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Effect of pre-tensioned rock bolts on stress redistribution around a roadway—insight from numerical modeling

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Journal of China University of Mining and Technology 2008年第4期18卷 509-515页

作者： GAO Fu-qiang KANG Hong-pu Mining and Designing Branch Central Coal Research Institute Beijing 100013 China

The importance of the pre-tensioned force of rock bolts has been recognized by more and more researchers. To investi- gate the effect of pre-tensioned rock bolts on stress redistribution around roadways, a numerical analysis was carried out using FLAC3D and a special post-process methodology, using surfer, is proposed to process the numerical simulation results. The results indicate that pre-tensioned rock bolts have a significant effect on stress redistribution around a roadway. In the roof, pre-tensioned rock bolts greatly increase vertical stress; as a result, the strength of the rock mass increased significantly which results in a greater capacity of bearing a large horizontal stress. The horizontal stress decreases in the upper section of the roof, indicating that pre-tensioned rock bolts significantly reduce the coefficient and the size of the region concentration of horizontal stress. At the lat- eral side, pre-tensioned rock bolts greatly increase the horizontal stress; therefore, the rock mass strength significantly increases which results also in a greater capacity of bearing a large vertical stress. The greater the size of pre-tensioned force, the larger the region of stress redistribution around a roadway is affected and the higher the size of the stress on the roadway surface the more the rock mass strength increases.

关键词：岩石牢固性压力分布数字模拟采矿工程

Pathologically triggered in situ aggregation of nanoparticles for inflammation-targeting amplification and therapeutic potentiation

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Acta Pharmaceutica Sinica B 2023年第1期13卷 390-409页

作者： qiang Nie Chenwen Li Yu Wang Yi Hu Wendan pu Qixiong Zhang Jiajun Cai Yongyao Lin Gang Li Chenping Wang Lanlan Li Yin Dou Jianxiang Zhang Department of Pharmaceutics College of PharmacyThird Military Medical University(Army Medical University)Chongqing 400038China Department of Radiology Chongqing University Cancer Hospital&Chongqing Cancer Institute&Chongqing Cancer HospitalChongqing 400030China State Key Lab of Trauma Burn and Combined InjuryInstitute of Combined InjuryThird Military Medical University(Army Medical University)Chongqing 400038China

Uncontrolled and persistent inflammation is closely related to numerous acute and chronic diseases.However,effective targeting delivery systems remain to be developed for precision therapy of inflammatory diseases.Herein we report a novel strategy for engineering inflammationaccumulation nanoparticles via phenolic functionalization.Different phenol-functionalized nanoparticles were first developed,which can undergo in situ aggregation upon triggering by the inflammatory/oxidative microenvironment.Phenolic compound-decorated poly(lactide-co-glycolide)nanoparticles,in particular tyramine(Tyr)-coated nanoparticles,showed significantly enhanced accumulation at inflammatory sites in mouse models of colitis,acute liver injury,and acute lung injury,mainly resulting from in situ cross-linking and tissue anchoring of nanoparticles triggered by local myeloperoxidase and reactive oxygen species.By combining a cyclodextrin-derived bioactive material with Tyr decoration,a multifunctional nanotherapy(TTN)was further developed,which displayed enhanced cellular uptake,antiinflammatory activities,and inflammatory tissue accumulation,thereby affording amplified therapeutic effects in mice with colitis or acute liver injury.Moreover,TTN can serve as a bioactive and inflammation-targeting nanoplatform for site-specifically delivering a therapeutic peptide to the inflamed colon post oral administration,leading to considerably potentiated in vivo efficacies.Preliminary studies also revealed good safety of orally delivered TTN.Consequently,Tyr-based functionalization is promising for inflammation targeting amplification and therapeutic potentiation of nanotherapies.

关键词： Inflammatory disease Reactive oxygen species Myeloperoxidase Targeted therapy Nanoparticles Surface engineering Triggerable aggregation Nanotherapy

The Role of Endoplasmic Reticulum Stress-related Apoptosis in Vascular Endothelium Pathogenesis

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Biomedical and Environmental Sciences 2018年第7期31卷 555-559页

作者： TAO Yong Kang SHI Jing YU pu Lin ZHANG Guo qiang Departments of Emergency China-Japan Friendship Hospital Department of Deriatric Medicine Beijing Hospital National Center of Gerontology

Vascular endothelium refers to a single layer of endothelial cells that line the inner surface of blood vessels,serving as barriers and transducers between the circulating blood in the lumen and the rest of the vessel wall.Endothelial cells play essential roles in many aspects of vascular biology,such as barrier functions,thrombosis/fibrinolysis,inflammation,angiogenesis,vasoconstriction and vasodilation.

关键词： ER UPR GRP The Role of Endoplasmic Reticulum Stress-related Apoptosis in Vascular Endothelium Pathogenesis HUVECs

Room-Temperature Magnetism of Ceria Nanocubes by Inductively Transferring Electrons to Ce Atoms from Nearby Oxygen Vacancy

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Nano-Micro Letters 2016年第1期8卷 13-19页

作者： Yue Kang qiang Leng Donglin Guo Dezhi Yang Yanping pu Chenguo Hu Department of Applied Physics Chongqing University School of public Affairs Chongqing University

Ceria(CeO_2) nanocubes were synthesized by a hydrothermal method and weak ferromagnetism was observed in room temperature. After ultraviolet irradiation, the saturation magnetization was significantly enhanced from*3.18×10^(-3) to *1.89×10^(-2) emug^(-1). This is due to the increase of oxygen vacancies in CeO_2 structure which was confirmed by X-ray photoelectron spectra. The first-principle calculation with Vienna ab-initio simulation package was used to illustrate the enhanced ferromagnetism mechanism after calculating the density of states(DOSs) and partial density of states(PDOSs) of CeO_2 without and with different oxygen vacancies. It was found that the increase of oxygen vacancies will enlarge the PDOSs of Ce 4f orbital and DOSs. Two electrons in one oxygen vacancy are respectively excited to 4f orbital of two Ce atoms neighboring the vacancy, making these electron spin directions on 4f orbitals of these two Ce atoms parallel. This superexchange interaction leads to the formation of ferromagnetism in CeO_2 at room temperature. Our work indicates that ultraviolet irradiation is an effective method to enhance the magnetism of CeO_2 nanocube, and the firstprinciple calculation can understand well the enhanced magnetism.

关键词： UV irradiation Oxygen vacancies Saturation magnetism Spin direction Superexchange interaction

Ligamentum teres hepatis as a graft for portal and/or superior mesenteric vein reconstruction:From bench to bedside

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World Journal of Gastrointestinal Surgery 2023年第4期15卷 674-686页

作者： Wen-Tao Zhu Hai-Tao Wang Qing-Hai Guan Fan Zhang Chang-Xi Zhang Feng-Ai Hu Bao-Lei Zhao Lei Zhou qiang Wei Hai-Bin Ji Ting-Liang Fu Xing-Yuan Zhang Rui-Tao Wang qiang-pu Chen Department of Hepatobiliary Surgery Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina Department of Hepatobiliary Surgery Binzhou Medical University Affiliated Yantai HospitalYantai 264110Shandong ProvinceChina Department of Hepatobiliary Surgery and Clinical Nutrition Center Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina Department of Clinical Medicine Laboratory Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina Department of Pediatric Surgery Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710061Shannxi ProvinceChina

BACKGROUND Pancreaticoduodenectomy combined with portal vein(PV)and/or superior mesenteric vein(SMV)resection in patients with pancreaticobiliary malignancy has become a common surgical procedure.There are various grafts currently used for PV and/or SMV reconstruction,but each of these grafts have certain limitations.Therefore,it is necessary to explore novel grafts that have an extensive resource pool,are low cost with good clinical application,and are without immune response rejection or additional damage to patients.AIM To observe the anatomical and histological characteristics of the ligamentum teres hepatis(LTH)and evaluate PV/SMV reconstruction using an autologous LTH graft in pancreaticobiliary malignancy patients.METHODS In 107 patients,the post-dilated length and diameter in resected LTH specimens were measured.The general structure of the LTH specimens was observed by hematoxylin and eosin(HE)staining.Collagen fibers(CFs),elastic fibers(EFs),and smooth muscle(SM)were visualized by Verhoeff-Van Gieson staining,and the expression of CD34,factor VIII-related antigen(FVIIIAg),endothelial nitric oxide synthase(eNOS),and tissue type plasminogen activator(t-PA)were detected using immunohistochemistry in LTH and PV(control)endothelial cells.PV and/or SMV reconstruction using the autologous LTH was conducted in 26 patients with pancreaticobiliary malignancies,and the outcomes were retrospectively analyzed.RESULTS The post-dilated length of LTH was 9.67±1.43 cm,and the diameter at a pressure of 30 cm H2O was 12.82±1.32 mm at the cranial end and 7.06±1.88 mm at the caudal end.Residual cavities with smooth tunica intima covered by endothelial cells were found in HE-stained LTH specimens.The relative amounts of EFs,CFs and SM in the LTH were similar to those in the PV[EF(%):11.23±3.40 vs 11.57±2.80,P=0.62;CF(%):33.51±7.71 vs 32.11±4.82,P=0.33;SM(%):15.61±5.26 vs 16.74±4.83,P=0.32].CD34,FVIIIAg,eNOS,and t-PA were expressed in both LTH and PV endothelial cells.The PV and/or SMV reconstructions were successfully comple

关键词： Ligamentum teres hepatis Pancreaticoduodenectomy Portal vein Superior mesenteric vein Vascular grafting Pancreaticobiliary malignancy

Application of a modified infratemporal fossa type B approach to the resection of lateral skull base tumors

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Chinese Medical Journal 2020年第18期133卷 2256-2258页

作者： Yu-Bin Xue pu Wang Yin Xia qiang Liu Wen-Yang Zhang Department of Otolaryngology Head and Neck Surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

The infratemporal fossa approach was designed for the removal of large tumors located at the temporal bone and lateral skull base.[1]This approach has several subtypes,including types A,B,C,and D.The infratemporal fossa type B(ITFB)approach exposes the petrous apex,clivus,and horizontal segment of the internal carotid artery(ICA)and is used to remove tumors in this area.[2]The classical ITFB approach to fully exposing the horizontal segment of the ICA includes subtotal resection of the petrous bone,removal of the anterior wall of the external auditory canal and zygomatic arch,resection of the articular disc and condylar process of the mandible,downward traction of the mandible,and transection of the mandibular branch of the trigeminal nerve and middle meningeal artery.

关键词： resection tumors auditory

不同生态区气象因子对花生产量相关性状的影响

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中国油料作物学报 2024年第3期46卷 676-686页

作者：张玉松何柳张云云何晓莹刘亚俊刘珏苏世强陈晓艳陆建美普兴林原小燕云南省农业科学院经济作物研究所云南昆明650205 云南大学农学院云南昆明650500 临沧市农业技术推广中心云南临沧677000 德宏州农业技术推广中心云南芒市678400 盐津县农业技术推广中心云南昭通657500 大理州农业科学研究院云南大理671600 云南省砚山县农业技术中心云南文山663100 东川区经济作物技术推广站云南昆明654100

分析气象因子对花生生长及产量的影响,探讨栽培生境与花生产量形成的关系,旨在为花生生产布局和高产栽培提供参考依据。以9个花生品种为材料,在云南7个不同生态区连续种植2年,采用方差分析、相关性分析和通径分析等方法,分析气象因子对... 详细信息

分析气象因子对花生生长及产量的影响,探讨栽培生境与花生产量形成的关系,旨在为花生生产布局和高产栽培提供参考依据。以9个花生品种为材料,在云南7个不同生态区连续种植2年,采用方差分析、相关性分析和通径分析等方法,分析气象因子对花生农艺性状及产量的影响。结果表明:德宏、大理、东川、临沧和盐津的温度和积温较高,花生结果数多,出仁率和产量较高,是种植花生的适宜区域。方差分析发现花生的生长发育和产量受基因型和环境因素的共同影响,较高的气温和积温有利于缩短花生结荚期进而缩短全生育期天数。通径分析表明产量构成因素中以百果重对产量的影响最大,气象因素中以积温的影响最大。温度越高地上部越高大,单株果数和饱果数越多,百果重和百仁重也就越高,从而增加花生产量。光照时间过长和昼夜温差过大不利于地上部生长和分枝结实。

关键词：花生生态区气象因子农艺性状产量

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Squamous cell carcinoma of the pancreas with liver metastasis： a case report

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Chinese Medical Journal 2008年第9期121卷 853-854页

作者： CHEN qiang-pu OU Kun GUAN Qing-hai ZHANG Fan Department of Hepatobiliary Surgery Affiliated Hospital of Binzhou Medical College Binzhou Shandong 256603 China

Squamous cell carcinoma of the pancreas is an unusual cancer of ductal cell origin. In a review of 6668 cases of exocrine pancreatic cancer from various registries reported from 1950 through 1985, the incidence of squamous carcinoma and adenosquamous carcinoma was 0.005% and 0.01%, respectively） We report a case of squamous cell carcinoma of the pancreas with liver metastasis.

关键词： squamous cell carcinoma pancreas liver metastasis

ELECTROCHEMICAL COPOLYMERIZATION OF 3-(4-FLUOROPHENYL)THIOPHENE AND 3-METHYLTHIOPHENE IN BORON TRIFLUORIDE DIETHYL ETHERATE

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Chinese Journal of Polymer Science 2006年第3期24卷 253-263页

作者：徐景坤 Zhen-hong Wei qiang Xiao Shou-zhi pu jiangxi Key Laboratory of Organic Chemistry Jiangxi Science and Technology Normal University Nanchang 330013 China

The copolymer poly（3-（4-fluorophenyl）thiophene-co-3-methylthiophene） was successfully prepared from mixtures of 3-（4-fluorophenyl）thiophene （FPT） and 3-methylthiophene （MET） via electrochemical oxidation in boron trifluoride diethyl etherate （BFEE） and its mixed electrolytes with acetonitrile （ACN）. The influence of monomer concentration ratios on the copolymerization was investigated by using linear sweep voltammetry and cyclic voltammetry. The structure and morphology of these copolymer films were elucidated by UV-Vis, infrared spectroscopy, elemental analysis, thermal analysis and scanning electron microscopy （SEM）, respectively. The results showed that the molar ratio of FPT and MeT units, when copolymer was electrodeposited from feed ratio of FPT：MeT = 1：2, was about 1.08：1. In addition, the introduction of ACN into BFEE has little effect on the properties of as-formed copolymers.

关键词： Polythiophenes 3-Methylthiophene Electrochemical polymerization Copolymers Boron trifluoride diethyl etherate.