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Journal of Geriatric Cardiology 2010年第3期7卷 131-137页

作者： Liu-Xin Wu qiang zen Dong-Chang qiang Institute of Aviation Medicine Chinese PLA Air Force Beijing 100036 China Chinese PLA General Hospital Beijing 100853 China

Objective Global cardiovascular risk assessment has been incorporated into current Chinese guidelines for the management of hypertension and hypercholesterolemia. The aim of our study is to determine the distribution of 10-year risk for ischemic cardiovascular disease （ICVD） among middle-aged Chinese adults, and to evaluate the usefulness of global risk assessment tools in the primary prevention of ICVD in Chinese *** Simplified prediction tools derived from the USA-PRC Collaborative Study of Cardiovascular Epidemiology cohort were applied to the Chinese Health Examination Database （CHED） 2008. 10-year risk for ICVD was estimated in 461 157 ICVD-free subjects （264 432 male and 196 725 female） aged 35 to 59 years. Results Among the male subjects, 82.4% had a 10-year risk for ICVD of 〈5%, 14.4% of 5% to 12.1% and 3.4 of≥ 12.2%, and in female subjects, 86.7% had a 10-year risk for ICVD of 〈5%, 12.1% of 5% to 12.0% and 1.2% of ≥ 12.1%. All subjects with predicted high level ICVD risk （≥ 12.2% in male or ≥ 12.1% in female） had either remarkably elevated （≥ 160 mmHg） blood pressure, significantly increased （≥ 6.22 mml/L） total serum cholesterol or *** Using the currently recommended prediction tools, only very small proportions of middle-aged Chinese men and women who were free of ICVD would be classified into high level risk group. These prediction tools are unlikely to help for the medical intervention decision making in Chinese adult patients with hypertension and/or hypercholesterolemia

关键词： cardiovascular disease hypertension hypercholesterolemia prevention Chinese

第二次世界大战中阿根廷与纳粹德国的关系初探

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军事历史研究 2006年第2期20卷 87-91页

作者：曾强夏正伟上海大学

第二次世界大战期间,阿根廷自称坚守中立政策,但是却与纳粹德国形成了被世人嗤鼻的暧昧关系。战时的阿根廷与纳粹德国的关系不仅呈现了二战期间国际关系的复杂性,而且影响到战时及战后拉美地区国际关系的走向和格局。

关键词：阿根廷纳粹德国关系第二次世界大战

载人飞船返回舱再入末段实时光电测量评估系统

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载人航天 2023年第5期29卷 684-692页

作者：袁红伟彭育兵贾鹏曾强安学广中国酒泉卫星发射中心酒泉732750

针对载人飞船返回舱再入末段(高度20 km以下)缺乏有效测量评估方法的问题,研制了一套基于小型光电经纬仪的测量评估系统。硬件系统由光电指向器、驱动控制机箱、室内操控盒和显控计算机组成,研发了具有系统监控、图像处理、数据传输功... 详细信息

针对载人飞船返回舱再入末段(高度20 km以下)缺乏有效测量评估方法的问题,研制了一套基于小型光电经纬仪的测量评估系统。硬件系统由光电指向器、驱动控制机箱、室内操控盒和显控计算机组成,研发了具有系统监控、图像处理、数据传输功能的管理平台软件,实现了在不同跟踪状态下的电路跟踪模型和复杂背景下的小目标智能识别融合算法。系统支持外引导、自跟踪2种模式跟踪返回舱再入末段至落地全过程。使用多站交汇算法获取返回舱降落轨道数据,实现返回舱落地后的快速落点测量,完成神舟十二至神舟十四号载人飞船返回段回收测量任务。结果表明:该系统为返回舱再入末段的轨道测量和状态评估提供了可靠手段,首次实现了返回舱再入末段高清图像的实时拍摄传输,为飞船指挥控制部门提供了科学、直观、准确的评估依据。

关键词：载人飞船返回舱再入末段光电经纬仪多站交汇测量评估

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江西大吉山钨矿床品位概率分布型式及其地质意义

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中国钨业 2017年第5期32卷 9-16页

作者：张立东吴开兴曾强廖泽忠曹平生刘才平江西大吉山钨业有限公司江西全南341801 江西理工大学资源与环境工程学院江西赣州341000 江西漂塘钨业有限公司江西大余341515

大吉山钨矿床是我国著名的大型钨多金属矿床,以外接触带石英脉型W-Mo-Bi矿体为主,兼具内接触带蚀变花岗岩型Ta-Nb-W-Be矿体,是南岭"五层楼+地下室"或"上脉下体"型钨矿床的典型代表。大吉山钨矿床品位的概率分布型式研究表明,无论是脉状... 详细信息

大吉山钨矿床是我国著名的大型钨多金属矿床,以外接触带石英脉型W-Mo-Bi矿体为主,兼具内接触带蚀变花岗岩型Ta-Nb-W-Be矿体,是南岭"五层楼+地下室"或"上脉下体"型钨矿床的典型代表。大吉山钨矿床品位的概率分布型式研究表明,无论是脉状矿体,还是蚀变花岗岩型矿体,WO_3品位均呈现出分布范围宽、低品位频数高、高品位频数低,即接近对数正态分布的概率分布型式,这暗示其钨成矿过程均较复杂,均受多种地质作用和/或物理化学条件控制。

关键词：大吉山石英型钨矿床蚀变花岗岩型钨矿床品位概率分布型式

轮胎压力监测系统及轮胎压力传感器的现状与发展

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传感器世界 2010年第8期16卷 6-10页

作者：邹向光宋国庆王振强李哓青中国电子科技集团公司第四十研究所黑龙江哈尔滨150001

介绍了汽车轮胎压力监测系统及轮胎压力传感器的种类、工作机制、特点和其发展现状,涉及了典型的硅压阻式、电容式轮胎压力传感器、无电池石英谐振式表面波轮胎压力传感器的研究状况,以及可直接与标准轮胎集成的声表面横波压力传感器等... 详细信息

介绍了汽车轮胎压力监测系统及轮胎压力传感器的种类、工作机制、特点和其发展现状,涉及了典型的硅压阻式、电容式轮胎压力传感器、无电池石英谐振式表面波轮胎压力传感器的研究状况,以及可直接与标准轮胎集成的声表面横波压力传感器等新型汽车轮胎压力传感器,并探讨了当前研究中需解决的问题和今后发展方向。

关键词：传感器轮胎压力监测系统(TPMS) 轮胎压力传感器(TPS)

First generation solar adaptive optics system for 1-m New Vacuum Solar Telescope at Fuxian Solar Observatory

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Research in Astronomy and Astrophysics 2016年第2期16卷 19-26页

作者： Chang-Hui Rao Lei Zhu Xue-Jun Rao Lan-qiang Zhang Hua Bao Xue-An Ma Nai-Ting Gu Chun-Lin Guan Dong-Hong Chen Cheng Wang Jun Lin zen-Yu Jin Zhong Liu Key Laboratory on Adaptive Optics Chinese Academy of Sciences Laboratory on Adaptive Optics Institute of Optics and Electronics Chinese Academy of Sciences Yunnan Astronomical Observatories Chinese Academy of Sciences

The first generation solar adaptive optics （AO） system, which consists of a fine tracking loop with a tip-tilt mirror （TTM） and a correlation tracker, and a high-order correction loop with a 37-element deformable mirror （DM）, a correlating Shack-Hartmann （SH） wavefront sensor （WFS） based on the ab- solute difference algorithm and a real time controller （RTC）, has been developed and installed at the 1-m New Vacuum Solar Telescope （NVST） that is part of Fuxian Solar Observatory （FSO）. Compared with the 37-element solar AO system developed for the 26-cm Solar Fine Structure Telescope, administered by Yunnan Astronomical Observatories, this AO system has two updates： one is the subaperture arrangement of the WFS changed from square to hexagon; the other is the high speed camera of the WFS and the corre- sponding real time controller. The WFS can be operated at a frame rate of 2100 Hz and the error correction bandwidth can exceed 100 Hz. After AO correction, the averaged residual image motion and the averaged RMS wavefront error are reduced to 0.06＂ and 45 nm, respectively. The results of on-sky testing obser- vations demonstrate better contrast and finer structures of the images taken with AO than those without AO.

关键词： adaptive optics -- high angular resolution -- sunspots -- granulation

Analysis of the 5' flanking sequence of the human norepinephrine transporter gene

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Cell Research 1998年第2期8卷 143-149页

作者： HUANG FANG JIAN FEI SHUN KAI MA LI HUAZHU ZHAO PING LIU GUO qiang CAI zen CAN YE LI HE GUO (Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China ) Shanghai Institute of Cell Biology Chinese Academy of Sciences Shanghai China

The human norepinephrine transporter(NET) gene was cloned and structurally analyzed. The far 5' fragment containing exon 1 (a non-coding exon) and exon 2 was sequenced. The transcription start site of the gene in human brain stem tissue was determined by primer extension analysis. It was found that the gene could be transcribed from multiple starting points. The 5' flanking sequence contains a proximal G-C rich region, one possible GSG elemeflt and several SP1 sites. However it does not contain TATA box and CAAT box motifS. Gel shift analysis with nuclear extracts from different tissues of mouse shows that the G-C rich region may be involved in tissue specific expression of the gene.

关键词： Norepinephrine transporter gene primer extension transcription regulation

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长期接触低剂量辐射人员唾液流率检测

中国临床研究 2012年第7期25卷 625-626页

作者：王军李广文高宗科赵增强张燕李卉程硕王娟王宇欣李翠霞王东平安源吕波涛艾玉郭静李刚陕西省宝鸡市解放军537医院口腔科第四军医大学口腔医学院口腔预防医学教研室四川大学华西公共卫生学院流行病教研室解放军534医院防疫所解放军451医院高压氧仓室西藏波密县78536部队医疗所

目的研究辐射特殊环境对工作人员唾液流率的影响,为其口腔疾病预防与治疗提供依据。方法以现场调查的方式对341名长期直接从事低剂量辐射接触工作的人员上午8:00～10:00时进行安静状态和刺激状态唾液流率检测,要求所有被检测者检查前8h... 详细信息

目的研究辐射特殊环境对工作人员唾液流率的影响,为其口腔疾病预防与治疗提供依据。方法以现场调查的方式对341名长期直接从事低剂量辐射接触工作的人员上午8:00～10:00时进行安静状态和刺激状态唾液流率检测,要求所有被检测者检查前8h不刷牙漱口,空腹。获得数据利用FoxPro6.0软件建立数据库,SPSS16.0软件进行统计分析。结果 341名长期接触低剂量辐射工作人员刺激唾液流率明显高于安静唾液流率[(0.311±0.231)vs(0.815±0.501)ml/min,P<0.05],但两项流率均低于文献报道的普通健康人群测量值。结论长期低剂量慢性辐射在某种程度上对人唾液腺有一定的损伤。安静唾液流率和刺激唾液流率作为人口腔唾液腺分泌功能的重要指标,可以反映长期低剂量辐射对涎腺功能的影响程度,同时也可为临床诊断和治疗提供参考。

关键词：辐射唾液流率唾液腺

Lead optimization and cellular targets identification of natural small-molecule STAT3 inhibitors targeting cancer stem cells

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Lead optimization and cellular targets identification of nat...

中国化学会第十二届全国天然有机化学学术会议

作者： Hong-Yan Ma Qing Zhang Liang-Xi Wen Xin-Ling zen Jin-Li Liu qiang Yu Jia-Wei Liu Ministry of Education Key Laboratory of Chinese Medicinal Plants Resource from Lingnan Research Center of Medicinal Plants Resource Science and EngineeringGuangzhou University of Chinese Medicine Departments of Pharmacology Shanghai Institute of Materia MedicaChinese Academy of Sciences

Signal transducer and activator of transcription 3(STAT3) is an oncogene constitutively activated in many human *** activated STAT3 plays a pivotal role in holding cancer sternness in cancer stem cells,which are essential for cancer initiation,relapse,metastasis and drug ***,STAT3 has been validated as a novel anti-cancer drug target and targeting cancer stem cells considered as a novel promising therapeutic strategy to treat human *** our continuing search for novel small-molecule STAT3 inhibitors from Chinese medicinal plaints,we have previously isolated a juglone analogue KT53504 from the roots of Polygonum cuspidatum as a potent small-molecule STAT3 signaling inhibitor(IC=7.7 μM).At the present study,we designed and synthesized a biotin-conjugated probe based on the structure-activity relationship study,and then identified its direct cellular targets of lead compound using biotin chemical probe as a ***,a series of novel juglone/triazole hybrids were prepared and identified by different spectroscopic techniques,these synthesized juglone/triazole hybrids were found to significantly inhibit STAT3 signaling activities with the IC values ranging from 0.75 to48.9μ*** them,WL011101 is the most potent small-molecule STAT3 inhibitor with nanomolar level(IC=0.75μM).WL011101 exhibits good druggability and may provide a novel promising lead for developing a novel anti-cancer agent targeting cancer stem cells.

关键词： Cancer stem cells Small-molecule STAT3 inhibitors Molecular probe Target identification Lead optimization

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教育学教学实施创新教育的几点思考

三明学院学报 2003年第3期20卷 131-134页

作者：曾念强三明高等专科学校初等教育系福建三明　365004

创新教育是当前的热门话题,在人类社会己步入知识经济时代,教育学教学应大胆进行教学改革,重视社会实践,提高教师素质,调动学生积极性,培养创造型人才。

关键词：教育学教学创新教育创造型人才