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Fine-tuning the structure-tolerance-antitumor efficacy axis of prodrug nanoassemblies via branched aliphatic functionalization

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Nano Research 2024年第4期17卷 2908-2918页

作者： Guanting Li Fengli Xia Hongying Xiao Shunzhe Zheng Shuwen Fu Han Qiao qianhui jin Xuanbo Zhang Dun Zhou Chutong Tian jin Sun Zhonggui He Bingjun Sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmaceutics College of PharmacyShenyang Pharmaceutical UniversityShenyang 110016China Emergency Department The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121001China

Small-molecule prodrug nanoassemblies have emerged as efficient antitumor drug delivery ***,in the case of camptothecins-based prodrug nanoassemblies,linear aliphatic side chain modification often results in rod-shaped or irregularly shaped nanoassemblies,which are highly unfavorable for sterilization through filtration,and may cause capillary blockage upon intravenous *** rational design of camptothecins-based prodrug nanoassemblies remains a ***,we propose that branched aliphatic alcohol(BAA)functionalization could fine-tune the structure-tolerance-antitumor efficacy axis of prodrug ***,four SN38-BAA prodrugs were synthesized by conjugating 7-ethyl-10-hydroxycamptothecin(SN38)with BAAs of varying lengths via a tumor redox-responsive disulfide bond,which self-assemble into uniform spherical *** length of BAA was found to significant impact the multiple drug delivery process,including colloidal stability,drug release profiles and ***,SN38-C21 NPs(SN38-11-heneicosanol nanoparticles),featuring the longest BAA,showcased multiple therapeutic advantages,ultimately culminating the optimal antitumor efficacy and *** findings underscore the potential of BAA functionalization in strengthening the therapeutic outcomes of prodrug nanoassemblies,and provide valuable insights for developing translational camptothecins-based nanomedicines.

关键词： prodrug nanoassembly self-assembly antitumor efficacy tolerance 7-ethyl-10-hydroxycamptothecin(SN_(3)8)

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浅析竞技体育服装中的功能性与个性化设计

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西部皮革 2024年第7期46卷 114-116页

作者：曾洋靳乾辉四川工商学院俄罗斯体育大学

文章对竞技体育服装的功能性与个性化设计进行了深度研究，强调两者在相互融合的同时，通过智能材料的应用和设计上的个性化创新，使设计美学与竞技运动功能性得以完美结合，从而满足运动员对体育服装的多元化需求。文章旨在激发对竞技... 详细信息

文章对竞技体育服装的功能性与个性化设计进行了深度研究，强调两者在相互融合的同时，通过智能材料的应用和设计上的个性化创新，使设计美学与竞技运动功能性得以完美结合，从而满足运动员对体育服装的多元化需求。文章旨在激发对竞技体育服装创新设计的思考，为竞技体育服装设计提供新的思路，以此增强体育服装的适应性和表达性。

关键词：体育服装功能性设计个性化设计

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Impact of the amount of PEG on prodrug nanoassemblies for efficient cancer therapy

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Asian Journal of Pharmaceutical Sciences 2022年第2期17卷 241-252页

作者： Yaqiao Li Lingxiao Li qianhui jin Tian Liu jin Sun Yongjun Wang Zhijun Yang Zhonggui He Bingjun Sun Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China

PEGylation has been widely used to improve the pharmacokinetic properties of prodrug self-assembled nanoparticles(prodrug-SANPs).However,the impacts of the amount of PEG on the self-assemble stability,cellular uptake,pharmacokinetics,and antitumor efficacy of prodrug-SANPs are still ***,selenoether bond bridged docetaxel dimeric prodrug was synthesized as the model *** prodrug-SANPs were designed by using different mass ratios of prodrugs to PEG(W_(prodrug)/W_(DSPE-mPEG2000)=10:0,9:1,8:2,7:3 and 6:4),and defined as Pure drug NPs,9:1NPs,8:2NPs,7:3 NPs and 6:4 NPs,***,8:2 NPs formed the most compact nanostructure,thus improving the self-assemble stability and pharmacokinetics *** addition,the difference of these prodrug-SANPs in cellular uptake was investigated,and the influence of PEG on cytotoxicity and antitumor efficacy was also clarified in *** 8:2 NPs exhibited much better antitumor efficacy than other prodrug-SANPs and even commercial *** findings demonstrated the pivotal role of the amount of PEG on prodrug-SANPs.

关键词： PEGylation Prodrug Self-assembly nanoparticles Docetaxel Oxidation responsive

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MANET分簇IDS报文丢弃攻击全局感知方案

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微型机与应用 2011年第17期30卷 49-53页

作者：靳倩慧姚国祥李佩暨南大学信息科学技术学院广东广州510632

在分析现有报文丢弃攻击检测算法的基础上,提出了一种基于簇首协作的报文丢弃攻击全局感知方案,利用IDS簇首协同监视节点报文收发状态,改进现有算法的监测方式和节点状态判定算法。仿真结果表明,该算法具有良好的检测率和误检率,在规避... 详细信息

在分析现有报文丢弃攻击检测算法的基础上,提出了一种基于簇首协作的报文丢弃攻击全局感知方案,利用IDS簇首协同监视节点报文收发状态,改进现有算法的监测方式和节点状态判定算法。仿真结果表明,该算法具有良好的检测率和误检率,在规避网络中的恶意节点以及维护网络正常吞吐量等方面具有较好的性能。

关键词：移动自组织网络丢弃攻击恶意节点检测入侵检测系统

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C-Type Antiferromagnetic Structure of Topological Semimetal CaMnSb2

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Chinese Physics Letters 2024年第3期41卷 119-125页

作者：李博曾旭涛徐千惠杨帆项俊森钟恒扬邓司浩何伦华徐菊萍殷雯鲁兴业刘慧颖胜献雷金文涛 School of Physics Beihang University Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of Sciences Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Spallation Neutron Source Science Center Songshan Lake Materials Laboratory

Determination of the magnetic structure and confirmation of the presence or absence of inversion （P） and time reversal （Τ） symmetry is imperative for correctly understanding the topological magnetic materials. He... 详细信息

关键词： Density functional theory

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基于Spring Boot+Vue技术的煤矿安全培训后台设计与实现

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现代信息科技 2024年第18期8卷 116-119,124页

作者：朱芊慧刘风华钱进张苏洋徐州工程学院数学与统计学院江苏徐州221111

为满足企业对煤矿安全培训的需求,克服传统培训方法的局限性,通过对Vue和Spring Boot技术进行研究,使用JDK、MySQL数据库和IDEA等工具,构建了一个更加高效、稳定且易于维护的后台管理系统,从而有效地解决传统培训方式存在的问题。更加... 详细信息

为满足企业对煤矿安全培训的需求,克服传统培训方法的局限性,通过对Vue和Spring Boot技术进行研究,使用JDK、MySQL数据库和IDEA等工具,构建了一个更加高效、稳定且易于维护的后台管理系统,从而有效地解决传统培训方式存在的问题。更加便利的系统培训资源使用、更灵活的课程安排、更具保障的学习进度监控,使煤矿安全的普及更加全面,相关安全人员专业水平不断提升。

关键词：煤矿安全 Spring Boot Vue MySQL数据库

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宫颈病变患者HPV基因分型检测及其临床意义分析

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中外医学研究 2024年第7期22卷 70-74页

作者：陈静金灿灿周皓鹏张茜蕙梅辉泰兴市人民医院江苏泰兴225400

目的:分析宫颈病变患者人乳头瘤病毒(HPV)基因分型检测及临床意义。方法:回顾性分析2021年5月—2023年5月泰兴市人民医院收治的125例宫颈病变患者的临床资料,均进行HPV基因分型检测。统计125例宫颈病变患者HPV感染阳性率、HPV基因分型情... 详细信息

目的:分析宫颈病变患者人乳头瘤病毒(HPV)基因分型检测及临床意义。方法:回顾性分析2021年5月—2023年5月泰兴市人民医院收治的125例宫颈病变患者的临床资料,均进行HPV基因分型检测。统计125例宫颈病变患者HPV感染阳性率、HPV基因分型情况(多重感染重复计算)。比较不同程度宫颈病变患者中HPV感染阳性率、高危型HPV感染阳性率。以病理检查为“金标准”,分析并比较液基薄层细胞学检查(TCT)单独诊断、TCT联合HPV基因分型诊断子宫颈癌的准确度、敏感度、特异度。结果:125例宫颈病变患者中,HPV感染阳性率为51.20%(64/125),HPV感染阳性患者中HPV基因型总数为92株,其中高危型HPV为63.04%(58/92),低危型HPV为36.96%(34/92)。高危型HPV感染阳性率最高的前5位基因型分别为HPV16(16.30%)、HPV18(11.96%)、HPV58(8.70%)、HPV53(6.52%)、HPV51(4.35%);低危型HPV感染阳性率最高的前3位基因型分别为HPV6(8.70%)、HPV11(7.61%)、HPV40(4.35%)。不同级别宫颈病变患者HPV感染阳性率、高危型HPV感染阳性率比较,差异有统计学意义(P0.05)。结论:宫颈病变类型与HPV基因分型密切相关,且不同宫颈病变恶性程度患者HPV感染阳性率、高危型HPV感染阳性率存在显著差异,因此HPV基因分型用于辅助子子宫颈癌筛查具有重要意义。

关键词：宫颈病变人乳头瘤病毒基因分型子宫颈癌

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COATS:Comprehensive observation on the atmospheric boundary layer three-dimensional structure during haze pollution in the North China Plain

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Science China Earth Sciences 2023年第5期66卷 939-958页

作者： qianhui LI Hongsheng ZHANG Xiaoye ZHANG Xuhui CAI Xipeng jin Lu ZHANG Yu SONG Ling KANG Fei HU Tong ZHU Tianjin Key Laboratory for Oceanic Meteorology Tianjin Meteorological Service CenterTianjin Meteorological BureauTianjin 300074China Laboratory for Climate and Ocean-Atmosphere Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Severe Weather and Key Laboratory of Atmospheric Chemistry of CMA Chinese Academy of Meteorological SciencesChina Meteorological Administration(CMA)Beijing 100081China State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

The North China Plain(NCP)is troubled by severe haze pollution and the evolution of haze pollution is closely related to the atmospheric boundary layer(ABL).However,experimental and theoretical studies on the physical-chemical processes of the ABL in the NCP are lacking,with many scientific problems to be *** solve these problems,the Comprehensive Observation on the Atmospheric boundary layer Three-dimensional Structure(COATS)during haze pollution was carried out in the NCP from 2016 to *** COATS experiment adopted a"point-line-surface"spatial layout,obtaining both spatial-temporal profiles of the meteorological and environmental elements in the ABL and the turbulent transport data of fine particulate matter(PM_(2.5))in winter and *** research achievements are as *** spatial-temporal distribution characteristics of the ABL structure and PM_(2.5)concentrations in NCP were *** typical thermal structure of persistent heavy haze events and the pollutant removal mechanism by low-level jets were *** was determined that the spatial structure of the ABL adjusted by the Taihang Mountains is responsible for the heterogeneous distribution of haze pollution in the NCP,and that mountain-induced vertical circulations can promote the formation of elevated pollution *** restraints of the atmospheric internal boundaries on horizontal diffusion of pollutants were *** contribution of the ABL to haze pollution in winter and summer was qualitatively compared and quantitatively *** turbulent transport nature behind the relationship between the atmospheric boundary layer height(ABLH)and surface PM_(2.5)concentrations was *** concept of"aerosol accumulation layer"was defined,and the applicability of the material method in determining ABLH was clarified.A measurement system for obtaining the turbulent flux of PM_(2.5)concentrations was developed,and the turbulence characteristics of PM_(2.5)concentrations w

关键词： COATS experiment Haze pollution ABL three-dimensional structure Aerosol accumulation layer Turbulent flux of PM_(2.5)concentrations North China Plain

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Research on High Position Directional Drilling for Gas Drainage in underground Coal Mine

Research on High Position Directional Drilling for Gas Drain...

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作者： qianhui JI Shijun HAO Xin jin China Coal Research Institute CCTEG Xi'an Research Institute

Aiming at reducing gas concentration in the return airway and the upper corner area,high position directional drilling,adopting underground directional drilling equipment,high-precision pilot borehole drilling technique and large diameter reaming drilling technique,was conducted in three gassy coal *** Wangjialing Coal Mine,gas density in upper corner area was reduced from 0.85% to 0.5% under the gas drainage through high position directional boreholes.A 1016 meter deep high position directional boreholes with 0.4 m vertical deviation and 0.6 m lateral deviation was accomplished in Zhangji Coal *** than 1.78 million m pure gas were extracted in 11 high position directional boreholes in Qinglong Coal *** results shows that high position directional drilling has significant advantages including relative accurate borehole trajectory control,increased effective borehole depth and considerable high gas drainage *** supplies an effect method to ensure mining safety.

关键词： high position directional drilling measuring while drilling gas drainage

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Electrical Structure of the Crust in Manas Earthquake Area, Xinjiang, China

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Earthquake Research in China 2000年第1期14卷 79-89页

作者： Zhao Guoze, Zhan Yan, Tang Ji, Zhao Junmeng, jin Guangwen, Deng qianhui, and Wang JijunInstitute of Geology, CSB, Beijing 100029, China Institute of Geology CSB Beijing 100029 China

Magnetotelluric sounding data obtained recently in Manas earthquake area were processed. In the result, curves of apparent resistivity, impedance phase, skewness and optimum rotation angle versus period and the real magnetic induction vectors were obtained. Then the data of all measuring points were interpreted by 2D automatic inversion. The result indicates that along the sounding profile the shallow crust can be divided into 5 segments and the deep crust can be divided into 3 segments, with faults or deep-seated fault zones as the contact boundaries between them. The sedimentary cover along the profile extents down to depth about 12 km in maximum and a low-resistivity body exists in the crust in southern section of the profile. The interpretation results are well consistent with geological and other geophysical data. The Manas M7. 7 earthquake occurred near a contact zone where the electrical structure of the crust sharply changes.

关键词： Magnetotelluric sounding Apparent resistivity Xinjiang Two-dimensional inversion Electrical structure

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