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Development of genipin crosslinked gelatin matrices on surface interaction: Enhancing the biocompatibility by attenuating sterile inflammation

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Chinese Journal of Chemical Engineering 2021年第10期34卷 205-215页

作者： qiang-song wang Gui-Fang wang Hai-Yun Zhang Fa-Quan Zhao Yuan-Lu Cui Tianjin Key Laboratory of Biomedical Materials Institute of Biomedical EngineeringChinese Academy of Medical Science&Peking Union Medical CollegeTianjin 300192China State Key Laboratory of Component-based Chinese Medicine Research Center of Traditional Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China

The inflammation can be stimulated by the surgical implantation and biomaterial presence through the foreign body via *** play a key role in the interaction of host tissue to implant *** present study,the immuno-inflammatory responses of genipin crosslinked gelatin matrices(GCGM)to macrophages in vitro and the host tissue surfaces in rats were *** results showed that the mechanical properties,swelling and degradation of gelatin matrices were improved by the crosslinking of genipin at physiological *** macrophage on the surface of GCGM could avoid to be *** interaction of macrophage and GCGM suggested that GCGM could reduce the inflammatory response with downregulating the production and m RNA expression of pro-inflammatory *** anti-inflammatory effect of GCGM was demonstrated to be related to inhibit nuclear factor kappa-B(NF-κB)signaling ***,gelatin matrices crosslinked with genipin could decrease the acute and chronic inflammatory response interacting with host tissue surfaces to enhance the biocompatibility in *** results showed that GCGM could avoid to active macrophages and were endowed with anti-inflammatory properties,suggesting the significant potential for clinical success with the development of immunomodulatory biomaterials.

关键词： Genipin Gelatin matrices Anti-inflammation Biocompatibility NF-κB

Segment-based traffic smoothing algorithm for VBR video stream

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第4期7卷 543-548页

作者： LIU Yun-qiang YU song-yu wang Xiang-wen ZHOU Jun Institute of linage Communication and Information Processing Shanghai Jiao Tong University Shanghai 200030 China

Transmission of variable bit rate (VBR) video, because of the burstiness of VBR video traffic, has high fluctuation in bandwidth requirement. Traffic smoothing algorithm is very efficient in reducing burstiness of the VBR video stream by trans- mitting data in a series of fixed rates. We propose in this paper a novel segment-based bandwidth allocation algorithm which dynamically adjusts the segmentation boundary and changes the transmission rate at the latest possible point so that the video segment will be extended as long as possible and the number of rate changes can be as small as possible while keeping the peak rate low. Simulation results showed that our approach has small bandwidth requirement, high bandwidth utilization and low computation cost.

关键词： Segmentation Traffic smoothing Variable bit rate (VBR) video

A Case Report of One-Point Gastric Cancer

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Chinese Journal of Clinical Oncology 2008年第4期5卷 309-310页

作者： Guoqing song qiang wang Department of Gastrointestinal Surgery Shengjing Hospital of China Medical University Shenyang 110004 Liaoning ProvinceChina.

Carcinoma of the stomach is the most common malignant tumor in China. Due to advanced endoscopic techniques and equipment, the detection of early gastric carcinoma （EGC） has increased worldwide. Yet gastric one-poin... 详细信息

关键词： gastric one-point cancer early gastric cancer endoscopic mucosal resection endoscopic submucosaldissection.

Synchronous Multiple Primary Gastric Carcinomas： A Case Report

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Clinical oncology and cancer researeh 2010年第1期7卷 64-66页

作者： Guo-qing song qiang wang Department of Gastrointestinal Surgery Shengjing Hospital of Chinese Medical University Shenyang 110004 Liaoning ProvinceChina.

IntroductionCarcinomas of the stomach are the most common malignant tumors in China. Due to the recent developments in diagnostic techniques and instrumentation, the early detection of gastric carcinoma （GC） has increased. Yet synchronous multiple primary gastric carcinomas, de- fined as 2 or more primary gastric carcinomas occurring in 1 patient simultaneously, are not frequently seen. The etiology of synchronous tumors is still unclear, and their coexistence can be problematic for surgeons, oncologists and pathologists in regards to diagnosis, treat- ment, and follow-up. Research has focused mainly on such issues as the frequency of occurrence of primary multiple carcinomas, identi- fication of high-risk groups, early diagnosis, treatment methods, and prognostic factors. The purpose of this article is to present a rare case of synchronous tumors and to review the literature addressing the surgical treatment for patients with multiple cancers.

关键词： multiple primary gastric carcinomas synchronous.

Kinetics of discontinuous precipitation in Cu–20Ni–20Mn alloy

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International Journal of Minerals,Metallurgy and Materials 2016年第3期23卷 323-329页

作者： Wei-bin Xie qiang-song wang Guo-liang Xie Xu-jun Mi Dong-mei Liu Xue-Cheng Gao State Key Laboratory for Fabrication and Processing of Non-ferrous Metals General Research Institute for Nonferrous Metals

The morphology and growth kinetics of discontinuous precipitation （DP） in a Cu-20Ni-20Mn alloy were investigated in the tem- perature range of523-573 K by optical microscopy, scanning electron microscopy, and transmission electron microscopy. A lamellar mixed structure consisting of alternating larnellae of a matrix and NiMn phase was observed in DP colonies. The volume fraction of regions formed by a DP reaction was determined by quantitative metallographic measurements. The kinetics of DP was evaluated on the basis of the John- son-MehI-Avrami Kohnogorov equation, which resulted in a time exponent of approximately 1.5. We confirmed that the nucleation of the discontinuous precipitate was confined to grain edges or boundaries at an early stage of the reaction. The activation energy of DP process was determined to be approximately （72.7 ± 7.2） kJ/mol based on the Arrhenius equation; this result suggests that DP is controlled by gn-ain boundary diffusion. The hardness values exhibited good correlation with the volume fraction of DP; this correlation was attributed to the plvsence of the ordered N iMn phase.

关键词： copper nickel manganese alloys: microstructural evolution precipitation kinetics

Microstructure and properties of Cu-Ni-Si-Zr alloy after thermomechanical treatments

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Rare Metals 2013年第2期32卷 144-149页

作者： Xiang-Peng Xiao Bai-Qing Xiong qiang-song wang Guo-Liang Xie Li-Jun Peng Guo-Xing Huang State Key Laboratory for Fabrication and Processing of Non-ferrous Metals General Research Institute for Nonferrous Metals Aluminum Corporation of China Limited Luoyang Copper Co. Ltd.

The effect of thermomechanical treatments on the microstructures and properties of Cu-2.1Ni-0.5Si- 0.2Zr alloy was investigated. The hot-rolled plates were solution treated at 920 ℃ for 1.5 h, quenched into water, cold rolled by 70 % reduction in thickness, and then aged at 400, 450 and 500 ℃for various times. The variation in tensile strength and electrical conductivity of the alloy was measured as a function of the aging time. The results show the peak strength value of 665 MPa for the alloy aged at 450 ℃ for 2 h. However, the electrical conductivity is observed to reach a maximum of 47 % IACS aged at 450℃for 8 h. OM, SEM, and TEM were used for microstructural inspection of the alloy. Precipitation occurs preferentially at deformation bands in the cold-rolled alloy. Properties behavior is discussed in the light of microstructural features.

关键词： Cu-Ni-Si-Zr alloy Precipitation Electricalconductivity Tensile strength Microstructural features

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： song He Li Li Sai wang Shao-Jiang wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

CD56^brightCD25^＋ NK cells are preferentially recruited to the maternal/fetal interface in early human pregnancy

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Cellular & Molecular Immunology 2015年第1期12卷 77-86页

作者： Yu Tao Yan-Hong Li Hai-Lan Piao Wen-Jie Zhou Di Zhang qiang Fu song-Cun wang Da-Jin Li Mei-Rong Du Laboratory for Reproductive Immunology Hospital and Institute of Obstetrics and Gynecology Fudan University Shanghai Medical College Shanghai KeyLaboratory of Female Reproductive Endocrine Related Diseases Shanghai China

Decidual natural killer （dNK） cells are believed to be critical for maintaining maternal/fetal tolerance and regulating placental vascular remodeling based upon their abundance and unique phenotype during early pregnancy. However, the mechanism for how the dNK cells play such important roles in successful pregnancy remains undefined. Here, we identified a subtype of dNK cells characterized as having a CD3-CD56^brightCD25^＋ phenotype. We found that CD56^brightCD25^＋ NK cells preferentially localize to the maternal/fetal interface during early human pregnancy. CD25^＋ dNK cells account for approximately 75% of CD25-expressing decidual immune cells （DICs）. However, less than 5% of CD25-positive peripheral blood mononuclear cells are CD25^＋ NK cells. Furthermore, CD25^＋ and CD25^- dNK cells exhibit distinct phenotypes： CD25^＋ dNK cells display a more activated phenotype and greater cytokine-secreting capacity. Interestingly, coculture of peripheral NK （pNK） cells with primary trophoblasts upregulates the percentage of CD25-expressing pNK cells, resulting in increased expression of activation markers and cytokine production by pNK cells. In addition, we demonstrated that the CXCL12/CXCR4 axis is crucial for the recruitment of CD25^＋ dNK cells and contributes to the accumulation of CD3^-CD56^brightCD25^＋ dNK cells at the maternal/fetal interface. Thus, our data reveal that the crosstalk between trophoblasts and pNK cells leads to the accumulation of CD3^-CD56^brightCD25^＋ dNK cells, which exert a regulating effect at the maternal/fetal interface.

关键词： CXCL12/CXCR4 CD3^-CD56^brightCD25^+ N K cells maternal/fetal interface trophoblasts

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei Zheng Tingwei Cao qiang wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning