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Chromosome-level assembly of triploid genome of Sichuan pepper(Zanthoxylum armatum)

Horticultural Plant Journal 2024年第2期10卷 437-449页

作者： Lizhi song Yue Huang Hao Zuo Ning Tang Zhengguo Li Wenbiao Jiao Feng Xu qiang Xu Zexiong Chen National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Huazhong Agricultural UniversityWuhanHubei 430070China Chongqing Key Laboratory of Economic Plant Biotechnology Chongqing University of Arts and SciencesChongqing 402160China School of Life Sciences Chongqing UniversityChongqing 400030China College of Horticulture and Gardening Yangtze UniversityJingzhouHubei 434025China College of Informatics Huazhong Agricultural UniversityWuhanHubei 430070China

As an important spice species in Rutaceae, the Sichuan pepper (Zanthoxylum armatum) can provide pungent and numbing taste, as well as aroma in its mature fruit. Here we assembled a chromosome-level genome of green prickly ash which was widely cultivated in a major production area including Chongqing and Sichuan province, China. We generated 712 Gb (~112×) PacBio long reads and 511 Gb (~82×) Hi-C data, and yielded an assembly of 99 pseudochromosomes with total size of 5.32 Gb and contig N50 of 796 kb. The genomic analyses and cytogenetic experiments both indicated that the cultivarZhuye Huajiao’ was a triploid. We identified a Zanthoxylum-specific whole genome duplication event emerging about 24.8 million years ago (Mya). We also detected a transposition burst event (0.3-0.4 Mya) responsible for the large genome size of Z. armatum. Metabolomic analysis of the Zanthoxylum fruits during development stages revealed profiles of39 volatile aroma compounds and 528 secondary metabolites, from which six types of sanshools were identified. Based on metabolomic and transcriptomic network analysis, we screened candidate genes encoding long chain acyl-CoA synthetase, fatty acid desaturase,branched-chain amino acid aminotransferase involved in sanshool biosynthesis and three genes encoding terpene synthase during fruit development. The multi-omics data provide insights into the evolution of Zanthoxylum and molecular basis of numbing and aroma flavor of Sichuan pepper.

关键词： Zanthoxylum armatum Genome Sanshool Terpenoid

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A novel dual serotonin transporter and M-channel inhibitor D01 for antidepression and cognitive improvement

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1457-1466页

作者： Yaqin Wei Xiangqing Xu qiang Guo song Zhao Yinli Qiu Dongli Wang Wenwen Yu Yani Liu KeWei Wang School of Pharmacy Xuzhou Medical UniversityXuzhou 221004China Institute of Pharmaceutical Research Jiangsu Nhwa Pharmaceutical Co.Ltd.&Jiangsu Key Laboratory of Central Nervous System Drug Research and DevelopmentXuzhou 221116China Department of Pharmacology School of PharmacyQingdao University Medical CollegeQingdao 266073China Institute of Innovative Drug Qingdao UniversityQingdao 266021China Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhou 510515China

Cognitive dysfunction is a core symptom common in psychiatric disorders including depression that is primarily managed by antidepressants lacking efficacy in improving *** this study,we report a novel dual serotonin transporter and voltage-gated potassium Kv7/KCNQ/M-channel inhibitor D01(a 2-methyl-3-aryloxy-3-heteroarylpropylamines derivative)that exhibits both anti-depression effects and improvements in cognition.D01 inhibits serotonin transporters(K_(i)=30.1±6.9 nmol/L)and M channels(IC_(50)=10.1±2.4μmol/L).D01 also reduces the immobility duration in the mouse FST and TST assays in a dose-dependent manner without a stimulatory effect on *** administrations of D01(20 and 40 mg/kg)can significantly shorten the immobility time in a mouse model of chronic restraint stress(CRS)-induced depression-like ***,D01 dose-dependently improves the cognitive deficit induced by CRS in Morris water maze test and increases the exploration time with novel objects in normal or scopolamine-induced cognitive deficits in mice,but not ***,D01 reverses the long-term potentiation(LTP)inhibition induced by *** together,our findings demonstrate that D01,a dual-target serotonin reuptake and M channel inhibitor,is highly effective in the treatment-resistant depression and cognitive deficits,thus holding potential for development as therapy of depression with cognitive deficits.

关键词： SERT 5-HT Kv7/KCNQ/M current D01 Depression Cognition

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Optimizing magnetoelastic properties by machine learning and high-throughput micromagnetic simulation

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Rare Metals 2024年第5期43卷 2251-2262页

作者： jian-Hu Gong Zheng-Ming Zhang Cheng-Liang Zhang Peng-qiang Hu Chao Zhou Dun-Hui Wang Sen Yang Division of Microelectronic Materials and Devices Hangzhou Dianzi UniversityHangzhou 310018China School of Physics MOEKey Laboratory forNonequilibrium Synthesis and Modulation of Condensed Matter and State Key Laboratory for Mechanical Behavior of MaterialsXi'an Jiaotong UniversityXi'an 710049China National Laboratory of Solid State Microstructures Nanjing UniversityNanjing210093China

Magnetoelastic couplings in giant magnetostrictive materials(GMMs)attract significant interests due to their extensive applications in the fields of spintronics and energy harvesting *** the role of the selection of materials and the response to external fields is essential for attaining desired functionality of a ***,machine learning(ML)models are conducted to predict saturation magnetostrictions(λ_(s))in RFe_(2)-type(R=rare earth)GMMs with different *** to ML-predicted composition–λsrelations,it is discovered that the values ofλshigher than1100×10^(-6)are almost situated in the composition space surrounded by 0.26≤x≤0.60 and 1.90≤y≤2.00 for the ternary compounds of Tb_(x)Dy_(1-x)Fe_(y).Assisted by ML predictions,the compositions are further narrowed down to the space surrounded by 0.26≤x≤0.32 and 1.92≤y≤1.97 for the excellent piezomagnetic(PM)performance in the Tb_(x)Dy_(1-x)Fe_(y)based PM device through our developed high-throughput(HTP)micromagnetic simulation(MMS)***,high sensitivities up to10.22-13.61 m T·MPa^(-1)are observed in the optimized range within which the available experimental data fall *** work not only provides valuable insights toward understanding the mechanism of magnetoelastic couplings,but also paves the way for designing and optimizing highperformance magnetostrictive materials and PM sensing devices.

关键词： Magnetostriction Piezomagnetic effect Machine learning Micromagnetic simulation

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Synthesis and potential osteogenic applications of Wnt3a-loaded ZIF-8 nanoparticles

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Chinese Chemical Letters 2024年第3期35卷 399-405页

作者： Hengfei Wang song Chen Zihan He Junyu Chen Zhou Zhu Qianbing Wan jian Wang Xibo Pei State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of ProsthodonticsWest China Hospital of StomatologySichuan UniversityChengdu 610041China Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher EducationStomatological Hospital of Chongqing Medical UniversityChongqing 400016China

The Wnt signaling pathway plays a critical role in bone homeostasis,and the related protein therapy strategies have been reported to have great potential in osseointegration;however,they face formidable challenges such as complex external environments and unavoidable protein *** this work,we report a novel approach combining the synthesis of metal–organic frameworks(MOFs)and protein encapsulation in a one-pot process based on zeolitic imidazolate framework-8(ZIF-8)and Wnt3a protein,with improved biomechanical behavior and enhanced protein biological *** combination was designed to enhance the Wnt3a protein function through the improved chemical stability provided by the ZIF-8 ***,the zinc ions contained in the ZIF-8 crystals induced bone homeostasis,further favoring the *** results showed that the Wnt3a protein-loaded ZIF-8 crystals served as efficient drug delivery vehicles to promote osteogenesis,preventing protein *** particular,Wnt3a-loaded ZIF-8 nanoparticles(Wnt3a@ZIF-8 NPs)had higher efficacy on bone marrow mesenchymal stem cells(BMSCs)than ZIF-8 NPs or Wnt3a proteins,contributing to the osteogenesis through ZIF-8 crystals and intracellular Wnt3a proteins released from Wnt3a@ZIF-8 ***,polymerase chain reaction(PCR)analysis showed that the osteogenic pathways were ***,the present one-pot process can open up new avenues to develop signaling protein-delivery systems for applications in protein therapy strategies.

关键词： Metal–organic frameworks Nanoparticle Drug release Osteogenesis Bone defects

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Ten-Minute Synthesis of a New Redox-Active Aqueous Binder for Flame-Retardant Li-S Batteries

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Energy & Environmental Materials 2024年第2期7卷 52-61页

作者： Tianpeng Zhang Borui Li Zihui song Wanyuan jiang Siyang Liu Runyue Mao Xigao jian Fangyuan Hu School of Materials Science and Engineering State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering Technology Innovation Center of High Performance Resin Materials (Liaoning Province) Key Laboratory of Energy Materials and Devices (Liaoning Province) Dalian University of Technology State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical Engineering School of Chemical Engineering Technology Innovation Center of High Performance Resin Materials (Liaoning Province) Key Laboratory of Energy Materials and Devices (Liaoning Province) Dalian University of Technology

As a critical role in battery systems,polymer binders have been shown to efficiently suppress the lithium polysulfide shuttling and accommodate volume changes in recent ***,preparation processes and safety,as the key criterions for Li-S batteries' practical applications,still attract less ***,an aqueous multifunction binder（named PEI-TIC） is prepared via an easy and fast epoxy-amine ring-opening reaction（10 min）,which can not only give the sulfur cathode a stable mechanical property,a strong chemical adsorption and catalytic conversion ability,but also a fire safety *** Li-S batteries based on the PEI-TIC binder display a high discharge capacity(1297.8 mAh g-1),superior rate performance(823.0 mAh g-1at 2 C),and an ultralow capacity decay rate of 0.035% over more than 800 *** under 7.1 mg cm-2S-loaded,the PEI-TIC electrode can also achieve a high areal capacity of 7.2 mA h g-1and excellent cycling stability,confirming its application ***,it is also noted that TG-FTIR test is performed for the first time to explore the flame-retardant mechanism of polymer *** work provides an economically and environmentally friendly binder for the practical application and inspires the exploration of the flame-retardant mechanism of all electrode components.

关键词： 3D cross-linked network environmentally friendly flame retardant Li-S batteries multifunction binder

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Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2137-2152页

作者： Tarik Zahr Vijay K.Boda jian Ge Lexiang Yu Zhongzhi Wu jianwen Que Wei Li Li qiang Naomi Berrie Diabetes Center Columbia UniversityNew YorkNY 10032USA Department of Molecular Pharmacology and Therapeutics Columbia UniversityNew YorkNY 10032USA Department of Pharmaceutical Sciences College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Drug Discovery Center College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Division of Digestive and Liver Diseases Columbia UniversityNew YorkNY 10032USA Center for Human Development Columbia UniversityNew YorkNY 10027USA Department of Pathology and Cell Biology Columbia UniversityNew YorkNY 10032USA Department of Medicine Columbia UniversityNew YorkNY 10032USA

Estrogen is imperative to mammalian reproductivity,metabolism,and ***,the hormone activating estrogen receptor(ERs)αcan cause major safety concerns due to the enrichment of ERαin female tissues and certain *** contrast,ERβis more broadly expressed in metabolic tissues and the ***,it is desirable to generate selective ERβagonist conjugates for maximizing the therapeutic effects of ERs while minimizing the risks of ERα***,we report the design and production of small molecule conjugates containing selective non-steroid ERβagonists Gtx878 or *** of aged mice with our synthesized conjugates improved aging-associated declines in insulin sensitivity,visceral adipose integrity,skeletal muscle function,and skin health,with validation in *** further uncovered the benefits of ERβconjugates in the skin using two inducible skin injury mouse models,showing increased skin basal cell proliferation,epidermal thickness,and wound ***,our ERβ-selective agonist conjugates offer novel therapeutic potential to improve aging-associated conditions and aid in rejuvenating skin health.

关键词： Estrogen receptorβ Aging Metabolism Skin injury Muscle metabolism Small molecule conjugates Regeneration Adiposity

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Improving mathematical model of burden distribution and correcting chute angle to cope with fluctuation of stock line

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Journal of Iron and Steel Research International 2024年第2期31卷 342-356页

作者： jian-sheng Chen Wen-guo Liu Hao Guo Wang Ding Qing-guo Xue Jing-song Wang Hai-bin Zuo State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China MCC Capital Engineering&Research Incorporation Limited Beijing100176China Hunan Valin Xiangtan Iron and Steel Co. Ltd.Xiangtan411101HunanChina

Accurate evaluations of the burden distribution are of critical importance to stabilize the operation of blast *** mathematical model and discrete element method(DEM)are two attractive methods for predicting burden *** on DEM,the initial velocities of the pellet,sinter,and coke were calculated,and the velocity attenuations of the above three particles between the burden and the chute were *** initial velocity and velocity attenuation were applied to a mathematical model for improving the ***,based on the improved model,a scheme for rectifying the chute angles was proposed to address the fluctuation of the stock line and maintain a stable burden *** validity of the scheme was confirmed via a stable burden distribution under different stock *** mathematical model has been successfully applied to evaluate the online burden distribution and cope with the fluctuation of the stock line.

关键词： Burden distribution Mathematical model Discrete element method Velocity attenuation Stock line fluctuation

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Effectiveness and safety of tenofovir amibufenamide in chronic hepatitis B patients

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World Journal of Gastroenterology 2024年第26期30卷 3261-3263页

作者： Li-Yang Meng Chao-Ting Yang jian-Feng Bao Jin-song Huang The Fourth Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Hepatology Hangzhou Xixi HospitalZhejiang University School of MedicineHangzhou 310023Zhejiang ProvinceChina

This letter to the editor relates to the study entitled“Tenofovir amibufenamide vs tenofovir alafenamide for treating chronic hepatitis B:A real-world study”,which was recently published by Peng et *** B virus infection represents a significant health burden worldwide and can lead to cirrhosis and even liver *** antiviral drugs currently used to treat patients with chronic hepatitis B infection still have many side effects,so it is crucial to identify safe and effective drugs to inhibit viral replication.

关键词： Tenofovir amibufenamide Chronic hepatitis B Non-alcoholic fatty liver disease Alanine transaminase normalization Virological response

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Exploring the combination of biochar‐amended soil and automated irrigation technology for water regulation and preservation in green infrastructure

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Deep Underground Science and Engineering 2024年第1期3卷 39-52页

作者： Honghu Zhu Yuanxu Huang Haihong song jian Chen songlei Han Tanwee Mazumder Ankit Garg School of Earth Sciences and Engineering Nanjing UniversityNanjingChina Department of Civil and Smart Engineering Construction Guangdong Engineering Center for Structure Safety and Health MonitoringShantou UniversityShantouChina Shanghai Municipal Engineering Design Co. LtdShanghaiChina Indian Institute of Technology Madras ChennaiIndia

Biochar is a carbon sink material with the potential to improve water retention in various ***,for the long‐term maintenance of green infrastructure,there is an additional need to regulate the water contents in the covers to maintain vegetation growth in semiarid *** this study,biochar‐amended soil was combined with subsurface drip irrigation,and the water preservation characteristics of this treatment were investigated through a series of one‐dimensional soil column *** ascertain the best treatment method specific to semiarid climatic conditions,the test soil was amended with 0%,1%,3%,and 5%*** irrigation devices equipped with soil moisture sensors were used to control the subsurface water content with the aim of enhancing vegetation *** soil column test lasted 150 h,during which the volumetric water contents and soil suction data were *** experimental results reveal that the soil specimen amended with 3%biochar is the most water‐saving regardless of the time *** with a higher biochar content(e.g.,5%)consumes a more significant amount of water due to the enhancement of the water‐holding *** on the experimental results,it can be concluded that the appropriate ratio can be determined within 1%–3%,which can reduce not only the amount of irrigated/used water but also the time *** technology can be explored for water content regulation in green infrastructure and the development of barriers for protecting the environment around deep underground waste containment.

关键词： biochar drip irrigation underground water preservation water regulation

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Metastatic stomach lymphoepithelioma-like carcinoma and immune checkpoint inhibitor therapy:A case report

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1436-1442页

作者： Guo-Feng Chen Jun Wang Yu Yan song Xu jian Chen Department of Gastroenterology Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Cancer Center Zhejiang UniversityHangzhou 310000Zhejiang ProvinceChina Department of Pathology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Pulmonary lymphoepithelioma-like carcinoma(PLELC)is a rare type of nonsmall-cell lung *** lymphoepithelioma-like carcinoma(LELC)metastasis secondary to PLELC has not been reported *** SUMMARY A 64-year-old female was admitted to our hospital for a regular gastroscopy examination with a 6-year history of surgical resection for left *** emission tomography/computed tomography suggested high accumulation of 18F-fludeoxyglucose in the gastric cardia *** gastrointestinal endoscopy confirmed a large mass at the stomach ***(IHC)of the biopsy suggested metastatic stomach *** gastrectomy showed that this 6.5 cm×5.0 cm mass was located in the stomach fundus near the *** examination showed a poorly differentiated carcinoma with prominent lymphoplasmacytic *** demonstrated that the tumor was positive for CK(AE1/AE3),p63,p40,p53,Ki-67(70%),and EGFR(3+)and negative for CK7,CK20,Her2,and *** situ hybridization analysis showed positive staining Epstein-Barr virus-encoded *** programmed cell death ligand 1(PD-L1)expression score was 98%,and the combined positive score was 100,with no evidence of microsatellite ***,the patient was unequivocally diagnosed with metastatic stomach LELC secondary to pulmonary *** discharge,this patient underwent PD-1 inhibitor treatment(toripalimab,240 mg)every 3 wk for ten cycles,and she has had no tumor *** For gastric LELC metastasis,PD-1 inhibitor therapy could become a new therapeutic approach,though there is still no evidence from large data sets to support this.

关键词： Stomach neoplasm Pulmonary lymphoepithelioma-like carcinoma Metastasis Immune checkpoint inhibitor Case report

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