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Introgression of lac6/tl1/du13 improves the palatability of japonica rice

The Crop Journal 2024年第4期12卷 1259-1265页

作者： Yong Yang Tao Zhang Yuliang Shi Yan Lu qianfeng li Xiaolei Fan lichun Huang Lu Chen Xuetang Song Qing liu Changquan Zhang Qiaoquan liu Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Zhongshan Biological Breeding Laboratory/Key Laboratory of Plant Functional Genomics of the Ministry of Education Agricultural College of Yangzhou UniversityYangzhou 225009JiangsuChina Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops/Jiangsu Key Laboratory of Crop Genetics and Physiology Yangzhou UniversityYangzhou 225009JiangsuChina Jiang Su(Wu Jin)Rice Research Institute Changzhou 213175JiangsuChina

Amylose content(AC)is a crucial determinant of the eating and cooking quality(ECQ)of rice,with low AC varieties exhibiting a softer texture and greater stickiness-attributes that enhance palatability and are desirable in specific culinary *** harness these traits,significant efforts have been made to manipulate AC to improve rice *** research utilized the MutMap+approach to identify LAC6/TL1,a gene that is an allele of Du13,responsible for low ***6 encodes a C2H2 zinc finger protein,which specifically increases the splicing efficiency of the Wxb allele without affecting the Wxa *** studies of LAC6 revealed that its proper integration could rectify the undesirable AC phenotype,whereas mutations within this gene led to reduced AC and were associated with shorter grain length and decreased thousand-grain *** these drawbacks,such mutations positively impact rice palatability,presenting a trade-off between grain size and eating *** address the challenges posed by the reduced grain weight associated with LAC6 mutations,we developed a specific molecular marker for LAC6,which has been effectively used in breeding programs to select lac6/tl1/du13 homozygous individuals with larger grain *** findings demonstrate that the“small grain”trait associated with lac6/tl1/du13 can be effectively mitigated through combined phenotype-based and marker-assisted *** study highlights the potential of lac6/tl1/du13 as a valuable gene for breeding novel,high-quality soft rice varieties through targeted breeding strategies.

关键词： Rice Dull endosperm Amylose content Wx Breeding

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基于EDEMpy的枸杞离散元仿真参数标定与试验

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农机化研究 2024年第9期46卷 30-38页

作者：虎小雅高垚垚王昱潭曲爱丽李乾峰魏迟宁夏大学机械工程学院银川750021 石嘴山工贸职业技术学院宁夏石嘴山753000 北京林业大学工学院北京100083

为探究枸杞离散元仿真边界参数的最优组合,提高离散单元仿真方法研究枸杞与采收机械作用机理的准确性,提升后续枸杞机械采收设备的研发效率及机械作业性能,选取EDEM中“Hertz-Mindlin with Johnson-Kendall-Roberts”凝聚力接触模型,通... 详细信息

为探究枸杞离散元仿真边界参数的最优组合,提高离散单元仿真方法研究枸杞与采收机械作用机理的准确性,提升后续枸杞机械采收设备的研发效率及机械作业性能,选取EDEM中“Hertz-Mindlin with Johnson-Kendall-Roberts”凝聚力接触模型,通过物理试验测量枸杞堆积角、枸杞-钢板静摩擦因数、枸杞-钢板碰撞恢复系数。在物理试验的基础上,采用基于EDEMpy的仿真试验方法对枸杞的接触参数进行试验研究,以枸杞颗粒的静摩擦因数、滚动摩擦因数、碰撞恢复系数、表面能JKR为影响因素,以堆积角为目标进行多因素试验,并建立回归模型。试验结果表明:对枸杞仿真堆积角影响显著的参数为枸杞-枸杞静摩擦因数、枸杞-枸杞滚动摩擦因数、表面能JKR。以实际堆积角为目标值,对回归模型进行优化分析,得到显著性参数最优组合值分别为:枸杞-枸杞静摩擦因数0.506,枸杞-枸杞滚动摩擦因数0.064,表面能JKR0.048,该组合下的仿真堆积角平均值为28.82°,与实际堆积角的偏差小于4%,边界参数标定结果可靠。研究结果可为枸杞离散元模型边界参数的选取提供参考。

关键词：枸杞离散元 EDEMpy 凝聚力参数标定堆积角

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秋水仙碱治疗经皮冠状动脉腔内成形术后血管再狭窄模型大鼠的效果及其机制研究

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实用心脑肺血管病杂志 2024年第9期32卷 67-72页

作者：赖春进黄石安王尧李浅峰广东医科大学附属医院心内科广东省湛江市524023 广东省东莞市台心医院心内科 523125 深圳大学第一附属医院康复医学科广东省深圳市518000 大鹏新区南澳人民医院神经康复科广东省深圳市518121

目的分析秋水仙碱治疗经皮冠状动脉腔内成形术(PTCA)后血管再狭窄模型大鼠的效果及其机制。方法本实验时间为2021年8月—2022年8月。在45只SPF级雄性SD大鼠中选取35只并建立PTCA后血管再狭窄模型。将建模成功的30只大鼠随机分为模型组... 详细信息

目的分析秋水仙碱治疗经皮冠状动脉腔内成形术(PTCA)后血管再狭窄模型大鼠的效果及其机制。方法本实验时间为2021年8月—2022年8月。在45只SPF级雄性SD大鼠中选取35只并建立PTCA后血管再狭窄模型。将建模成功的30只大鼠随机分为模型组、培哚普利组、秋水仙碱组,各10只;将剩余10只未建模的大鼠设为正常组。正常组与模型组不进行干预,培哚普利组接受培哚普利0.4 mg·kg^(-1)·d^(-1)灌胃干预,秋水仙碱组接受秋水仙碱0.1 mg·kg^(-1)·d^(-1)灌胃干预,均干预30 d。干预结束后每组取3只大鼠,采用HE染色观察颈动脉病理改变情况并计算血管再狭窄面积和血管再狭窄率;干预结束后每组取3只大鼠,采用TUNEL法检测血管平滑肌细胞凋亡率;干预结束后每组取2只大鼠,采用Western blotting法检测颈动脉组织中IL-6、IL-1β、TNF-α蛋白相对表达水平;干预结束后每组取2只大鼠,采用荧光定量PCR法检测颈动脉组织中IL-6、IL-1β、TNF-αmRNA相对表达水平。结果HE染色结果显示,模型组大鼠血管内膜增厚且管腔狭窄明显,血管新生内膜排列严重紊乱;培哚普利组与秋水仙碱组大鼠管腔狭窄程度均较模型组有所减轻,其中秋水仙碱组减轻更为明显。培哚普利组、秋水仙碱组血管再狭窄面积小于模型组、血管再狭窄率低于模型组,秋水仙碱组血管再狭窄面积小于培哚普利组、血管再狭窄率低于培哚普利组(P<0.05)。模型组血管平滑肌细胞凋亡率低于正常组,培哚普利组、秋水仙碱组血管平滑肌细胞凋亡率高于正常组、模型组,秋水仙碱组血管平滑肌细胞凋亡率高于培哚普利组(P<0.05)。模型组、培哚普利组、秋水仙碱组颈动脉组织中IL-6、IL-1β、TNF-α蛋白及其mRNA相对表达水平高于正常组,培哚普利组、秋水仙碱组颈动脉组织中IL-6、IL-1β、TNF-α蛋白及其mRNA相对表达水平低于模型组,秋水仙碱组颈动脉组织中IL-6、IL-1β、TNF-α蛋白及其mRNA相对表达水平低于培哚普利组(P<0.05)。结论秋水仙碱可有效治疗PTCA后血管再狭窄模型大鼠,其机制可能与秋水仙碱可诱导血管平滑肌细胞凋亡、通过抑制炎症因子的生成来减轻炎症反应有关。

关键词：冠状动脉再狭窄经皮冠状动脉腔内成形术秋水仙碱大鼠治疗结果

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Starch biosynthesis in cereal endosperms: An updated review over the last decade

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Plant Communications 2021年第5期2卷 1-22页

作者： lichun Huang Hongyan Tan Changquan Zhang qianfeng li Qiaoquan liu Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding State Key Laboratory of Hybrid RiceKey Laboratory of Plant Functional Genomics of the Ministry of EducationCollege of AgricultureYangzhou UniversityYangzhou 225009China Co-Innovation Center for Modern Production Technology of Grain Crops of Jiangsu Province Key Laboratory of Crop Genetics and Physiology of Jiangsu ProvinceYangzhou UniversityYangzhou 225009China

Starch is a vital energy source for living organisms and is a key raw material and additive in the food and non-food *** has received continuous attention in multiple research *** endosperm of cereals(e.g.,rice,corn,wheat,and barley)is the most important site for the synthesis of storage *** 2010,several excellent reviews summarized key progress in various fields of starch research,serving as important references for subsequent *** the past 10 years,many achievements have been made in the study of starch synthesis and regulation in *** present review provides an update on research progress in starch synthesis of cereal endosperms over the past decade,focusing on new enzymes and non-enzymatic proteins involved in starch synthesis,regulatory networks of starch synthesis,and the use of elite alleles of starch synthesis-related genes in cereal breeding *** also provide perspectives on future research directions that will further our understanding of cereal starch biosynthesis and regulation to support the rational design of ideal quality grain.

关键词： cereal starch biosynthesis regulation network endosperm development quality improvement

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自来水厂精准加氯初步探索

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贵州科学 2024年第2期42卷 66-69页

作者：魏连通李前峰张航谢健杨少博卢志国家城市供水水质监测网贵阳监测站贵州贵阳550001 贵州筑水环境监测有限公司贵州贵阳550001

消毒是净水工艺中至关重要的环节,消毒剂过多或过少都会带来不好的结果。本文围绕原水、沉后水精准加氯,初步绘制出加氯量与余氯的曲线,根据曲线计算出的理论值与实测值相比基本一致。精准加氯不仅可以解决水中消毒剂忽高忽低造成浪费,... 详细信息

消毒是净水工艺中至关重要的环节,消毒剂过多或过少都会带来不好的结果。本文围绕原水、沉后水精准加氯,初步绘制出加氯量与余氯的曲线,根据曲线计算出的理论值与实测值相比基本一致。精准加氯不仅可以解决水中消毒剂忽高忽低造成浪费,也能保证水质各项指标控制在规定范围内。加氯量与余氯曲线能够对净水工艺中水厂精准加氯起到指导作用。

关键词：次氯酸钠精准加氯消毒

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THE GLOBAL liPSCHITZ SOLUTION FOR A PEEliNG MODEL

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数学物理学报:B辑英文版 2023年第5期43卷 2263-2278页

作者：黎前锋张永前 School of Mathematical Sciences and Shanghai Key Laboratory of Pure Mathematics and Mathematical Practice East China Normal UniversityShanghai 200241China School of Mathematical Sciences Fudan UniversityShanghai 200433China

This paper focusses on a peeling phenomenon governed by a nonlinear wave equation with a free *** the hypotheses that the total variation of the intial data and the boundary data are small,the global existence of a weak solution to the nonlinear problem(1.1)-(1.3)is proven by a modified Glimm *** regularity of the peeling front is established,and the asymptotic behaviour of the obtained solution and the peeling front at infinity is also studied.

关键词： peeling model nonlinear wave solution free boundary Glimm scheme

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OsbZIP09,a Unique OsbZIP Transcription Factor of Rice,Promotes Rather Than Suppresses Seed Germination by Attenuating Abscisic Acid Pathway

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Rice science 2021年第4期28卷 358-367,I0021-I0023页

作者： Wang Chuxin Zhu Chengchao Zhou Yu Xiong Min Wang Jindong Bai Huang Lu Chenya Zhang Changquan liu Qiaoquan li qianfeng Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Key Laboratory of Crop Genetics and Physiology of Jiangsu Province College of AgricultureYangzhou UniversityYangzhou 225009China Co-Innovation Center for Modern Production Technology of Grain Crops of Jiangsu Province/Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education Yangzhou UniversityYangzhou 225009China

We successfully identified a novel and unique OsbZIP transcription factor,OsbZIP09,whose mutants exhibited longer seeds and less severe pre-harvest sprouting than the wild type,but shared similar germination rate as the wild type under normal germination *** expression of OsbZIP09 was induced by abscisic acid(ABA)and declined as the germination *** a nucleus-localized transcription factor,the conserved binding motif of OsbZIP09 was identified via DNA affinity purification sequencing *** evidences indicated that OsbZIP09 directly enhanced the expression of ABA catabolism gene ABA8ox1,thus reducing ABA *** addition,OsbZIP09 also directly bound to the promoter of LEA3 gene to inhibit its expression,thus further alleviating the suppressive effect of ABA on seed *** results demonstrated that OsbZIP09 likely functions as a brake of the ABA pathway to attenuate the inhibitory effect of ABA on rice seed germination via dual strategies.

关键词： OsbZIP09 pre-harvest sprouting abscisic acid seed germination ABA8ox1 gene LEA3 gene rice transcription factor

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Introgression of lac6/tl1/du13 improves the palatability of japonica rice

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The Crop Journal 2024年第4期 1259页

作者： Yong Yang Tao Zhang Yuliang Shi Yan Lu qianfeng li Xiaolei Fan lichun Huang Lu Chen Xuetang Song Qing liu Changquan Zhang Qiaoquan liu

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Generation of selectable marker-free soft transgenic rice with transparent kernels by downregulation of SSSⅡ-2

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The Crop Journal 2020年第1期8卷 53-61页

作者： Zhihao Xu Meimei Yu Youwei Yin Cenwen Zhu Wen Ji Changquan Zhang qianfeng li Honggen Zhang Shuzu Tang Hengxiu Yu Qiaoquan liu Jiangsu Key Laboratory of Crop Genetics and Physiology Key Laboratory of Plant Functional Genomics of the Ministry of EducationJiangsu Key Laboratory of Crop Genomics and Molecular BreedingJiangsu Co-Innovation Center for Modern Production Technology of Grain CropsCollege of AgricultureYangzhou University

The amylose content(AC) of rice endosperm starch varies from 0 to 35%,and is associated with rice cooking and eating *** rice has low AC,generally between 6% and 15%,and its eating quality is high whether it is consumed hot or ***,the appearance quality of current soft rice cultivars needs to be improved,especially opaque *** genetic engineering has improved some agronomic traits of soft rice varieties,but not endosperm *** the present study,a RNAi construct of the soluble starch synthase Ⅱ-2(SSSⅡ-2) and the hygromycin phosphotransferase(HPT) gene were introduced into an elite japonica rice variety,Kangtiaowuyunjing(KWY8) by *** selectable marker-free(SMF) transgenic lines were obtained,and SSSⅡ-2 expression was significantly downregulated in selected transgenic lines,resulting in lower AC of the *** physicochemical properties of the transgenic rice kernels,including gel consistency(GC) and rapid visco analyzer(RVA) profile,differed significantly from those of wild-type rice and were similar to those of a soft rice variety,Nanjing 46(NJ46).These findings indicate that the cooking,eating,and processing qualities of transgenic rice are comparable to those of ***,the transgenic rice endosperm retained a transparent appearance under low-moisture ***,SMF SSSⅡ-2 RNAi rice provides a resource for breeding soft rice with transparent endosperm.

关键词： Rice(Oryza sativa L.) SSSⅡ-2 RNAi Starch quality SMF transgenic lines

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Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2194-2209页

作者： Zhilin li qianfeng Zhang Zhiqian li Long Ren Dayi Pan Qiyong Gong Zhongwei Gu Hao Cai Kui Luo Department of Radiology Huaxi MR Research Center(HMRRC)Clinical Research Center for BreastDepartment of Breast SurgeryDepartment of Thoracic Surgery and Institute of Thoracic OncologyFrontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China Hospital Sichuan UniversityChengdu 610041China Functional and Molecular Imaging Key Laboratory of Sichuan Province and Research Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610041China Department of Radiology West China Xiamen Hospital of Sichuan UniversityXiamen 361021China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Key Laboratory of Research and Development for Natural ProductsSchool of PharmacyYunnan UniversityKunming 650500China

Despite the great potential of anti-PD-L1 antibodies for immunotherapy,their low response rate due to an immunosuppressive tumor microenvironment has hampered their *** address this issue,we constructed a cell membrane-coated nanosystem(mB4S)to reverse an immunosuppressive microenvironment to an immuno-supportive one for strengthening the anti-tumor *** this system,Epirubicin(EPI)as an immunogenic cell death(ICD)inducer was coupled to a branched glycopolymer via hydrazone bonds and diABZI as a stimulator of interferon genes(STING)agonist was encapsulated into *** internalization of mB4S,EPI was acidic-responsively released to induce ICD,which was characterized by an increased level of calreticulin(CRT)exposure and enhanced ATP ***,diABZI effectively activated the STING *** with mB4S in combination with an anti-PD-L1 antibody elicited potent immune responses by increasing the ratio of matured dendritic cells(DCs)and CD8+T cells,promoting cytokines secretion,up-regulating M1-like tumor-associated macrophages(TAMs)and down-regulating immunosuppressive myeloid-derived suppressor cells(MDSCs).Therefore,this nanosystem for co-delivery of an ICD inducer and a STING agonist achieved promotion of DCs maturation and CD8+T cells infiltration,creating an immuno-supportive microenvironment,thus potentiating the therapy effect of the anti-PD-L1 antibody in both 4T1 breast and CT26 colon tumor mice.

关键词： Glycopolymer Polymer prodrug Immunogenic cell death Nanoassembly Epirubicin STING pathway Immuno-supportive microenvironment Immunotherapy

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