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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian Li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li qiang su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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The Effect of Basalt Fiber on Concrete Performance under a sulfate Attack Environment

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Journal of Renewable Materials 2023年第1期11卷 233-244页

作者： qiang su Jinming Xu Department of Civil Engineering Shanghai UniversityShanghai200444China

To enhance the sulfate attack resistance performance of concrete,sulfate erosion test was carried out on basalt fiber concrete with different contents,selecting a concentration of 5%sulfate solution and using a dry−wet cycle mechanism attack of basalt fiber-reinforced concrete(BFRC).Every 15 dry−wet cycles,the mass,compressive strength,splitting tensile strength,and relative dynamic elastic modulus of BFRC were tested,and the SO_(4)^(2−)con-centration was *** work demonstrates that the mass,relative dynamic elastic modulus,compressive and splitting tensile strength of BFRC reveal a trend of climb up and then decline with the process of the dry−wet *** fiber can enhance the sulfate corrosion resistance of concrete by delaying the erosion of concrete induced by SO_(4)^(2−)and increasing the bearing and anti-deformation capacities of concrete by improving its inter-nal ***,when mixing 0.2%basalt fiber into concrete,the strength deterioration rate will be reduced when the peak values of splitting tensile and compressive strength appear at 60 and 75 times the alter-nating dry−wet cycles,*** effects will occur when the fiber volume fraction exceeds 0.2%.The research in this paper can provide a foundation for the engineering applications of basalt fiber concrete.

关键词： Concrete basalt fiber dry−wet cycle compressive strength splitting tensile strength

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阿戈美拉汀缓解APP/PS1转基因小鼠焦虑及抑郁样行为的机制

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中国组织工程研究 2025年第6期29卷 1176-1182页

作者：李甜任俞桦高艳萍苏强山西医科大学基础医学院生理学系细胞生理学教育部重点实验室细胞生理学山西省重点实验室山西省太原市030001 山西医科大学汾阳学院医学检验系山西省汾阳市032200

背景:阿戈美拉汀在临床上用于治疗焦虑、抑郁等相关精神行为异常。前期研究证实,阿戈美拉汀能够有效缓解阿尔茨海默病模型小鼠的认知行为、海马突触可塑性及脑病理特征,然而阿戈美拉汀能否改善阿尔茨海默病模型小鼠的焦虑和抑郁样行为... 详细信息

背景:阿戈美拉汀在临床上用于治疗焦虑、抑郁等相关精神行为异常。前期研究证实,阿戈美拉汀能够有效缓解阿尔茨海默病模型小鼠的认知行为、海马突触可塑性及脑病理特征,然而阿戈美拉汀能否改善阿尔茨海默病模型小鼠的焦虑和抑郁样行为仍不清楚。目的:探究阿戈美拉汀对APP/PS1(阿尔茨海默病)转基因小鼠焦虑和抑郁样行为的改善效应及分子机制。方法:①将18只APP/PS1转基因小鼠随机分为模型对照组(n=9)、模型干预组(n=9),将18只野生型小鼠随机分为对照组(n=9)、干预组(n=9),模型干预组与干预组小鼠腹腔注射阿戈美拉汀10 mg/(kg·d),连续注射31 d后进行高架十字迷宫、强迫游泳行为学实验与海马组织mRNA测序。②取小鼠海马神经元细胞株(HT22)、脑微血管内皮细胞株(bEnd.3),分别分4组培养:空白组不加入任何药物,药物组加入20µmol/L阿戈美拉汀,模型组加入10µmol/Lβ-淀粉样蛋白1-42,实验组加入10µmol/Lβ-淀粉样蛋白1-42+20µmol/L阿戈美拉汀,培养24 h后,免疫印迹检测HT22细胞S416p-tau和S9p-GSK3β的蛋白表达,免疫印迹检测bEnd.3细胞低密度脂蛋白受体相关蛋白1、糖基化终产物受体的蛋白表达。结果与结论:①在高架十字迷宫实验中,模型对照组小鼠的探索开放臂时间与开放臂进入次数均少于对照组(P<0.05),模型干预组小鼠的探索开放臂时间与开放臂进入次数均多于模型对照组(P<0.05);在强迫游泳测试中,模型对照组小鼠的不动时间长于对照组(P<0.05),模型干预组小鼠的不动时间短于模型对照组(P<0.05);海马组织mRNA测序显示,阿戈美拉汀可以增强APP/PS1小鼠海马区低密度脂蛋白受体相关蛋白1的表达。②免疫印迹检测显示,模型组HT22细胞S416p-tau蛋白表达高于空白组(P<0.05),实验组HT22细胞S416p-tau蛋白表达低于模型组(P<0.05),药物组HT22细胞S9p-GSK3β蛋白表达高于空白组(P<0.05),实验组HT22细胞S9p-GSK3β蛋白表达高于模型组(P<0.05),实验组bEnd.3细胞低密度脂蛋白受体相关蛋白1蛋白表达高于模型组(P<0.05)。③结果表明,阿戈美拉汀可通过促进脑内β-淀粉样蛋白和tau的清除来缓解阿尔茨海默病小鼠的焦虑和抑郁样行为。

关键词：阿尔茨海默病阿戈美拉汀 APP/PS1转基因小鼠焦虑抑郁

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Rational Design of Biomolecules/Polymer Hybrids by Reversible Deactivation Radical Polymerization (RDRP) for Biomedical Applications

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Chinese Journal of Polymer Science 2021年第9期39卷 1093-1109页

作者： Jie Zhou Xiao-Yuan Zhang Zhi-qiang su State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Advanced Functional Polymer CompositesBeijing University of Chemical TechnologyBeijing 100029China

Hybrids,produced by hybridization of proteins,peptides,DNA,and other new biomolecules with polymers,often have unique functional *** properties,such as biocompatibility,stability and specificity,lead to various smart *** review mainly introduces biomolecule polymer hybrid materials by reversible deactivation radical polymerization(RDRP),emphasizing reverse addition-fragmentation chain transfer(RAFT)polymerization,and nitroxide mediated polymerization(NMP).It includes the methods of RDRP to improve the biocompatibility of biomedical materials and organisms by surface *** key to the current synthesis of biomolecule polymer hybrids is to control ***,this review describes several different kinds of biomolecule polymer hybrid materials and their applications in the biomedical *** progresses provide ideas for the investigation of biodegradable and highly bioactive biomedical soft tissue *** research hotspots of nanotechnology in biomedical fields are controlled drug release materials and gene therapy carrier *** showed that RDRP method could improve the therapeutic effect and reduce the dosage and side effects of the ***,by means of RDRP,the original materials can be modified to develop intelligent polymer materials as membrane materials with selective permeability and surface modification.

关键词： Biomolecule-polymer hybrids RDRP Biomedical applications Drug release Nanotechnology

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Effect and mechanism of encapsulation on aging characteristics of quantum-dot light-emitting diodes

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Nano Research 2021年第1期14卷 320-327页

作者： Zinan Chen qiang su Zhiyuan Qin Shuming Chen Guangdong University Key Lab for Advanced Quantum Dot Displays and Lighting Shenzhen Key Lab for Advanced Quantum Dot Displays and Lightingand Department of Electrical and Electronic EngineeringSouthern University of Science and TechnologyShenzhen 518055China Key Laboratory of Energy Conversion and Storage Technologies(Southern University of Science and Technology) Ministry of EducationShenzhen 518055China

The aging characteristics,e.g.,the evolution of efficiency and luminance of quantum-dot light-emitting diodes(QLEDs)are greatly affected by the *** encapsulated with ultraviolet curable resin,the efficiency is increased over time,a known phenomenon termed as positive aging which remains one of the unsolved *** developing a physical model and an analytical model,we identify that the efficiency improvement is mainly attributed to the suppression of hole leakage current that is resulted from the passivation of ZnMgO *** further encapsulated with desiccant,the positive aging effect *** take the advantage of positive aging,the desiccant is incorporated after the positive aging process is *** the new encapsulation method,the QLED exhibits a high external quantum efficiency of 20.19%and a half lifetime of 1,267 h at an initial luminance of 2,800 cd·m^(-2),which are improved by 1.4 and 6.0 folds,respectively,making it one of the best performing *** work provides an in-depth and systematic understanding of the mechanism of positive aging and offers a practical encapsulation way for realizing efficient and stable QLEDs.

关键词： quantum-dot light-emitting diodes positive aging encapsulation ZnO defects

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Research in Astronomy and Astrophysics 2014年第9期14卷 1055-1060页

作者： Ding-qiang su Xiang-Qun Cui Department of Astronomy Nanjing University Key Laboratory of Modern Astronomy and Astrophysics (Nanjing University) Ministry of Education National Astronomical Observatories/Nanjing Institute of Astronomical Optics and Technology(NIAOT) Chinese Academy of Sciences

China will establish a 2-meter space-based astronomical telescope. Its main science goals are performing a sky survey for research about dark matter and dark energy, and high resolution observations. Some experts suggest that this space telescope should be installed inside the Chinese space station. In accord with this suggestion we put forward our first configuration, i.e., to adopt a coude system for this telescope. This coude system comes from the Chinese 2.16 m telescope＇s coude system, which includes a relay mirror so that excellent image quality can be obtained. In our second configuration, we suggest that the whole space telescope fly freely as an independent satellite outside the space station. When it needs servicing, for example, changing in- struments, refilling refrigerant or propellant, etc., this space telescope can fly near or even dock with the core space station. Although some space stations have had accom- panying satellites, the one we propose is a space telescope that will be much larger than other accompanying satellites in terms of weight and volume. On the basis of the second configuration, we also put forward the following idea： the space station can be composed of several large independent modules if necessary.

关键词： instruments -- space telescope -- space station -- survey -- high angu- lar resolution

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STUDY ON THE CENTRALIZATION STRATEGY OF THE BLOOD ALLOCATION AMONG DIFFERENT DEPARTMENTS WITHIN A HOSPITAL

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Journal of Systems Science and Systems Engineering 2018年第4期27卷 417-434页

作者： Jingnan Duan qiang su Yanhong Zhu Yuanshan Lu School of Economies and Management Tongii University Shanghai 200092 China Shanghai General Hospital Shanghai 200080 China

By far, the researches on how to distribute blood products among different departments in hospital have not been further studied, though the problem of blood shortage and wastage that caused by improper blood allocation is severe, which may endanger patient＇s lives and impose considerable costs on hospitals. In order to solve this problem, this paper mainly studies on how to distribute the blood items among different departments within a hospital and investigates the allocation approach with the novel management method by centralizing the inventory of several different departments. By integrating the blood inventory requirements of some departments, the hospital could reduce the rate of blood shortage and wastage effectively, release the pressure of the occupancy of resources and reduce the bullwhip effect of blood products. This paper illustrates the centralization principle in hospital and formulates the mixed integer programming model to work out the optimal allocation network scheme and the optimal inventory setting for every department. And the results of the numerical example demonstrate that this centralization method could considerably reduce blood shortage and wastage in hospital by about 72% and 90% respectively. Furthermore, it could decrease the total cost by about 108,540 RMB a month on blood supply chain management in the hospital and improve the effect of some certain surgeries by transfusing the fresh blood to patients.

关键词： Blood allocation inventory management centralization strategy bullwhip effect

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EXTENDED WARRANTY STRATEGIES FOR ONLINE SHOPPING suPPLY CHAIN WITH COMPETING suPPLIERS CONSIDERING COMPONENT RELIABILITY

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Journal of Systems Science and Systems Engineering 2017年第6期26卷 753-773页

作者： Xinghong Qin qiang su Samuel H. Huang 1.School of Economics and Management Tongji University Shanghai 200092 China 2.School of Business Planning Chongqing Technology and Business University Chongqing 400067 China 3.Department of Mechanical and Materials Engineering University of Cincinnati Cincinnati OH 45221 USA

This article presents the issue of extended warranty and management strategies in a three-echelon competing online shopping supply chain with price- and base warranty period-dependent demand. We employ game theory to develop decision models to explore the interactions between component suppliers and the manufacturer, as well as competition between two component suppliers. Products and extended warranty are sold by an online store, which is the leader in the Stackelberg game. Two scenarios are considered： either the manufacturer offers a prepaid extended warranty to customers or doses not. In each scenario, base warranties are assumed to be bundled with products. Our results show that when the manufacturer＇s repair costs change in a proper range, providing extended warranty can benefit both the manufacturer and the online store; otherwise, the manufacturer has no incentive to offer the extended warranty. Reducing repair costs, improving component reliability, or shortening the base warranty period allows the manufacturer to realize significantly better value of the extended warranty. High component reliability benefits both the manufacturer and the online store, with the manufacturer reaping more benefit. Extending the length of the base warranty adversely affects profit of the manufacturer and the value of the extended warranty.

关键词： Extended warranty online shopping supply chain game theory online shopping

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Quantum quenches in the Dicke model:Thermalization and failure of the generalized Gibbs ensemble

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Chinese Physics B 2020年第12期29卷 198-204页

作者： Xiao-qiang su You-Quan Zhao College of Physics and Information Engineering ShanXi Normal UniversityLinfen 041004China

Quantum quenches in the Dicke model were studied both in the thermodynamic limit and the finite *** the integrable situation in the thermodynamic limit,the generalized Gibbs ensemble can effectively describe the energylevel occupations for the quench within the normal phase,but it fails for the quench to the superradiant *** the finite systems which are considered non-integrable,the post quench systems were studied by comparing with the thermal *** canonical ensembles are directly available for the quench within the normal *** the increasing of the target coupling strength over the equilibrium phase transition critical point,sudden changes take place for the effective temperature and the distance to the thermal *** thermalization was also studied by comparing with the results of the microcanonical ensembles.

关键词： quantum quench generalized Gibbs ensemble thermalization Dicke model

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Optical system for extremely large spectroscopic survey telescope

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 158-174页

作者： Ding-qiang su Hua Bai Xiangyan Yuan Xiangqun Cui Key Laboratory of the Ministry of Education School of Astronomy and Space ScienceNanjing UniversityNanjing 210023China Nanjing Institute of Astronomical Optics and Technology(NIAOT) Chinese Academy of SciencesNanjing 210042China University of Chinese Academy of Sciences Nanjing 211135China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China

This article presents research work on a spectroscopic survey *** idea is as follows:for such a telescope,a pure reflecting optical system is designed,which should have an aperture and a field of view(FOV)both as large as possible and excellent image quality,and then a strip lensm(lens-prism)atmospheric dispersion corrector(S-ADC)is added,only for correcting the atmospheric *** the fund limitation and the simplicity of scaling up,some 12-m telescopes are designed as ***,Korsch,and Meinel put forward the four-mirror Nasmyth systems I and II,which are used in this *** of 1.5°,2°,and 2.5°are *** all systems,the image qualities are *** the S-ADC relaxes the optical glass size restriction,this 12-m telescope with a FOV of 2.5°can be magnified in proportion to a 16-m *** etendue(from Frenchétendue)and focal surface will now be the largest in the *** such a telescope,a pure reflecting optical system can also be obtained.A subsequent coudésystem is designed with excellent image quality.

关键词： telescopes spectroscopic survey

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