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International Journal of Minerals,Metallurgy and Materials 2022年第8期29卷 1589-1595页

作者： Dong Wu Wenya Li qiang chu Yangfan Zou Xichang Liu Yanjun Gao State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding TechnologiesNorthwestern Polytechnical UniversityXi’an 710072China Capital Aerospace Machinery Company Beijing 100076China

The bobbin tool friction stir welding process was used to join 6 mm thick 5A06 aluminum alloy *** microscope was used to characterize the *** electron backscatter diffraction(EBSD)identified the effect of non-homogeneous microstructure on the tensile *** was observed that the grain size in the top of the stir zone(SZ)is smaller than that in the centre *** lowest ratio of recrystallization and density of the geometrically-necessary dislocations(GNDs)in the SZ was found in the middle near the thermo-mechanically affected zone(TMAZ)being 22%and 1.15×10^(−13) m^(−2),*** texture strength of the heat-affected zone(HAZ)is the largest,followed by that in the SZ,with the lowest being in the *** were additional interfaces developed which contributed to the strengthening mechanism,and their effect on tensile strength was *** tensile tests identified the weakest part in the joint at the interfaces,and the specific reduction value is about 93 MPa.

关键词： friction stir welding bobbin-tool local microstructure strengthening mechanisms adjustable-gap

Neutrophil extracellular traps in gastrointestinal cancer

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World Journal of Gastroenterology 2021年第33期27卷 5474-5487页

作者： Zi-qiang chu Ke-Cheng Zhang Lin Chen Graduate School Chinese PLA General HospitalBeijing 100853China Institute of Basic Medical Sciences Chinese PLA General HospitalBeijing 100853China Department of General Surgery Chinese PLA General Hospital First Medical CenterBeijing 100853China

Gastrointestinal(GI)cancer is a high-risk malignancy and is characterized by high mortality and morbidity *** extracellular traps(NETs),a weblike structure consisting of chromatin DNA with interspersed cytoplasmic and granule proteins,are extruded by activated neutrophils to entrap and kill bacteria and ***,accumulating evidence shows that NETs are related to the progression and metastasis of *** clinical studies,NETs infiltrate primary GI cancer tissues and are even more abundant in metastatic *** quantity of NETs in peripheral blood is revealed to be associated with ascending clinical tumour stages,indicating the role of NETs as a prognostic markers in GI ***,several inhibitors of NETs or NET-related proteins have been discovered and used to exert anti-tumour effects in vitro or in vivo,suggesting that NETs can be regarded as targets in the treatment of GI *** this review,we will focus on the role of NETs in gastric cancer and colorectal cancer,generalizing their effects on tumour-related thrombosis,invasion and *** reports are also listed to show the latest evidences of how NETs affect GI ***,notwithstanding the scarcity of systematic studies elucidating the underlying mechanisms of the interaction between NETs and cancer cells,we highlight the potential importance of NETs as biomarkers and anti-tumour therapeutic targets.

关键词： Neutrophil extracellular traps Gastric cancer Colorectal cancer Biomarkers Therapeutic targets

Mesothelin targeted nano-system enhanced chemodynamic therapy and tirapazamine chemotherapy via lactate depletion

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Nano Research 2023年第5期16卷 7108-7118页

作者： Guodong Cao Wei Cao Jiawei Zhang Qing Chen Junjie Chen qiang chu qiang Sun Maoming Xiong Bo Chen Xiang Li Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 231300China Department of General Surgery The Second Affiliated Hospital of Zhejiang University Medical CollegeHangzhou 310027China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Jiangsu Key Laboratory of Biological Cancer Cancer instituteXuzhou Medical UniversityXuzhou 221002China Department of surgery the People’s Hospital of Hanshan CountyMa’anshan 238101China

The enhanced permeability and retention(EPR)effect alone is not enough for nanoparticles to reach the *** of active and passive targeting may be an effective drug delivery *** ferric-tannic acid complex nanocapsules(HFe-TA)may effectively degrade and release Fe^(2+) ions,Fe^(2+)ions induce the production of·OH,however,the fenton reaction needs amount of H_(2)O_(2)to enhance chemodynamic *** to their deficiencies,such nanoparticles cannot realize intravenous drug ***,the mesothelin-targeted membrane(MTM)was constructed to realize accurate delivery nano-system,mesothelin antibody was expressed on the 293T cell membrane to prepare a *** oxidase(Lox)was loaded on HFe-TA to obtain Lox@***@HFe-TA was coated with MTM to develop the MTM ***(TPZ)therapy also requires hypoxia *** MTM nanosystem combined with TPZ can significantly kill tumour cells and inhibit metastasis in vivo and in *** also tested the biological safety of the *** this study,we overcame the EPR defects via the MTM nanosystem,which can realize acute targeted delivery to the tumour site,lactate depletion,promoted reactive oxygen species(ROS)induction,enhanced the effect of TPZ,demonstrating a potential synergistic combination of cancer therapy with better efficacy and biosafety.

关键词： mesothelin lactate oxidase tumor metastasis synergetic cancer therapy chemodynamic therapy

1,n-Thiosulfonylation using thiosulfonates as dual functional reagents

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Chinese Chemical Letters 2022年第11期33卷 4732-4739页

作者： Danhua Ge Jia-Wei Chen Pei Xu Jinyin Pan Xue-qiang chu Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringNanjing Tech UniversityNanjing 211816China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy School of PharmacyXuzhou Medical UniversityXuzhou 221004China Sartorius Stedim(Shanghai)Trading Co. Ltd.Shanghai 200000China

In recent years,the direct introduction of sulfonyl and sulfenyl groups into unsaturated substrates by using thiosulfonates as unique dual functional reagents has inarguably provided chemists a new platform for the diverse synthesis of important S-containing *** 1,n-thiosulfonylation reactions usually feature simple procedures,100%atom economy,and high *** review focuses on the recent advancements in the transformations of thiosulfonates through 1,n-thiosulfonylation involving the formation of two distinct C-S bonds under transition-metal-catalyzed or metal-free conditions,where thiosulfonates act as both a sulfonyl and a sulfenyl component.

关键词： Thiosulfonylation Thiosulfonates Dual functional reagents Difunctionalization Atomic economy

Removal of sulfamethoxazole by nanofiltration membrane

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第11期11卷 868-878页

作者： Su-hua WU Hua-qiang chu Bing-zhi DONG Jun-ru ZHOU Yu HUANG School of Environmental Science and Engineering Tongji University Shanghai 200092 China Shanghai Purge Filtration Technology Co. Ltd Shanghai 200444 China

The retention of sulfamethoxazole (SMZ) by nanofiltration (NF) membranes is strongly influenced by the pH value of the solution. The retention of SMZ reaches its peak value when the solution pH rises above its pKa2 value as the compound transforms into a negatively charged species. Charge repulsion is the main mechanism involved in SMZ removal by NF membranes. In this study, the removal of SMZ by NF membranes, as a function of solution chemistry, was examined at pH 8.9 to investigate the effect of solution conditions on charge repulsion. The results show that the retention of negatively charged SMZ is relatively independent of SMZ concentration, and an increase in the ionic strength of the solution causes a relatively small reduction in retention. A small effect of humic acid (HA) on SMZ retention was noticed at pH 8.9, which can be explained by a small but insignificant improvement in the zeta potential of the membrane caused by HA at high pH values. However, it was found that SMZ concentration in the feed decreased significantly in solutions containing tannic acid (TA). The Adams-Bohart model was applied to our experimental data and was found to be suitable for describing the initial part of the breakthrough curves. The adsorptive parameters of the membrane were determined.

关键词： Pharmaceutically active compounds (PhACs) Nanofiltration (NF) membrane Electronic exclusion Adsorption Sulfamethoxazole (SMZ)

Pre-collision Granites and Post-collision Intrusive Assemblage of the Kelameili-Harlik Orogenic Belt

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Acta Geologica Sinica(English Edition) 1999年第3期73卷 316-329页

作者： GU Lianxing HU Shouxi chu qiang YU chunshui XIAO Xinjian State Key Laboratory of Mineral Deposit Research Nanjing University Nanjing Jiangsu 210093

The main types of intrusive rocks in the Kelameili-Harlik Hercynian orogenic belt include calc-alkaline granites, diabase dykes, kaligranites and alkaline granites. Investigation in field geology, petrology, mineralogy and geochemistry shows that the calc-alkaline granites belong to the syntexis-type (or I-type) and were formed in a pre-collisional magmatic arc environment. In consideration of the fact that kaligranites have many features of alkaline granites with higher consolidation temperatures than the calc-alkaline granites and show a discontinuity of minor element and REE evolution in respect to the calc-alkaline granites, they could not have been derived by differentiation of magmas for the calc-alkaline granites, but are likely to have been generated in an environment analogous to that for alkaline granites. The triplet of basic dyke swarms, kaligranites and alkaline granites could be regarded as a prominent indication of the initial stage of post-collisional delamination and extension. These rocks might have originated from underplating and intraplating of mantle-derived magmas at varying levels with varying degrees of partial melting, mixing, and interchange of crustal and mantle materials

关键词： granite intrusive rock orogenic belt lithosphere continental collision Xinjiang

ATP-responsive hollow nanocapsules for DOX/GOx delivery to enable tumor inhibition with suppressed P-glycoprotein

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Nano Research 2021年第1期14卷 222-231页

作者： Huimin Zhu Guodong Cao Yike Fu Chao Fang qiang chu Xiang Li Yulian Wu Gaorong Han State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Surgery Second Affiliated Hospital Zhejiang University School of Medicine Zhejiang UniversityHangzhou 310000China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311200China

Multidrug resistance(MDR)restricts chemotherapy efficacy due to P-glycoprotein(P-gp)mediated drug efflux,whereas current approaches to suppressing P-gp expression suffer from intrinsic challenges,such as low transfection,high toxicity and poor ***,hollow ferric-tannic acid complex nanocapsules(HFe-TA),which can be effectively degraded by the reaction with adenosine triphosphate(ATP),are synthesized for the delivery of glucose oxidase(GOx)and doxorubicin(DOX)for tumor *** findings indicate that the intracellular ATP is significantly decreased due to the combined effect of HFe-TA degradation and GOx-mediated glucose *** with this ATP down-regulation,P-gp expression of tumor cells is suppressed remarkably,which in turn promotes the intracellular accumulation and anticancer efficacy of *** addition,the production of•OH by Fe ions released from HFe-TA is promoted by the by-products of the oxidation of glucose process by *** consequence,HFe-TA nanocapsules loaded with DOX and GOx enable significant inhibition effect to tumors both in vitro and in vivo due to the synergistic effect of cascade *** study has therefore provided an alternative therapeutic platform for effective tumor inhibition with the potential in overcoming intrinsic MDR.

关键词： adenosine triphosphate(ATP)-responsive P-glycoprotein(P-gp)suppression nanocapsules multi-model tumor therapy

Design of 2.1GHz CMOS Low Noise Amplifier

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The Journal of China Universities of Posts and Telecommunications 2006年第1期13卷 71-74页

作者： LI En-ling SONG Lin-hong YANG Dang-qiang XUE Ying chu Meng Science School Xi'an University of Technology Xi'an 710048 P.R. China

This paper discusses the design of a fully differential 2.1 GHz CMOS low noise amplifier using the TSMC 0.25 μm CMOS process. Intended for use in 3G, the low noise amplifier is fully integrated and without off-chip components. The design uses an LC tank to replace a large inductor to achieve a smaller die area, and uses shielded pad capacitances to improve the noise performance. This paper also presents evaluation results of the design.

关键词： LNA LC tank noise figure shielded pads

Changes of Soil Water, Organic Matter, and Exchangeable Cations Along a Forest Successional Gradient in Southern China

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Pedosphere 2007年第3期17卷 397-405页

作者： YAN Jun-Hua ZHOU Guo-Yi ZHANG De-qiang chu Guo-Wei South China Institute of Botany Chinese Academy of Sciences Guangzhou 510650 （China）

Information on the distribution patterns of soil water content （SWC）, soil organic matter （SOM）, and soil exchangeable cations （SEC） is important for managing forest ecosystems in a sustainable manner. This study investigated how SWC, SOM, and SEC were influenced in forests along a successional gradient, including a regional climax （monsoon evergreen broad-leaved forest, or MEBF）, a transitional forest （coniferous and broad-leaved mixed forest, or MF）, and a pioneer forest （coniferous Masson pine （Pinus rnassoniana） forest, or MPF） of the Dinghushan Biosphere Reserve in the subtropical region of southern China. SWC, SOM, and SEC excluding Ca^2＋ were found to increase in the soil during forest succession, being highest in the top soil layer （0 to 15 cm depth） except for Na^＋. The differences between soil layers were largest in MF. This finding also suggested that the nutrients were enriched in the topsoil when they became increasingly scarce in the soil. There were no significant differences （P = 0.05） among SWC, SOM, and SEC. A linear, positive correlation was found between SWC and SOM. The correlation between SOM and cation exchange capacity （CEC） was statistically significant, which agreed with the theory that the most important factor determining SEC is SOM. The ratio of K^＋ to Na^＋ in the topsoil was about a half of that in the plants of each forest. MF had the lowest exchangeable Ca^2＋ concentration among the three forests and Ca^2＋：K^＋ in MPF was two times higher than that in MF. Understanding the changes of SWC, SOM, and CEC during forest succession would be of great help in protecting all three forests in southern China.

关键词： forest succession soil exchangeable cations soil organic matter soil water content

A review of linear friction welding of Ni -based superalloys

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1382-1391页

作者： Xiawei Yang Tingxi Meng qiang chu Yu Su Zhenguo Guo Rui Xu Wenlong Fan Tiejun Ma Wenya Li State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding TechnologiesNorthwestern Polytechnical UniversityXi’an 710072China Xi’an Aerospace Engine Co.Ltd. Xi’an 710100China

Ni-based superalloys are one of the most important materials employed in high-temperature applications within the aerospace and nuclear energy industries and in gas turbines due to their excellent corrosion,radiation,fatigue resistance,and high-temperature *** friction welding(LFW)is a new joining technology with near-net-forming characteristics that can be used for the manu-facture and repair of a wide range of aerospace *** paper reviews published works on LFW of Ni-based superalloys with the aim of understanding the characteristics of frictional heat generation and extrusion deformation,microstructures,mechanical proper-ties,flash morphology,residual stresses,creep,and fatigue of Ni-based superalloy weldments produced with LFW to enable future optim-um utilization of the LFW process.

关键词： Ni-based superalloys linear friction welding microstructures mechanical properties flash morphology