检索结果-南通市图书馆

Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 210-216页

作者： qiang Guo Mao-Lin Wang Kai Zhong Jia-Long Li Tie-Min Jiang hao Wen Tuerganaili Aji Ying-Mei Shao Department of Hepatobiliary and Echinococcosis Surgery Digestive and Vascular Surgery CenterFirst Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054China Clinical Medical Research Center of Echinococcosis and Hepatobiliary Disease of Xinjiang Uygur Autonomous Region Urumqi 830054China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaXinjiang Medical UniversityUrumqi 830054China

Alveolar echinococcosis(AE)is a lethal parasitic disease caused by Echinococcus multilocularis larvae,and more than 90%of pri-mary AE lesions occur in the *** of the affected individ-uals remain asymptomatic and the disease is often diagnosed at an advanced *** infection may spread to organs adjacent to the liver or distant locations,eventually causing end-stage multi-ple organ *** metastasis of AE is the most fatal with an inci-dence rate of 0.2%[1].

关键词： organs echinococcosis metastasis

Recent progress on fabrication, spectroscopy properties, and device applications in Sn-doped CdS micro-nano structures

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2024年第9期45卷 7-27页

作者： Bo Cao Ye Tian Huan Fei Wen hao Guo Xiaoyu Wu Liangjie Li Zhenrong Zhang Lai Liu qiang Zhu Jun Tang Jun Liu State Key Laboratory of Dynamic Measurement Technology School of Semiconductors and PhysicsNorth University of ChinaTaiyuan 030051China Shanxi Province Key Laboratory of Quantum Sensing and Precision Measurement North University of ChinaTaiyuan 030051China School of Instrument Science and Technology Xi'an Jiaotong UniversityXi'an 710049China

One-dimensional semiconductor materials possess excellent photoelectric properties and potential for the construction of integrated nanodevices. Among them, Sn-doped CdS has different micro-nano structures, including nanoribbons,nanowires, comb-like structures, and superlattices, with rich optical microcavity modes, excellent optical properties, and a wide range of application fields. This article reviews the research progress of various micrometer structures of Sn-doped CdS, systematically elaborates the effects of different growth conditions on the preparation of Sn-doped CdS micro-nano structures, as well as the spectral characteristics of these structures and their potential applications in certain fields. With the continuous progress of nanotechnology, it is expected that Sn-doped CdS micro-nano structures will achieve more breakthroughs in the field of optoelectronics and form cross-integration with other fields, jointly promoting scientific, technological, and social development.

关键词： Sn-doped CdS micro-nano structure superlattices optical microcavity

Interplay between mesenchymal stem cells and macrophages:Promoting bone tissue repair

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第4期16卷 375-388页

作者： Fei-Fan Zhang Yang hao Kuai-Xiang Zhang Jiang-Jia Yang Zhi-qiang Zhao Hong-Jian Liu Ji-Tian Li Molecular Biology Lab Henan Luoyang Orthopedic Hospital(Henan Provincial Orthopedic Hospital)Zhengzhou 450000Henan ProvinceChina Graduate School Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Graduate School Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina Department of Orthopaedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

The repair of bone tissue damage is a complex process that is well-orchestrated in time and space,a focus and difficulty in orthopedic *** recent years,the success of mesenchymal stem cells(MSCs)-mediated bone repair in clinical trials of large-area bone defects and bone necrosis has made it a candidate in bone tissue repair engineering and regenerative *** are closely related to *** one hand,MSCs regulate the immune regulatory function by influencing macrophages proliferation,infiltration,and phenotype polarization,while also affecting the osteoclasts differentiation of *** the other hand,macrophages activate MSCs and mediate the multilineage differentiation of MSCs by regulating the immune *** cross-talk between MSCs and macrophages plays a crucial role in regulating the immune system and in promoting tissue *** full use of the relationship between MSCs and macrophages will enhance the efficacy of MSCs therapy in bone tissue repair,and will also provide a reference for further application of MSCs in other diseases.

关键词： Bone tissue damage Inflammation Macrophages Mesenchymal stem cells Tissue regeneration

I-DCGAN and TOPSIS-IFP:A simulation generation model for radiographic flaw detection images in light alloy castings and an algorithm for quality evaluation of generated images

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Foundry 2024年第3期21卷 239-247页

作者： Ming-jun Hou hao Dong Xiao-yuan Ji Wen-bing Zou Xiang-sheng Xia Meng Li Ya-jun Yin Bao-hui Li qiang Chen Jian-xin Zhou State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China Xinjiang Technology(Jiangsu)Co. Ltd.Nantong 226100JiangsuChina Southwest Technique and Engineering Research Institute Chongqing 400039China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The intelligent detection technology driven by X-ray images and deep learning represents the forefront of advanced techniques and development trends in flaw detection and automated evaluation of light alloy ***,the efficacy of deep learning models hinges upon a substantial abundance of flaw *** existing research on X-ray image augmentation for flaw detection suffers from shortcomings such as poor diversity of flaw samples and low reliability of quality *** this end,a novel approach was put forward,which involves the creation of the Interpolation-Deep Convolutional Generative Adversarial Network(I-DCGAN)for flaw detection image generation and a comprehensive evaluation algorithm named TOPSIS-IFP.I-DCGAN enables the generation of high-resolution,diverse simulated images with multiple appearances,achieving an improvement in sample diversity and quality while maintaining a relatively lower computational ***-IFP facilitates multi-dimensional quality evaluation,including aspects such as diversity,authenticity,image distribution difference,and image distortion *** results indicate that the X-ray radiographic images of magnesium and aluminum alloy castings achieve optimal performance when trained up to the 800th and 600th epochs,*** TOPSIS-IFP value reaches 78.7%and 73.8%similarity to the ideal solution,*** to single index evaluation,the TOPSIS-IFP algorithm achieves higher-quality simulated images at the optimal training *** approach successfully mitigates the issue of unreliable quality associated with single index *** image generation and comprehensive quality evaluation method developed in this paper provides a novel approach for image augmentation in flaw recognition,holding significant importance for enhancing the robustness of subsequent flaw recognition networks.

关键词： light alloy casting flaw detection image generator discriminator comprehensive evaluation index

Circadian disturbance induces erectile dysfunction by impairing endothelial function

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2024年第2期26卷 205-211页

作者： Tao Li Yi-Ting Jiang Xin-Zhu Qi Peng Chen Jun-hao Zhang Fu Luo Jun Qiao Jiang Gu Guang-Shi Du qiang Wang Department of Urology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Urology Guizhou Provincial People's HospitalGuiyang 550002China Department of Otorhinolaryngology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Guizhou Institute for Food and Drug Control Guiyang 550004China Department of Reproductive Center Guizhou Provincial People's HospitalGuiyang 550002China Translational Medicine Research Center of Guizhou Medical University Guiyang 550025China

In order to explore the impact of circadian disturbance on erectile function,we randomly divided 24 adult male rats into groups of control(light on at 8:00 *** off at 8:00 p.m.),dark/dark(DD;constant dark),light/light(LL;constant light),and shift dark/light(DL;light off at 8:00 *** on at 8:0o p.m.).Four weeks later,erectile function was measured and corpora cavernosa were harvested for *** maximum intracavernous pressure(mlcP)and mCP/mean arterial pressure(MAP)ratio in the DD,LL,and DL groups were significantly lower than that in the control *** LL and DL groups showed significantly attenuated endothelial nitric oxide synthase(eNOS),while DD,LL,and DL showed reduced neuronal nitric oxide synthase(nNOS)at both mRNA and protein *** production of nitric oxide(NO)and cyclic guanosinemonophosphate(cGMP)was inhibited by altered light/dark cycles to varying *** disturbance impaired endothelial function and contributed to erectile *** the core circadian elements,mRNA expression of circadian locomotor output cycles kaput(Clock)and brain/muscle aryl-hydrocarbon receptor nuclear translocator-like protein 1(Bmal1)was elevated in the DL group,but their protein expression was not significantly ***,LL,and DL increased period 1(Per1)and Per3 levels,while LL and DL increased PER1 *** significant difference was found for Per2levels,and PER2 and PER3 concentrations were not significantly ***,LL and DL significantly increased cryptochrome-1(CRY1)and CRY2 at both mRNA and protein *** altered light/dark rat model showed that circadian disturbance contributed to erectile dysfunction probably by impairing endothelial ***,the core circadian elements were detected in the corpora cavernosa,but these were ***,which circadian element regulates erectile function and how it works need further analysis.

关键词： circadian disturbance endothelial function erectile function light/dark cycle NO/cGMP

Highly efficient difference-frequency generation for mid-infrared pulses by passively synchronous seeding

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Power Laser Science and Engineering 2021年第1期9卷 42-47页

作者： Kun Huang Yinqi Wang Jianan Fang Huaixi Chen Minghang Xu qiang hao Ming Yan Heping Zeng State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Shanghai Key Laboratory of Modern Optical System and Engineering Research Center of Optical Instrument and SystemMinistry of EducationSchool of Optical Electrical and Computer EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Jinan Institute of Quantum Technology Jinan 250101China CAS Center for Excellence in Ultra-intense Laser Science Shanghai 201800China Shanghai Research Center for Quantum Sciences Shanghai 201315China

We have proposed and experimentally demonstrated a novel scheme for efficient mid-infrared difference-frequency generation based on passively synchronized fiber lasers. The adoption of coincident seeding pulses in the nonlinear conversion process could substantially lower the pumping threshold for mid-infrared parametric emission. Consequently,a picosecond mid-infrared source at 3.1 μm was prepared with watt-level average power, and a maximum power conversion efficiency of 77% was realized from pump to down-converted light. Additionally, the long-term stability of generated power was manifested with a relative fluctuation as low as 0.17% over one hour. Thanks to the all-optical passive synchronization and all-polarization-maintaining fiber architecture, the implemented laser system was also featured with simplicity, compactness and robustness, which would favor subsequent applications beyond laboratory operation.

关键词： mid-infrared fiber laser nonlinear optics difference-frequency generation

Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 392-397页

作者： Yong-Dan Zhao Yidan Wang Rongrong Wang Lina Chen Hengtong Zuo Xi Wang Jihong qiang Geng Wang Qingxia Li Canqi Ping Shuqiu Zhang hao Wang School of Pharmacy Shanxi Medical UniversityTaiyuan 030001China National Center for Nanoscience and Technology Beijing 100190China Artemisinin Research Center Institute of Chinese Materia MedicaBeijing 100700China

Artemisinin(ART)resistance has been an emerging clinical problem,severely compromising antimalarial efficacy and threatening the global malaria elimination *** intensive studies about the molecular mechanism for ART resistance are under way,no effective therapeutic targets for reversing resistance have been ***,we explore glutathione(GSH)as a therapeutic target to develop a thermo-responsive nanoplatform to specifically co-deliver ART and GSH synthesis inhibitor(L-buthionine sulfoximine,BSO)in a sustained manner,effectively reversing ART resistance in *** combining with BSO,ART exerts increased antimalarial activity with reduced half-maximal inhibitory concentration(IC50)by 7.43-fold in ART-resistant *** work reveals that the GSH in ART-resistant parasites can be a promising therapeutic target for reversing ART resistance,paving the way for developing drug candidates and intelligent nanomedicines in malaria therapy.

关键词： Nanomedicines Drug delivery Artemisinins resistance Malaria Glutathione

Rapid thermal sensors with high resolution based on an adaptive dual-comb system

在线全文

学校读者我要写书评

暂无评论

Frontiers of Information Technology & Electronic Engineering 2019年第5期20卷 674-684页

作者： Yi-zheng GUO Ming YAN qiang hao Kang-wen YANG Xu-ling SHEN He-ping ZENG Shanghai Key Laboratory of Modem Optical System Engineering Research Center of Optical Instrument and System (Ministry of Education) School of Optical-Electrical and Computer Engineering University of Shanghai for Science and Technology Shanghai 200093 China State Key Laboratory of Precision Spectroscopy East China Normal University Shanghai 200062 China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China

We report a high-resolution rapid thermal sensing based on adaptive dual comb spectroscopy interrogated with a phase-shifted fiber Bragg grating(PFBG). In comparison with traditional dual-comb systems, adaptive dual-comb spectroscopy is extremely simplified by removing the requirement of strict phase-locking feedback loops from the dual-comb configuration. Instead, two free-running fiber lasers are adopted as the light sources. Because of good compensation of fast instabilities with adaptive techniques, the optical response of the PFBG is precisely characterized through a fast Fourier transform of the interferograms in the time domain. Single-shot acquisition can be accomplished rapidly within tens of milliseconds at a spectral resolution of 0.1 pm, corresponding to a thermal measurement resolution of 0.01 ℃. The optical spectral bandwidth of the measurement also exceeds 14 nm, which indicates a large dynamic temperature range. It shows great potential for thermal sensing in practical outdoor applications with a loose self-control scheme in the adaptive dual-comb system.

关键词： Interferometers Fiber sensors Laser spectroscopy

A case study of regional eco-hydrological characteristics in the Tao River Basin, northwestern China, based on evapotranspiration estimated by a coupled Budyko Equation-crop coefficient approach

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2015年第11期58卷 2103-2112页

作者： LI ChangBin ZHANG XueLei QI JiaGuo WANG ShuaiBing YANG LinShan YANG WenJin ZHU GaoFeng hao qiang Key Laboratory of Western China’s Environmental Systems (Ministry of Education) Lanzhou University Center for Global Change and Earth Observations Michigan State University Ocean College Zhejiang University

In a case study in Tao River Basin, China, we derived a high spatial-resolution regional distribution of evapotranspiration(ET) using the single crop coefficient method and Budyko equation. We then further analyzed the spatio-temporal characteristics of this diverse eco-hydrological basin from 2001–2010. The results suggest that the single crop coefficient method based on leaf area index captures better spatial and temporal dynamics of the regional ET than did the Budyko Equation method. The rising temperature was the main reason for the increasing ET in the Tao River Basin during 2001–2010. Areas with high ET efficiency were distributed mainly in the areas where the vegetation coverage was high, and a lower runoff coefficient responded. The estimated spatial patterns of ET allowed an improved understanding of the eco-hydrological processes within the Tao River Basin and the method used might be generalized as a reference for future regional-scale eco-hydrological research.

关键词：中国西北部洮河流域系数法方程法水文特征区域生态蒸散发量作物

Genome-wide analysis of Panonychus citrimicro RNAs witha focus on potential insecticidal activity of 4 micro RNAs toeggs and nymphs

在线全文

学校读者我要写书评

暂无评论

Insect Science 2024年第2期31卷 354-370页

作者： Chuan-Zhen Li Yu-Hang Liu Deng Pan Meng-hao Xia qiang Zhang Yu-Chuang Li Guo-Rui Yuan Jin-Jun Wang Wei Dou Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwestUniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina

Panonychus citriMcGregor(Acari:Tetranychidae),a destructive citrus pest,causes considerable annual economic losses due to its short lifespan and rapid ***(miRNA)-induced RNA interference is a promising approachfor pest control because of endogenous regulation of pest growth and *** for miRNAs with potential insecticidal activity ***,genome-wide analysis ofmiRNAs at different developmental stages was conducted,resulting in the identificationof 136 miRNAs,including 73 known and 63 novel miRNAs.A total of 17 isomiRNAsand 12 duplicated miRNAs were ***-1 and miR-252-5p were identified asreference miRNAs *** *** on differential expressionanalysis,treatments with miR-let-7a and miR-315 mimics and the miR-let-7a antagomirsignificantly reduced the egg hatch rate and resulted in abnormal egg ***-expression or downregulation of miR-34-5p and miR-305-5p through feeding significantlydecreased the adult eclosion rate and caused molting *** 4 miRNAs,miR-let-7a,miR-315,miR-34-5p,and miR-305-5p,had important regulatory functions and insectici-dal properties in egg hatching and adult *** general,these data advance our un-derstanding of miRNAs in mite biology,which can assist future studies on insect-specificmiRNA-based green pest control technology.

关键词： growth and development microRNAs Panonychus citri referencemiRNAs regulation small RNA libraries