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BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu mao-Ju Tang man Luo Xiao-Wu Zhong qiang ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

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Exact solution for capillary interactions between two particles with fixed liquid volume

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Applied mathematics and Mechanics(English Edition) 2016年第12期37卷 1597-1606页

作者： Fengxi ZHOU qiang ma School of Civil Engineering Lanzhou University of Technology

The capillary interactions, including the capillary force and capillary suction, between two unequal-sized particles with a fixed liquid volume are investigated. The cap- illary interaction model is used within the Young-Laplace framework. With the profile of the meridian of the liquid bridge, the capillary suction, and the liquid volume as state variables, the governing equations with two-fixed-point boundary axe first derived using a variable substitution technique, in which the gravity effects are neglected. The capillary suction and geometry of the liquid bridge with a fixed volume are solved with a shooting method. In modeling the capillary force, the Gorge method is applied. The effects of var- ious parameters including the distance between two particles, the ratio of particle radii, and the liquid-solid contact angles are discussed.

关键词： liquid bridge Young-Laplace equation fixed liquid volume shootingmethod

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Single color image super-resolution using sparse representation and color constraint

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Journal of Systems Engineering and Electronics 2020年第2期31卷 266-271页

作者： XU Zhigang ma qiang YUAN Feixiang School of Computer and Communication Lanzhou University of TechnologyLanzhou 730050China

Color image super-resolution reconstruction based on the sparse representation model usually adopts the regularization norm(e.g.,L1 or L2).These methods have limited ability to keep image texture detail to some extent and are easy to cause the problem of blurring details and color artifacts in color reconstructed *** paper presents a color super-resolution reconstruction method combining the L2/3 sparse regularization model with color channel *** method converts the low-resolution color image from RGB to *** L2/3 sparse regularization model is designed to reconstruct the brightness channel of the input low-resolution color *** the color channel-constraint method is adopted to remove artifacts of the reconstructed highresolution *** method not only ensures the reconstruction quality of the color image details,but also improves the removal ability of color *** experimental results on natural images validate that our method has improved both subjective and objective evaluation.

关键词： color image sparse representation super-resolution L2/3 regularization norm color channel constraint

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Monotone Chains in Modulus of Two Classes of Dirichlet Coefficients

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Acta mathematica Sinica,English Series 2023年第6期39卷 1101-1114页

作者： Guang Shi Lü qiang ma School of mathematics Shandong UniversityJi'nan 250100P.R.China

Let f1,...,fkand g1,...,qkbe non-CM newforms of square-free *** byλ_(sym)jf_(i)(n)the coefficients of the Dirichlet expansion of L(sym^(j)f_(i),s)andν1,...,νkthe distinct positive integers such thatλ_(sym)jf_(i)(νi)≠*** this paper,we obtain that there exist infinitely many positive integers m such that 0<λ_(sym)jf_(1)(m+ν1)|<|λ_(sym)jf_(2)(m+ν2)|<…<|λ_(sym)jf_(k)(m+νk)|.For coefficients of the Dirichlet expansion of L(sym^(j1)f×sym^(j2)g,s),we have a similar result.

关键词： Dirichlet coefficients Sato-Tate conjecture

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An experimental study on dynamic response for MICP strengthening liquefiable sands

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Earthquake Engineering and Engineering Vibration 2016年第4期15卷 673-679页

作者： Han Zhiguang Cheng Xiaohui ma qiang Department of Civil Engineering Tsinghua University Beijing 100084 China Institute of Airforce Engineering Design Beijing 100070 China

The technology of bio-gronting is a new technique for soft ground improvement. many researchers have carried out a large number of experiments and study on this topic. However, few studies have been carried out on the dynamic response of solidified sand samples, such reducing liquefaction in sand. To study this characteristic of microbial-strengthened liquefiable sandy foundation, a microorganism formula and grouting scheme is applied. After grouting, the solidified samples are tested via dynamic triaxial testing to examine the cyclic performance of solidified sand samples. The results indicate that the solidified sand samples with various strengths can be obtained to meet different engineering requirements, the use of bacteria solution and nutritive salt is reduced, and solidified time is shortened to 1-2 days. Most importantly, in the study of the dynamic response, it is found that the MICP grouting scheme is effective in improving liquefiable sand characteristic, such as liquefaction resistance.

关键词： bacteria bio-grouting microorganism induced CaCO3 precipitation (MICP) grouting scheme design dynamic response

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Composite filtering with feedback information

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Journal of Systems Engineering and Electronics 2007年第1期18卷 54-56页

作者： He You Xiong Wei ma qiang Dept. of Electronic Engineering Naval Aeronautical Engineering Inst. Yantai 264001 P. R. China

The optimal fusion solution with feedback information for a hybrid multisensor data fusion system is presented. In this system, a part of sensors process their data locally to produce local tracks, and another part of sensors only provide detection reports These tracks and detection reports are communicated to a central site where track fusion and composite filtering are performed. The comparative results on the simulations suggest the feedback information from the center can greatly improve the tracking performance of the local node.

关键词： Data fusion Hybrid system Multisensor tracking Filtering

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PENALTY-FACTOR-FREE STABILIZED NONCONFORMING FINITE ELEMENTS FOR SOLVING STATIONARY NAVIER-STOKES EQUATIONS

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Journal of Computational mathematics 2022年第5期40卷 728-755页

作者： Linshuang He Minfu Feng qiang ma School of mathematics Sichuan UniversityChengdu 610064China

Two nonconforming penalty methods for the two-dimensional stationary Navier-Stokes equations are studied in this *** methods are based on the weakly continuous P1 vector fields and the locally divergence-free(LDF)finite elements,which respectively penalize local divergence and are discontinuous across *** methods have no penalty factors and avoid solving the saddle-point *** existence and uniqueness of the velocity solution are proved,and the optimal error estimates of the energy norms and L^(2)-norms are ***,we propose unified pressure recovery algorithms and prove the optimal error estimates of L^(2)-norm for *** design a unified iterative method for numerical experiments to verify the correctness of the theoretical analysis.

关键词： Stationary Navier-Stokes equations Nonconforming finite elements Penalty stabilization methods DG methods Locally divergence-free.

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Second-Order Two-Scale Analysis Method for the Heat Conductive Problem with Radiation Boundary Condition in Periodical Porous Domain

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Communications in Computational Physics 2013年第9期14卷 1027-1057页

作者： qiang ma Junzhi Cui LSEC ICMSECThe Academy of Mathematics and Systems ScienceCAS100190BeijingChina

In this paper a second-order two-scale(SOTS)analysismethod is developed for a static heat conductive problem in a periodical porous domain with radiation boundary condition on the surfaces of *** using asymptotic expansion for the temperature field and a proper regularity assumption on the macroscopic scale,the cell problem,effective material coefficients,homogenization problem,first-order correctors and second-order correctors are obtained *** characteristics of the asymptotic model is the coupling of the cell problems with the homogenization temperature field due to the nonlinearity and nonlocality of the radiation boundary *** error estimation is also obtained for the original solution and the SOTS’s approximation *** the corresponding finite element algorithms are developed and a simple numerical example is presented.

关键词： Periodic structure porousmaterial radiation boundary condition second-order twoscale method

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Lithospheric structure and evolution of the North China Craton:An integrated study of geophysical and xenolith data

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Science China Earth Sciences 2021年第2期64卷 205-219页

作者： Jianping ZHENG Bing XIA Hongkun DAI qiang ma School of Earth Sciences State Key Laboratory of Geological Processes and Mineral ResourcesChina University of GeosciencesWuhan 430074China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China

Determination of the physical and chemical structures of the inaccessible continental lithosphere by comprehensive geophysical and geochemical studies can provide valuable information on its formation and *** studies from various disciplines have revealed complex lithospheric modification of the North China Craton(NCC),but less attention has been paid to an integrated study from different *** we provide an integrated constraint on the lithospheric mantle structure of the NCC by comprehensive semiology,gravity and thermal studies with xenolith data involving depth(levels in the lithosphere),property(chemical and physical),and timing(formation and reworking ages).Our results suggest that the NCC has a relatively heterogeneous lithospheric *** margins and internal weak zones,especially in the eastern NCC,are generally underlain by the fertile,weakly metasomatized mantle with generally young formation *** contrast,its core tends to preserve the refractory,strongly metasomatized mantle with ages roughly coupled to the overlying Archean *** a lithospheric structure shows the preferential modification of the lithospheric mantle in the eastern NCC and in the peripheral regions of the western *** interior of the craton,especially most of the western NCC,remains stable and has been weakly modified.

关键词： Lithospheric thermal and density structure Peridotite xenolith Heterogeneous mantle replacement North China Craton

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A Proof of First Digit Law from Laplace Transform

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Chinese Physics Letters 2019年第7期36卷 1-5页

作者： Mingshu Cong Bo-qiang ma School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking University Beijing 100871 Center for High Energy Physics Peking University Beijing 100871

The first digit law, also known as Benford’s law or the significant digit law, is an empirical phenomenon that the leading digit of numbers from real world sources favors small ones in a form log(1 + 1/d), where d= 1, 2,..., *** a law has been elusive for over 100 years because it has been obscure whether this law is due to the logical consequence of the number system or some mysterious mechanism of nature. We provide a simple and elegant proof of this law from the application of the Laplace transform, which is an important tool of mathematical methods in physics. It is revealed that the first digit law originates from the basic property of the number system, thus it should be attributed as a basic mathematical knowledge for wide applications.

关键词： The first digit law significant digit wide applications

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