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Neural Regeneration Research 2013年第26期8卷 2424-2431页

作者： Xiuyan Guo Lei Zhu li Zheng Jianqi li qianfeng Wang Zhiliang Yang Shanghai Key Laboratory of Magnetic Resonance East China Normal University School of Psychology and Cognitive Science East China Normal University Department of Psychology Fudan University Department of Physics East China Normal University

Episodic memories are composed of various interrelated elements, including those specific to items of central interest and those pertaining to related features, such as the color, shape, size, spatial location, temporal order, and media or modalities of presentation. Memory about a core item （such as a word, object, or picture） is called item memory while memory about the context or related fea- tures of a core item is defined as source memory. What determines which sources within an episode are successfully remembered is of particular interest to researchers. Behavioral evidence suggests that the orientation of a memory task influences whether the related source of the item will be re- membered later. This study explored changes in the hippocampus and prefrontal cortex while par- ticipants completed two tasks： an item-oriented task and a source-oriented task. We used functional MRI to investigate the neural mechanisms by which task orientation influences source encoding. We found that subsequent source memory effects in the right prefrontal cortex and hippocampus were modulated by task orientation, whereas task orientation modulated item memory effects in the prefrontal cortex. These findings highlight the possibility that the hippocampus contributes to the intentional encoding of item-source associations, whereas the prefrontal cortex is biased toward processing information to which attention is directed.

关键词： neural regeneration neuropsychology learning source memory task orientation hippocampus prefrontal cortex functional MRI grants-supported paper neuroregeneration

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车辆动载对高填边坡的动力响应分析

路基工程 2024年第5期 153-157页

作者：后钱峰李清滢刘再兴上海宝冶集团有限公司建筑设计研究院上海201900 昆明理工大学建筑工程学院昆明650500

以云南某高填边坡为对象,建立有限元模型,对不同车载、车速及车载作用位置下的边坡动力响应进行分析,研究车辆动载对高填边坡的影响。结果表明:车载、车速及车载作用位置三个影响因素中,车载对高填边坡的影响最大;车辆动载作用下,车载... 详细信息

以云南某高填边坡为对象,建立有限元模型,对不同车载、车速及车载作用位置下的边坡动力响应进行分析,研究车辆动载对高填边坡的影响。结果表明:车载、车速及车载作用位置三个影响因素中,车载对高填边坡的影响最大;车辆动载作用下,车载振源附近边坡位移最大;边坡最小稳定系数与车载呈线性递减型关系,而与车速及车载作用位置均呈指数递增型关系。

关键词：高填边坡车辆动载位移场稳定性有限元

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混合锌源法制备甘氨酸锌新工艺研究

河北工业科技 2015年第6期32卷 538-542页

作者：徐志伟冯辉宋秋月李前锋王秀茹河北东华冀衡化工有限公司河北武邑053400

为提高甘氨酸锌生产的综合转化率,提出了一条混合锌源法合成甘氨酸锌的新工艺。该工艺首次反应以乙酸锌、氧化锌、甘氨酸为原料,在水相中进行反应合成,混合液经反应、冷却、结晶、过滤,滤液作为二次反应的母液,固体晾干后即为产品甘氨... 详细信息

为提高甘氨酸锌生产的综合转化率,提出了一条混合锌源法合成甘氨酸锌的新工艺。该工艺首次反应以乙酸锌、氧化锌、甘氨酸为原料,在水相中进行反应合成,混合液经反应、冷却、结晶、过滤,滤液作为二次反应的母液,固体晾干后即为产品甘氨酸锌。根据产品的量向母液中补加对应量的甘氨酸和氧化锌继续反应,将反应液循环利用。当甘氨酸与锌源的物质的量比为2∶1时,首次反应的适宜操作条件如下:n(氧化锌)∶n(乙酸锌)=5∶1,m(水)∶m(甘氨酸)为3∶1,反应时间为2.0h,反应温度为90℃,首次收率为55.39%。母液循环使用4次后,收率仍能接近100%,且不影响产品品质。各种检测分析表明,此工艺合成的甘氨酸锌符合国家标准。

关键词：化学反应工程甘氨酸锌锌源甘氨酸氧化锌乙酸锌

liN9 confers paclitaxel resistance in triple negative breast cancer cells by upregulating CCSAP

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Science China(life Sciences) 2020年第3期63卷 419-428页

作者： Hongna Lai Rui Wang Shunying li qianfeng Shi Zijie Cai Yudong li Yujie liu Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Breast Tumour Center Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Division of Vascular Surgery First Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510080China

liN9 functions to regulate cell mitotic *** of liN9 expression is associated with development of human *** this study we assessed the association of liN9 expression with paclitaxel resistance and clarified the underlying mechanisms for the first ***9 expression in breast cancer tissues was retrieved from publicly available online databases and statistically *** TNBC cell lines MDA-MB-231 and MDA-MB-468 and their corresponding paclitaxelresistant sublines 231PTX and 468PTX were used to assess the expression of liN9 by qRT-PCR and Western blot,cell growth by cell counting,cell viability by MTS assay,and cell apoptosis by flow *** data showed that high liN9 expression in breast cancer patients receiving chemotherapy was related to poor overall survival(OS).liN9 expression was upregulated in paclitaxel-resistant TNBC cells compared to their parental *** of liN9 or treatment of paclitaxel-resistant TNBC cells with a bromo-and extra-terminal domain inhibitor(BETi)JQ1 which also decreased liN9 expression enhanced the sensitivity of paclitaxel-resistant TNBC cells to ***,decreased liN9 in resistant cell lines reduced tumor cell viability,promoted multinucleated cells formation and induced tumor cell apoptosis,potentially by directly regulating microtubule-binding protein *** conclusion,high liN9 expression contributed to poor clinical outcomes and paclitaxel resistance in TNBC and BETi,targeting liN9 expression,could be a reversible drug for PTX-resistant TNBC patients.

关键词： liN9 triple negative breast cancer paclitaxel resistance BET inhibitor

Effect of initial gravimetric water content and cyclic wetting-drying on soil-water characteristic curves of disintegrated carbonaceous mudstone

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Transportation Safety and Environment 2019年第3期1卷 230-240页

作者： ling Zeng Fan li Jie liu qianfeng Gao Hanbing Bian School of Civil Engineering Changsha University of Science&Technology School of Traffic&Transportation Engineering Changsha University of Science&Technology Laboratoire de Génie Civil et géo-Environnement Universitéde Lille

The soil-water characteristic curve(SWCC)is often used to estimate unsaturated soil properties(***,permeability,volume change,solute and thermal diffusivity).The SWCC of soil samples is significantly affected by cyclic *** examine how water content and cyclic wetting-drying affect the SWCC of disintegrated carbonaceous mudstone(DCM),SWCC tests were implemented using a pressure-plate *** addition,SWCC models for DCM considering the initial gravimetric water content and cyclic wetting-drying were *** test results showed that the volumetric water content(θ)of the DCM first decreased rapidly and then became stable as matric suction(s)*** initial water content affected the SWCC by altering the pore structure of the *** a given number of wetting-drying cycles,the higher the initial water content,the higher the stabilizedθ.At a given s value,θdecreased as the number of wetting-drying cycles increased,which suggests that cyclic wetting-drying reduces the water-holding capacity of *** Gardner model for DCM was constructed considering initial water content and cyclic wetting-drying,and was effective at describing and predicting the SWCC model for DCM.

关键词： embankment engineering disintegrated carbonaceous mudstone soil-water characteristic curve initial gravimetric water content cyclic wetting-drying

神经传导速度测定联合表面肌电图检查在脑卒中偏瘫患者中的应用价值分析

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当代医药论丛 2023年第16期21卷 38-41页

作者：洪盈盈薛开禄李浅峰于力争张姣林文政深圳市大鹏新区南澳人民医院康复医学科广州深圳518121 深圳平乐骨伤科医院广州深圳518010

目的:探讨分析神经传导速度测定联合表面肌电图检查在脑卒中偏瘫患者中的应用价值。方法:选取深圳市大鹏新区南澳人民医院收治的脑卒中偏瘫患者46例为研究对象,对患者的健侧肢体(纳入常模组)和患侧肢体(纳入研讨组)均进行神经传导速度... 详细信息

目的:探讨分析神经传导速度测定联合表面肌电图检查在脑卒中偏瘫患者中的应用价值。方法:选取深圳市大鹏新区南澳人民医院收治的脑卒中偏瘫患者46例为研究对象,对患者的健侧肢体(纳入常模组)和患侧肢体(纳入研讨组)均进行神经传导速度测定联合表面肌电图检查,并对检查结果进行对比分析。结果:研讨组腓总神经、胫神经的运动神经传导速度和感觉神经传导速度均低于常模组,差异有统计学意义(P<0.05)。研讨组的胫骨前肌、腓肠肌积分肌电值(IEMG)和协同收缩率均高于常模组,差异有统计学意义(P<0.05)。结论:脑卒中偏瘫患者通过进行神经传导速度测定联合表面肌电图检查能够对神经损伤情况及肌张力、肌力水平进行了解,掌握患者的详细病情,为临床康复治疗提供依据。

关键词：神经传导速度测定表面肌电图检查脑卒中偏瘫

Brassinosteroid and gibberellin coordinate rice seed germination and embryo growth by regulating glutelin mobilization

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The Crop Journal 2021年第5期

作者： Min Xiong lingyi Chu qianfeng li Jiawen Yu Yihao Yang Peng Zhou Yong Zhou Changquan Zhang Xiaolei Fan Dongsheng Zhao Changjie Yan Qiaoquan liu

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论油田内部小型企业改制的模式

西南石油学院学报 1998年第2期20卷 91-93页

作者：张明泉刘谦峰赵仕兵李燕敏西南石油学院经济管理系中原油田企业管理办公室

对于油田内部小型企业而言，尽管已经在体制改革的某些方面取得了成绩，但与改革的总体目标相比，仍存在较大的差距。如何进一步搞活这些内部小型企业已经成为我国各油田普遍关心的一个紧迫问题。文章探讨了我国油田内部小型企业体制改... 详细信息

对于油田内部小型企业而言，尽管已经在体制改革的某些方面取得了成绩，但与改革的总体目标相比，仍存在较大的差距。如何进一步搞活这些内部小型企业已经成为我国各油田普遍关心的一个紧迫问题。文章探讨了我国油田内部小型企业体制改革的环境条件和这些企业存在的主要问题，研究了油田内部小型企业进行股份合作制改造的现实意义和改革模式的选择，提出了油田内部小型企业进行股份合作制改造应遵循的基本程序。

关键词：小型企业股份合作制企业改制模式油田

The First-principles Study on the Occupation Behavior and the Ductility Mechanism of Zr in Ni-Ni_3Al System with Lattice Misfit

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Journal of Materials Science & Technology 2014年第5期30卷 517-522页

作者： Yuxi Wu Wanglin Zhang Jia Guo Jieshan Hou Xiuyan li Renzhong Huang Xiufang Ma qianfeng Zhang Institute of Molecular Engineering and Applied Chemistry Anhui University of Technology Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences College of Physics Science and Technology Shenyang Normal University

The influence of lattice misfit on the occupation behavior and the ductility effect of Zr in Ni-Ni3Al alloys were explored. It is found in energy analysis that the preferable site of Zr between Ni sublattice and Al sublattice will change under different lattice misfit, however, the Zr prefers to segregate Ni phase rather than Ni3Al phase in all lattice misfit range, which makes it impossible for Zr to go into Ni3Al phase to occupy Al sublattice in Ni-Ni3Al system. Bond order （BO） analysis shows that the localized ductility effect of Zr differs in different region, and the comparison between Zr-free and Zr-doped BO analysis successfully explain the mechanism of the embrittlement of Ni-Ni3Al alloys and the ductility effect of Zr.

关键词： Zirconium Lattice misfit Occupation behavior Ductility Embrittlement