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血清β-CTX、IL-32水平与强直性脊柱炎的相关性研究

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颈腰痛杂志 2024年第5期45卷 885-889页

作者：邬永祥褚强强徐胜前褚锋丁景成王平安徽医科大学第三附属医院/合肥市第一人民医院全科医学科安徽合肥230001 安徽医科大学第三附属医院/合肥市第一人民医院风湿免疫科安徽合肥230001

目的探讨血清骨Ⅰ型胶原交联C端末端肽β(β-CTX)、白介素-32(IL-32)对强直性脊柱炎(AS)的预测价值。方法将59例AS患者设为研究组,122例骨关节炎患者设为对照组。分别采用全自动血液分析仪检测患者包括白细胞(WBC)、中性粒细胞(NE)、... 详细信息

目的探讨血清骨Ⅰ型胶原交联C端末端肽β(β-CTX)、白介素-32(IL-32)对强直性脊柱炎(AS)的预测价值。方法将59例AS患者设为研究组,122例骨关节炎患者设为对照组。分别采用全自动血液分析仪检测患者包括白细胞(WBC)、中性粒细胞(NE)、淋巴细胞(L)、血小板(PLT)在内的血常规检查指标。免疫比浊法检测患者的C反应蛋白水平(CRP)。酶联免疫吸附法检测患者的β-CTX、IL-32水平。利用Logistic回归方程计算患者发生AS的独立预测因素。绘制受试者工作曲线(ROC),根据曲线下面积(AUC)评价患者血清β-CTX、IL-32水平预测发生AS的诊断效能。结果患者PLT、CRP、WBC、β-CTX、IL-32水平为发生AS的影响因素。患者血清β-CTX、IL-32水平预测AS发生的AUC分别为(0.781)、(0.773),两者联合检测AUC(0.859)明显高于单项检测。患者血清β-CTX、IL-32水平预测AS0~Ⅱ级、Ⅲ~IV级的AUC分别为(0.726)、(0.801),两者联合检测AUC(0.895)明显高于单项检测。结论血清β-CTX、IL-32水平可有效预测患者是否发生AS,并且可与作为AS分级诊断的有效辅助指标。

关键词：强直性脊柱炎血清骨Ⅰ型胶原交联C端末端肽β 白介素-32

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春节期间烟花爆竹燃放对PM_(2.5)水溶性离子的影响

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广州化工 2024年第6期52卷 165-171,190页

作者：夏娟陈阳郭卉丁华黄拓刘德华钟强强吕明李颖力合科技(湖南)股份有限公司湖南长沙410205 湖南省生态环境监测中心湖南长沙410004

对2021年2月13日18日(农历腊月二十二-次年正月初七)时段内湖南省益阳市、岳阳市、长沙市、株洲市常规参数及PM_(2.5)水溶性离子进行监测,研究春节期间四城市的PM_(2.5)与水溶性离子变化趋势及烟花爆竹燃放对PM_(2.5)和水溶性离子的影... 详细信息

对2021年2月13日18日(农历腊月二十二-次年正月初七)时段内湖南省益阳市、岳阳市、长沙市、株洲市常规参数及PM_(2.5)水溶性离子进行监测,研究春节期间四城市的PM_(2.5)与水溶性离子变化趋势及烟花爆竹燃放对PM_(2.5)和水溶性离子的影响。结果表明,PM_(2.5)浓度变化趋势在春节期间呈“前期高、后期低”的特点,四城市中的峰值出现在长沙市12日3:00,浓度高达461μg/m^(3);受烟花爆竹燃放影响,在PM_(2.5)水溶性离子中,SO_(4)^(2-)、Mg^(2+)、Cl^(-)、K^(+)浓度与占比高值时段与烟花爆竹集中燃放时段对应,在相关性分析中,4种水溶性离子在春节期间相关性系数均在85%以上;烟花爆竹燃放对株洲市PM_(2.5)的贡献最大,贡献值和贡献率分别为3778.44μg/m^(3)、88.51%。

关键词：春节 PM_(2.5) 水溶性离子烟花爆竹贡献值

Single-order soft x-ray spectra with spectroscopic photon sieve

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Chinese Physics B 2020年第5期29卷 225-228页

作者： Yu-Lin Gao Lai Wei qiang-qiang Zhang Zu-Zua Yang Wei-Min Zhou Lei-Feng Cao Hi-tech Research and Development Centre China Academy of Engineering PhysicsBeijing 100094China China Jiuyuan Hi-Tech Equipment Corporation Limited Beijing 100094China National Key Laboratory for Laser Fusion Research Center of Laser FusionMianyang 621900China

A single-order diffraction transmission grating named spectroscopic photon sieve(SPS)for soft x-ray region is proposed and demonstrated in this *** SPS consists of many circular pinholes located randomly,and can realize both free-standing diffractions and the suppression of higher-order *** this paper,the basic concept,numerical simulations,and calibration results of a 1000-lines/mm SPS for soft x-ray synchrotron radiation are *** predicted by theoretical calculations,the calibration results of a 1000-lines/mm SPS verify that the higher-order diffractions can be significantly suppressed along the symmetry *** the current nanofabrication technique,the SPS can potentially have a higher line density,and can be widely used in synchrotron radiation,laser-induced plasma diagnostics,and astrophysics.

关键词： higher-order diffraction suppression extreme ultraviolet and soft x-rays single-order diffraction grating

Antioxidant and antiaging effect of traditional Thai rejuvenation medicines in Caenorhabditis elegans

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Journal of Integrative Medicine 2021年第4期19卷 362-373页

作者： Sutticha Ruangchuay qiang-qiang Wang Liang-yi Wang Jing Lin Yong-chao Wang Guo-huan Zhong Katesarin Maneenoon Ze-bo Huang Sasitorn Chusri Faculty of Traditional Thai Medicine Prince of Songkla UniversityHat YaiSongkhla 90110Thailand School of Food Science and Engineering South China University of TechnologyGuangzhou 510641Guangdong ProvinceChina Guangdong Province Key Laboratory for Biotechnology Drug Candidates School of Biosciences and BiopharmaceuticsGuangdong Pharmaceutical University.Guangzhou 510006Guangdong ProvinceChina Natural Product Research Center of Excellence Prince of Songkla UniversityHat YaiSongkhla 90J10Thailand School of Health Science Mae Fah Luang UniversityMuangChiang Rai 57100Thailand

Objective: This study explored the rejuvenation mechanisms of Thai polyherbal medicines using different approaches, including in vitro methods, as well as a well-defined nematode model, Caenorhabditis ***: THP-R-SR012 decoction was selected from 23 polyherbal medicines, based on metal-chelating and chain-breaking antioxidant capacities. The influences of this extract on the survival and some stress biomarkers of C. elegans under paraquat-induced oxidative stress were evaluated. Furthermore, lifespan analysis and levels of lipofuscin accumulation were examined in senescent nematodes. The phytochemical profile of THP-R-SR012 was ***: Supplementation with THP-R-SR012 decoction significantly increased the mean lifespan and reduced the oxidative damage to C. elegans under oxidative stress conditions. Further, THP-R-SR012 supplementation slightly influenced the lifespan and the level of lipofuscin accumulation during ***-related phytochemical constituents of THP-R-SR012 decoction were rutin, naringenin, 3,4-dihydroxybenzoic acid, gallic acid, glycyrrhizic acid, demethoxycurcumin and 18 a-glycyrrhetinic ***: The antioxidant potential of THP-R-SR012 was due to its scavenging properties, its enhancement of antioxidant-related enzyme activities, and the presence of the antioxidant-related *** results support the traditional use of THP-R-SR012 decoction as a tonic for nourishing and strengthening the whole body.

关键词： Antioxidants Caenorhabditis elegans Herbal formula Lifespan extension Rejuvenation medicine

Syntheses,Crystal Structures and Properties of Two Coordination Polymers Based on Bisbenzimidazole

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Chinese Journal of Structural Chemistry 2021年第7期40卷 871-877,838页

作者： JIA qiang-qiang WAN Min TONG Liang XING Zheng WANG Guo-Xi CHEN Li-Zhuang School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Two novel coordination polymers Bim(C=O)CuI]_(2)(1)and[Bim(C=O)CdCl_(2)]_(2)(2)based on the flexible ligand bis(1H-benzo[d]imidazol-2-yl)methane(Bim)were synthesized via volatilization *** crystalize in monoclinic and triclinic crystal systems and adopt space group of P2_(1/c)and P1,*** compounds were characterized by elemental analysis,infrared spectroscopy and powder X-ray diffraction ***,methylene(-CH2-)in Bim was oxidized to carbonyl(C=O),which increases its extra-cyclic conjugation *** 1 and 2,their maximum emission wavelength of fluorescence around 440 and 475 nm indicates the potential as promising light-emissive ***,Co^(2+)ion shows a quenching effect on the fluorescence of compound ***,both compounds possess remarkable structure stability.

关键词： bisbenzimidazole ligand crystal structure fluorescence methylene carbonyl

Remote sensing image encryption algorithm utilizing 2D Logistic memristive hyperchaotic map and SHA-512

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Science China(Technological Sciences) 2024年第5期67卷 1553-1566页

作者： LAI qiang LIU Yuan YANG Liang School of Electrical and Automation Engineering East China Jiaotong UniversityNanchang330013China

The two-dimensional Logistic memristive hyperchaotic map(2D-LMHM)and the secure hash SHA-512 are the foundations of the unique remote sensing image encryption algorithm(RS-IEA)suggested in this *** proposed map is formed from the improved Logistic map and the memristor,which has wide phase space and hyperchaotic range and is exceptionally excellent to be utilized in specific *** proposed image algorithm uses the permutation-assignment-diffusion *** generates two position matrices in a progressive manner to achieve an efficient random exchange of pixel positions,assignment is carried through on the image pixels of the permutated image to entirely remove the original image information,strengthening the relationship between permutation and diffusion,and loop diffusion in two different directions can use subtle changes of pixels to affect the whole *** random key and plain-image SHA-512 hash values are used to produce an additional key,which is then utilized to figure out the permutation parameters and the initial value of a chaotic *** experimental results with the average NPCR=99.6094%(NPCR:number of pixels change rate),average UACI=33.4638%(UACI:unified average changing intensity),100%pass rate of the targets in the test set,the average correlation coefficient is 0.00075,and the local information entropy is 7.9025,which shows that the algorithm is able to defend against a variety of illegal attacks and provide more trustworthy protection than some of the existing state-of-the-art algorithms.

关键词： chaos memristive hyperchaotic map remote sensing SHA-512 image encryption RS-IEA

A new 3D plastoelastohydrodynamic lubrication model for rough surfaces

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Friction 2024年第6期12卷 1176-1193页

作者： Shengyu YOU Jinyuan TANG qiang WANG State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China

Plastoelastohydrodynamic lubrication of rough surfaces(R-PEHL)is a cutting-edge area of research in interface fluid-structure coupling *** existing R-PEHL model calculates the elastic-plastic deformation of rough surface by the Love equation in a semi-infinite space smooth surface,which deviates from the actual ***,it is an innovative work to study the exact solution of elastic-plastic deformation of rough surface and its influence on the solution results of R-PEHL *** this paper,a new contact calculation model of plastoelastohydrodynamic lubrication(PEHL)with three-dimensional(3D)rough surface is proposed by integrating numerical method of EHL and finite element *** new model eliminates an original error introduced by the assumption of semi-infinite space in contact calculation,providing wide applicability and high *** the given rough surfaces and working conditions,the study reveals that:(1)the oil film pressure calculated by the new model is lower than that of the smooth surface in semi-infinite space by 200–800 MPa;(2)the Mises stress of the new model is 2.5%–26.6%higher than that of the smooth surface in semi-infinite space;(3)compared with the semi-infinite space assumption,the rough surface plastic deformation of the new model is increased by 71%–173%,and the local plastic deformation singularity may appear under the semi-infinite space assumption;(4)the plastic deformation caused by the first contact cycle on the rough surface of the new model accounts for 66.7%–92.9%of the total plastic deformation,and the plastic deformation of the semi-infinite space accounts for 50%–83.3%.This study resolves the contradiction between the smooth surface assumption and the rough surface in the existing R-PEHL model,establishing a solid logic foundation for the accurate solution of R-PEHL model.

关键词： rough surface plastoelastohydrodynamic lubrication(PEHL) asperity plastic deformation semi-infinite space

Exclusive Hypothesis Testing for Cox's Proportional Hazards Model

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Journal of Systems Science & Complexity 2024年第5期37卷 2157-2172页

作者： WU qiang TONG Xingwei DUAN Xiaogang School of Statistics Beijing Normal University

Exclusive hypothesis testing is a new and special class of hypothesis testing. This kind of testing can be applied in survival analysis to understand the association between genomics information and clinical information about the survival time. Besides, it is well known that Cox's proportional hazards model is the most commonly used model for regression analysis of failure time. In this paper,the authors consider doing the exclusive hypothesis testing for Cox's proportional hazards model with right-censored data. The authors propose the comprehensive test statistics to make decision, and show that the corresponding decision rule can control the asymptotic Type Ⅰ errors and have good powers in theory. The numerical studies indicate that the proposed approach works well for practical situations and it is applied to a set of real data arising from Rotterdam Breast Cancer Data study that motivated this study.

关键词： Comprehensive test statistics Cox’s proportional hazards model exclusive hypothesis testing right-censored data Type I error

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涡旋压缩机平衡铁结构对阻力矩的影响研究

压缩机技术 2024年第1期 8-13,37页

作者：刘兴旺蒋强强刘晓明陈荣道李远航李登辉兰州理工大学石油化工学院甘肃兰州730050 压缩机技术国家重点实验室(压缩机技术安徽省实验室) 合肥安徽230031

针对涡旋压缩机平衡铁随主轴旋转时产生的阻力损失问题,提出了圆角结构及机翼型结构平衡铁。运用Fluent有限元分析软件,结合滑移网格技术对平衡铁工作区域模拟,研究了3种不同结构平衡铁所受的压差阻力矩和摩擦阻力矩,对比分析了不同结... 详细信息

针对涡旋压缩机平衡铁随主轴旋转时产生的阻力损失问题,提出了圆角结构及机翼型结构平衡铁。运用Fluent有限元分析软件,结合滑移网格技术对平衡铁工作区域模拟,研究了3种不同结构平衡铁所受的压差阻力矩和摩擦阻力矩,对比分析了不同结构产生的阻力矩大小。结果表明:压差阻力矩占总阻力矩的90%以上,总阻力矩随转速的增大而增大;相对于样机平衡铁,前后端面为圆角的平衡铁总阻力矩减小了30%~50%之间;机翼型平衡铁总阻力矩减小了55%~65%之间。

关键词：涡旋压缩机有限元分析平衡铁阻力矩结构优化