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Synthesis of AZT-Phosphonate,Phosphonothioate and Phosphonoselenoate

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Chinese Chemical Letters 2002年第11期13卷 1057-1058页

作者： qiangxiao YongJU 等 TheKeyLaboratoryofBiorrganicPhosphorusChemistry MinistryofEducationDepartmentofChemistrySchoolofLifeSciencesandEngineeringTsinghuaUniversityBeijing100084 TheKeyLaboratoryofBiorrganicPhosphorusChem

Phosphonate, phosphonothioate and phosphonoselenoate derivatives of AZT were synthesized in an expeditious way and high yields.

关键词： AZT phosphonate phosphonothioate phosphonoselenoate hydrogenphosphonate.

Effect of Alkali Treatment on the Structure and Catalytic Properties of ZSM-5 Zeolite

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Chinese Chemical Letters 2005年第1期16卷 115-118页

作者： ZiYunLI XinSUN qiangxiao ShouHeXIANG CollegeofChemistry NankaiUniversityTianjin300071

Catalytic properties of ZSM-5 zeolite samples pretreated with NaOH solution have been investigated. The samples are characterized by XRD, SEM, chemical analysis, and N2 adsorption. The results indicate that mesopores are created in ZSM-5 crystals under alkali treatment without change the microporous structure and acidic strength of the zeolite, but the crystallinity is greatly decreased under severe treatment. IR indicates that the concentration of silanol is greatly enriched by alkali treatment. The etherification activities of ZSM-5 zeolites are greatly increased by alkali-treatment. The noticeably improved catalytic activity of treated samples is ascribed to the formation of mesopores and greatly enriched silanol group.

关键词： Alkali treatment ZSM-5 zeolite ETBE etherification.

Two-dimensional polyacrylamide gel electrophoresis analysis of indomethacin-treated human colon cancer cells

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World Journal of Gastroenterology 2005年第16期11卷 2420-2425页

作者： Yan-LiCheng Gui-YingZhang Zhi-qiangxiao Fa-QingTang DepartmentofGastroenterology XiangyaHospitalCentralSouthUniversityChangsha410008HunanProvinceChina KeyLaboratoryofCancerProteomicsofChineseMinistryofHealth XiangyaHospitalCentralSouthUniversityChangsha410008HunanProvinceChina DepartmentofClinicalLaboratory XiangyaHospitalCentralSouthUniversityChangsha410008HunanProvinceChina

AIM: To establish the two-dimensional gel electrophoresis (2-DE) profiles of indomethacin (IN)-treated human colon cancer cell line HCT116, and to provide a new way to study its anti-tumor molecular mechanism through analyzing a variety of protein ***: Two-DE profiles of HCT116 were established in IN-treated and untreated groups. Total proteins were separated by immobilized pH gradient-based 2-DE. The gels were stained by silver, scanned by ImageScanner,and analyzed with Image Master ***: Clear background, well-resolved and reproducible 2-DE patterns of HCT116 cells were acquired in IN-treated and untreated group. The average deviation of spot position was 0.896±0.177 mm in IEF direction and 1.106±0.289 mm in SDS-PAGE direction respectively. In IN-treated group,1 169±36 spots were detected and 1 061±32 spots were matched, the average matching rate was 90.6% in three gels. In untreated group, 1 256±50 spots were detected and 1 168±46 spots were matched, the average matching rate was 93.0% in three gels. Forty-five differential protein spots were displayed between IN-treated and untreated groups. Of which, 34 protein spots decreased and 9showed higher expression in IN-treated group, and only two protein spots showed an expression in untreated ***: Two-DE profiles of IN-treated and untreated HCT116 cells were established. Apparent 45 different protein spots were detected in IN-treated and untreated HCT116 cells. The analysis on differential protein spots may serve as a new way to study the molecule mechanism of IN-treated colon cancer.

关键词： Gel electrophoresis Indomethacin Colon cancer

Comparative proteome analysis of untreated and Helicobacter pylori-treated HepG2

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World Journal of Gastroenterology 2005年第22期11卷 3485-3489页

作者： YanZhang Xue-GongFan RenChen Zhi-qiangxiao Xue-PingFeng Xue-FeiTian Zhao-HuiChen DepartmentofInfectiousDiseases XiangyaHospitalCentralSouthUniversityChangsha410008HunanProvinceChina MedicalResearchCenter XiangyaHospitalCentralSouthUniversityChangsha410008HunanProvinceChina

AIM: To investigate the pathological effect of Helicobacter pylori (H pylori) on human hepatic cells, proteomic methods were used to find and to identify proteins that were overexpressed in HepG2 cells treated by H pylori. METHODS: H pylori was co-cultured with HepG2 for 6 h. Two-dimensional gel electrophoresis was used to gain the protein expression pattern of untreated and H pylori-treated HepG2. After staining and image analysis, spots of interest were isolated and subjected to mass spectrometry. RESULTS: Seven proteins, which were up-regulated in H pylori -treated HepG2 cells, were identified. These proteins included integrin beta-1, protein kinase C alpha, LIM/ homeobox protein Lhx1, eIF-2-beta, MAP kinase kinase 3, PINCH protein and Ras-related protein Rab-37, which involved in transcription regulation, signal transduction, metabolism and so on, CONCLUSION: H pylori may exert the pathological effect on HepG2 cells by up-regulating the expression of some proteins.

关键词： H pylori HepG2 cells

The Relationship Between Temperature & Sunshine and Spring-Sown Wheat Quality

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Agricultural Sciences in China 2003年第12期2卷 1329-1337页

作者： CAOGuang-cai WUDong-bing SUNQun qiangxiao-lin CHENHe-qin DONGMei KOUHao WANGJian-lin HOULi-bai LIMeng InstituteofCropBreedingandCultivation ChineseAcademyofAgriculturalSciencesBeijing100081P.R.China DepartmentofSeedScienceandTechnology ChinaAgriculturalUniversityBeijing100094P.R.China AgriculturalInstitute TibetanAcademyofAgriculturalandAnimalSciencesLasa850002P.R.China ShenyangAgriculturalUniversity Shenyang11o161P.R.China AgriculturalSciencesInstituteofTibetanRikazePrefecture Rikaze857000P.R.China AgriculturalandAnimalCollegeofTibet Linzhi860000P.R.China ChinaNationalBureauofMeteorology Beijing100081P.R.China

In order to study the relationship between temperature & sunshine and spring-sown wheat qua lity, a spring-sown experiment with 3 wheat varieties was conducted in Rikaze, Lasa, Linzhi, Beijing and Shenyang from 1998 to 2001. The results indicated that significant difference on some quality characteristics of experimental wheat varieties were observed from different locations and different years. The results also showed: protein content was positively correlated with wet gluten content, falling number, the average day temperature and sunshine hours from heading to maturation; and negatively correlated with the growing days and the average diurnal temperature difference from sowing to maturation; wet gluten content was positively correlated with the average day temperature and sunshine hours during the same period. Sedimentation value and falling number were positively correlated with the average sunshine hours from sowing to maturation. The basic way of wheat production in Tibet was as follows: mainly developing medium gluten wheat varieties, suitably planting weak gluten wheat varieties, introducing some inland excellent varieties.

关键词： Temperature Sunshine Spring-sown wheat Quality Correlation

新发展阶段黄河下游滩区综合提升治理方案研究

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水利发展研究 2023年第10期23卷 6-11页

作者：暴入超汪贝咸强孝陈擎桢黄河勘测规划设计研究院有限公司河南郑州450003 国家电投集团黄河上游水电开发有限责任公司青海西宁810008

黄河下游滩区是黄河行滞洪沉沙区域,也是滩区居民赖以生存的家园。针对黄河下游滩区仍有近百万居民防洪安全缺乏保障、下游不利河道形态使得黄河防洪形势依然严峻等问题,文章在系统分析总结以往研究成果的基础上,考虑新发展阶段国家战... 详细信息

黄河下游滩区是黄河行滞洪沉沙区域,也是滩区居民赖以生存的家园。针对黄河下游滩区仍有近百万居民防洪安全缺乏保障、下游不利河道形态使得黄河防洪形势依然严峻等问题,文章在系统分析总结以往研究成果的基础上,考虑新发展阶段国家战略及沿黄河经济社会高质量发展有关要求,综合分析提出了黄河下游滩区治理的3种方案,从防洪安全、社会经济发展、生态保护及投资管理等方面构建综合评价模型,对3种方案进行分析评价,最终提出推荐的滩区综合提升治理方案。

关键词：黄河下游滩区二级悬河滩区治理防洪生态保护高质量发展

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铁路平车车体强度计算方法对比分析

机械工程师 2018年第3期 128-129,132页

作者：齐双强卢瑜挺付强小孙飞云张国荣包头北方创业有限责任公司内蒙古包头014032 路通弹簧有限公司内蒙古包头014032

以某通用平车车体强度计算为例,对比分析俄罗斯及我国铁路货车车体强度规范中的计算方法与评定标准,为车体结构设计和强度分析提供可靠的理论依据。分析结果表明,俄罗斯的车体强度设计规范所考虑的基本载荷与载荷组合情况较我国的车体... 详细信息

以某通用平车车体强度计算为例,对比分析俄罗斯及我国铁路货车车体强度规范中的计算方法与评定标准,为车体结构设计和强度分析提供可靠的理论依据。分析结果表明,俄罗斯的车体强度设计规范所考虑的基本载荷与载荷组合情况较我国的车体强度设计规范所考虑的完整、全面。采用我国的车体强度设计规范计算出的结果更为保守些。

关键词：铁路平车车体强度计算方法