled and randomized(1:1:1)to receive subcutaneous injections of 300 mg CM310,150 mg CM310,or placebo every 2 weeks for 16 weeks,followed by an 8-week follow-up *** primary endpoint was the proportion of patients achieving≥75%improvement in the Eczema Area and Severity Index(EASI-75)score from baseline at week *** and pharmacodynamics were also ***:At week 16,the proportion of EASI-75 responders from baseline was significantly higher in the CM310 groups(70%[28/40]for high-dose and 65%[26/40]for low-dose)than that in the placebo group(20%[8/40]).The differences in EASI-75 response rate were 50%(high ***,95%CI 31%-69%)and 45%(low ***,95%CI 26%-64%),with both P values<***310 at both doses also significantly improved the EASI score,Investigator’s Global Assessment score,daily peak pruritus Numerical Rating Scale,AD-affected body surface area,and Dermatology Life Quality Index compared with ***310 treatment reduced levels of thymus and activation-regulated chemokine,total immunoglobulin E,lactate dehydrogenase,and blood *** incidence of treatment-emergent adverse events(TEAEs)was similar among all three groups,with the most common TEAEs reported being upper respiratory tract infection,atopic dermatitis,hyperlipidemia,and *** severe adverse events were deemed to be attributed to ***:CM310 at 150 mg and 300 mg every 2 weeks demonstrated significant efficacy and was well-tol

关键词： CM310 Moderate-to-severe atopic dermatitis Interleukin-4 receptor alpha Adults