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Frontiers of Structural and Civil Engineering 2023年第8期17卷 1281-1294页

作者： Yantao ZHU qiangqiang jia Kang ZHANG Yangtao LI Zhipeng LI Haoran WANG State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China National Dam Safety Research Center Wuhan 430010China Changjiang Institute of Survey PlanningDesignand ResearchWuhan 430010China

Concrete is widely used in various large construction projects owing to its high durability,compressive strength,and ***,the tensile strength of concrete is low,and concrete cracks *** in the concrete structure will result in changes in parameters such as the frequency mode and curvature mode,which allows one to effectively locate and evaluate structural *** this study,the characteristics of the curvature modes in concrete structures are analyzed and a method to obtain the curvature modes based on the strain and displacement modes is ***,various indices for the damage diagnosis of concrete structures based on the curvature mode are introduced.A damage assessment method for concrete structures is established using an artificial bee colony backpropagation neural network *** proposed damage assessment method for dam concrete structures comprises various modal parameters,such as curvature and *** feasibility and accuracy of the model are evaluated based on a case study of a concrete gravity *** results show that the damage assessment model can accurately evaluate the damage degree of concrete structures with a maximum error of less than 2%,which is within the required accuracy range of damage identification and assessment for most concrete structures.

关键词： hydraulic structure curvature mode damage detection artifical neural network artificial bee colony

Lead-free bilayer heterometallic halide perovskite with reversible phase transition and photoluminescence properties

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Chinese Chemical Letters 2023年第4期34卷 590-594页

作者： qiangqiang jia Ting Shao Liang Tong Changyuan Su Dawei Fu Haifeng Lu Institute for Science and Applications of Molecular Ferroelectrics Key Laboratory of the Ministry of Education for Advanced Catalysis MaterialsZhejiang Normal UniversityJinhua 321004China Ordered Matter Science Research Center Jiangsu Key Laboratory for Science and Applications of Molecular FerroelectricsSoutheast UniversityNanjing 211189China School of Environment and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212002China

The layered heterometallic halide perovskites, as a newly explored material, have attracted great scientific attention. As one of the representatives of perovskite, lead-free or lead-substituted perovskite materials are widely applied in photovoltaic, sensors, catalysis, detectors and other fields. Therefore, it is urgent to carry out more systematic exploration and expand applicable preresearch, so as to make more interesting discoveries in this new hot spot. As an interesting candidate, heterometallic compounds will introduce more structural adjustability and novel physical properties, which is the main feature to be selected as the research hotspot. Here, we reported a lead-free bilayer heterometallic Ruddlesden-Popper(RP) type perovskite, [(MACH)_(2)CsAgBiBr_(7)](MACH = cyclohexanemethylamine), which possesses a reversible phase transition at 379.6 K/375.1 K during heating-cooling cycle. Besides, it exhibits reddish-brown light emission under 365 nm, meanwhile, CIE chromaticity coordinate is(0.32, 0.45) on the yellow side and correlated color temperature is about 6000 K. Moreover, both the experimental data and theoretical calculation results suggest that [(MACH)_(2)CsAgBiBr_(7)] shows indirect semiconducting characteristics. In summary, this work will inspire the design of lead-free heterometallic perovskite materials for the application of sensors and light-emitting diodes(LEDs) fields.

关键词： Lead-free Heterometallic Perovskite Phase transition Photoluminescence

Study on the mechanism of cholic acid derivatives in traditional Chinese medicine based on the regulation of gene expression

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 35-41页

作者： Yongchun Huang Jie Zhang Pengxiang Zhao Yufeng Ma qiangqiang jia Shoude Zhang State Key Laboratory of Plateau Ecology and Agriculture Qinghai UniversityXining 810016China Department of Pharmacy Medical College of Qinghai UniversityXining 810016China Pharmacy Intravenous Admixture Services Qinghai University Affiliated HospitalXining 810016China

Objective:To investigate the pharmacological action and mechanism of cholic acid derivatives in traditional Chinese medicine(TCM)based on the regulation of gene ***:Genome-wide gene expression profiles of Michigan Cancer Foundation-7(MCF-7)cells treated with or without 4 cholic acid derivatives were detected by gene chip *** in upregulated and downregulated genes were analyzed using the Connectivity Map(CMap)*** affinity between cholic acid derivatives and the potential target was confirmed by molecular *** cholic acid derivative-regulated pathway enrichment analysis was performed by the STRING database,and the potential pathway was confirmed by in vitro experiments on MD Anderson-Metastatic Breast-231(MDA-MB-231)***:Compared with the reference genome in the CMap database,the gene expression profiles of cholic acid derivatives were similar to those of antipsychotic,anticancer,anti-inflammatory,and antiinfective *** them,4 derivatives were associated with antianxiety drugs,and molecular docking results showed that these compounds may act by binding to the ligand-binding site of gammaaminobutyric acid(GABA)***,the cytoskeletal pathway is one of the pathways enriched in the *** them,ursodeoxycholic acid showed significant inhibitory activity on the cytoskeleton formation of MDA-MB-231 ***:The gene expression detection method,combined with CMap and pathway enrichment analysis,could be used to study the mechanism of the active ingredients of *** addition,our research showed that cholic acid derivatives have a potential affinity for membrane receptors,where they can exert anxiolytic activity by modulating opioid receptor,GABA receptor,and dopamine ***,ursodeoxycholic and chenodeoxycholic acid inhibit cytoskeleton formation,probably by acting on membrane proteins to activate the corresponding cytoskeletal pathways.

关键词： Cholic acid derivatives Gene chip CMap Pathway enrichment analysis Membrane receptors Cytoskeleton

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纵向磁场对聚能射流极限拉伸系数的影响

爆炸与冲击 2016年第6期36卷 759-766页

作者：马彬黄正祥祖旭东肖强强贾鑫南京理工大学机械工程学院江苏南京210094

在分析纵向磁场能够增强聚能射流稳定性的基础上,根据聚能射流的运动方程以及聚能射流的塑性失稳条件,推导得到了聚能射流在纵向磁场中的极限拉伸系数计算公式,并计算了有、无磁场情况下极限拉伸系数的比值。通过两种炸高下的实验研究... 详细信息

在分析纵向磁场能够增强聚能射流稳定性的基础上,根据聚能射流的运动方程以及聚能射流的塑性失稳条件,推导得到了聚能射流在纵向磁场中的极限拉伸系数计算公式,并计算了有、无磁场情况下极限拉伸系数的比值。通过两种炸高下的实验研究对理论模型进行了验证。结果表明:由于磁场的存在而引起的电磁力抑制了聚能射流颈缩的发展,进而延长了射流成型的惯性拉伸阶段,最终使聚能射流在磁场中的极限拉伸系数在一定程度上得到了增加;理论和实验所得结果吻合较好。运用所建立模型可以较准确地反映磁场对聚能射流极限拉伸系数的影响。

关键词：流体力学极限拉伸系数纵向磁场聚能射流稳定性

Juvenile hormone membrane signaling phosphorylates USP and thus potentiates 20-hydroxyecdysone action in Drosophila

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Science Bulletin 2022年第2期67卷 186-197,M0004页

作者： Yue Gao Suning Liu qiangqiang jia Lixian Wu Dongwei Yuan Emma Y.Li Qili Feng Guirong Wang Subba R.Palli jian Wang Sheng Li Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and Technology&School of Life SciencesSouth China Normal UniversityGuangzhou 510631China Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhou 514779China International Department The Afﬁliated High School of South China Normal UniversityGuangzhou 510631China Lingnan Guangdong Laboratory of Modern Agriculture Genome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Department of Entomology College of AgricultureFood and EnvironmentUniversity of KentuckyLexington 40546USA Department of Entomology University of MarylandCollege Park 20742USA

Juvenile hormone(JH) and 20-hydroxyecdysone(20 E) coordinately regulate development and metamorphosis in insects. Two JH intracellular receptors, methoprene-tolerant(Met) and germ-cell expressed(Gce), have been identified in the fruit fly Drosophila melanogaster. To investigate JH membrane signaling pathway without the interference from JH intracellular signaling, we characterized phosphoproteome profiles of the Met gce double mutant in the absence or presence of JH in both chronic and acute *** through a potential receptor tyrosine kinase and phospholipase C pathway, JH membrane signaling activated protein kinase C(PKC) which phosphorylated ultraspiracle(USP) at Ser35, the PKC phosphorylation site required for the maximal action of 20 E through its nuclear receptor complex Ec RUSP. The usp;mutant, in which Ser was replaced with Ala at position 35 by genome editing, showed decreased expression of Halloween genes that are responsible for ecdysone biosynthesis and thus attenuated 20 E signaling that delayed developmental timing. The usp;mutant also showed lower Yorkie activity that reduced body size. Altogether, JH membrane signaling phosphorylates USP at Ser35 and thus potentiates 20 E action that regulates the normal fly development. This study helps better understand the complex JH signaling network.

关键词： Juvenile hormone Receptor tyrosine kinase Phosphoproteomics USP 20-Hydroxyecdysone action Yorkie activity

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： jia Zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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羟基封端聚丁二烯的临界点色谱定量方法研究

色谱 2020年第2期38卷 238-243页

作者：汪明芳贾强强王月荣章弘扬张敏胡坪上海市功能性材料化学重点实验室华东理工大学化学与分子工程学院上海200237 上海市新药设计重点实验室华东理工大学药学院上海200237

为建立混合物中羟基封端聚丁二烯(HTPB)的临界点色谱定量方法,以C18为固定相,考察了HTPB在四氢呋喃-乙腈和四氢呋喃-水两种流动相体系下的临界点色谱条件。结果表明,四氢呋喃-乙腈体积比为70.7∶29.3以及四氢呋喃-水体积比为92∶8时,HTP... 详细信息

为建立混合物中羟基封端聚丁二烯(HTPB)的临界点色谱定量方法,以C18为固定相,考察了HTPB在四氢呋喃-乙腈和四氢呋喃-水两种流动相体系下的临界点色谱条件。结果表明,四氢呋喃-乙腈体积比为70.7∶29.3以及四氢呋喃-水体积比为92∶8时,HTPB的保留值与其相对分子质量无关。将该临界点色谱方法用于胶黏剂混合组分中HTPB的测定,结果表明,HTPB在46.7~216.4 mg/L范围内呈良好线性关系,相关系数(r)>0.99,检出限为4.2 mg/L。自配HTPB和矿物油双组分样品的加标回收率为89.2%~101.1%,相对标准偏差小于0.66%(n=6)。应用该方法对市售聚氨酯胶黏剂进行检测,测定结果为HTPB成分占26.6%。该方法快速、准确,能满足聚合物混合产品的生产质量控制和失效分析的要求。

关键词：临界点色谱羟基封端聚丁二烯胶黏剂定量分析

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大坝深孔泄水建筑物淤堵物清理技术探讨

中国水利 2023年第22期 62-65页

作者：李星田金章贾强强国家大坝安全工程技术研究中心武汉430010 长江勘测规划设计研究有限责任公司武汉430010

深孔泄水建筑物是大坝重要组成结构,发生淤堵会导致闸门启闭困难,严重影响大坝安全运行。总结了淤堵闸门启门力计算模型、淤堵物水下探测及清理技术现状,梳理了深孔淤堵物清理的技术难点,提出水下环境重构、闸门启门力计算、深孔清淤装... 详细信息

深孔泄水建筑物是大坝重要组成结构,发生淤堵会导致闸门启闭困难,严重影响大坝安全运行。总结了淤堵闸门启门力计算模型、淤堵物水下探测及清理技术现状,梳理了深孔淤堵物清理的技术难点,提出水下环境重构、闸门启门力计算、深孔清淤装备等方面的对策,同时指出未来还需进一步研究水下环境高精度重构技术、构建闸门启门力数值模型、研发多类型淤堵物一体化清理机器人等,以期提升大坝应对灾害的能力。

关键词：深孔泄水建筑物水下环境重构闸门启门力清淤装备

阿卡波糖与格列吡嗪对降低2型糖尿病患者血糖的疗效对比

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糖尿病新世界 2023年第10期26卷 112-115页

作者：朱为国梁鸣贾强强江苏省连云港市灌云县人民医院药学部江苏连云港222200

目的研究2型糖尿病患者采用阿卡波糖、格列吡嗪治疗的治疗效果和药理价值。方法选取2022年1—12月于连云港市灌云县人民医院中就诊的2型糖尿病患者120例为研究对象,采用随机数表法分为两组,每组60例。采用格列吡嗪治疗的为格列吡嗪组,... 详细信息

目的研究2型糖尿病患者采用阿卡波糖、格列吡嗪治疗的治疗效果和药理价值。方法选取2022年1—12月于连云港市灌云县人民医院中就诊的2型糖尿病患者120例为研究对象,采用随机数表法分为两组,每组60例。采用格列吡嗪治疗的为格列吡嗪组,采用阿卡波糖治疗的为阿卡波糖组,比较两组血糖水平、治疗效果、不良反应发生率。结果阿卡波糖组的糖化血红蛋白、空腹血糖、餐后2 h血糖优于格列吡嗪组,差异有统计学意义(P0.05)。结论将阿卡波糖用于2型糖尿病患者治疗中,可更好地稳定血糖,在用药安全性上亦满足了患者需求。

关键词：阿卡波糖格列吡嗪 2型糖尿病血糖效果分析

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16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang jia jia Shengjie Yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering