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New Frontiers on Intracellular cGAS Activation:Molecular Mechanisms,Cellular Signaling,and Therapeutic Strategies

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Chemical Research in Chinese Universities 2024年第4期40卷 632-645页

作者： song Xingrui LING Xiaoting LIU Hailong ZHAO qiang LI Xiangjun LAI Weiyi WANG Hailin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing10085P.R.China School of Chemical Sciences University of Chinese Academy of SciencesBeijing101408P.R.China

Cyclic GMP-AMP(cGAMP)synthase(cGAS)plays a pivotal role in the innate immune *** the primary DNA sensor in cells,cGAS binds to dsDNA in the cytoplasm and forms cGAS-DNA liquid-liquid phase separation(LLPS)and activates its catalytic *** activation triggers the cGAS-stimulator of interferon genes(STING)signaling pathway,establishing an efficient system for pathogen *** pathogen surveillance,cGAS performs a diverse range of roles,involved in inflammatory response,metabolic homeostasis,DNA damage repair,and cell *** biological functions regulate cellular physiological homeostasis and influence the occurrence and development of *** review provides an overview of the structure,localization,and intracellular biological functions of the cGAS-STING signaling pathway and cGAS-DNA ***,we discuss their contribution to the development of tumors,autoimmune diseases,and inflammatory diseases and highlight the innovative strategies in modulating cGAS activity,either through activation or inhibition,as a promising therapeutic approach.

关键词： Cyclic GMP-AMP(cGAMP)synthase(cGAS)-stimulator of interferon genes(cGAS-STING) Liquid-liquid phase separation(LLPS) Biological function Disease

Robotic vs laparoscopic abdominoperineal resection for rectal cancer:A propensity score matching cohort study and metaanalysis

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1280-1290页

作者： Li song Wen-Qiong Xu Zheng-qiang Wei Gang Tang Department of Gastrointestinal Surgery Chengdu Fifth People's HospitalChengdu 610000Sichuan ProvinceChina Department of Nephrology Chengdu Fifth People's HospitalChengdu 610000Sichuan ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Division of Biliary Tract Surgery Department of General SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Robotic surgery(RS)is gaining popularity;however,evidence for abdominoperineal resection(APR)of rectal cancer(RC)is *** To compare the efficacy of RS and laparoscopic surgery(LS)in APR for *** We retrospectively identified patients with RC who underwent APR by RS or LS from April 2016 to June *** regarding short-term surgical outcomes were compared between the two *** reduce the effect of potential confounding factors,propensity score matching was used,with a 1:1 ratio between the RS and LS groups.A meta-analysis of seven trials was performed to compare the efficacy of robotic and laparoscopic APR for RC *** Of 133 patients,after propensity score matching,there were 42 patients in each *** postoperative complication rate was significantly lower in the RS group(17/42,40.5%)than in the LS group(27/42,64.3%)(P=0.029).There wasno significant difference in operative time(P=0.564),intraoperative transfusion(P=0.314),reoperation rate(P=0.314),lymph nodes harvested(P=0.309),or circumferential resection margin(CRM)positive rate(P=0.314)between the two *** meta-analysis showed patients in the RS group had fewer positive CRMs(P=0.04),lesser estimated blood loss(P<0.00001),shorter postoperative hospital stays(P=0.02),and fewer postoperative complications(P=0.002)than patients in the LS *** Our study shows that RS is a safe and effective approach for APR in RC and offers better short-term outcomes than LS.

关键词： Robotic surgery Laparoscopic surgery Abdominoperineal resection Postoperative complications Propensity score

Role of CD36 in central nervous system diseases

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Neural Regeneration Research 2024年第3期19卷 512-518页

作者： Min Feng qiang Zhou Huimin Xie Chang Liu Mengru Zheng Shuyu Zhang songlin Zhou jian Zhao School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Department of Orthopedic Oncology Second Affiliated Hospital of Naval Medical UniversityShanghaiChina Key Laboratory of Neuroregeneration of jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsJiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Stomatology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Medical College of Nantong University NantongJiangsu ProvinceChina

CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic ***36 was recently found to be widely expressed in various cell types in the nervous system,including endothelial cells,pericytes,astrocytes,and ***36 mediates a number of regulatory processes,such as endothelial dysfunction,oxidative stress,mitochondrial dysfunction,and inflammatory responses,which are involved in many central nervous system diseases,such as stroke,Alzheimer’s disease,Parkinson’s disease,and spinal cord ***36 antagonists can suppress CD36 expression or prevent CD36 binding to its ligand,thereby achieving inhibition of CD36-mediated pathways or ***,we reviewed the mechanisms of action of CD36 antagonists,such as Salvianolic acid B,tanshinone IIA,curcumin,sulfosuccinimidyl oleate,antioxidants,and small-molecule ***,we predicted the structures of binding sites between CD36 and *** sites can provide targets for more efficient and safer CD36 antagonists for the treatment of central nervous system diseases.

关键词： animal experiments antagonists CD36 antagonist central nervous system diseases clinical trial curcumin microRNA salvianolic acid B small-molecule drugs sulfosuccinimidyl oleate

Effects of projectile parameters on the momentum transfer and projectile melting during hypervelocity impact

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Defence Technology（防务技术） 2024年第2期32卷 89-103页

作者： Wenjin Liu Qingming Zhang Renrong Long Zizheng Gong Ren jiankang Xin Hu Siyuan Ren qiang Wu Guangming song State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China Beijing Institute of Spacecraft Environment Engineering China Academy of Space TechnologyBeijing100094China

The effects of projectile/target impedance matching and projectile shape on energy,momentum transfer and projectile melting during collisions are investigated by numerical *** comparing the computation results with the experimental results,the correctness of the calculation and the statistical method of momentum transfer coefficient is *** shapes of aluminum,copper and heavy tungsten alloy projectiles striking aluminum,basalt,and pumice target for impacts up to 10 km/s are *** influence mechanism of the shape of the projectile and projectile/target density on the momentum transfer was *** an increase in projectile density and length-diameter ratio,the energy transfer time between the projectile and targets is *** projectile decelerates slowly,resulting in a larger cratering *** energy consumed by the projectile in the excavation stage increased,resulting in lower mass-velocity of ejecta and momentum transfer *** numerical simulation results demonstrated that for different projectile/target combinations,the higher the wave impedance of the projectile,the higher the initial phase transition velocity and the smaller the mass of phase *** results can provide theoretical guidance for kinetic impactor design and material selection.

关键词： Hypervelocity impact Energy partitioning Impact melting Momentum transfer

Effect of Ti contents on interfacial bonding, mechanical and thermal properties of Mo-Cu composites

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Tungsten 2024年第3期6卷 549-554页

作者： jian-Ru Chu Xiao-song jiang Tian-Yan Liu Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Reactor Engineering Research Sub-Institute Nuclear Power Institute of China

Mo-Cu composites are widely used in electronic packaging, vacuum technology, microwave devices and other fields due to their excellent properties, such as excellent electrical and thermal conductivity, low adjustable ...

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Theoretical and experimental investigations on an X-shaped vibration isolator with active controlled variable stiffness

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1371-1386页

作者： Zeyu CHAI J.T.HAN Xuyuan song jian ZANG Yewei ZHANG Zhen ZHANG College of Aerospace Engineering Shenyang Aerospace UniversityShenyang 110136China Jacobs School of Engineering University of California San DiegoSan Diego CA 92122U.S.A. Key Laboratory of Vibration and Control of Aero-Propulsion System Ministry of EducationNortheastern UniversityShenyang 110819China

A novel X-shaped variable stiffness vibration isolator(X-VSVI)is *** Runge-Kutta method,harmonic balance method,and wavelet transform spectra are introduced to evaluate the performance of the X-VSVI under various *** layer number,the installation angle of the X-shaped structure,the stiffness,and the active control parameters are systematically *** addition,a prototype of the X-VSVI is manufactured,and vibration tests are carried *** results show that the proposed X-VSVI has a superior adaptability to that of a traditional X-shaped mechanism,and shows excellent vibration isolation performance in response to different amplitudes and forms of ***,the vibration isolation efficiency of the device can be improved by appropriate adjustment of parameters.

关键词： bionic vibration isolation X-shaped structure variable stiffness structure nonlinear dynamics prototype experiment

Divergent defluorocarboxylation of α-CF_(3) alkenes with formate via photocatalyzed selective mono-or triple C-F bond cleavage

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Science China Chemistry 2024年第1期67卷 368-373页

作者： Xing-Yu Wang Pei Xu Wen-Wen Liu Hao-qiang jiang song-Lei Zhu Dong Guo Xu Zhu jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy School of PharmacyXuzhou Medical UniversityXuzhou 22100China

Unprecedented divergent synthesis of gem-difluorovinylacetic acid and glutaric acid derivatives fromα-CF_(3)alkenes with formate as the carbonyl source was *** reaction can undergo selective mono-or triple C-F bond cleavage by simply switching the photocatalyst and hydrogen atom transfer(HAT)catalyst under visible-light-induced conditions at room *** acts as both the C1 source and the reductant through the generation of CO_(2)^(·-)species,which underwent Giese radical addition to electron-deficient alkenes to trigger the consecutive C-F bond cleavage and carboxylation process.

关键词： C-F bond activation defluorocarboxylation carbon dioxide radical anion visible light

Solidification crack characteristics and sensitivity of peritectic steel

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Journal of Iron and Steel Research International 2024年第7期31卷 1668-1679页

作者： Ya-qiang Li jian-hua Liu Zi-ming Wang Ying-ying Li Yang He Xiao-wei Li Department of Automotive Engineering Hebei Vocational University of Technology and EngineeringXingtai 054000HebeiChina Hebei Special Vehicle Modification Technology Innovation Center Hebei Vocational University of Technology and EngineeringXingtai 054000HebeiChina Institute of Engineering Technology University of Science and Technology BeijingBeijing 100083China School of Petroleum and Natural Gas Engineering Changzhou UniversityChangzhou 213164JiangsuChina

The characteristics and sensitivity of solidification cracks in peritectic steels were investigated using directional solidifi-cation *** cracks were observed in both hypoperitectic steels(12CrlMoV,15CrMo)and hyper-peritectic steel(20CrMo)during solidification at growth velocities of 15,50,and 80 pm/*** the dendritic boundaries,sulphide precipitates were found,promoting crack *** on the statistical analysis of interdendritic cracks in peritectic steels,the area ratio(RA)of interdendritic cracks in a directional solidification structure was proposed to evaluate the crack sensitivity of peritectic ***,the crack sensitivities of peritectic steels(12CrlMoV,15CrMo,and 20CrMo)were tested,evaluated,and compared with the surface crack rates of three types of steels produced from a steel *** results demonstrated that RA was in good agreement with that of the steel plant,and the crack sensitivity of 12CrlMoV steel was the strongest,followed by that of 15CrMo and 20CrMo ***,RA can be used to evaluate the crack sensitivity of peritectic steel.

关键词： Peritectic steel-Directional solidification Growth velocity Dendritic structure Solidification crack Crack sensitivity

Conquer coronary artery perforation with magic hands

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Journal of Geriatric Cardiology 2024年第4期21卷 379-386页

作者： Yi-Lun ZOU jian-qiang LI Ding-Yu WANG Yong-Tai GONG Li SHENG Yue LI Department of Cardiology the First Affiliated Hospital of Harbin Medical UniversityHarbinChina

Coronary artery perforation(CAP) poses a significant challenge for interventional cardiologists. Management of CAP depends on the location and severity of the perforation. The conventional method for addressing the perforation of large vessels involves the placement of a covered stent, while the perforation of distal and collateral vessels is typically managed using coils, autologous skin, subcutaneous fat, microspheres, gelatin sponge, thrombin or other substances. However, the above techniques have certain limitations and are not applicable in all scenarios. Our team has developed a range of innovative strategies for effectively managing CAP. This article provides an insightful review of the various tips and tricks for the treatment of CAP.

关键词： coronary sponge perforation